Biological Or Biochemical Patents (Class 702/19)
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Patent number: 12213784Abstract: A sensor having improved shelf life is provided for determining concentration of a biomarker in a liquid sample. The sensor functions by electrochemical detection and requires use of a biomolecule, e.g., an enzyme that catalyzes an electron transfer reaction specific for the biomarker. The sensor requires use of a quaternary ammonium compound as a bio-linker. It further requires crosslinking of the biomolecule for improved stability.Type: GrantFiled: December 11, 2017Date of Patent: February 4, 2025Assignee: Northeastern UniversityInventors: Yunqing Du, Ming L. Wang
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Patent number: 12216111Abstract: Systems and methods are provided for characterizing shuttle capture events in a nanopore sensor. The method first collects time-dependent current blockage signatures for at least one bias voltage. The method then identifies each signature as corresponding to a permanent or transient event. The method then generates a protein dynamics landscape (PDL) for the transient event signatures. The PDL comprises a set of histograms of nanopore current data and characterizes current through the nanopore during shuttle capture events. The method can then comprise identifying an entrance level blockage value based on the permanent event signatures. Permanent event captures can be determined by time duration which is larger than a certain threshold time value. Applying a voltage between the fluidic chambers above a threshold voltage level can be used to control that the vast majority of events are permanent.Type: GrantFiled: January 26, 2024Date of Patent: February 4, 2025Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Lene V. Hau, Jene A. Golovchenko
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Patent number: 12213766Abstract: A method for synchronizing operation of a heart assist pump device to a patient's cardiac cycle includes obtaining a signal from a motor of a heart assist pump device and filtering the signal to remove noise. The method also includes determining a speed synchronization start point at which time the motor of the heart assist pump device will begin a change in speed of operation based on the filtered signal. The method further includes modulating a speed of the motor of the heart assist pump device to a target speed at the speed synchronization start point, thereby synchronizing the change in speed of operation with a patient's cardiac cycle.Type: GrantFiled: June 22, 2023Date of Patent: February 4, 2025Assignee: TC1 LLCInventors: Alexander Medvedev, Shunzhou Yu, Ren You
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Patent number: 12217843Abstract: Methods and devices involving using a bolus calculator to account for an uncertainty of a carbohydrate estimate to reduce a risk of hypoglycemia and/or a risk of hyperglycemia. More specifically, methods and devices using an algorithm executed by a processor of the bolus calculator and using a carbohydrate estimate and a measure defining the uncertainty of the carbohydrate estimate to determine the probability of hypoglycemia and/or hyperglycemia if the carbohydrate estimate is an overestimate or an underestimate, and subsequently providing recommendations and alerts to a user.Type: GrantFiled: April 17, 2019Date of Patent: February 4, 2025Assignee: Roche Diabetes Care, Inc.Inventor: David L. Duke
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Patent number: 12216989Abstract: A method and a system for tracking and managing data is disclosed. The method and system compile the tracked data into a user-accessible message and sends the user-accessible message to a subscriber periodically. A tracking device tracks selected data stored in at least one database and sends the tracked selected data to a user database. A data compiling device receives the tracked selected data and compiles the tracked selected data into a pre-determined form. The pre-determined form is then sent to the subscriber in an email or a cellular text message. The data stored in the at least one database includes image data and content data. The data is frequently updated to contain new files and new status of existing content data.Type: GrantFiled: June 5, 2023Date of Patent: February 4, 2025Assignee: ERIK M. PELTON & ASSOCIATES, PLLCInventor: Erik Pelton
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Patent number: 12217632Abstract: A Method and Apparatus for Comparing Colors have been disclosed. In one implementation a compliant membrane which is substantially transparent with an area having a shade/color is placed on the user's skin to see what the shade/color will look like on the skin. In one implementation a compliant substrate which is largely transparent with an area having a shade/color is placed on an inanimate object to see how the shade/color will appear on the inanimate object without the substrate itself causing an unnecessary barrier between the inanimate object and the shade/color.Type: GrantFiled: December 15, 2023Date of Patent: February 4, 2025Inventor: Lee Kaplan
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Patent number: 12209948Abstract: In one embodiment, a method of building an optimized color flow cytometry panel is disclosed using a full spectrum flow cytometer with five excitation lasers and five corresponding detection modules. In another embodiment, a graphical user interface is disclosed generated by a server computer from a fluorochrome database and displayed by a client computer to assist in the selection of a set of fluorochromes for use in an assay to analyze biological samples. The GUI can display spectra graphs to visually show how fluorochromes may overlap and can generate similarity indexes for the paired fluorochrome interference and a complexity index for overall many to many interferences generated by a selected group or set of fluorochromes.Type: GrantFiled: June 26, 2021Date of Patent: January 28, 2025Assignee: Cytek Biosciences, Inc.Inventors: Maria Jaimes, Zhenyu Zhang, Jian Zhou, Huimin Gu, Qing Shao, Ming Yan, David Vrane
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Patent number: 12203134Abstract: Provided herein are methods for determining the mislocalization of an analyte by capturing the analyte on an array and measuring the mislocalization distance.Type: GrantFiled: December 22, 2022Date of Patent: January 21, 2025Assignee: 10x Genomics, Inc.Inventors: Monica Nagendran, Jonathan Cheng, Eswar Prasad Ramachandran Iyer
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Patent number: 12201492Abstract: A method of processing data comprises receiving, at a processor, first data comprising a plurality of values; receiving second data comprising one or more directives and association information; retrieving a first set of records from the first data using a first subset of the second data; generating a second set of records from the second data using a second subset of the second data; generating, based on a third subset of the second data, a plurality of records associations, the plurality of records associations including one or more of: first relationships between records of the first set of records, second relationships between records of the second set of records, and third relationships between records of the first set of records and the second set of records; storing the plurality of records associations in a structured format; and generating feedback data based on the plurality of records associations.Type: GrantFiled: September 30, 2021Date of Patent: January 21, 2025Assignee: R2DIO, Inc.Inventors: Thomas Pirrie Treynor, Li-Yun Arthur Kung
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Patent number: 12205674Abstract: A method for determining the genetic relationship of a conceptus with sperm and oocyte providers is provided, comprising receiving conceptus, sperm provider, and oocyte provider sequence data; aligning the received sequence data to a reference genome; identifying single nucleotide polymorphisms (SNPs) in the sperm provider, oocyte provider, and conceptus sequence data; imputing missing gaps in the sperm provider sequence data and the oocyte provider sequence data using an imputation reference; calculating a paternal consistency score between the sperm provider and the conceptus; calculating a maternal consistency score between the oocyte provider and conceptus; and classifying the sperm provider and/or the oocyte provider as related to the conceptus if the paternal consistency score and/or the maternal consistency score exceeds the predetermined threshold.Type: GrantFiled: June 19, 2020Date of Patent: January 21, 2025Assignee: CooperSurgical, Inc.Inventors: John Burke, Brian Rhees, Joshua David Blazek, Michael Jon Large
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Patent number: 12203922Abstract: An electrochemical measurement apparatus includes: a tank containing electrolytic solution and a sample that generates or consumes measurement target substances in the electrolytic solution; a plurality of uniformly mixed working electrodes; and a counter electrode; the apparatus adapted to simultaneously apply a voltage between each of the working electrodes and the counter electrode; and the apparatus configured to measure a current that flows between each of the working electrodes and the counter electrode; wherein any two working electrode groups are mutually different in at least any of the determined voltage, presence/absence of a molecular modification of an electrode surface, and a species of the molecular modification; and whereby a distribution in measurement area of the currents that flow through the working electrodes is acquired.Type: GrantFiled: September 21, 2020Date of Patent: January 21, 2025Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke Ino, Yusuke Kanno, Tomokazu Matsue, Kumi Inoue, Ryota Kunikata, Hiroyuki Hayashi, Atsushi Suda
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Patent number: 12193515Abstract: An aerosol generating device includes: a heater configured to generate an aerosol by heating an aerosol generating material; a proximity sensor configured to measure a distance between a user of the aerosol generating device and the aerosol generating device; and a controller electrically connected to the heater and the proximity sensor and configured to control the heater on the basis of the distance measured by the proximity sensor.Type: GrantFiled: April 13, 2021Date of Patent: January 14, 2025Assignee: KT&G CORPORATIONInventor: Won Kyeong Lee
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Patent number: 12198786Abstract: Provided herein are methods, processes, systems and machines for non-invasive assessment of genetic variations. In particular, provided herein are methods, processes, systems and machines for non-invasive assessment of copy number variations. In some aspects, copy number variations include aneuploidies (e.g., trisomy 13, 18, or 21). In some aspects, copy number variations include microdeletions or microduplications.Type: GrantFiled: November 19, 2020Date of Patent: January 14, 2025Assignee: SEQUENOM, INC.Inventor: Gregory Hannum
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Patent number: 12193414Abstract: An animal management system has one or more imaging devices, and a computing device coupled to the one or more image devices for receiving one or more images captured by the one or more imaging devices, processing at least one image using an artificial intelligence (AI) pipeline for: (i) detecting and locating in the image one or more animals, (ii) for each detected animal: (a) generating at least one section of the detected animal, (b) determining a plurality of key points in each section, (c) generating an embedding for each section based on the plurality of key points in the section, and (d) combining the embeddings for generating an identification of the detected animal with a confidence score. Key points and bounding boxes may also have associated confidence scores.Type: GrantFiled: February 26, 2024Date of Patent: January 14, 2025Assignee: One Cup Productions Ltd.Inventors: Jeffrey Shmigelsky, Mocha Shmigelsky, Madison Lovett, Philip Cho
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Patent number: 12190999Abstract: Conventionally, deep learning-based methods have shown some success in ligand-based drug design. However, these methods face data scarcity problems while designing drugs against novel targets. Embodiments of the present disclosure provide systems and methods that leverage the potential of deep learning and molecular modeling approaches to develop a drug design pipeline, which can be useful for cases where there is limited or no availability of target-specific ligand datasets. Inhibitors of other proteins, structurally similar to the target protein are screened at the active site of the target protein to create an initial target-specific dataset. Transfer learning is implemented to learn features of target-specific dataset and design new chemical entities/molecules using a deep generative model. A deep predictive model is used predict docking scores of newly designed/identified molecules.Type: GrantFiled: December 29, 2020Date of Patent: January 7, 2025Assignee: TATA CONSULTANCY SERVICES LIMITEDInventors: Arijit Roy, Sowmya Ramaswamy Krishnan, Navneet Bung, Gopalakrishnan Bulusu
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Patent number: 12187765Abstract: A crystallization method for making high-quality molecular crystals containing complexes of diacylglycerol (DAG)-effector proteins and ligands thereof. For example, some of such crystals are of a quality sufficient for crystal-structure determination by X-ray crystallography with a spatial resolution of at least 3.0 ? or, in some cases, of about 1 ?. At least some embodiments of the crystallization method and of the molecular crystals produced thereby can beneficially be used, e.g., to provide high-resolution guides for the design and development of exogenous agonists of DAG-effector proteins of therapeutic interest.Type: GrantFiled: August 31, 2022Date of Patent: January 7, 2025Inventors: Tatyana I. Igumenova, Sachin S. Katti
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Patent number: 12191002Abstract: The present invention relates to a method for determining one or more intrinsic properties of a DNA component from a plurality of measurements obtained over a time period from a cell culture, with each cell comprising the DNA component, wherein the DNA component is involved in transcription of one or more target signals, wherein the plurality of measurements comprises measurements relating to the density of the cell culture over the time period and measurements relating to the amount of the one or more target signals in the cell culture over the time period.Type: GrantFiled: February 14, 2023Date of Patent: January 7, 2025Assignee: Microsoft Technology Licensing, LLCInventors: Neil Dalchau, Andrew Nicholas John Brojer Phillips, Paul Grant
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Patent number: 12188956Abstract: One embodiment provides a system for analyzing a motion of a complex system. During operation, the system obtains movement data associated with the motion over a time interval and computes, over the time interval, a distribution of energy associated with the motion based on the obtained movement data. The system further identifies energy peaks based on the distribution of the energy over the time interval, computes an energy-occurrence-frequency distribution based on the identified energy peaks over a predetermined energy range, and generates a motion-analysis result for the complex system based on the computed energy-occurrence-frequency distribution.Type: GrantFiled: October 3, 2019Date of Patent: January 7, 2025Assignee: Surge Motion Inc.Inventors: Jeffrey Tai Kin Cheung, Derek T. Cheung, Vicky L. Cheung, Gary N. Jin
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Patent number: 12181566Abstract: There is provided an information processing device that processes detection information of an external recognition sensor. The information processing device includes: a recognition unit that performs recognition processing on an object on the basis of a detection signal of the sensor; and a processing unit that performs fusion processing on first data before the recognition by the recognition unit and another data. The information processing device further includes a second recognition unit that performs recognition processing on the object on the basis of a detection signal of a second sensor. The processing unit performs fusion processing on third data before the recognition by the second recognition unit and the first data, fusion processing on fourth data after the recognition by the second recognition unit and the first data, and the like.Type: GrantFiled: January 8, 2024Date of Patent: December 31, 2024Assignee: Sony Semiconductor Solutions CorporationInventor: Shinji Igarashi
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Patent number: 12178582Abstract: Provided herein are systems and methods for calculating patient information. The method includes determining a transfer matrix, recording electric potentials via a first set of recording electrodes located at a first set of recording locations to create a first set of recorded signals, and calculating patient information for a set of target locations by applying the transfer matrix to the first set of recorded signals. The transfer matrix is a characterization of electrical properties of tissue between the first set of recording locations and the set of target locations.Type: GrantFiled: November 8, 2019Date of Patent: December 31, 2024Assignee: ACUTUS MEDICAL, INC.Inventors: Gunter Scharf, Christoph Scharf, Derrick Ren-yu Chou, Graydon Ernest Beatty, R. Maxwell Flaherty, J. Christopher Flaherty
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Patent number: 12183437Abstract: Embodiments of a method and/or system can include generating a set of target-associated molecules (e.g., spike-in molecules) associated with one or more biological targets; generating one or more spike-in mixtures based on processing the set of target-associated molecules with one or more samples including the one or more biological targets; performing one or more Sanger sequencing operations on the one or more spike-in mixtures; determining one or more abundance metrics based on chromatogram-related outputs from the one or more Sanger sequencing operations; and/or facilitating characterization of one or more medical conditions based on the one or more abundance metrics.Type: GrantFiled: August 1, 2022Date of Patent: December 31, 2024Assignee: BILLIONTOONE, INC.Inventors: David Tsao, Oguzhan Atay
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Patent number: 12174175Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.Type: GrantFiled: October 28, 2020Date of Patent: December 24, 2024Assignee: S.D. Sight Diagnostics Ltd.Inventors: Amir Zait, Arnon Houri Yafin, Dan Gluck, Sharon Pecker, Yochay Shlomo Eshel, Sarah Levy Schreier, Joseph Joel Pollak
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Patent number: 12175660Abstract: There is provided an information provision method for providing support information for supporting a judgement based on information obtained from a tissue section. The method includes: obtaining a digital bright-field image of a tissue section stained to be observable in a bright field; creating an analysis score by obtaining, combining, and scoring multiple kinds of information on the bright-field image; and presenting the analysis score as the support information.Type: GrantFiled: February 6, 2020Date of Patent: December 24, 2024Assignee: KONICA MINOLTA, INC.Inventors: Etsuko Futaya, Hideki Goda
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Patent number: 12174207Abstract: The present disclosure relates to blood sample preparation devices and methods. In some embodiments, a method for preparing a blood sample comprises: receiving at a sample preparation machine a sample container containing the blood sample; scanning an identifier of the sample container, the identifier containing information indicative of a characteristic of at least one of the sample container or the blood sample contained therein, actuating, after the scanning, and based on the information, the sample container to repeatedly change a position of the sample container; determining, based on the information, whether the sample container should be centrifuged; and transporting the sample container to a centrifuge to be centrifuged and then to a storage compartment when the determining indicates that the sample container should be centrifuged, and to the storage compartment without entering the centrifuge when the determining indicates that the sample container should not be centrifuged.Type: GrantFiled: April 14, 2023Date of Patent: December 24, 2024Assignee: Babson Diagnostics, Inc.Inventors: Eric Olson, Kathryn Wong, Christopher Dipasquale, Scott Salmon, Steven Bellofatto, Steven Madsen, Courtney Nicholls
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Patent number: 12176066Abstract: Embodiments of a method and/or system for facilitating characterization of one or more conditions can include: generating a set of target-associated molecules; generating a reference-associated set of molecule; facilitating generation of at least one spike-in mixture; determining one or more abundance metrics based on an analysis of the at least one spike-in mixture; and facilitating the characterization of the one or more conditions based on the one or more abundance metrics.Type: GrantFiled: March 24, 2023Date of Patent: December 24, 2024Assignee: BILLIONTOONE, INC.Inventors: David Tsao, Oguzhan Atay
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Patent number: 12175801Abstract: Described herein relates to a system of and method for predicting and/or casting votes via a brain-computer interface. The voting system may be configured to allow at least one user to input and/or cast a vote using their brain activity. Additionally, the voting system uses a machine learning and/or classifying algorithm for classification of the brain data and prediction of the vote of the user. The voting system is also configured to synchronize brain activity to the at least one user, such that each vote may be correctly tallied to the at least one user, eliminating fraudulent voting via false identification, or the like. The voting system may also allow at least one user having a motor disability to vote without requiring any movement and/or physical assistance, such that the at least one user with a motor disability may maintain voting privacy.Type: GrantFiled: November 7, 2023Date of Patent: December 24, 2024Assignee: University of South FloridaInventors: Rupal Agarwal, Marvin Andujar
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Patent number: 12174142Abstract: The present solution describes an automated system for analyzing analytical gels or blots, such as electrophoresis gels. The system can automatically detect the lanes within the gel and convert the lane into a feature vector that can be compared to reference datasets. Based on a comparison of the feature vector to the reference datasets, the system can automatically classify the feature vector (and the test sample in the lane) into a phenotype group.Type: GrantFiled: June 26, 2023Date of Patent: December 24, 2024Assignee: Quest Diagnostics Investments LLCInventors: Nilesh Saratkar, Stanley Naides, Michelle A. Cleveland
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Patent number: 12171554Abstract: In some examples, a medical system includes a medical device. The medical device may include a housing configured to be implanted in a target site of a patient, a light emitter configured to emit a signal configured to cause a fluorescent marker to emit a fluoresced signal into the target site, and a light detector that may be configured to detect the fluoresced signal. The medical system may include processing circuitry configured to determine a characteristic of the fluorescent marker based on the emitted signal and the fluoresced signal. The characteristic of the fluorescent marker may be indicative of a presence of a compound in the patient, and the processing circuitry may be configured to track the presence of the compound of the patient based on the characteristic of the fluorescent marker.Type: GrantFiled: September 18, 2023Date of Patent: December 24, 2024Assignee: Medtronic, Inc.Inventors: John E. Burnes, James K. Carney, Jonathan L. Kuhn, Mark J. Phelps, Jesper Svenning Kristensen, Rodolphe Katra
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Patent number: 12168800Abstract: Methods for evaluating microsatellite instability (MSI) analyze nucleic acid sequence reads corresponding to a plurality of marker regions for MSI. The marker regions may include long homopolymers and/or short tandem repeats (STRs). For a target homopolymer, a histogram of homopolymer signal values is calculated based on flow space signal measurements for the homopolymer region in the sequence reads. A score per marker based on features of the histogram of homopolymer signal values is determined for each marker region corresponding to the target homopolymers. For a target STR, the method includes calculating a histogram of repeat lengths for sequence reads corresponding to the marker region of the target STR. A score per STR marker is calculated based on features of the histogram of repeat lengths. A plurality of per marker scores may be combined to form a total MSI score for the sample.Type: GrantFiled: December 5, 2023Date of Patent: December 17, 2024Assignee: Life Technologies CorporationInventor: Sameh El-Difrawy
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Patent number: 12163950Abstract: The present invention relates to novel synthetic odorant receptors capable of cell surface localization upon cellular expression. Specifically, the present invention provides synthetic odorant receptors having a consensus amino acid sequence deduced from a plurality of odorant receptors within an odorant receptor family, wherein the consensus amino acid sequence represents the mostly frequently present amino acid residues for each amino acid position deduced from a plurality of odorant receptors within an odorant receptor family. Additionally, the present invention provides methods of use, methods of synthesis, and cell lines expressing one or more of such novel synthetic odorant receptors.Type: GrantFiled: June 26, 2019Date of Patent: December 10, 2024Assignee: Duke UniversityInventors: Hiroaki Matsunami, Kentaro Ikegami, Maira Nagai, Claire De March
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Patent number: 12156722Abstract: A pulse rate detection device includes: a moving image obtaining device configured to obtain a moving image captured by photographing a body surface of a subject, a pulse rate obtaining device configured to obtain a pulse rate of the subject on the basis of change of a pixel value of the body surface in the moving image, a reliability obtaining device configured to obtain reliability of the obtained pulse rate, and an output device configured to output the obtained pulse rate, if the obtained reliability is equal to or greater than predetermined reliable criteria and, if the obtained reliability is less than reliable criteria and change of the obtained pulse rate is within a predetermined appropriate range.Type: GrantFiled: March 27, 2020Date of Patent: December 3, 2024Assignee: AISIN CORPORATIONInventor: Michael Jones
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Patent number: 12159397Abstract: The present application is directed to a method and system for determining at least one physical and/or chemical characteristic of a keratinous surface of a user, the method comprising the steps of: —receiving data corresponding to at least one image of the keratinous surface, —processing the image by applying at least one machine learning model to said image, —returning at least one numerical value corresponding to a grade of the characteristic of the keratinous surface to be determined.Type: GrantFiled: July 15, 2019Date of Patent: December 3, 2024Assignee: L'OrealInventors: Matthieu Perrot, Emmanuel Malherbe, Thierry Wasserman, John Charbit, Panagiotis-alexandros Bokaris
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Patent number: 12159721Abstract: A modeling computing device for predicting relative patient hazards based on predicted patient pharmaceutical adherence is provided. The modeling computing device includes a processor configured to receive a set of adherence data associated with adherence to a pharmaceutical prescription by a patient. The processor is also configured to determine a set of predictive adherence scores and determine a variability score associated with the set of predictive adherence scores. The processor is further configured to integrate the set of predictive adherence scores and the variability score into a feature value. The processor is also configured to identify a hazard regression model and to apply the feature value to the hazard regression model to generate an integrated patient hazard model. The processor is also configured to process the integrated patient hazard model to determine a risk level associated with the patient, and transmit an alert based on the risk level.Type: GrantFiled: October 16, 2020Date of Patent: December 3, 2024Assignee: Express Scripts Strategic Development, Inc.Inventors: Alexi E. Makarkin, Christopher G. Lehmuth
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Patent number: 12159718Abstract: A method of evaluating pancreatic cancer includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated, and (II) an evaluating step of evaluating a state of pancreatic cancer in the subject by calculating a value of a formula using the amino acid concentration data of the subject obtained at the obtaining step and the formula previously established for evaluating the state of pancreatic cancer, including an explanatory variable to be substituted with the concentration value of the amino acid.Type: GrantFiled: May 4, 2021Date of Patent: December 3, 2024Assignee: Ajinomoto Co., Inc.Inventors: Nobukazu Ono, Atsuko Shinhara, Takahiko Muramatsu, Shinya Kikuchi, Hiroshi Yamamoto, Koichi Shiraishi, Kazuhiro Katayama, Nobuyasu Fukutake, Masahiko Higashiyama, Shinichi Ohkawa, Makoto Ueno, Yohei Miyagi, Naoyuki Okamoto
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Patent number: 12152969Abstract: Provided is a method for preparing a tissue section, including treating a tissue specimen with a clearing agent and at least one labeling agent to obtain a cleared and labeled tissue specimen; generating a three-dimensional (3D) image of the cleared and labeled tissue specimen; performing an image slicing procedure on the 3D image to generate a plurality of two-dimensional (2D) images; identifying a target 2D image among the plurality of 2D images to obtain a distance value of D1, which indicates the distance between the target 2D image and a predetermined surface of the 3D image; preparing a hardened tissue specimen from the cleared and labeled tissue specimen; and cutting the hardened tissue specimen near a predetermined site to obtain a tissue section, wherein the distance between the predetermined site and a surface of the hardened tissue specimen corresponding to the predetermined surface of the 3D image is D1.Type: GrantFiled: January 4, 2021Date of Patent: November 26, 2024Inventors: Ann-Shyn Chiang, Dah-Tsyr Chang, I-Ching Wang, Jia-Ling Yang, Shun-Chi Wu, Yen-Yin Lin, Yu-Chieh Lin
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Patent number: 12154684Abstract: A computer-implemented method, computer program product and computing system for: monitoring a bedside monitoring device to detect the occurrence of alarms, thus defining detected alarms; processing the detected alarms to determine their authenticity; and if a detected alarm is determined to be non-authentic, adjusting one or more monitoring criteria that was instrumental in producing the non-authentic detected alarm.Type: GrantFiled: July 7, 2023Date of Patent: November 26, 2024Assignee: CALMWAVE, INC.Inventors: Ophir Ronen, Justin Kearns, Keith Boudreau, Christian Bauer, Michael Gruzynski, David Garner, Thomas Dziedzic
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Patent number: 12150780Abstract: An electronic device is provided. The electronic device includes a motion sensor, at least one optical sensor, a processor operatively connected to the motion sensor and the at least one optical sensor, and a memory operatively connected to the processor. The memory may store instructions that cause, when executed, the processor to monitor user state information based on signals received through the motion sensor and the at least one optical sensor, to acquire a sensor value by controlling the at least one optical sensor based on the monitoring, to calculate blood pressure change information according to a user's sleep based on the sensor value, and to provide guide information according to the blood pressure change information.Type: GrantFiled: March 11, 2022Date of Patent: November 26, 2024Assignee: Samsung Electronics Co., Ltd.Inventors: Sunok Jung, Choonghee Ahn, Hongji Lee
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Patent number: 12154662Abstract: An analysis method of analyzing a nucleic acid sequence of a patient sample with a computer, may include: obtaining first nucleic acid sequence data derived from a tumor cell collected from a patient, and second nucleic acid sequence data derived from a non-tumor cell collected from the patient; detecting a somatic mutation based on the first nucleic acid sequence data; detecting a germline mutation based on the second nucleic acid sequence data; selecting a presentation form for information on the germline mutation among candidate forms; and creating an analysis report in the selected form.Type: GrantFiled: June 19, 2020Date of Patent: November 26, 2024Assignee: SYSMEX CORPORATIONInventors: Kenichiro Suzuki, Reiko Watanabe, Mizuho Kawate, Kosuke Kai, Hiroko Onoe
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System and method for determining critical suspension speed of impeller in solid-liquid stirred tank
Patent number: 12146819Abstract: A system and method for determining a critical suspension speed of an impeller in a solid-liquid stirred tank belongs to the technical field of critical speed determination. A relationship is established between a voltage of a measurement electrode and a solid-liquid suspension state to avoid the problems of strong subjectivity and large deviation appearing in existing critical suspension speed determination based on empirical formulas and human eye observation. An electrode voltage ratio is taken as a determination criterion, which is only related to a spatial density of solid particles in a liquid phase.Type: GrantFiled: September 7, 2022Date of Patent: November 19, 2024Assignee: QINGDAO UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Datong Wang, Ting Xu, Hao Wang, Fujun Lu, Peng Guo, Changhai Zhou, Xu Yang, Tao Yue -
Patent number: 12146827Abstract: Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.Type: GrantFiled: June 29, 2023Date of Patent: November 19, 2024Assignee: BECKMAN COULTER, INC.Inventor: Michael Kapinsky
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Patent number: 12146869Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.Type: GrantFiled: July 14, 2023Date of Patent: November 19, 2024Assignee: MATTERWORKS INCInventors: Timothy Kassis, Jefferson Pruyne, Mark D. Simon, Mimoun Cadosch Delmar Akerman, Jennifer Campbell, Ana Henriques Da Costa, Laura Kolinsky, John M. Geremia
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Patent number: 12144611Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.Type: GrantFiled: September 22, 2015Date of Patent: November 19, 2024Assignee: Dexcom, Inc.Inventors: Naresh C. Bhavaraju, Michael A. Bloom, Leif N. Bowman, Alexandra Lynn Carlton, Katherine Yerre Koehler, Hari Hampapuram, Jonathan Hughes, Lauren Hruby Jepson, Apurv Ullas Kamath, Anna Leigh Davis, Peter C. Simpson, Stephen J. Vanslyke
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Patent number: 12142378Abstract: Presented are concepts for detecting recurrence of a medical condition in a subject previously treated for the medical condition. One such concept comprises, using natural language processing, extracting information from a data set comprising information relating to the subject prior to and/or during the subject's previous treatment for the medical condition. The extracted information is reformulated into structured data based on a standardized model. A data retrieval request comprising a structured query adhering to a template is obtained and, based on the structured query of the data retrieval request, data is retrieved from the structured data.Type: GrantFiled: January 16, 2019Date of Patent: November 12, 2024Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Yiyi Hu, Yan Li, Zuofeng Li, Huichuan Sun, Mao Hua Yang, Jian Zhou, Jia Fan
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Patent number: 12138607Abstract: Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.Type: GrantFiled: December 24, 2020Date of Patent: November 12, 2024Assignee: MEDISCA PHARMACEUTIQUE INC.Inventor: Panagiota Danopoulos
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Patent number: 12138427Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.Type: GrantFiled: May 2, 2024Date of Patent: November 12, 2024Assignee: Dexcom, Inc.Inventor: Thomas A. Peyser
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Patent number: 12142352Abstract: A modular patient analytics system, including: an integrated machine learning module configured to receive patient data and to apply machine learning models to the received patient data; machine learning services that includes default machine learning models and trained machine learning models; a testing service configured to receive real time patient data, to run a machine learning model to produce a model output, and to provide the model output to the integrated machine learning module; a model training service configured to receive site training data, to train a machine learning model using the site training data, and to provide the trained machine learning model to the machine learning services; and a classification service configured to receive and provide pseudo labels for patient data from the site data for use in semi supervised learning of machine learning models as well as model validation on updated and existing machine learning models.Type: GrantFiled: October 4, 2019Date of Patent: November 12, 2024Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Bilal Bashir, Trevor Merrill
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Patent number: 12142349Abstract: The present disclosure addresses the technical problem related to the identification of microbial basis of a disease in microbiome. A system and method for identification of key driver responsible for bringing a change in a microbial population has been disclosed. A subset of common taxa between the ‘control’ and ‘case’ dataset is chosen and corresponding microbial association network is created. The method involves the characterization of the important community level changes between two association networks (‘control’ and ‘case’) that are obtained for a particular disease or condition. A taxon in the diseased state with an altered set of associations (identified by a high network shift score), while still being increasingly important (identified with a positive increase in betweenness) for the whole network, necessarily holds a key significance in the identification of key driver.Type: GrantFiled: May 14, 2019Date of Patent: November 12, 2024Assignee: Tata Consultancy Services LimitedInventors: Sharmila Shekhar Mande, Kuntal Kumar Bhusan
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Patent number: 12135832Abstract: An input apparatus for operating and/or controlling a technical device includes a plurality of sensor elements which can be arranged spatially distributed in the oral cavity of a user. An interface circuit is coupled to the sensor elements and is configured to detect a respective current tongue position and/or tongue movement by means of the sensor elements. The interface circuit generates one or more control signals depending on the respective current tongue position and/or tongue movement and transmits the one or more control signals to the technical device. Advantageously, the sensor elements each include a transponder which is configured to receive an interrogation signal from the interface circuit and, in response thereto, to transmit an individually coded response signal to the interface circuit.Type: GrantFiled: December 1, 2022Date of Patent: November 5, 2024Assignee: Universität StuttgartInventor: Carsten Mehring
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Patent number: 12136218Abstract: The present disclosure relates to a method for predicting biomarker expression from a medical image. The method for predicting biomarker expression includes receiving a medical image, and outputting indices of biomarker expression for the at least one lesion included in the medical image by using a first machine learning model.Type: GrantFiled: October 15, 2021Date of Patent: November 5, 2024Assignee: LUNIT INC.Inventors: Jae Hong Aum, Chanyoung Ock, Donggeun Yoo
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Patent number: 12135263Abstract: Disclosed is a washing method for a staining bath in a smear sample preparing apparatus. The staining bath is able to accommodate a glass slide having a specimen smeared thereon, and stores therein a staining liquid for staining the specimen smeared on the glass slide to perform a staining process. The washing method includes: receiving information related to a washing condition; and executing a washing operation for the staining bath, according to the received information.Type: GrantFiled: October 15, 2020Date of Patent: November 5, 2024Assignee: SYSMEX CORPORATIONInventors: Junya Ikuta, Noriyuki Nakanishi, Yugo Harada, Seiya Shinabe