Biological Or Biochemical Patents (Class 702/19)
  • Patent number: 10665442
    Abstract: A mass spectrometer is provided that includes a precursor ion candidate selector, a product ion scan measurement condition setter, a product ion spectral data obtainer, a compound database file generator, and an MRM measurement condition candidate generator. The precursor ion candidate selector selects precursor ion candidates from mass spectrometric data. The product ion scan measurement condition setter combines the precursor ion candidates with a plurality of candidate values of cleavage energy to set a product ion scan measurement condition. The product ion spectral data obtainer carries out MS/MS measurement to obtain product ion spectral data. The compound database file generator generates a compound database file in which the product ion scan measurement condition and the product ion spectral data are associated with each other.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: May 26, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Takeshi Ashida
  • Patent number: 10662697
    Abstract: The invention relates to a method for detecting an object in an opening area of a first door (5) of a motor vehicle (1) using at least one first distance sensor (9, 10, 11), the at least one first distance sensor (9, 10, 11) being arranged in and/or on the first door (5) and having a detection area (17, 18, 19), in which a current opening angle (?2) of the first door (5) is detected and the detection area (17, 18, 19) is adapted on the basis of the detected opening angle (?2), a state variable of at least one component of the motor vehicle (1) which differs from the first door (5) being determined, the state variable describing a position and/or an operational setting of the at least one component, and the detection area (17, 18, 19) of the at least one first distance sensor (9, 10, 11) additionally being adapted on the basis of the determined state variable.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: May 26, 2020
    Assignee: Valeo Schalter und Sensoren GmbH
    Inventor: Alice Frapsauce
  • Patent number: 10664978
    Abstract: A method for using a synthetically trained neural network for tracking particle movement in video microscopy data includes receiving, as input, video microscopy data representing images of particles that move between video frames. The method includes using a synthetically trained neural network to track movement of the particles between the video frames, wherein the synthetically trained neural network comprises a neural network that is trained on a plurality of different simulated video microscopy data sets. The method further includes outputting, by the synthetically trained neural network, an indication of movement of the particles between the video frames.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: May 26, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Jay Mack Newby, M. Gregory Forest, Samuel Kit Bunn Lai
  • Patent number: 10657643
    Abstract: A method for identifying biomarker-positive tumor cells is disclosed. The method includes, for example, reading a first digital image and a second digital image into memory, the first and second digital image depicting the same area of a first slide; identifying a plurality of nuclei and positional information of said nuclei by analyzing the light intensities in the first digital image; identifying cell membranes which comprise the biomarker by analyzing the light intensities in the second digital image and by analyzing the positional information of the identified nuclei; and identifying biomarker-positive tumor cells in said area, wherein a biomarker-positive tumor cell is a combination of one identified nucleus and one identified cell membrane that surrounds the identified nucleus.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: May 19, 2020
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Srinivas Chukka, Quan Yuan
  • Patent number: 10655124
    Abstract: The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: May 19, 2020
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Hongkai Zhang, Jia Xie
  • Patent number: 10655181
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 19, 2020
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • Patent number: 10656154
    Abstract: The present application relates to a kit for diagnosing pancreatic cancer, a method for providing information for diagnosing pancreatic cancer using the kit, and a method for diagnosing pancreatic cancer using same, wherein the kit includes an antibody specifically binding to complement factor B protein and an antibody specifically binding to carbohydrate antigen 19-9 protein. According to the present application, it is possible to provide a marker for diagnosing pancreatic cancer having enhanced sensitivity and specificity.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 19, 2020
    Assignee: JW HOLDINGS CORPORATION
    Inventors: Young Ki Paik, Min Jung Lee
  • Patent number: 10658084
    Abstract: An improved basal insulin management system and an improved user interface for use therewith are provided. User interfaces are provided that dynamically display basal rate information and corresponding time segment information for a basal insulin program in a graphical format. The graphical presentation of the basal insulin program as it is being built by a user and the graphical presentation of a completed basal insulin program provides insulin management information to the user in a more intuitive and useful format. User interfaces further enable a user to make temporary adjustments to a predefined basal insulin program with the adjustments presented graphically to improve the user's understanding of the changes. As a result of being provided with the user interfaces described herein, users are less likely to make mistakes and are more likely to adjust basal rates more frequently, thereby contributing to better blood glucose control and improved health outcomes.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: May 19, 2020
    Assignee: Insulet Corporation
    Inventors: Sandhya Pillalamarri, Jorge Borges, Susan Mercer
  • Patent number: 10655182
    Abstract: Disclosed herein is a method for diagnosing a renal allograft recipient's risk for developing fibrosis of the allograft and allograft loss. The method includes determining the expression levels of certain microRNAs, which have been determined to be predictive of an allograft recipient's risk. Also disclosed herein is a method of treating a renal allograft recipient to inhibit fibrosis of the allograft and allograft loss, as well as kits for use in the methods disclosed herein.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: May 19, 2020
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Barbara Murphy, Weijia Zhang
  • Patent number: 10656091
    Abstract: An optical sensor (1) for detecting a chemical species includes a substrate (3), a mesoporous matrix (5) disposed on the substrate, and a microporous matrix (7) disposed within the mesoporous matrix. The microporous matrix (7) includes an indicator dye (9) dispersed therein, the indicator dye (9) exhibiting changes in its optical properties in response to the presence of the chemical species. This arrangement significantly increases the amount of dye present, while allowing the medium to be analyzed greater access through the porous structure, thereby increasing the performance of the sensor.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 19, 2020
    Assignee: CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA—RECHERCHE ET DEVELOPPEMENT
    Inventors: Emmanuel Scolan, Bernard Wenger, Raphael Pugin
  • Patent number: 10650914
    Abstract: The present invention relates to a fresh water acute criteria prediction method based on a quantitative structure-activity relationship for metals. An unknown toxic endpoint of a metal is predicted according to a quantitative relationship between structural characteristics of heavy metal ions and acute toxicity effects of aquatic organisms, and hazard concentrations for protecting the aquatic organisms of different proportions are derived from sensitivity distribution analysis on different species. The fresh water acute criteria prediction method is a method for establishing a metal toxicity predictive model by integrating physicochemical structural parameters of heavy metals and toxic mechanisms of different aquatic organisms and applying the metal toxicity predictive model to prediction of an unknown criteria reference value.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 12, 2020
    Inventors: Yunsong Mu, Fengchang Wu, Haiqing Liao, Yingchen Bai, Xiaoli Zhao, Ying Wang
  • Patent number: 10650913
    Abstract: A method, which includes: extracting one or more calculation-target water molecules that influence at least interaction energy between the target molecule and some of the drug candidate molecules, but not the interaction energy between the target molecule and all of the drug candidate molecules; and calculating each interaction energy between the target molecule and each of the drug candidate molecules with only considering the one or more calculation-target water molecules as water molecules treated positively in a calculation of each interaction energy, and with considering the one or more calculation-target water molecules only in a calculation of interaction energy which the one or more calculation-target water molecules influence, wherein the method is a method for calculating interaction energy between the target molecule and the drug candidate molecules using a calculator.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: May 12, 2020
    Assignee: FUJITSU LIMITED
    Inventor: Hiroyuki Sato
  • Patent number: 10647752
    Abstract: The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: May 12, 2020
    Assignees: INSERM (Institut National de la Santé et de la Recherche Medicale), Fondation Imagine, Assistance Publique-Hopitaux de Paris (APHP), Université Paris Descartes, Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne, CNAM—Conservatoire National des Arts at Metier
    Inventors: Zakia Belaid-Choucair, Olivier Hermine, Matthieu Montes, Carmen Garrido-Fleury, Renaud Seigneuric, Guillaume Marcion
  • Patent number: 10638667
    Abstract: Systems and Methods for Augmented-Human Field Inspection Tools for Automated Phenotyping Systems and Agronomy Tools. In one embodiment, a method for plant phenotyping, includes: acquiring a first set of observations about plants in a field by a trainer. The trainer carries a sensor configured to collect observations about the plant, and the first set of observations includes ground truth data. The method also includes processing the first set of observations about the plants by a trait extraction model to generate instructions for a trainee; and acquiring a second set of observations about the plants by a trainee while the trainee follows the instructions.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: May 5, 2020
    Assignee: X Development LLC
    Inventors: William Regan, Matthew Bitterman, David Brown, Elliott Grant, Zhiqiang Yuan
  • Patent number: 10642870
    Abstract: Data processing systems and methods according to various embodiments are adapted for automatically detecting and documenting privacy-related aspects of computer software. Particular embodiments are adapted for: (1) automatically scanning source code to determine whether the source code include instructions for collecting personal data; and (2) facilitating the documentation of the portions of the code that collect the personal data. For example, the system may automatically prompt a user for comments regarding the code. The comments may be used, for example, to populate: (A) a privacy impact assessment; (B) system documentation; and/or (C) a privacy-related data map. The system may comprise, for example, a privacy comment plugin for use in conjunction with a code repository.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: May 5, 2020
    Assignee: OneTrust, LLC
    Inventors: Priya Malhotra, Kabir A. Barday, Mihir S. Karanjkar, Steven W. Finch, Ken A. Browne, Nathan W. Heard, Aakash H. Patel, Jason L. Sabourin, Richard L. Daniel, Dylan D. Patton-Kuhl, Jonathan Blake Brannon
  • Patent number: 10636637
    Abstract: A method for processing chromatographic peaks in chromatographic systems comprising comparing a first peak with a second peak; and determining whether the first peak and second peak should be grouped together.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: April 28, 2020
    Assignee: LECO Corporation
    Inventors: Jihong Wang, Peter Markel Willis
  • Patent number: 10636146
    Abstract: A medical image processing method of determining a fractional flow reserve through a stenosis of a coronary artery from medical image data is disclosed. The medical image data comprises a set of images of a coronary region of a patient. The coronary region includes the stenosis. The method comprises: reconstructing a three dimensional model of a coronary artery tree of the patient from the medical image data; determining stenosis dimensions from the three dimensional model of the coronary artery tree of the patient; simulating blood flow in the three dimensional model of the coronary artery tree of the patient to determine modeled flow rates; using an analytical model depending on the stenosis dimensions to predict a modeled pressure drop over the stenosis from the modeled flow rates; and determining the fractional flow reserve through the stenosis from the modeled pressure drop.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 28, 2020
    Assignee: Singapore Health Services Pte Ltd
    Inventors: Liang Zhong, Jun Mei Zhang, Ru San Tan
  • Patent number: 10627279
    Abstract: A measuring device includes a first body, a second body slidably combined with the first body, a first pressure sensing component, and a control unit. The first body is for supporting a cup receiving liquid. The first pressure sensing component is disposed between the first body and the second body for sensing weight of the cup and the liquid and generating a signal corresponding to the weight. The control unit is electrically connected to the first pressure sensing component. The control unit determines a volume variation of the liquid according to a weight variation of the cup and the liquid calculated based on a difference between signals transmitted from the first pressure sensing component at different time points.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 21, 2020
    Assignee: Wistron Corporation
    Inventors: Wen-Hsin Hsiao, Hao-Chen Weng, Shiuan-De Chen, Chien Huang, Wei-Kuo Lee
  • Patent number: 10628766
    Abstract: Method and system for enabling dynamic capacity planning are disclosed. In an embodiment, a plurality of operational inputs are configured to forecast a demand volume and generate a dynamic capacity planning schedule. For example, said plurality of operational inputs include raw data received from a server. Further, historical data is processed based on said plurality of operational inputs to create a plurality of contextual data elements. Furthermore, said demand volume is forecasted and said dynamic capacity planning schedule is generated using at least a part of the historical data and a current capacity planning requirement, said current capacity planning requirement is being generated dynamically by said server. In addition, said dynamic capacity planning schedule is rendered based on said forecasted demand volume and said rendered dynamic capacity planning schedule is clustered into a plurality of work reports associated with said plurality of contextual data elements.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: April 21, 2020
    Assignee: Tata Consultancy Services Limited
    Inventors: Sumukh Sudhakar Sirmokadam, Mahesh Kshirsagar, Sumit Raut, Muralidharan Somasundaram, Sumit Inderjeet Juneja
  • Patent number: 10627389
    Abstract: Methods are provided for assessing a cellular breast sample. Aspects of the methods include flow cytometrically obtaining sample data, cellular data, and combinations thereof, and then assessing the cellular breast sample based on the obtained data. In addition, compositions, e.g., kits, systems and programming, useful in practicing various embodiments of the methods are provided.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: April 21, 2020
    Assignee: IncellDx, Inc.
    Inventors: Keith Shults, Amanda Noel Chargin, Seyedhamed Jafarianmohamady
  • Patent number: 10621411
    Abstract: A method for laser microdissection includes detecting at least a portion of an object to be dissected in an image-producing manner in a laser microdissection system and generating a first digital object image. A first processing specification is defined based on the first digital object image. In a first processing step, the object is processed using a laser beam of the laser microdissection system in accordance with the first processing specification. At least a portion of the object is detected in an image-producing manner and a second digital object image is generated. A second processing specification is defined during execution of the first processing step based on the second digital object image. In a second processing step, the object is processed using the laser beam of the laser microdissection system in accordance with the second processing specification.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: April 14, 2020
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Falk Schlaudraff, Andrew Lee, Florian Hoffmann
  • Patent number: 10619214
    Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 14, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan
  • Patent number: 10621414
    Abstract: Methods and systems for implementing health monitoring based on changes in body dimensions derived from images of a human collected over long periods of time are presented herein. An image based medical diagnosis system precisely measures body dimensions, changes in body dimensions over time, or both, and identifies whether any measured dimensions, changes in dimensions, or both, have exceeded one or more threshold values indicative of the onset or recurrence of a medically significant condition. In another further aspect, an alert is communicated to medical professionals to further investigate the medical condition of the human user. In one aspect, body dimensions are estimated based on a known value of a reference dimension identifiable in each of the plurality of images. In some examples, the distance between facial features in an image is normalized with respect to the measured inter-pupillary distance associated with that image.
    Type: Grant
    Filed: February 16, 2019
    Date of Patent: April 14, 2020
    Inventors: Howard Jason Harrison, Ryszard M. Pluta
  • Patent number: 10614920
    Abstract: An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the given presenting cancer at the time when it would have first been detectable using the known diagnostic technique. A first probability of the cancer being present in a first set of one or more clinically significant remote sites is determined based on the estimated initial characteristics. A second probability of the cancer being present in the first set of one or more clinically significant remote sites is determined based on actual current characteristics of the given presenting cancer. The first and second probabilities are used to estimate incremental risk of incurring presence of the cancer at the first set of one or more clinically significant remote sites by delaying therapy for a unit time.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 7, 2020
    Assignee: International Business Machines Corporation
    Inventors: Jonathan Lenchner, Charity Wayua
  • Patent number: 10614370
    Abstract: A cloud computing architecture and system for interaction with and use of quantum processing devices is presented. In one aspect, the invention comprises a unified platform as a service for interacting with various quantum processing devices. In another aspect, the invention provides an architecture and methodology for accessing and using a variety of quantum processing devices. Other aspects of the invention incorporate various software modules that provide additional functionality for users of quantum processing devices.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 7, 2020
    Assignee: QC Ware Corp.
    Inventors: Matthew C. Johnson, David A. B. Hyde, Peter McMahon, Kin-Joe Sham, Kunle Tayo Oguntebi, Asier Ozaeta Rodriguez
  • Patent number: 10612061
    Abstract: The present invention provides for heterologous expression of beta-glucosidase (BGL) polypeptides encoded by Humicola grisea, Candida wickerhamii, Aspergillus aculeatus, Aspergillus oryzae, Penicillium decumbens, Chaetomium globosum, Neocallimastix frontalis, Debaryomyces hansenii, Kluyveromyces marxianus, or Phytophthora infestans in host cells, such as the yeast Saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed BGL. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: April 7, 2020
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: John McBride, Erin Wiswall
  • Patent number: 10607147
    Abstract: A method for estimating a number of occupants in a region comprises receiving a time series of sensor values detected over a period of time by a motion sensor sensing motion in the region. A spread parameter indicative of the spread of the sensor values is determined. The number of occupants in the region is estimated based on the spread parameter.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: March 31, 2020
    Assignee: ARM Limited
    Inventors: Yordan Petrov Raykov, Emre Özer, Ganesh Suryanarayan Dasika
  • Patent number: 10607343
    Abstract: A computer implemented method of generating at least one shape of a region of interest in a digital image is provided.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: March 31, 2020
    Assignee: NANTOMICS, LLC
    Inventors: Bing Song, Gregory Chu
  • Patent number: 10595739
    Abstract: An anatomical mapping system including a plurality of mapping electrodes disposed in or near an anatomical structure and configured to detect activation signals of physiological activity, each of the plurality of mapping electrodes having an electrode location, and a processing system associated with the plurality of mapping electrodes, and configured to record the detected activation signals and associate one of the plurality of mapping electrodes with each recorded activation signal. The processing system further configured to determine a dominant frequency at each electrode location, and determine a wavefront vector at each electrode location based on a difference between the dominant frequency at a first electrode location and the dominant frequency at neighboring electrode locations.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: March 24, 2020
    Assignee: Boston Scientific Scimed Inc
    Inventors: Pramodsingh Hirasingh Thakur, Shibaji Shome, Allan C. Shuros, Shantha Arcot-Krishnamurthy, Barun Maskara, Sunipa Saha
  • Patent number: 10595807
    Abstract: A method for vascular assessment is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to produce a stenotic model over the vasculature, the stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature. The method, in some embodiments, further comprises obtaining a flow characteristic of the stenotic model, and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: March 24, 2020
    Assignee: CathWorks Ltd
    Inventors: Ifat Lavi, Ran Kornowski, Idit Avrahami, Nessi Benishti, Guy Lavi
  • Patent number: 10597724
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: March 24, 2020
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • Patent number: 10592637
    Abstract: Disclosed is a computer-implemented method of screening a patient for end organ damage due to infection. The method entails receiving patient data relating to an identified patient in a computing system including a processor and memory coupled to the processor, wherein the memory stores programmable instructions executable by the processor. The presence of Systematic Inflammatory Response Syndrome is determined and then the presence or absence of a high probability of end organ damage due to infection. Each of the determining steps includes receiving, on a graphical user interface, one or more user selections presented on the graphical user interface and executing programmable instructions based on received user selections.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: March 17, 2020
    Assignee: Luminare Incorporated
    Inventors: Narasimheswara Sarma Velamuri, Marcus Joel Christian Persson Rydberg
  • Patent number: 10591436
    Abstract: A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and compensates a portion of the remaining error with a residual function. The amount of error compensation provided by the primary and residual functions may be adjusted with a weighing coefficient. The compensation method including a primary function and a residual function may be used to determine analyte concentrations having improved accuracy from output signals including components attributable to error.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 17, 2020
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Huan-Ping Wu, Bern Harrison, Eric Maurer
  • Patent number: 10593036
    Abstract: The present invention addresses the problem of developing a simple sperm inspection method and device for reflecting fertility. In the present invention, a simple sperm inspection method and device having a high correlation with fertility can be provided by suspending a sperm population in an inspection liquid and measuring a quality indicator value for each sperm, stratifying the sperm population on the basis of the sperm quality indicator value, and evaluating the quality of the sperm on the basis of the quality indicator value of one or a plurality of groups in the stratified population. This standard can predict fertility with higher precision through use of a graph in which the quality indicator values for individual sperm of the sperm population are arranged in sequence. Sperm motility is preferably used as a sperm quality indicator.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 17, 2020
    Assignee: Livestock Improvement Association of Japan, Inc.
    Inventors: Masashi Kinukawa, Kyoko Uchiyama
  • Patent number: 10591463
    Abstract: A method for predicting the phenotypic stability of a cell line comprises the steps of culturing the cell line over an assay period, and generating an environmental response fingerprint for the cell line at a plurality of different time points over the assay period, wherein each environmental response fingerprint is generated by determining the environmental response of the cells in the presence of each of a plurality of chemical cell stressors. The plurality of environmental response fingerprints are compared to detect change in the environmental response fingerprint over the assay period. The level of change in the environmental response fingerprint over the assay period is indicative of the level of predicted phenotypic instability in the cell line. The environmental response may be growth response, productivity response, or another detectable environmental response.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 17, 2020
    Assignee: Valitacell Limited
    Inventors: Ben Thompson, David James, Jerry Clifford
  • Patent number: 10584380
    Abstract: The invention provides methods of analyzing an individual's mtDNA by transforming available reference sequences into a directed graph that compactly represents all the information without duplication and comparing sequence reads from the mtDNA to the graph to identify the individual or describe their mtDNA. A directed graph can represent all of the genetic variation found among the mitochondrial genomes across all of a number of reference organisms while providing a single article to which sequence reads can be aligned or compared. Thus any sequence read or other sequence fragment can be compared, in a single operation, to the article that represents all of the reference mitochondrial sequences.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: March 10, 2020
    Assignee: Seven Bridges Genomics Inc.
    Inventors: Devin Locke, Piotr Szamel
  • Patent number: 10586376
    Abstract: In an automated method of determining potential efficacy of immunotherapy approaches, an automated slide scanning system with an image acquisition unit is provided. A sample slide with a mounted tissue sample is received by the automated slide scanning system. One or more slide images of the tissue sample are acquired with the image acquisition unit. At least one cell segmentation process is executed on the slide image in order to identify tissue cells. The cells are analyzed with at least one cell classification algorithm in order to identify a tumor cell percent positivity value and an immune cell percent positivity value, and a treatment efficacy score is subsequently calculated. Further features provided include pixel to pixel image registration, reconstruction, composite multi-layer viewing, and other image management tools.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: March 10, 2020
    Assignee: OPTRASCAN, INC.
    Inventors: Abhijeet Gholap, Anagha Jadhav, Gurunath Kamble
  • Patent number: 10586200
    Abstract: Embodiments of the present invention are directed at providing a sequential multiple hypothesis testing system. In one embodiment, feedback is collected for hypothesis tests of a multiple hypothesis tests. Based on the collected feedback, a sequential p-value is calculated for each of the hypothesis tests utilizing a sequential statistic procedure that is designed to compare an alternative case with a base case for a respective hypothesis test. A sequential rejection procedure can then be applied to determine whether any of the hypothesis tests have concluded based on the respective p-value. A result of the determination can then be output to apprise a user of a state of the multiple hypothesis test. This process can then be repeated until a maximum sample size is reached, termination criterion is met, or all tests are concluded. Other embodiments may be described and/or claimed.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: March 10, 2020
    Assignee: Adobe Inc.
    Inventors: Mohammad Ghavamzadeh, Alan John Malek, Yinlam Chow, Sumeet Katariya
  • Patent number: 10586267
    Abstract: A method for generating recommendations for a user from a product database is provided. The method comprises determining a taxonomy for the product database, said taxonomy comprising a plurality of attributes assigned to each product in the product database; performing an exploratory procedure in which the user is systematically exposed to products from the product database in order to test the user's preference for products in the product database; and generating a style profile for the user based on the user's indicated preferences.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: March 10, 2020
    Assignee: Curio Search, Inc.
    Inventors: Christopher Sandman, Bharat Vijay, Anand Ramani, Ram Bhoopalam
  • Patent number: 10584384
    Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: March 10, 2020
    Assignee: Celera Corporation
    Inventors: Dov Shiffman, James J. Devlin, Judy Z. Louie, Eric Boerwinkle
  • Patent number: 10580516
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: March 3, 2020
    Assignee: CELMATIX, INC.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Patent number: 10580515
    Abstract: The systems and methods described herein include a technique for generating both reproducible and interpretable gene signatures. The technique involves resampling a data set and choosing genes having a high frequency of emergence. In particular, the systems and methods described herein include repeated sampling of data sets, ranking genes based on frequency of occurrence in gene signatures generated through the repeated sampling process, and iteratively selecting the best gene signature.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 3, 2020
    Assignee: Philip Morris Products S.A.
    Inventors: Yang Xiang, Julia Hoeng
  • Patent number: 10580523
    Abstract: Apparatus, systems and methods for pre-processing, analyzing, and storing genomic data through a scalable, distributed analysis system across a network is presented.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 3, 2020
    Assignee: Nant Holdings IP, LLC
    Inventor: Patrick Soon-Shiong
  • Patent number: 10569133
    Abstract: A measurement system includes a first measurement unit configured to measure floor reaction forces of golfer's left and right legs, a second measurement unit that is attached to the upper body of a golfer and configured to measure an angular velocity of the golfer, and a processing unit. The processing unit calculates, based on measurement results of the first measurement unit and the second measurement unit, a first energy which is a kinetic energy of the golfer during a swing.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 25, 2020
    Assignee: Bridgestone Sports Co., Ltd.
    Inventor: Tomotaka Ishihara
  • Patent number: 10568556
    Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: February 25, 2020
    Assignee: Optiscan Biomedical Corporation
    Inventors: Jennifer H. Gable, James R. Braig, Kenneth I. Li, Mark Wechsler, Peng Zheng, Richard Keenan
  • Patent number: 10564102
    Abstract: In one aspect of the present disclosure an optical measurement device includes a sample holder defining a sample plane, wherein the sample holder is configured to arrange a sample carrier including an array of measurement positions in the sample plane, an illumination unit configured to illuminate the sample plane, a detector and an optical imaging system configured to image the sample plane including the array of measurement positions onto the detector, the optical imaging system including two or more curved reflective elements adapted to image the sample plane onto the detector with a magnification of between 2:1 and 1:2 and the detector being configured to take an image of all measurement positions of the array of measurement positions at a time.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: February 18, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Joachim Wietzorrek
  • Patent number: 10559385
    Abstract: What is disclosed is a system and method for forecasting and imputing an unknown vital measurement of a patient. Temporally successive patient vital measurements are received which comprise irregularly sampled observations {y1, . . . , yN}, where yj denotes the jth observation at time tj, and N is the number of samples. The vital measurements are then provided to a model trained using historical data of patient vital measurements. The model generates a parameter set ?=(A,B,C), where A is a state transition matrix, B is a control matrix, and C is a matrix which maps state-space variables to observation variables. The parameters are used to obtain state-space variable zt which, in turn, is used to forecast an unknown observation yN+1 or to impute an unknown observation yt, where 1<t<N. The historical data is then updated with the forecasted observation yN+1 or the imputed unknown observation yt.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: February 11, 2020
    Assignee: CONDUENT BUSINESS SERVICES, LLC
    Inventors: Abhishek Sengupta, Bhupendra Singh Solanki, Prathosh Aragulla Prasad, Vaibhav Rajan, Katerina Ocean Sinclair, Stephen Fullerton, Satya Narayan Shukla
  • Patent number: 10560552
    Abstract: Systems and methods for performing genomic information compression, transmission, and decompression are provided. A system for compression, transmission, and decompression of genomic information includes a first computer associated with a first index and a second computer associated with a second index, each index containing reference permutations of nucleic acid sequence portions, each permutation associated with a reference number. The first computer uses input genomic information and the first index to produce a compressed representation of the genomic information, and transmits the compressed representation to the second computer. The second computer uses the compressed representation and the second index to assemble a data representation of the genomic information. The compressed representation comprises references to permutations, indications of locations of each permutation in the input information, indications of variations to permutations, and/or indications of sequence length.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: February 11, 2020
    Assignee: NOBLIS, INC.
    Inventors: Sterling Thomas, Nate Dellinger, Mychal Ivancich
  • Patent number: 10550362
    Abstract: An automatic processing device of culture plates (2) including a support frame (3); a slide (4) for removably housing a culture plate (2) and movably mounted on the support frame (3) selectively displaceable between a first loading position, a plurality of image-acquiring positions, and a first unloading position; a camera (6) of a linear type, provided with telecentric optic (7) and a trilinear sensor, and arranged acquire a multiplicity of linear images of corresponding linear portions of an upper surface of the culture plate (2), during the displacing of the slide (4); a first lighting device (11) orientated such as to illuminate the linear portions of an upper surface of the culture plate (2); an advancing device (14) of the slide (4) configured such as to enable obtaining a constant and substantially vibration-free advancing speed of the slide (4) in the image-acquiring zone; and an electronic control device (9) of a functioning of the camera (6), of the lighting device and of the advancing device (14).
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: February 4, 2020
    Assignee: Copan Italia S.p.A.
    Inventor: Daniele Triva
  • Patent number: 10546102
    Abstract: A mechanism is provided in a data processing system for generating healthcare work item recommendations based on predictive analytics. An analytics engine executing on the data processing system performs analytics to discover patterns in patient records data and to generate one or more risk scores using one or more predictive models. Each of the one or more risk scores represents a probability of a respective healthcare consideration. Each of the one or more risk scores has an associated set of contributing factors. A decision system executing on the data processing system generates a healthcare recommendation for a given patient having a given risk score based on the given risk score, a predictive model used to generate the given risk score, and a given set of contributing factors associated with the given risk score.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: January 28, 2020
    Assignee: International Business Machines Corporation
    Inventors: Kasun L. Attanapola, Katherine D. ChengLi, Perry R. Giffen, Sukhwinder Lall, Mihaela Rotaru, Leila Sadat Rezai