Material Characteristic Of Lens Patents (Class 623/6.56)
  • Patent number: 10561763
    Abstract: Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material that is used to form a coating, layer, or bulk substance that can be a solid, a gel or a fluid. The oxygen-carrier is most conveniently prepared by oxidation of a precursor compound, the structure of which determines its thermal stability and thus how rapidly oxygen is released at any given temperature.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: February 18, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Henry Ralph Rawls, Ahsan Ullah Khan
  • Patent number: 10476405
    Abstract: An element including: a first electrode; an intermediate layer; and a second electrode, the first electrode, the intermediate layer, and the second electrode being disposed in this order, the intermediate layer including an organic polymer material, where a molecular structure of the organic polymer material includes a structure represented by the following formula (1) where R1 is a carbonyl group, an ether group, a thioether group, or organopolysiloxane, and R1 may form a cyclic structure (an imide group) with R2; and R2 to R6 are organic groups that may be identical or different, where each of the organic groups may have a valency of 2 or more and may form another structure:
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: November 12, 2019
    Assignee: Ricoh Company, Ltd.
    Inventors: Junichiro Natori, Tsuneaki Kondoh, Tomoaki Sugawara, Yuko Arizumi, Takahiro Imai, Mizuki Otagiri
  • Patent number: 10195225
    Abstract: Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: February 5, 2019
    Assignee: PromiSight
    Inventors: Tongalp H. Tezel, Andrea S. Gobin, Martin G. O'Toole
  • Patent number: 9879035
    Abstract: A composition for fabricating an organic film, an organic light-emitting display apparatus manufactured using the same, and a method of manufacturing the organic light-emitting display apparatus, the composition comprising a first compound that includes n substituents Y, and m polymerizable groups P1, wherein n is selected from 1, 2, 3, and 4; m is selected from 1, 2, 3, and 4; OP1 of the first compound is equal to or greater than 2.8 and equal to or less than 4.8; OP1 being (total number of atoms of the first compound)/{(number of carbon atoms of the first compound)?(number of oxygen atoms of the first compound)}; and RP1 of the first compound is equal to or greater than 0.01 and equal to or less than 0.46; RP1 being {(number of carbon atoms of the substituent Y)X n}/(number of carbon atoms of the first compound).
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: January 30, 2018
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventors: Jinho Kwack, Seungyong Song, Taewook Kang, Youngseo Choi, Changmok Kim, Daebeom Shin, Yonghyuck Lee
  • Patent number: 9873613
    Abstract: Disclosed herein are radically initiated process involving tris(trimethylsilyl)silane that are suitable for surface functionalization or formation of composite materials based on functionalized nanoparticles.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: January 23, 2018
    Assignee: Functionalize, Inc.
    Inventor: Michael Toutonghi
  • Patent number: 9750849
    Abstract: Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material that is used to form a coating, layer, or bulk substance that can be a solid, a gel or a fluid. The oxygen-carrier is most conveniently prepared by oxidation of a precursor compound, the structure of which determines its thermal stability and thus how rapidly oxygen is released at any given temperature.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: September 5, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Henry Ralph Rawls, Ahsan Ullah Khan
  • Patent number: 9579191
    Abstract: An ophthalmic lens system comprises a lens body with a curved outer surface and an assembly including a plurality of spaced apart nanostructures. The assembly covers at least a portion of the curved outer surface.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: February 28, 2017
    Assignee: Novartis AG
    Inventors: Xin Hong, David Meadows, Qiwen Zhan, Mutlu Karakelle
  • Patent number: 9492272
    Abstract: Intraocular implants and methods of making intraocular implants are provided. The intraocular implants can improve the vision of a patient, such as by increasing the depth of focus of an eye of a patient. In particular, the intraocular implants can include a mask having an annular portion with a relatively low visible light transmission surrounding a relatively high transmission central portion such as a clear lens or aperture. This construct is adapted to provide an annular mask with a small aperture for light to pass through to the retina to increase depth of focus. The intraocular implant may have an optical power for refractive correction. The intraocular implant may be implanted in any location along the optical pathway in the eye, e.g., as an implant in the anterior or posterior chamber.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: November 15, 2016
    Assignee: AcuFocus, Inc.
    Inventors: Bruce A. Christie, Alexei N. Kosmynine
  • Patent number: 9381080
    Abstract: An intraocular lens (IOL) with excellent non-glistening characteristics comprising at least one copolymer comprising: (a) one or more first monomeric subunits comprising a polymerized acrylate and/or methacrylate group, at least one side group comprising (i) an aryloxy moiety, and (ii) an aliphatic carbon moiety linking the aryloxy moiety with the polymerized acrylate or methacrylate group, wherein the aliphatic carbon moiety comprises at least one hydroxyl substituent, (b) one or more second monomeric subunits different from the first monomeric subunits comprising a polymerized acrylate and/or methacrylate group, and comprising at least one alkoxyalkyl side group, (c) one or more third monomeric subunits different from the first and second monomeric subunits, the third monomeric subunits comprising a polymerized acrylate and/or methacrylate group, and comprising at least one alkylene oxide side group, wherein the first monomeric subunit is present in a greater amount by weight than the second monomeric subun
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 5, 2016
    Assignee: Benz Research and Development Corp.
    Inventors: Patrick H. Benz, Adam Reboul
  • Patent number: 9265866
    Abstract: Various embodiments of stents with a polymeric body with radiopaque metallic particles incorporated in the stent body.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: February 23, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Pamela A. Kramer-Brown, David C. Gale, Vincent J. Gueriguian, Yunbing Wang
  • Patent number: 9005282
    Abstract: The invention relates to a intraocular lens system having a flexible anterior lens accommodation material behind the lens. The accommodation material may comprise of one or more macromers, which, when polymerized, adjust the properties of the accommodation material. The anterior lens is flexible such that the curvature of the lens changes during accommodation. The anterior lens may be used alone or in combination with a posterior lens.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: April 14, 2015
    Assignee: Calhoun Vision, Inc.
    Inventors: Shiao H. Chang, Okihiro Nishi, Kayo Nishi, Jerry Kaeni, Ken Chuang
  • Patent number: 8932352
    Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: January 13, 2015
    Assignee: University of Rochester
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani
  • Patent number: 8900298
    Abstract: Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: December 2, 2014
    Assignee: PowerVision, Inc.
    Inventors: David Anvar, Andrew Goodwin, David Chazan
  • Patent number: 8901190
    Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: December 2, 2014
    Assignees: University of Rochester, Rochester Institute of Technology
    Inventors: Thomas Smith, Wayne H. Knox, Li Ding, Dharmendra Jani, Jeffrey G. Linhardt
  • Publication number: 20140336758
    Abstract: The invention relates to a method for hydrophilizing surfaces of polymer workpieces. The method has a step (a) of pretreating the workpiece surfaces in a high-frequency gas plasma which is produced on the basis of an inert gas in order to clean and activate the workpiece surfaces; a step (b) of precoating the pretreated workpiece surfaces with polyacrylic acid using a high-frequency gas plasma made of a gas mixture, said gas mixture being composed of an inert gas and a first gas made of biocompatible, polymerizable carboxy group-containing monomers; and a step (c) of subsequently coating the precoated workpiece surfaces using a second gas substantially containing acrylic acid monomers.
    Type: Application
    Filed: February 1, 2013
    Publication date: November 13, 2014
    Inventors: Martin Görne, Thomas Kordick
  • Publication number: 20140316521
    Abstract: Systems and methods for rewritable aberration-corrected gradient-index intraocular lenses are provided. Various embodiments relate to rewritable aberration-corrected gradient-index intraocular lenses. Some embodiments provide for polymer materials and processing to create full or partial rewritable phakic or pseudophakic intraocular lenses which allow for adjustable visual performance by doctors. Various methods to fabricate and adjust the lenses with optical and/or mechanical properties customized to the individual patient are also disclosed.
    Type: Application
    Filed: April 21, 2014
    Publication date: October 23, 2014
    Inventors: Robert R. McLeod, Michael Cole
  • Publication number: 20140252667
    Abstract: A cast mould for manufacturing a contact lens or an intraocular lens, wherein the cast mould is provided with a central part and a bearing ring and a flexible connection between the central part and the bearing ring. Further, an injection mould is provided for manufacturing such a cast mould and a method for manufacturing such a cast mould. The injection mould is provided with a mould cavity with a plunger biased by a spring towards the mould cavity which serves for compensating shrinkage which occurs during the curing of the plastic injected into the injection mould. Also described is a method for manufacturing a contact lens or intraocular lens with the aid of the cast mould, as well as a contact lens or intraocular lens obtained with this method.
    Type: Application
    Filed: June 11, 2012
    Publication date: September 11, 2014
    Applicant: INNOVALENS B.V.
    Inventors: Emerentius Maria Josephus Antonius Van Dijk, Joery Johannes Sinkeldam
  • Patent number: 8778381
    Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 15, 2014
    Assignee: Allergan, Inc.
    Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
  • Patent number: 8759414
    Abstract: Described is the use of polymers with a high refractive index for ophthalmic products and a process for the production thereof.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: June 24, 2014
    Assignee: Coronis GmbH
    Inventors: Wolfgang Müller-Lierheim, Joachim Storsberg, André Laschewsky, Eckhard Görnitz, Elsbeth Winter
  • Publication number: 20140172094
    Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.
    Type: Application
    Filed: September 13, 2013
    Publication date: June 19, 2014
    Inventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech, Michael D. Lowery, Daniel Urbaniak
  • Publication number: 20140135916
    Abstract: Disclosed are devices, methods and systems for treatment of eye disease, including open angle glaucoma and narrow angle glaucoma. Implants are described herein that create a directed flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can include a variety of features, including extruded features, such as rings and pegs, which can assist in preventing ocular tissue from collapsing onto the implant and occluding fluid pathways.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 15, 2014
    Applicant: Transcend Medical, Inc.
    Inventors: Luke Clauson, Steven John, David Lari, Sean Ianchulev, Michael Schaller
  • Publication number: 20140111763
    Abstract: A method is provided for addressing myopia progression or inclination to myopia in which the influence of accommodative lag stress on myopia is reduced or eliminated to counter eye axial length growth. User depth of focus is increased to relieve stress from overall accommodative effort and stress from accommodation and accommodative lag to retard myopia progression and enable continuous and long tem treatment by the user.
    Type: Application
    Filed: June 8, 2012
    Publication date: April 24, 2014
    Applicant: VISIONEERING TECHNOLOGIES, INC.
    Inventor: Richard A. Griffin
  • Patent number: 8685089
    Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: April 1, 2014
    Assignee: The Regents of the University of Colorado
    Inventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech
  • Patent number: 8680172
    Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: March 25, 2014
    Assignee: Visiogen, Inc.
    Inventor: Xiugao Liao
  • Publication number: 20130268072
    Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.
    Type: Application
    Filed: September 27, 2012
    Publication date: October 10, 2013
    Inventors: Thomas Smith, Wayne H. Knox, Li Ding, Dharmendra Jani, Jeffrey G. Linhardt
  • Publication number: 20130245756
    Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.
    Type: Application
    Filed: April 23, 2013
    Publication date: September 19, 2013
    Inventor: Xiugao Liao
  • Patent number: 8500806
    Abstract: An intraocular lens has a polymeric optic defined by a harder posterior layer and a softer anterior layer. Haptics having a fulcrum attached to the posterior layer and a resistance arm attached to the anterior layer are provided. A bias is provided to the haptic to rotate the haptics about the fulcrum and cause the resistance arm to deform the softer anterior layer about the harder posterior layer to increase the optical power of the lens. As the haptic rotates, it axially displaces the optic anteriorly to additionally increase the optical power. The optical power is adjustable in response to stresses induced by the eye. The haptics are subject to a pre-bias that urges the haptics to rotate or bend about the fulcrum. Temporary restraints are provided to the haptics to retain a stressed shape of the lens against the bias during a post-implantation healing period.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: August 6, 2013
    Inventor: Andrew F. Phillips
  • Patent number: 8500807
    Abstract: The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly when exposed to light.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: August 6, 2013
    Assignee: Carl Zeiss Meditec SAS
    Inventors: Pascal Bernard, Marc Dolatkhani, Anne Pagnoux, Christophe Hupin
  • Publication number: 20130197637
    Abstract: The invention relates to a novel method for preparing materials whose properties can be manipulated after fabrication. In this process, a base material is created in a manner that provides spaces or voids which can then be filled with a modifying composition. The method is particularly useful in the manufacture of light adjustable optical elements such as intraocular lenses.
    Type: Application
    Filed: December 12, 2012
    Publication date: August 1, 2013
    Applicant: CALHOUN VISION, INC
    Inventor: CALHOUN VISION, INC
  • Patent number: 8470034
    Abstract: The material of the invention is obtained by radical polymerization from a mixture of acrylic and/or methacrylic monomers. The mixture further contains at least one transfer agent, preferably from the thiol family, that substantially enhances the flexibility of the polymer material thus obtained, and reduces the tackiness thereof. The polymer material thus obtained is intended for making ophthalmologic implants, and more particularly, intraocular lenses.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: June 25, 2013
    Assignee: Acrylian
    Inventor: Jean Terrisse
  • Patent number: 8439974
    Abstract: The present invention relates to a method of determining the IOL refractive index for an ocular replacement material for replacing tissue in the capsular bag comprising combining a neutral (non-correcting) reference refractive index (“NRRI”) of between 1.421 and 1.450 with a refractive index correction factor (“RICF”) ascertained by reference to the refractive power required to correct the patient's refractive error. The present invention also relates to methods of treating presbyopia, myopia and hyperopia using the above method.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: May 14, 2013
    Assignee: Vision CRC Limited
    Inventors: Arthur Ho, Brien Anthony Holden, Fabrice Manns, Jean-Marie Arthur Parel
  • Publication number: 20130110235
    Abstract: An accommodating intraocular lens. The lens includes a substantially-rigid anterior member having an extrusion aperture. First transparent deformable material is disposed anterior to the posterior side of the anterior member. Second transparent deformable material is disposed adjacent the posterior surface of the first material, the second material having a different degree of deformability than the first material and having an index of refraction different from the index of refraction of the first material. This forms a refractive deformable interface between the body of first material and the body of the second material. Force applied to the second material causes that material to be extruded through the aperture so as to form a curved, refractive interface with the body of first material. A method for installation of the accommodating intraocular lens is also provided.
    Type: Application
    Filed: June 29, 2011
    Publication date: May 2, 2013
    Applicant: The Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: James T. Schwiegerling
  • Patent number: 8377126
    Abstract: Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: February 19, 2013
    Assignee: Bausch & Lomb Incorporated
    Inventors: Joseph A. McGee, David Paul Vanderbilt, Paul L. Valint, Jr.
  • Patent number: 8343214
    Abstract: A method and related apparatus to treat a cataract where the cataractous lens is pierced and the resulting opening is mechanically maintained using a lens system device such as a pinhole device, expandable tubular lens, a stent or similar small diameter device, some of which are capable of supporting a secondary intraocular lens. The resulting passageway or lumen created in the cataractous lens allows visible light to better reach the retina, thus improving vision. This lens system device that can be placed into an in situ cataract provides for a much simpler surgical technique and reduces related pre and post operative procedures and potential complications. Intraocular lenses may also be used in concert with this invention. The apparatus and technique can be applied to humans as well as animals.
    Type: Grant
    Filed: October 18, 2009
    Date of Patent: January 1, 2013
    Assignee: Cateract Innovations LLC
    Inventor: David Maxwell Kleinman
  • Patent number: 8337551
    Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer which has only one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming comonomers are disclosed.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: December 25, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Jeffrey G. Linhardt, Ivan M. Nunez, Joseph A. McGee, Jennifer Hunt, Michele Alton, Drazen Pavlovic, Devon A. Shipp
  • Patent number: 8337553
    Abstract: The invention is directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: December 25, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra M. Jani, Candido D. Pinto
  • Patent number: 8308800
    Abstract: Intraocular lenses with high contrast haptics, materials and methods for making optical blanks and lenses, and methods of use are disclosed and claimed. Such lenses may provide easily recognizable visual cues that may be used to detect and correct misorientation of lenses prior to and during use.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: November 13, 2012
    Inventor: Milton W. Chu
  • Publication number: 20120259411
    Abstract: An ophthalmic lens system comprises a lens body with a curved outer surface and an assembly including a plurality of spaced apart nanostructures. The assembly covers at least a portion of the curved outer surface.
    Type: Application
    Filed: April 4, 2012
    Publication date: October 11, 2012
    Applicant: Novartis AG
    Inventors: Xin Hong, David Meadows, Qiwen Zhan, Mutlu Karakelle
  • Publication number: 20120245684
    Abstract: Some embodiments provide a copolymer comprising: an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyldialkylsiloxy pendant group. The copolymers may be useful as soft acrylic haptics for intraocular lenses. Some embodiments further relate to intraocular lenses having a hydrophobic soft acrylic optic and a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic bodies and a silicone haptic. Related copolymeric composite materials as well as additional embodiments of intraocular lenses, are also described herein.
    Type: Application
    Filed: June 6, 2012
    Publication date: September 27, 2012
    Applicant: Visiogen, Inc.
    Inventor: Xiugao Liao
  • Publication number: 20120232651
    Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
    Type: Application
    Filed: April 6, 2012
    Publication date: September 13, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech
  • Publication number: 20120232648
    Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.
    Type: Application
    Filed: April 6, 2012
    Publication date: September 13, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech
  • Patent number: 8247064
    Abstract: This invention relates to coating a surface wherein the coated surface inhibits foulants such as cell and/or protein and/or prion adhesion or formation. In particular, the coated surface may be part of a medical device which inhibits bacterial adhesion and colonisation, thrombus formation and/or prion, blood protein and/or protein formation.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: August 21, 2012
    Assignee: The University Court of the University of Dundee
    Inventors: Qi Zhao, Eric Abel
  • Publication number: 20120158133
    Abstract: An intraocular lens comprising a hydrophobic lens body (1), at the surface of which there is provided a hydrophilic layer (2) to achieve a reflection-free transition of the incident light.
    Type: Application
    Filed: August 25, 2010
    Publication date: June 21, 2012
    Applicant: Miro GmbH
    Inventor: Wolfgang Mueller-Lierheim
  • Patent number: 8133274
    Abstract: Intraocular lenses containing a photochromic agent, are disclosed. Specifically, the foldable intraocular lens of the present invention comprises an optic body made from a crosslinked material comprising at least one monomer, a crosslinker, a UV absorber, and a photochromic agent which has a maximum absorption peak of about 400-500 nm in its excited state. The lens has a glass transition temperature of about 37° C. or lower. Methods for making these intraocular lenses are also taught.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: March 13, 2012
    Assignee: Medennium, Inc.
    Inventors: Stephen Q. Zhou, Christopher D. Wilcox, Christine J. Liau
  • Publication number: 20120046743
    Abstract: An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 23, 2012
    Inventor: Leonard Pinchuk
  • Patent number: 8109999
    Abstract: The invention relates to an artificial intraocular lens consisting of a polymer material which permits a change of the optical properties of the artificial intraocular lens when exposed to light. This enables the lens to be exactly adjusted to the required visual acuity upon implantation thereof.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: February 7, 2012
    Inventor: Norbert Hampp
  • Patent number: 8088314
    Abstract: Provided are a process for producing an intraocular lens capable of inhibiting secondary cataract that may occur after the insertion of an intraocular lens and a secondary-cataract-inhibiting intraocular lens obtained by the above process, and the process is for producing a surface-treated intraocular lens, which comprises irradiating the surface of an intraocular lens with active light that works to decompose oxygen molecules to generate ozone and that also works to decompose the ozone to generate active oxygen, in the presence of oxygen, and the lens is a secondary-cataract-inhibiting intraocular lens obtained by the above process.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: January 3, 2012
    Assignee: Hoya Corporation
    Inventors: Hiroyuki Matsushima, Hidetoshi Iwamoto
  • Patent number: 8071704
    Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Bausch & Lomb Incorporated
    Inventors: Weihong Lang, Yu-Chin Lai
  • Publication number: 20110295367
    Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.
    Type: Application
    Filed: August 2, 2011
    Publication date: December 1, 2011
    Inventor: Kevin H. Cuevas
  • Publication number: 20110270389
    Abstract: A device and method for forming an adaptive optic in the capsule of a human eye is disclosed, comprising a capsular interface enclosing an optically acceptable medium. The device establishes a physiologic range of optical power in response to a range of ciliary contractile states. The preferred bi-phasic medium of the device is comprised of a solid three dimensional polymeric network suspended in a liquid aqueous phase and bonded to a capsular interface. The polymeric network provides shape to the capsular interface, optical power, and a physiologic response to the suspensory ligament. The three dimensional network of the bi-phasic medium mimics the stacked fiber configuration and elasticity of a natural lens. An alternative embodiment utilizing a single phase medium is also disclosed with associated structural features provided in the capsular interface.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 3, 2011
    Inventors: Liane Clamen Glazer, Paul Glazer, Michael T. Milbocker