Biological Or Biochemical Patents (Class 702/19)
  • Patent number: 11367508
    Abstract: Disclosed herein are systems, methods, and compositions useful for determining cellular pathway disruption comprising the use of RNA expression level information. This determined level of disruption can assist in the identification of genetic variants that alter pathway activity, to correlate these variants with disease state and disease progression, and to identify those therapeutics most likely to be effective and which should be avoided.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: June 21, 2022
    Assignee: Tempus Labs, Inc.
    Inventors: Nike T. Beaubier, Joshua S K Bell, Catherine Igartua, Hailey B. Lefkofsky, Lee F. Langer, Joshua Drews
  • Patent number: 11367006
    Abstract: A system and method that takes in a data set comprising molecular structure data and properties of interest, e.g., ADMET, EC50, IC50, etc., and determines the substructures that cause or do not cause the property of interest. The substructures may then be used to filter out potentially harmful new proposed/generated molecules or create a new data set of known active/inactive substructures of a property of interest that may fulfill other obligations. The system comprises a substructure extraction module which further comprises a scaffold extraction module and a comparison module. A scaffold extraction module clusters, searches, and extracts substructures in question while a comparison module compares the bioactivity of each molecule with and without each substructure in question to determine the substructures effect on the property of interest.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: June 21, 2022
    Assignee: RO5 INC.
    Inventors: Gintautas Kamuntavicius, Aurimas Pabrinkis, Orestis Bastas, Alwin Bucher, Alvaro Prat, Mikhail Demtchenko, Sam Christian Macer, Zygimantas Jocys, Roy Tal, Charles Dazler Knuff
  • Patent number: 11367245
    Abstract: In an example a method includes identifying, by a processor, in a data model of at least a portion of a three-dimensional object, an object property associated with a location in the three-dimensional object. A data model of a virtual build volume comprising at least a portion of the three-dimensional object may be generated in which an association with an object property is dispersed beyond the location.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: June 21, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Matthew A Shepherd, Jake Wright, Hector Jose Lebron, Vanessa Verzwyvelt, Morgan T Schramm
  • Patent number: 11367521
    Abstract: A system and method for generating a mesodermal outline nourishment program comprises a computing device configured to obtain an undifferentiated connective tissue workup as a function of a connective tissue system, determine a mesodermal outline as a function of the undifferentiated connective tissue workup, wherein determining comprises obtaining a mesodermal group as a function of a connective database, and determining the mesodermal outline as a function of the mesodermal group and undifferentiated connective tissue workup using a mesodermal machine-learning model, generate an outline signature as a function of the mesodermal outline, wherein generating comprises receiving a normal range as a function of a mesodermal guideline, and generating the outline signature as a function of the normal range and mesodermal outline using a signature machine-learning model, identify an edible as a function of the outline signature, and output a nourishment program as a function of the edible.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: June 21, 2022
    Assignee: KPN INNOVATIONS, LLC.
    Inventor: Kenneth Neumann
  • Patent number: 11365448
    Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 21, 2022
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Wai Kwun Rossa Chiu, Wenli Zheng
  • Patent number: 11367004
    Abstract: Techniques are provided for replacing image assays using real world data and real word evidence RNA-seq analysis for assessing biologic pathways for identifying molecular subtypes. Systems of a methods diagnose HER2 status for a patient, by identifying discordant HER2 status result between the HER2 status from immunohistochemistry (IHC) and the HER2 status from fluorescence in-situ hybridization (FISH) and diagnosing HER2 status based gene expression data.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: June 21, 2022
    Assignee: TEMPUS LABS, INC.
    Inventors: Louis Fernandes, Caroline Epstein, Joshua S K Bell, Nike Tsiapera Beaubier, Gary Palmer
  • Patent number: 11357411
    Abstract: There is provided a system for measuring a physiological parameter of a person indicative of physiological pathology, comprising: a plurality of remote non-contact sensors, each of a different type of sensing modality, at least one hardware processor executing a code for: simultaneously receiving over a time interval, from each of the plurality of remote non-contact sensors monitoring a person, a respective dataset, extracting, from each respective dataset, a respective sub-physiological parameter of a plurality of sub-physiological parameters, analyzing a combination of the plurality of sub-physiological parameters, and computing a physiological parameter indicative of physiological pathology according to the analysis, wherein an accuracy of the physiological parameter computed from the combination is higher than an accuracy of the physiological parameter independently computed using any one of the plurality of sub-physiological parameters.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: June 14, 2022
    Assignee: NEC Corporation Of America
    Inventors: Tsvi Lev, Yaacov Hoch
  • Patent number: 11355219
    Abstract: According to one embodiment, a genotype estimation device includes: an acquirer configured to acquire a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known; and an estimator configured to estimate the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and output an estimation result.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: June 7, 2022
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Topon Paul, Arika Fukushima, Shinya Umeno
  • Patent number: 11352672
    Abstract: The present disclosure provides methods and reagents for the diagnosis, prognosis or the monitoring of breast cancer, including various subtypes of breast cancer including, for example, estrogen receptor (ER) negative breast cancer, ER positive breast cancer, triple negative breast cancer (TNBC) and other subtypes of breast cancer.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 7, 2022
    Assignee: Garvan Institute of Medical Research
    Inventors: Susan Clark, Elena Zotenko, Clare Stirzaker, Glenn Francis
  • Patent number: 11348368
    Abstract: A system and method are disclosed for generating a teleconference space for two or more communication devices using a computer coupled with a database and comprising a processor and memory. The computer generates a teleconference space and transmits requests to join the teleconference space to the two or more communication devices. The computer stores in memory identification information for each of the two or more communication devices. Each of the two or more communication devices stores audiovisual data pertaining to one or more users associated with each of the two or more communication devices. Each communication device converts the audiovisual data into facial expressions data, generates emotions data from the facial expressions data, generates attention data from the emotions data, and transmits the attention data from the communication device to the computer. The computer displays the attention data.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: May 31, 2022
    Assignee: Nextiva, Inc.
    Inventors: Tomas Gorny, Jean-Baptiste Martinoli, Tracy Conrad, Lukas Gorny
  • Patent number: 11344200
    Abstract: A method of luminance lifetime imaging includes receiving incident photons at an integrated photodetector from luminescent molecules. The incident photons being received through one or more optical components of a point-of-care device. The method also includes detecting arrival times of the incident photons using the integrated photodetector. A method of analyzing blood glucose includes detecting luminance lifetime characteristics of tissue using, at least in part, an integrated circuit that detects arrival times of incident photons from the tissue. The method also includes analyzing blood glucose based upon the luminance lifetime characteristics.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: May 31, 2022
    Assignee: Tesseract Health, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
  • Patent number: 11341631
    Abstract: The present disclosure is directed to a method and system for automatically detecting a physiological condition from a medical image of a patient. The method may include receiving the medical image acquired by an imaging device. The method may further include detecting, by a processor, target objects and obtaining the corresponding target object patches from the received medical image. And the method may further include determining, by the processor, a first parameter using a first learning network for each target object patch. The first parameter represents the physiological condition level of the corresponding target object, and the first learning network is trained by adding one or more auxiliary classification layers. This method can quickly, accurately, and automatically predict target object level and/or image (patient) level physiological condition from a medical image of a patient by means of a learning network, such as 3D learning network.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: May 24, 2022
    Assignee: SHENZHEN KEYA MEDICAL TECHNOLOGY CORPORATION
    Inventors: Qi Song, Shanhui Sun, Feng Gao, Junjie Bai, Hanbo Chen, Youbing Yin
  • Patent number: 11335087
    Abstract: The present disclosure relates to a method and system for object identification. A method for object identification is provided, comprising: acquiring a first image presenting at least a part of an object from a user; identifying a category of the object through a pre-established object identification model based on the first image, to obtain at least one result; searching a rule database containing at least one set of confusable object categories using the at least one result, to determine whether there is a confusable object category corresponding to the at least one result; and if there is a confusable object category corresponding to the at least one result in the rule database, returning the at least one result and the confusable object category corresponding thereto to the user.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: May 17, 2022
    Assignee: Hangzhou Glority Software Limited
    Inventors: Qingsong Xu, Qing Li
  • Patent number: 11336891
    Abstract: A video decoding method includes obtaining an encoded bitstream of an original video content; decoding the encoded bitstream based on a residual coding scheme and signaling information; and presenting the original video content. The decoding the encoded bitstream includes: obtaining encoded residual information associated with the encoded bitstream, wherein the residual information includes at least a remainder, and performing a decoding process on the encoded residual information to obtain a transform domain coefficient using a Markov decision process (MDP) based on a current state, a Rice parameter, and a next state.
    Type: Grant
    Filed: October 24, 2020
    Date of Patent: May 17, 2022
    Assignee: TENCENT AMERICA LLC
    Inventors: Cheung Auyeung, Xiang Li, Shan Liu
  • Patent number: 11334352
    Abstract: A system for generating an immune protocol including a computing device configured to receive an immune biomarker, retrieve an immune profile, assign the immune profile to an immune category, determine, using the immune category and the immune profile, an elimination plan, including identifying an effect on the immune profile for each nutrition element consumed by the user, determine at least a nutrition element that contributes to the immune category, create, using the elimination plan, a reintroduction phase, including identifying a frequency associated with the nutrition element determined in the elimination plan, and identifying a magnitude associated with the nutrition element determined in the elimination plan, identify a plurality of protocol elements, wherein each contains a nutrient amount intended to prevent autoimmune disease, and generate an immune protocol as a function of the elimination plan, the reintroduction phase, and the plurality of protocol elements.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: May 17, 2022
    Assignee: KPN INNOVATIONS, LLC.
    Inventor: Kenneth Neumann
  • Patent number: 11335450
    Abstract: A dehydration amount prediction method for hemodialysis and an electronic device using the same are provided, and the method includes the following steps. Physiological data and hemodialysis treatment data of a first patient are obtained. The first patient is determined to belong to one of groups, wherein the groups are respectively associated with a plurality of prediction models. A target prediction model corresponding to the one of the groups is selected from the prediction models. The physiological data and the hemodialysis treatment data are provided to the target prediction model to generate a recommended dehydration amount by the target prediction model.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: May 17, 2022
    Assignee: Wistron Corporation
    Inventors: Yu-Hui Lien, Chih-Yi Chien
  • Patent number: 11327089
    Abstract: The purpose of the present invention is to provide an automatic analysis device capable of determining, through a simple processing, whether or not idle aspirate has occurred. The automatic analysis device according to the present invention determines whether or not idle aspirate has occurred, by calculating a parameter which specifies whether or not the length of a portion of a path through which the sample passes inside a dispensing probe is shorter than that during normal aspirate, the portion being actually filled with a sample (see FIG. 4).
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: May 10, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Masafumi Shimada, Isao Yamazaki, Masaharu Nishida, Yoko Inoue
  • Patent number: 11328215
    Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: May 10, 2022
    Assignee: Babylon Partners Limited
    Inventors: Laura Helen Douglas, Pavel Myshkov, Robert Walecki, Iliyan Radev Zarov, Konstantinos Gourgoulias, Christopher Lucas, Christopher Robert Hart, Adam Philip Baker, Maneesh Sahani, Iurii Perov, Saurabh Johri
  • Patent number: 11320443
    Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: May 3, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Hiroya Umeki, Kenta Imai, Yoshihiro Yamashita, Shunsuke Sasaki, Akihiro Endou
  • Patent number: 11320280
    Abstract: Systems and methods are provided for determining location data corresponding to a location of a user, retrieving candidate locations for pickup or drop-off locations based on the location data corresponding to the location of the user, and determining a safety score for each of the candidate locations. The systems and methods further select a best candidate location using the safety score associated with each of the candidate locations and provide a recommendation for a pickup or drop-off location comprising the best candidate location.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: May 3, 2022
    Assignee: Uber Technologies, Inc.
    Inventors: Kapil Gupta, Houtan Shirani-Mehr, Mir Shahrouz Takyar, Jaikumar Ganesh
  • Patent number: 11322234
    Abstract: A medical condition based content filter mechanism is provided that analyzes patient information associated with a patient to identify medical condition(s) associated with the patient and correlating the medical condition(s) with one or more medical condition content indicator data structures specifying negative content indicators and/or positive content indicators. A user specific content indicator dictionary data structure (USCID) is generated based on the correlation and used to process received content to filter out portions of the content matching the negative content indicators or present portions of the content matching the positive content indicators, thereby generating modified content that is output to the patient via a content access application executing on a computing device associated with the patient.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: May 3, 2022
    Assignee: International Business Machines Corporation
    Inventors: Kristin E. McNeil, Robert C. Sizemore, David B. Werts, Sterling R. Smith
  • Patent number: 11311129
    Abstract: The present disclosure relates to a smart bottle holder and a daily water consumption monitoring method and system thereof. The smart bottle holder includes a bottle holder main body for accommodating a bottle, and a control unit provided in a bottom part of the bottle holder main body. The control unit includes a weighing module, for obtaining a total weight of the bottle and water therein; a controller; a communication module, for sending water consumption data to an external terminal; and a power module, for supplying power to the weighing module, controller, and communication module. Compared with the prior art, the present disclosure has stronger structural mobility and wider range of applications. Also, the present disclosure is more power-saving and environmentally friendly and can provide more accurate water consumption statistics.
    Type: Grant
    Filed: June 16, 2021
    Date of Patent: April 26, 2022
    Assignee: XIAMEN SIENLUO TRADING CO., LTD.
    Inventor: Honghui Chen
  • Patent number: 11311668
    Abstract: Examples of determining and using physiological response estimates with glucose monitoring and insulin dosing systems and methods are disclosed. For example, one method includes receiving a selection of food items from a predefined catalog of food items as being part of a meal associated with a user profile, the catalog including nutritional information corresponding to food items in the catalog; determining nutritional information of the meal based on the nutritional information of each selected food item; receiving a notification from a user interface that a user associated with the user profile has started eating the meal; receiving successive indications of the user's glucose levels; computing a physiological response estimate associated with the user profile and the meal based on the successive indications of the user's glucose levels and the nutritional information of the meal.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: April 26, 2022
    Assignee: Verily Life Sciences LLC
    Inventor: Ganesh Balachandran
  • Patent number: 11315659
    Abstract: Methods and systems for searching genomes for potential nucleotide-guided nuclease off-target sites are provided. Also provided are methods of searching genomes for potential off-target deadCas9 binding sites. In some embodiments, the methods include ranking the potential off-target sites based on the number and location of mismatches, insertions, and/or deletions in the DNA, RNA, or DNA/RNA guide sequence relative to the genomic DNA sequence at a putative target site in the genome, allowing the selection of better target sites and/or experimental confirmation of off-target sites.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: April 26, 2022
    Assignee: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Thomas James Cradick, Gang Bao, Peng Qiu
  • Patent number: 11315029
    Abstract: Systems and methods are disclosed for receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient, applying a machine learning model, which may also be known as a machine learning system, to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated, and outputting the at least one characteristic of the target specimen and/or the at least one characteristic of the target image.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: April 26, 2022
    Assignee: PAIGE.AI, INC.
    Inventors: Supriya Kapur, Christopher Kanan, Thomas Fuchs, Leo Grady
  • Patent number: 11309062
    Abstract: A system for evaluating a DNA sample and determining whether the sample contains related individuals and/or unrelated individuals with high levels of alleles sharing. Trained and pre-validated machine learning algorithms are to rapidly and probabilistically assess the presence of relatives in a DNA mixture. To make a probabilistic determination, the system evaluates aspect of the sample that have not be considered before, such as peak heights, peak height ratios, maximum peak heights, minimum peak heights, ratios of allele heights to one another, number of contributors using maximum allele count method, and quantitative measures of the amount of DNA contributed by the male and female organisms. The system identifies whether a DNA sample has contributors that are not readily identifiable based on the data and can thus improve downstream analysis.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: April 19, 2022
    Assignee: Syracuse University
    Inventors: Michael Marciano, Jonathan D. Adelman
  • Patent number: 11309061
    Abstract: Provided are parallel computational methods and their implementation on memory-distributed architectures for a peptide identification tool, called HiCOPS, that enables more than 100-fold improvement in speed over existing HPC proteome database search tools. HiCOPS empowers the supercomputing database search for comprehensive identification of peptides and all their modified forms within a reasonable timeframe. Searching Gigabytes of experimental mass spectrometry data against Terabytes of databases demonstrates peptide identification in minutes compared to days or weeks, providing multiple orders of magnitude improvements in processing times. Also provided is a theoretical framework for a novel overhead-avoiding strategy, resulting in superior performance evaluation results for key metrics including execution time, CPU utilization, and I/O efficiency.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: April 19, 2022
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Muhammad Haseeb, Fahad Saeed
  • Patent number: 11305145
    Abstract: The present invention relates to a body resistance physical exercise device with monitoring and fitness tracking ties comprising: a) an electrical monitoring element configured to measure information relative to exercise parameters during repetitive motions performed with said device; and b) an elastomeric band adapted to enable the repetitive motions, wherein the resistance of the elastomeric band is capable of being adjusted.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: April 19, 2022
    Assignee: HYFIT LTD
    Inventor: Guy Bar
  • Patent number: 11307189
    Abstract: A sensor element (4) is used to apply a heating pulse to a pharmaceutical product (6). Chemical or structural information about the pharmaceutical product is determined by measuring a response of the sensor element (4) during the heating pulse. The response is dependent on a heat transfer characteristic of the pharmaceutical product (6).
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 19, 2022
    Inventors: Kamaljit Singh Chana, Saranjit Sihra, Pavinder Sagoo, Maxwell Adams, Vikram Sridhar
  • Patent number: 11291763
    Abstract: An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: April 5, 2022
    Assignee: Tandem Diabetes Care, Inc.
    Inventors: Michael L. Blomquist, Thomas Alan Savard
  • Patent number: 11294939
    Abstract: Data processing systems and methods according to various embodiments are adapted for automatically detecting and documenting privacy-related aspects of computer software. Particular embodiments are adapted for: (1) automatically scanning source code to determine whether the source code include instructions for collecting personal data; and (2) facilitating the documentation of the portions of the code that collect the personal data. For example, the system may automatically prompt a user for comments regarding the code. The comments may be used, for example, to populate: (A) a privacy impact assessment; (B) system documentation; and/or (C) a privacy-related data map. The system may comprise, for example, a privacy comment plugin for use in conjunction with a code repository.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: April 5, 2022
    Assignee: OneTrust, LLC
    Inventors: Priya Malhotra, Kabir A. Barday, Mihir S. Karanjkar, Steven W. Finch, Ken A. Browne, Nathan W. Heard, Aakash H. Patel, Jason L. Sabourin, Richard L. Daniel, Dylan D. Patton-Kuhl, Jonathan Blake Brannon
  • Patent number: 11295129
    Abstract: The iris recognition device includes an iris camera module used for collecting iris characteristics of a user, and at least one fill light component used for providing a supplementary light source for the iris camera module. When the iris recognition device is used for collecting the iris characteristics of the user, the supplementary light source provided by the fill light component reduces reflective spots on the iris or make reflective spots in areas other than iris such as sclera and pupil, thereby improving precision of the collected iris characteristics of the user.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: April 5, 2022
    Assignee: NINGBO SUNNY OPOTECH CO., LTD.
    Inventors: Yiwu Gu, Mengjie Luo, Xinke Tang, Jiewei Xu, Shixin Xu, Lin Huang
  • Patent number: 11295866
    Abstract: Described herein are computer systems and methods for generating, in silico, one or more virtual patients. The one or more virtual patients can be used, for example, to conduct a virtual clinical trial, such as to determine an efficacy of a therapy or medical device. The one or more virtual patients mathematically represent a physiological system in an actual patient for a health condition. Also, the one or more virtual patients can be used, for example, to determine an adverse effect from a therapy or any other deviation from a therapy, or compliance of a patient suffering from a health condition on a therapeutic protocol.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 5, 2022
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Doris Fuertinger, Franz Kappel, Peter Kotanko, Stephan Thijssen
  • Patent number: 11284818
    Abstract: Glucose exposure can be indicative of a number of potential underlying health conditions. The present disclosure is directed to measuring glucose exposure, determined, for example, on an hourly basis. This glucose exposure, in at least one embodiment, represents a current glucose level over the span of given period (e.g., a portion of 24 hours). If a patient's glucose exposure exceeds a glucose threshold or limit (for a 24 hour period in some embodiments), then a variety of treatments may be administered to the patient to help lower overall glucose exposure (e.g., during the 24 hour period).
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: March 29, 2022
    Assignee: TT1 Products, Inc.
    Inventors: Harold Philpott Southerland, III, Todd Furneaux, Juan Pablo Frais, Roger Steven Mazze
  • Patent number: 11288316
    Abstract: An example method includes determining a point from a data set closest to a particular data point using a particular metric and scoring a particular data point based on whether the closest point shares a similar characteristic, selecting a subset of metrics based on the metric score to generate a subset of metrics, evaluating a metric-lens combination by calculating a metric-lens score based on entropy of shared characteristics across subspaces of a reference map generated by the metric-lens combination, selecting a metric-lens combination based on the metric-lens score, generating topological representations using the received data set, associating each node with at least one shared characteristic based on member data points of that particular node sharing the shared characteristic, scoring groups within each topological representation based on entropy, scoring topological representation based on the group scores, and providing a visualization of at least one topological representation based on the graph sco
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: March 29, 2022
    Assignee: Ayasdi AI LLC
    Inventors: Jennifer Kloke, Harlan Sexton
  • Patent number: 11281933
    Abstract: An information processing device includes a categorizing section and a display control section. The categorizing section extracts a material component image identified as a material component from plural images obtained by imaging a sample fluid containing plural types of material element, and categorizes the extracted material component image serving as a detected component by predetermined category. The display control section performs control to re-categorize a material component image serving as the detected component already categorized into a different category, such that, when selection of a movement destination category is received in a state in which a first image list of detected components is being displayed, in a subsequent state in which the first image list and a second image list for the movement destination are being displayed at the same time, a material component image selected from the first image list is moved to the second image list.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 22, 2022
    Assignees: ARKRAY, Inc., SUMITOMO LIFE WELFARE AND CULTURE FOUNDATION
    Inventors: Koji Fujimoto, Shinya Nakajima, Kenichi Nagao
  • Patent number: 11274947
    Abstract: A measurement device (1) including a measurement module (2) and a communication module (3), in which the measurement module (2) has at least one sensor (4) for measuring a physical or chemical quantity. In the position of use, an interface (5) is provided for the communication between the measurement module (2) and the communication module (3). The measurement module (2) has a measurement module housing (6) and the communication module (3) has a communication module housing (7), which can be interconnected in a mechanically releasable manner and form in the connected state a closed measurement device housing (15).
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: March 15, 2022
    Assignee: Testo SE & Co. KGaA
    Inventor: Andreas Derr
  • Patent number: 11276479
    Abstract: Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: March 15, 2022
    Assignees: Nantomics, LLC, Nant Holdings IP, LLC
    Inventors: Andrew Nguyen, John Zachary Sanborn, Charles Joseph Vaske, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Stephen Charles Benz
  • Patent number: 11266347
    Abstract: A method for generating a flow profile of an inhalation device is described. The method comprises the step of measuring acoustic emissions induced by inhalation flow through the inhalation device. The method further comprises the step of detecting peak frequencies in the measured acoustic emissions and generating a flow profile based on the detected peak frequencies. A corresponding device is also described.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: March 8, 2022
    Assignee: Novartis AG
    Inventors: Peter Matthewson, Laure Mahé
  • Patent number: 11264137
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient using a centrality ranking of the brain of the patient. One of the methods includes obtaining brain data of a patient, wherein the brain data comprises, for each of a plurality of pairs of parcellations formed from a set of parcellations where each pair comprises a first parcellation and a second parcellation, data characterizing a number of tracts connecting the first parcellation and the second parcellation; determining a network graph from the brain data; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; determining a centrality ranking of the plurality of nodes of the network graph according to the respective measures of centrality; generating a mental health prediction for the patient using the determined centrality ranking.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: March 1, 2022
    Assignee: Omniscient Neurotechnology Pty Limited
    Inventors: Michael Edward Sughrue, Stephane Philippe Doyen, Peter James Nicholas, Hugh Monro Taylor
  • Patent number: 11263444
    Abstract: A method for studying the behavior of an animal in an experimental area including stimulating the animal using a stimulus device; collecting data from the animal using a data collection device; analyzing the collected data; and developing a quantitative behavioral primitive from the analyzed data. A system for studying the behavior of an animal in an experimental area including a stimulus device for stimulating the animal; a data collection device for collecting data from the animal; a device for analyzing the collected data; and a device for developing a quantitative behavioral primitive from the analyzed data. A computer implemented method, a computer system and a nontransitory computer readable storage medium related to the same. Also, a method and apparatus for automatically discovering, characterizing and classifying the behavior of an animal in an experimental area. Further, use of a depth camera and/or a touch sensitive device related to the same.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: March 1, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Sandeep Robert Datta, Alexander B. Wiltschko
  • Patent number: 11264138
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a mental health prediction for a patient. One of the methods includes obtaining brain data captured by one or more sensors characterizing a brain of a patient; determining a network graph from the brain data, wherein: a node of the network graph corresponds to a parcellation in the brain of the patient, and a subset of nodes of the network graph corresponds to a particular functional area of the brain; generating, for each of a plurality of nodes in the network graph, a measure of centrality of the node; generating, for the particular functional area of the brain and using the generated measures of centrality, a health score representing a measure of health of the functional area of the brain; generating a mental health prediction for the patient using the health score.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: March 1, 2022
    Assignee: Omniscient Neurotechnology Pty Limited
    Inventors: Michael Edward Sughrue, Stephane Philippe Doyen, Peter James Nicholas, Bradley Allan Fernald
  • Patent number: 11263748
    Abstract: A generalizable and interpretable deep learning model for predicting biomarker status and biomarker metrics from histopathology slide images is provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: March 1, 2022
    Assignee: TEMPUS LABS, INC.
    Inventors: Stephen Yip, Irvin Ho, Lingdao Sha, Boleslaw Osinski, Aly Azeem Khan, Andrew J. Kruger, Michael Carlson, Abel Greenwald, Caleb Willis
  • Patent number: 11263541
    Abstract: Systems and methods are disclosed to build and execute a decision system based on multiple machine learned decision models. In embodiments, the decision system performs a hashing technique to reduce relevant features of the input data into a feature vector for each decision model. The feature vector reduces the dimensionality of the feature universe of the input data, and its use allows the decision models to be trained and executed using less computing resources. In embodiments, the decision system implements an ensembled decision model that makes decisions based on a combination function that combines the decision results of the individual models in the ensemble. The decision models employ different hashing techniques to hash the input features differently, so that errors caused by the feature hashing of individual models are reduced in the aggregate.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: March 1, 2022
    Assignee: Oracle International Corporation
    Inventors: Jean-Baptiste Tristan, Adam Pocock, Michael Wick, Guy Steele
  • Patent number: 11263534
    Abstract: A system and method that produces an accurate probability distribution representative of a target molecule that may be used in pharmacokinetics and analogous applications. A generator is seeded from a variational autoencoder during training and is then used after training in series with a second variational autoencoder to produce the probability distributions from molecular tensors.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: March 1, 2022
    Assignee: RO5 INC.
    Inventors: Alvaro Prat, Alwin Bucher, Zygimantas Jocys, Roy Tal, Charles Dazler Knuff
  • Patent number: 11264118
    Abstract: Methods and systems for monitoring and determining antimicrobial resistance and antimicrobial treatment using genomic subtype information. Various embodiments utilize molecular epidemiology and next-generation sequencing technologies (NGS) to monitor multi-drug resistant pathogens and provide early insight into emergent microbial threats.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 1, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Sitharthan Kamalakaran, Pramod Mayigowda, Henry Lin, Sonia Chothani
  • Patent number: 11259709
    Abstract: A wearable physiological sensor has a housing and a gas-permeable support structure carried by the housing, which contacts the skin of the subject. An air space is provided between the support structure and the housing. Movement of the support structure relative to the housing is sensed. This provides a sensor which is comfortable for the subject and provides good sensitivity in that motion being detected (e.g. an arterial pulse) only needs to impart kinetic energy to the support structure, with a relatively low inertia.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: March 1, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ronaldus Maria Aarts, Laurentia Johanna Huijbregts
  • Patent number: 11253159
    Abstract: Modular, miniaturized cardiovascular sensors, systems, methods, and wearable devices for the non-obtrusive evaluation, monitoring, and high-fidelity mapping of cardiac mechanical and electromechanical forces and central arterial blood pressure are presented herein. The sensor manufacturing process is also presented. Using accelerometers, the sensors register body-surface (preferably torso-surface) movements and vibrations generated by cardiac forces. The sensors may contain single-use or reusable components, which may be exchanged to fit different body sizes, shapes, and anatomical locations; they may be incorporated into clothing, bands, straps, and other wearable arrangements. The invention presents a practical, noninvasive solution for electromechanical mapping of the heart, which is useful for a wide range of healthcare applications, including the remote monitoring of heart failure status and the guidance of cardiac resynchronization therapy.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: February 22, 2022
    Inventor: Vladimir Shusterman
  • Patent number: 11257570
    Abstract: Systems and methods are provided for processing a melting or dissociation curve of a DNA or other sample, for example, during PCR processing. In some embodiments, detection of the melting point and melting curve behavior can be enhanced by taking a derivative of the curve, and detecting peaks in the differential dissociation curve. In some embodiments, the derivative operation can comprise the use of edge-processing, or other detection algorithms. In some embodiments, the dissociation analysis can comprise removing low-frequency (or pedestal) components of the differential dissociation curve. In some embodiments, the differential dissociation curve can exhibit a smoothed or more regular appearance than the raw detected data.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 22, 2022
    Assignee: Applied Biosystems, LLC
    Inventor: Francis T. Cheng
  • Patent number: 11256723
    Abstract: Disclosed is a pesticide residue detection data platform based on high resolution mass spectrum, the Internet and data science, and a method for automatically generating a detection report. The platform includes allied laboratories, a detection result database of the allied laboratories, four basic sub-databases, a data collection system and an intelligent data analysis system. The intelligent analysis system reads data according to conditions set by a user, performs various statistical analyses according to a statistical analysis model, generates charts, obtains a comprehensive conclusion, and returns an analysis result to the client ends of the allied laboratories.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: February 22, 2022
    Inventors: Guofang Pang, Yi Chen, Chunlin Fan, Xiaobo Zou, Yuehong Sun, Qiaoying Chang, Kun Hou, Bing Fang, Ruobin Bai