Biological Or Biochemical Patents (Class 702/19)
  • Patent number: 11955226
    Abstract: An information processing apparatus includes a processor, and a memory storing a program. The program, when executed by the processor, causes the information processing apparatus to: acquire a medical image obtained by imaging a subject, acquire an inspection result of the medical image, perform inference on the medical image; and control outputting of an inference result of the medical image inference to an external device based on the inspection result of the medical image.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: April 9, 2024
    Assignees: CANON KABUSHIKI KAISHA, CANON MEDICAL SYSTEMS CORPORATION
    Inventor: Kohtaro Umezawa
  • Patent number: 11954146
    Abstract: A method and system for providing a data analysis in the form of a customized geographic visualization on a graphical user interface (GUI) on a remote client computing device using only a web browser on the remote client device. The system receives a user's selected data analysis to be performed by the system for display on the remote client device. The system verifies the data access permissions of the user to render a data analysis solution customized to that particular user, and automatically prevents that user from gaining access to data analysis solutions to which that user is prohibited. The system is configured to respond to the user's data analysis request, perform the necessary computations on the server side on the fly, and send a dataset interpretable by the client device's web browser for display on the client device or on a device associated with the client device.
    Type: Grant
    Filed: January 6, 2023
    Date of Patent: April 9, 2024
    Assignee: Blue Cross and Blue Shield Association
    Inventors: Teresa Nguyen Clark, Michael Steven Weinberg, Carlos Ricardo Villarreal, Nathania Hau, Jelani Akil McLean, Abigail Berube, Trent Tyrone Haywood
  • Patent number: 11950935
    Abstract: A system for generating a hypoglycemia risk signal associated with exercise-induced Hypoglycemia. The system can include a processor configured to obtain a blood glucose signal (BGstart), a ratio of absolute insulin on board over total daily insulin signal (IOBabs/TDI), and an initial glycemic slope signal (S0); generate a hypoglycemia risk signal based on a hypoglycemia prediction algorithm that determines the probability of a user being hypoglycemic during or after exercise based on the obtained BGstart, IOBabs/TDI and S0.
    Type: Grant
    Filed: February 8, 2023
    Date of Patent: April 9, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Marc D. Breton, Najib Ben-Brahim
  • Patent number: 11950923
    Abstract: Systems, methods, and apparatuses monitor mammal conditions, report condition changes, and provide neurocode-based treatment in response to condition changes. A mammal implantable controller includes modules to monitor, wirelessly communicate to external computers, and administer treatment received from a remote computer based on monitoring of changes in mammal condition as analyzed by the remote computer. External computers can be provided in the form of a mobile device (e.g., smartphone/tablet), resident treatment pods, and treatment servers. Treatment can be provided to change biological function or trigger cell death in cancer cells.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: April 9, 2024
    Assignee: Electroceuticals, LLC
    Inventors: Eleanor Schuler, Luis M. Ortiz, Kermit D. Lopez
  • Patent number: 11955207
    Abstract: The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 9, 2024
    Assignee: Emerald Cloud Lab, Inc.
    Inventors: Alex M. Yoshikawa, Anand V. Sastry, Asuka Ota, Ben C. Kline, Bradley M. Bond, Brian M. Frezza, Cameron R. Lamoureux, Catherine L. Hofler, Cheri Y. Li, Courtney E. Webster, Daniel J. Kleinbaum, George N. Stanley, George W. Fraser, Guillaume Robichaud, Hayley E. Buchman, James R. McKernan, Jonathan K. Leung, Paul R. Zurek, Robert M. Teed, Ruben E. Valas, Sean M. Fitzgerald, Sergio I. Villarreal, Shayna L. Hilburg, Shivani S. Baisiwala, Srikant Vaithilingam, Wyatt J. Woodson, Yang Choo, Yidan Y. Cong
  • Patent number: 11950900
    Abstract: Elderly people suffer from health issues, and timely detection can save lives. State of the art techniques either make certain assumptions or require clinical data in order to perform the frailty detection, which affects the quality as well as cause inconvenience to the users. The disclosure herein generally relates to patient monitoring and, more particularly, to frailty detection using pedometer sensor data, PIR sensor data, and door sensor data. The system determines activity levels of the user being monitored, based on data from the pedometer sensors, PIR sensors, and door sensors, and based on the determined activity levels, further determines whether the user has frailty or not.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: April 9, 2024
    Assignee: TATA CONSULTANCY SERVICES LIMITED
    Inventors: Ramesh Balaji, Srinivasa Raghavan Venkatachari, Anirudh Thenguvila Purushothaman
  • Patent number: 11952409
    Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: April 9, 2024
    Assignee: IMMATICS BIOTECHNOLOGIES GMBH
    Inventors: Jens Hukelmann, Heiko Schuster, Lena Wullkopf, Christoph Schraeder, Jens Fritsche, Daniel Johannes Kowalewski, Michael Roemer, Oliver Schoor
  • Patent number: 11954926
    Abstract: A method, and corresponding apparatus, for identifying a feature in an image comprises determining a plurality of characteristic values for each pixel or group of pixels within the image, and determining a confidence value for a target area of the image on the basis of the plurality of characteristic values of the pixels within the target area. Each of the plurality of characteristic values relates to a different characteristic of the feature. The confidence value is indicative of whether the feature is represented by the target area of the image.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 9, 2024
    Assignee: AIVF Ltd.
    Inventors: Daniella Marder Gilboa, Ron Uriel Maor, Ron Weiner, Daniel S. Seidman
  • Patent number: 11944472
    Abstract: The radiographic system includes an exposure table on which a breast of a subject is placed, a compression plate that compresses the breast placed on the exposure table, a marker having a two-dimensional pattern provided on the compression plate, a radiation source that irradiates the compressed breast with radiation, a camera that captures a visible light image including the marker, and a processor that derives height information of the compression plate with respect to the exposure table based on a marker image showing the marker reflected in the visible light image.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: April 2, 2024
    Assignee: FUJIFILM CORPORATION
    Inventor: Junya Morita
  • Patent number: 11948663
    Abstract: Contemplated systems and methods use high-accuracy in silico HLA analysis to so establish a transplant match database suitable for transplantation, and particularly stem cell and solid organ transplant.
    Type: Grant
    Filed: March 29, 2023
    Date of Patent: April 2, 2024
    Assignee: Nant Holdings IP, LLC
    Inventors: Patrick Soon-Shiong, John Zachary Sanborn
  • Patent number: 11941434
    Abstract: A task processing method, a processing apparatus, and a computer system are provided. Implementation of the method includes: generating, by a first processing apparatus, a plurality of tasks, and determining task description information of the plurality of tasks, where the task description information of the plurality of tasks is used to indicate a dependency relationship between the plurality of tasks; sending an instruction to a second processing apparatus, where the instruction includes the plurality of tasks and the task description information of the plurality of tasks; and receiving the instruction, and processing the plurality of tasks based on the dependency relationship between the plurality of tasks. The method can effectively reduce a waiting delay, fully exploit a computing capability of an acceleration chip, and improve task processing efficiency.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: March 26, 2024
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Wei Li, Xiong Gao, Hou Fun Lam, Tao Ma
  • Patent number: 11941544
    Abstract: Nominal values of parameters, and perturbations of the nominal values, that are associated with previously defined radiation treatment plans are accessed. For each treatment field of the treatment plans, a field-specific planning target volume (fsPTV) is determined based on those perturbations. At least one clinical target volume (CTV) and at least one organ-at-risk (OAR) volume are also delineated. Each OAR includes at least one sub-volume that is delineated based on spatial relationships between each OAR and the CTV and the fsPTV for each treatment field. Dose distributions for the sub-volumes are determined based on the nominal values and the perturbations. One or more dose prediction models are generated for each sub-volume. The dose prediction model(s) are trained using the dose distributions.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: March 26, 2024
    Assignee: SIEMENS HEALTHINEERS INTERNATIONAL AG
    Inventors: Perttu Niemela, Jari Lindberg, Tuomas Jyske, Maria Cordero Marcos, Esa Kuusela
  • Patent number: 11937912
    Abstract: A method comprising at least one light source configured to generate a light of at least one wavelength and project the light over an optical path, a sample device, the device containing a sample obtained from exhalation of a person, a vortex mask configured to receive the light after the light passes through at least a portion of the sample device, the vortex mask including a series of concentric circles etched in a substrate, the vortex mask configured to provide destructive interference of coherent light received from the at least one light source, a detector configured to detect and measure wavelength intensities from the light in the optical path, the wavelength intensities being impacted by the light passing through the sample, the detector receiving the light that remained after passing through the vortex mask, and a processor configured to provide measurement results based on the wavelength intensities.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: March 26, 2024
    Assignee: Hyperspectral Corp.
    Inventors: David M. Palacios, Harry Hopper
  • Patent number: 11934450
    Abstract: A system and method utilizing three-dimensional (3D) data to identify objects. A database of profiles can be created for goods, product, object, or part information by producing object representations that permit rapid, highly-accurate object identification, matching, and obtaining information about the object. The database can be part of a different recognition system than the system used to identify the object. The profiles can be compared to a profile of an unknown object to identify, match, or obtain information about the unknown object, and the profiles can be filtered to identify or match the profiles of known objects to identify and/or gather information about an unknown object. Comparison, filtering, and identification may be performed prior to, subsequent to, or in conjunction with other systems, such as image-based machine learning algorithms.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: March 19, 2024
    Assignee: SKUSUB LLC
    Inventors: Keith H. Meany, Matthew Antone
  • Patent number: 11926873
    Abstract: The present invention relates to a method of creating a biomarker profile, the method comprising the steps of: obtaining a sample of biofluid from a subject, wherein the sample is stored on a sample collection apparatus; removing the sample from the sample collection apparatus; extracting nucleic acids from the sample; sequencing the extracted nucleic acids to generate sequence data; and analyzing the sequence data using a two-step analytical methodology to create the biomarker profile. The present invention is also directed to methods of determining the sex of an in utero fetus, predicting onset of a migraine in a subject, and of tracking athletic performance in a subject.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: March 12, 2024
    Assignee: The Translational Genomics Research Institute
    Inventor: Matthew Huentelman
  • Patent number: 11928985
    Abstract: Methods, computer program products, and systems are presented. The method computer program products, and systems can include, for instance: predicting an exhibited sentiment of a certain user on being presented one or more candidate education segment, wherein the predicting is in dependence on historical sentiment parameter values of one or more user on being exposed to presented educational content, the historical sentiment parameter values being stored in a data repository, wherein the presented education segments comprise digital media content adapted for playing by a digital media player; selecting at least one of the one or more candidate education segment in dependence on a result of the predicting so that a selected at least one of the one or more candidate education resulting from the selecting is personalized for the certain user; and presenting to the certain user the selected at least one of the one or more candidate education segment.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 12, 2024
    Assignee: International Business Machines Corporation
    Inventors: Geetha Karna, Sreekanth L. Kakaraparthy, Kuntal Dey
  • Patent number: 11929144
    Abstract: The present invention provides a method of detecting mutational signatures in a DNA sample. The invention relates to method of detecting signatures arising from rearrangements in the DNA in the sample and determining the contributions of known rearrangement signatures to said rearrangements. In particular embodiments, the contributions are determined by computing the cosine similarity between the rearrangement mutations in said catalogue and the rearrangement mutational signatures. The rearrangement signatures are classified based on whether they are clustered or not, whether they are tandem duplications, deletions, inversions or translocations and on the basis of their size.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: March 12, 2024
    Assignee: Genome Research Limited
    Inventors: Serena Nik-Zainal, Mike Stratton, Dominik Glodzik
  • Patent number: 11929159
    Abstract: Method of determining insulin injection amount, computer storage medium, and devices, the method includes including: obtaining characteristic information and a blood glucose content at a current time of a target user; and determining an insulin injection amount at each time of the target user based on the characteristic information of the target user, the blood glucose content at the current time of the target user, a predetermined blood glucose prediction model, and a predetermined insulin injection amount prediction model. The method can facilitate the determination of the insulin injection amount at each time.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: March 12, 2024
    Assignees: SHANGHAI SIXTH PEOPLE'S HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Weiping Jia, Bin Sheng, Jian Zhou, Ruhan Liu, Liang Wu, Huating Li
  • Patent number: 11929167
    Abstract: A sensing device monitors and tracks food intake events and details. A processor, appropriately programmed, controls aspects of the sensing device to capture data, store data, analyze data and provide suitable feedback related to food intake. More generally, the methods might include detecting, identifying, analyzing, quantifying, tracking, processing and/or influencing, related to the intake of food, eating habits, eating patterns, and/or triggers for food intake events, eating habits, or eating patterns. Feedback might be targeted for influencing the intake of food, eating habits, or eating patterns, and/or triggers for those. The sensing device can also be used to track and provide feedback beyond food-related behaviors and more generally track behavior events, detect behavior event triggers and behavior event patterns and provide suitable feedback.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: March 12, 2024
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Katelijn Vleugels, Ronald Marianetti, II
  • Patent number: 11923067
    Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 5, 2024
    Assignee: LightLab Imaging, Inc.
    Inventors: Joseph M. Schmitt, Hiram Bezerra, Christopher Petroff, Ajay Gopinath
  • Patent number: 11921222
    Abstract: A plant tracking apparatus, system, and method for tracking planting locations of a plurality of plants configured to be planted in a ground surface using a planting utensil having a handle, a blade, and a shaft defined between the handle and the blade is disclosed herein. The plant tracking apparatus includes a housing configured to be coupled to the planting utensil. The plant track apparatus further includes a Global Navigation Satellite System (GNSS) sensor, a planting sensor, and a controller positioned within or coupled to the housing. The controller is configured to record location data from the GNSS sensor in response to a planting signal from the planting sensor. In certain embodiments, the controller may determine the planting signal by comparing data from the planting sensor to a predetermined motion profile.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: March 5, 2024
    Inventor: Corey Craig
  • Patent number: 11923091
    Abstract: A method and system for remote diagnosis of a congestive heart failure in humans is presented. The method includes receiving a facial image of a patient, wherein the facial image is retrieved from a data store and captured from the patient; extracting, from the facial image, at least one facial feature indicative of a heart condition; classifying the extracted at least one facial feature using a classifier, wherein the classifier maps a plurality of candidate facial features to a plurality of scores indicating a stage of the heart condition; and determining a positive diagnosis and the stage of the heart condition of the patient based on the plurality of scores.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: March 5, 2024
    Inventors: Baruch Schler, Jonathan Schler
  • Patent number: 11918375
    Abstract: A system, according to various embodiments, includes eyewear (or any other suitable wearable device) that includes at least one environmental pollution monitoring sensor (e.g., at least one light pollution, air pollution, radioactive pollution, thermal pollution, and/or noise pollution sensor) that may be used to monitor the presence of environmental pollution adjacent a wearer of the eyewear. The system may further include one or more health monitoring sensors to determine the health effects of the environmental pollution on the wearer. In certain circumstances, the system may alert the user to potentially harmful environmental conditions, or convey preventative healthcare advice to the wearer.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: March 5, 2024
    Assignee: BEIJING ZITIAO NETWORK TECHNOLOGY CO., LTD.
    Inventors: Richard Chester Klosinski, Jr., Meghan Kathleen Murphy, Matthew Allen Workman, Jay William Sales
  • Patent number: 11922017
    Abstract: The subject technology provides compact, searchable, random-access storage of genome data, particularly for large datasets, such as an entire human genome. The genome data may be stored in binary format, and compressed, in part, by leveraging characteristics of genome data itself, and in a way that maintains searchability of the stored compressed data.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: March 5, 2024
    Assignee: Apple Inc.
    Inventors: Haibao Tang, Richard A. Bloomfield, Jr.
  • Patent number: 11913958
    Abstract: The present invention relates to methods for the in vitro diagnosis of lung cancer in a subject, comprising the detection of progastrin using at least one progastrin-binding antibody. According to the method of the invention, the subject is diagnosed with a lung cancer when progastrin is detected in the sample.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 27, 2024
    Assignee: ECS-Progastrin SA
    Inventor: Alexandre Prieur
  • Patent number: 11911201
    Abstract: The present disclosure relates to systems and methods for positioning a region of interest (ROI). The systems may obtain an image of an object captured by an imaging device. The systems may extract image information of the image. The systems may obtain feature information of a region of interest (ROI) in the object. The systems may determine position information of the ROI in the image using a positioning model based on the image information of the image and the feature information of the ROI.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: February 27, 2024
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Feng Yao, Jia Zhao
  • Patent number: 11910784
    Abstract: An animal management system has one or more imaging devices, and a computing device coupled to the one or more image devices for receiving one or more images captured by the one or more imaging devices, processing at least one image using an artificial intelligence (AI) pipeline for: (i) detecting and locating in the image one or more animals, (ii) for each detected animal: (a) generating at least one section of the detected animal, (b) determining a plurality of key points in each section, (c) generating an embedding for each section based on the plurality of key points in the section, and (d) combining the embeddings for generating an identification of the detected animal with a confidence score. Key points and bounding boxes may also have associated confidence scores.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: February 27, 2024
    Inventors: Jeffrey Shmigelsky, Mocha Shmigelsky, Madison Lovett, Philip Cho
  • Patent number: 11903698
    Abstract: Disclosed are methods, apparatuses, etc. for determination and application of a metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: February 20, 2024
    Assignee: Medtronic Minimed, Inc.
    Inventors: Lane Desborough, Cesar C. Palerm, Salman Monirabbasi
  • Patent number: 11908547
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for governing phenotypic outcomes in plants. One method includes obtaining a model input comprising time series data, wherein the time series data comprises, for each previous time point of one or more previous time points, at least one of i) first multi-omics data corresponding to a plant at the previous time point, or ii) phenotypic data corresponding to the plant at the previous time point; and processing the model input using a machine learning model to obtain a model output that comprises, for each future time point of one or more of future time points, a prediction of at least one of i) a phenotype of the plant at the future time point, or ii) second multi-omics data corresponding to the plant at the future time point.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: February 20, 2024
    Assignee: X Development LLC
    Inventors: Bradley Michael Zamft, Logan Graham
  • Patent number: 11906509
    Abstract: Systems and methods are provided for characterizing shuttle capture events in a nanopore sensor. The method first collects time-dependent current blockage signatures for at least one bias voltage. The method then identifies each signature as corresponding to a permanent or transient event. The method then generates a protein dynamics landscape (PDL) for the transient event signatures. The PDL comprises a set of histograms of nanopore current data and characterizes current through the nanopore during shuttle capture events. The method can then comprise identifying an entrance level blockage value based on the permanent event signatures. Permanent event captures can be determined by time duration which is larger than a certain threshold time value. Applying a voltage between the fluidic chambers above a threshold voltage level can be used to control that the vast majority of events are permanent.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: February 20, 2024
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Lene V. Hau, Jene A. Golovchenko
  • Patent number: 11901043
    Abstract: Disclosed is a sequence analysis method for analyzing nucleic acid sequence, the sequence analysis method including: obtaining a plurality of read sequences read from the nucleic acid sequence; and determining each nucleic acid sequence by aligning each read sequence with reference to a single reference sequence, wherein the reference sequence includes at least a first rearrangement sequence and a second rearrangement sequence that is different from the first rearrangement sequence.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 13, 2024
    Assignees: National Cancer Center, Mitsui Knowledge Industry Co., Ltd., Sysmex Corporation
    Inventors: Mamoru Kato, Hideya Kuwabara, Tomohiro Sakuma, Fumio Inoue, Kenichiro Suzuki
  • Patent number: 11896368
    Abstract: The present disclosure relates to methods and systems of determining swimming metrics of a user during a swimming session. The method can include receiving, by a processor circuit of a user device, motion information from one or more motion sensors of the user device; determining, by the processor circuit using the motion information, a first set of rotational data of the user device, wherein the first set of rotational data is expressed in a first frame of reference; converting, by the processor circuit, the first set of rotational data into a second set of rotational data, wherein the second set of rotational data is expressed in a second frame of reference; determining, by the processor circuit, one or more swimming metrics of the user; and outputting the one or more swimming metrics.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 13, 2024
    Assignee: Apple Inc.
    Inventors: Bharath Narasimha Rao, Craig H. Mermel, Karthik Jayaraman Raghuram, Hung A. Pham, Adam S. Howell, Rami Y. Hindiyeh, James P. Ochs, Vinay R. Majjigi, Alexander Singh Alvarado, Sunny K. Chow, Umamahesh Srinivas, Xing Tan, Ronald K. Huang, Edith Merle Arnold, Robin T. Guers, Gunes Dervisoglu, Adeeti Ullal
  • Patent number: 11901063
    Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: February 13, 2024
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Alexander Scherrer, Karl-Heinz Kuefer, Philipp Suess, Michael Bortz
  • Patent number: 11899022
    Abstract: The disclosure features methods of identifying specific drug candidates for disease treatment, the methods including: for pairs of associated expressed proteins in a protein-protein interaction network for a plurality of biological samples, comparing relative concentration values of the associated proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values, identifying a set of proteins involved in dysregulated protein-protein interactions in the network based on the outliers, and predicting an efficacy of one or more drug candidates from among a set of drug candidates for treating a disease based on the identified set of proteins and information about one or more of proteins, protein complexes, biological pathways, and functional modules targeted by the set of drug candidates.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: February 13, 2024
    Assignee: The General Hospital Corporation
    Inventors: Wilhelm Haas, Cyril Benes
  • Patent number: 11900604
    Abstract: Described herein is an adaptive expert system comprising a computing device having a memory that stores programmatic instructions and a processor that executes the programmatic instructions. The adaptive expert system receives sample data comprising at least one of raw data, optical data, and electropherogram data from a DNA analysis device, said data generated from a sample containing DNA. The adaptive expert system determines at least one characteristic of the sample data. The adaptive expert system utilizes the at least one characteristic to classify the sample data and apply a predefined parameter set to the said sample data to generate an output.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: February 13, 2024
    Assignee: ANDE Corporation
    Inventors: Eugene Tan, Hua Jiang, Richard F. Selden
  • Patent number: 11891427
    Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: February 6, 2024
    Assignee: IMMATICS BIOTECHNOLOGIES GMBH
    Inventors: Jens Hukelmann, Heiko Schuster, Lena Wullkopf, Christoph Schraeder, Jens Fritsche, Daniel Johannes Kowalewski, Michael Roemer, Oliver Schoor
  • Patent number: 11890079
    Abstract: Noninvasive methods and apparatus for detecting blood volume imbalances in a mammalian subject are disclosed. The method includes obtaining baseline measurements of at least three physiological parameters from a subject wherein the parameters are selected from the group consisting of heart rate, electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity. Measurements of electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity are taken at one or more extremities of the subject such as the calf, ankle, forearm, thigh, fingers and toes. The physiological parameters for which baseline measurements were obtained are then monitored to detect changes from the baseline measurements that indicate blood volume imbalances.
    Type: Grant
    Filed: January 23, 2021
    Date of Patent: February 6, 2024
    Inventor: Thomas Sandgaard
  • Patent number: 11893937
    Abstract: Provided are a pixel circuit, a driving method thereof, an array substrate, a display panel, and a display device. The pixel circuit includes a drive module, a first initialization module, and a data write module. A control terminal of the drive module is electrically connected to a first node, a first terminal of the drive module is electrically connected to a first power supply voltage terminal, and a second terminal of the drive module is electrically connected to a first electrode of a light-emitting element. The first initialization module includes a first N-type transistor and a second N-type transistor, where a control terminal of the first N-type transistor is electrically connected to a scan signal terminal, a first terminal of the first N-type transistor is electrically connected to a first reference signal terminal, a second terminal is electrically connected to a first terminal of the second N-type transistor.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: February 6, 2024
    Assignee: Wuhan Tianma Microelectronics Co., Ltd.
    Inventor: Qinyuan Zhang
  • Patent number: 11895235
    Abstract: A system for tracking clusters in an immutable sequential listing is disclosed. The system includes at least a processor and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the processor to receive a new record, obtain a sub-listing of an immutable sequential listing, wherein the sub-listing comprises a biological extraction cluster description posting of a biological extraction cluster and a cluster key, update the biological extraction cluster description posting using the new record, generate a new sub-listing and update the new sub-listing to the immutable sequential listing.
    Type: Grant
    Filed: February 21, 2023
    Date of Patent: February 6, 2024
    Assignee: KPN INNOVATIONS, LLC.
    Inventor: Kenneth Neumann
  • Patent number: 11892388
    Abstract: A simulation device for analyzing behavior of a granular material that includes a plurality of particles includes a first parameter acquisition unit that acquires a first parameter including a parameter relating to the granular material, a second parameter calculation unit that calculates a second parameter, when a particle group including the plurality of particles is coarsely viewed as a single coarse-view particle, the second parameter relating to the coarse-view particle, and a coarse-view particle behavior analysis unit that analyzes a behavior of the coarse-view particle based on the first parameter and the second parameter. The second parameter calculation unit calculates the second parameter by solving a characteristic equation that uses a relationship between an elastic energy of the particle group and an elastic energy of the coarse-view particle.
    Type: Grant
    Filed: November 25, 2022
    Date of Patent: February 6, 2024
    Assignees: SUMITOMO METAL MINING CO., LTD., University Public Corporation Osaka
    Inventors: Motoaki Saruwatari, Hideya Nakamura
  • Patent number: 11884927
    Abstract: This invention provides compositions and methods for providing high product yield of transgenes expressed in cyanobacteria and microalgae.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: January 30, 2024
    Assignee: The Regents of the University of California
    Inventors: Anastasios Melis, Cinzia Formighieri
  • Patent number: 11883258
    Abstract: A method for generating a three-dimensional digital model of a dental arch of a patient. The method includes projection of at least one light beam onto the arch, so as to draw at least one light mark on the arch, and simultaneously, displacement of the arch across the beam and acquisition, during the displacement, of a series of updated images of the arch each showing an updated projection defined by the projected mark. The method includes identification of the updated projection on each updated image, then search for a three-dimensional digital model, called “updated model”, exhibiting a best fit with all the updated projections.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 30, 2024
    Assignee: DENTAL MONITORING
    Inventors: Philippe Salah, Guillaume Ghyselinck, Thomas Pellissard, Laurent Debraux
  • Patent number: 11887736
    Abstract: Systems and methods for evaluating clinical comparative efficacy using real-world health data are provided herein. The method includes obtaining health trajectories for members of a healthcare system. The method also includes identifying index events in the health trajectories, and segmenting the health trajectories with index events into sub-trajectories such that each sub-trajectory ends at a different index event. The method also includes generating a digital fingerprint for each sub-trajectory by either (i) generating a raw data vector, or (ii) applying representation learning to generate an embedding vector. The method also includes identifying sub-trajectories that are similar to a patient sub-trajectory by either (i) performing a stratified search, or (ii) performing a nearest-neighbor search on the embedding vectors of the members. The method also includes ranking treatment strategies for the patient based on outcomes of the treatment strategies, according to the identified similar sub-trajectories.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: January 30, 2024
    Assignee: ELEVANCE HEALTH, INC.
    Inventors: Beau Norgeot, Theodore Goldstein, Axel Bernal, Chinmay Belthangady, Herman Sahota, Nicholas Guggemos, Paula Alves, Rajas Kale, Stefanos Giampanis, William Stedden, Rachel Lissak, Bobby Samuel
  • Patent number: 11877699
    Abstract: The present invention relates to a food processor (10). It is described to hold (110) a first food product in a food chamber, wherein food processing means are configured to process at least the first food product in the food chamber. An ingredient identification module determines (120) if either sucrose or fructose is the dominant sugar in the first food product to be processed. A processing unit determines (130) a processing protocol for processing the first food product, wherein determination of the processing protocol comprises utilization of the determined dominant sugar in the first food product. The food processing means processes (140) at least the first food product in the food chamber.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: January 23, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jiani Tang, Jingwei Tan
  • Patent number: 11879829
    Abstract: Methods for classifying fluorescent flow cytometer data are provided. In some instances, methods include processing the flow cytometer data with a supervised algorithm configured to cluster the fluorescent flow cytometer data into distinct populations according to the relationship of data points to relevant threshold values. In embodiments, methods include determining a measure of spillover spreading by calculating spillover spreading coefficients and combining them in a spillover spreading matrix. In some embodiments, populations of fluorescent flow cytometer data are adjusted to subtract the magnitude of spillover spreading. In embodiments, spillover spreading adjusted populations are partitioned after potential partitions are evaluated relative to the threshold values. In embodiments, partitioned populations of fluorescent flow cytometer data are classified (i.e., phenotyped) according to a hierarchy. Systems and computer-readable media for classifying fluorescent flow cytometer data are also provided.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: January 23, 2024
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventor: Richard Lee Halpert
  • Patent number: 11881296
    Abstract: The disclosure provides methods for improving the function of systems regimens, devices by identifying, quantifying, and implementing at least one inherent variability pattern which is based on patterns learned from a specific subject or from other subjects including subject's variability patterns, such as, DNA, genes, nucleic acids, RNA, proteins, cells, organs, biological pathway(s), or whole body variability. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of system's regimens, for improving biological systems functions. Any system used by humans, or affect human function, wherein the parameters are updated using inherent variabilities signatures with and without other individualized patterns from a subject or from other subjects, can increase the accuracy and efficacy of the system for achieving the desired goal.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 23, 2024
    Assignee: OBERON SCIENCES ILAN LTD.
    Inventor: Yaron Ilan
  • Patent number: 11882237
    Abstract: Aspects relate to an apparatus and methods for monitoring human trustworthiness. The apparatus includes at least an interface configured to facilitate telecommunication for a participant, a plurality of sensors configured to detect a plurality of signals from the participant, at least a computing device comprising at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to receive a plurality of signals from the plurality of sensors, generate a participant trustworthiness classifier as a function of a participant trustworthiness machine-learning algorithm, train the participant trustworthiness classifier using at least a training sample, wherein the at least a training sample correlates the plurality of signals to responses of known trustworthiness, and determine a participant trustworthiness as a function of the participant trustworthiness classifier.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: January 23, 2024
    Inventors: Bradford R Everman, Brian Bradke
  • Patent number: 11875880
    Abstract: A method is disclosed for calculating and recalculating protein confidence values by recalculating peptide confidence values in proteomic analysis. A plurality of scans are performed of a sample that is proteolytically digested into surrogate peptide analytes. A plurality of spectra are obtained, and a plurality of peptides are identified. A protein database is searched for proteins matching peptides from the plurality of peptides. Peptide confidence values are determined for the set of peptides. A protein confidence value is calculated for each protein in the set of proteins. A protein from the set of proteins with a largest protein confidence value is selected, the largest protein confidence value for the protein is saved, the protein from the set of proteins is removed, and peptides corresponding to the protein is removed from the set of peptides. The protein confidence value is recalculated for each protein in the set of proteins.
    Type: Grant
    Filed: November 9, 2019
    Date of Patent: January 16, 2024
    Assignee: DH Technologies Development Pte Ltd.
    Inventor: Ignat V. Shilov
  • Patent number: 11874212
    Abstract: A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: January 16, 2024
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Bo Ye, Wenbo Zheng, Huan Qi, Zhaoyang Li
  • Patent number: 11874290
    Abstract: In a sample pretreatment device, a container storage section (2) holds multiple containers, including a first well plate having wells in an N×M matrix form and a second well plate having N elongated wells whose length corresponds to M wells in one row of the first well plate or M elongated wells whose length corresponds to N wells in one column of the first well plate. A dispensing section (3) includes: a platform (30) on winch containers can be placed; a pipette unit (311, 312) including an M-channel tip corresponding to M wells in one row of the first well plate or an N-channel tip corresponding to N wells in one column of the first well plate; and a pump unit (313) for suctioning/ejecting a liquid from/into a container on the platform through the pipette unit. A transfer section (4) transfers containers between the container storage section and the platform. A controller (5) controls operations of the dispensing section and the transfer section.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: January 16, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Naoki Kaneko, Ritsuko Yoda, Akihito Korenaga