Biological Or Biochemical Patents (Class 702/19)
  • Patent number: 11026641
    Abstract: Systems and methods are provided for classifying a tissue mass as malignant or benign. The method includes identifying a region of interest in the tissue mass in computed tomography (CT) imaging data, segmenting the CT imaging data to delimit at least a portion of the tissue mass into image segments, extracting a set of radiomic parameters indicative of the tissue mass. The set of radiomic parameters may include tissue mass location, tissue mass shape, tissue mass surface characteristic, or tissue mass texture distribution indicative of the amount of image segments identified. The method also includes generating a report classifying the indeterminate lung nodule as being malignant or benign based on the set of radiomic parameters of the indeterminate lung nodule.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 8, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Vanderbilt University
    Inventors: Tobias Peikert, Ronald A. Karwoski, Fabien Maldonado, Srinivasan Rajagopalan, Brian J. Bartholmai
  • Patent number: 11031101
    Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: June 8, 2021
    Assignee: 23andMe, Inc.
    Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
  • Patent number: 11028149
    Abstract: Provided is a method capable of producing a protein at a high level using a cultured animal cell, comprising culturing a cell that expresses APES (Antibody Production Enhancing Sequence) and into which a DNA encoding a desired polypeptide has been introduced, thereby producing the desired polypeptide. APES contains a nucleotide sequence related to nuclear factor ?B inhibitor ? (NfkBia) and has a function of decreasing the intracellular expression of NfkBia.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: June 8, 2021
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hisahiro Tabuchi, Tomoya Sugiyama
  • Patent number: 11030276
    Abstract: A computer implemented system for genomic data sorting, comprising alignment and position mapping. The system maps each read to a position on the reference genome with which the read is associated, followed by sorting these reads by their mapped positions.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: June 8, 2021
    Assignee: 10X GENOMICS, INC.
    Inventor: Alexander Y. Wong
  • Patent number: 11020025
    Abstract: Systems and methods are disclosed to objectively identify sub-second behavioral modules in the three-dimensional (3D) video data that represents the motion of a subject. Defining behavioral modules based upon structure in the 3D video data itself—rather than using a priori definitions for what should constitute a measurable unit of action—identifies a previously-unexplored sub-second regularity that defines a timescale upon which behavior is organized, yields important information about the components and structure of behavior, offers insight into the nature of behavioral change in the subject, and enables objective discovery of subtle alterations in patterned action. The systems and methods of the invention can be applied to drug or gene therapy classification, drug or gene therapy screening, disease study including early detection of the onset of a disease, toxicology research, side-effect study, learning and memory process study, anxiety study, and analysis in consumer behavior.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 1, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Sandeep Robert Datta, Alexander Bame Wiltschko, Matthew J. Johnson
  • Patent number: 11017208
    Abstract: A system and a method to analyze a phenotypical response of cells to a treatment are disclosed in which a model development module receives images of a plurality of reference cell carriers and treatment information associated with the plurality of reference cell carriers, identifies parameters of cells in the image that distinguish those reference cell carriers to which the treatment has been applied from other reference cell carriers, and trains a model using the identified parameters. A high-content imaging system includes an image capture device, and the image acquisition module receives from the image capture device a plurality of images of cell carriers to be evaluated. The model application module applies the trained model to the plurality of images of the cell carriers to be evaluated to predict a concentration of the treatment applied to each of the cell carriers evaluated.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 25, 2021
    Assignee: Molecular Devices, LLC
    Inventors: Avrum Isaac Cohen, Dihui Hong
  • Patent number: 11013431
    Abstract: Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: May 25, 2021
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Wesley Scott Harper
  • Patent number: 11011276
    Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 18, 2021
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, CHANG GUNG UNIVERSITY
    Inventors: Chun-Hsien Chen, Yi-Ju Tseng, Hsin-Yao Wang, Wan-Ying Lin, Chih-Kuang Chen
  • Patent number: 11011273
    Abstract: The present inventive subject matter provides apparatus, systems, and methods in which a diagnostic test is identified, where the diagnostic test is for determining whether a particular treatment is effective for a particular patient based on one or more characteristics of a patient's cells. When a treatment is developed with the potential to treat one or more diseases, the drug can have different effects on different cell lines related to the diseases. A machine learning system is programmed to infer a measurable cell characteristic, out of many different measurable cell characteristics, that has a desirable correlation with the sensitivity data of different cell lines to a treatment. The machine learning system is programmed to then determine, based on the correlation, a threshold level of the cell characteristic the patient should exhibit in order to recommend administering the treatment.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: May 18, 2021
    Assignee: NantOmics, LLC
    Inventors: Stephen Charles Benz, Shahrooz Rabizadeh, Christopher Szeto, Paul Weingarten, Chunlin Tao
  • Patent number: 11003313
    Abstract: An exemplary method includes a sporting event statistics recording system that provides a graphical user interface for display, the graphical user interface including an icon representative of a participant in the sporting event, detects a first user input associated with the icon, determines that the first user input is associated with a first action performed during the sporting event, records a first statistic for the sporting event based on the participant represented by the icon and the first action associated with the first user input associated with the icon, detects a second user input associated with the icon, determines that the second user input is associated with a second action performed during the sporting event, and records a second statistic for the sporting event based on the participant represented by the icon and the second action associated with the second user input associated with the icon.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: May 11, 2021
    Assignee: OLLIE SPORTS LLC
    Inventors: Tyson Lawrence, Scott Ashton
  • Patent number: 11004200
    Abstract: The present disclosure may provide a method for perfusion analysis. The method may include: obtaining a plurality of scan images corresponding to a plurality of time points; obtaining a plurality of time-density discrete points based on the plurality of scan images; determining an initial time-density curve based on the plurality of time-density discrete points, the initial time-density curve indicating a density variation of a contrast agent in an organ or tissue over time, the organ or tissue corresponding to a pixel or voxel in the plurality of scan images; obtaining a first perfusion model; determining a first perfusion parameter based on the first perfusion model and the initial time-density curve; obtaining a second perfusion model; and determining a second perfusion parameter based on the second perfusion model and the first perfusion parameter.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: May 11, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Fan Long, Jieyan Ma
  • Patent number: 11002743
    Abstract: A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. A method of verifying the accuracy of an analyte monitoring device includes receiving control information, receiving a fluid sample, identifying the fluid sample as a control solution, and analyzing the control solution.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: May 11, 2021
    Assignee: INTUITY MEDICAL, INC.
    Inventors: Kelley J. Lipman, Michael F. Tomasco, Peter Uy-Vu Ly, Jennifer Y. Blomo, Paul D. Reynolds, John F. Larkin, Robin S. Gaffney, Kimberly J. Tansey, Christopher L. Stewart, Raul Escutia, Robert W. Bowers
  • Patent number: 11004541
    Abstract: A computer-implemented system for determining a genomic testing status of a patient may include at least one processor programmed receive, from a source, unstructured information from a plurality of patient records associated with a patient; determine, using a first machine learning model, a primary patient record from among the plurality of patient records, wherein at least a portion of information represented in the primary patient record correlates to genomic testing; determine, using a second machine learning model and based on unstructured information from one at least one of the patient records, a likelihood of an occurrence of genomic testing for the patient; determine a genomic testing status of the patient based on the determined likelihood of the occurrence of genomic testing; and display a user interface comprising an indicator of the genomic testing status of the patient and a link to the primary patient record.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: May 11, 2021
    Assignee: FLATIRON HEALTH, INC.
    Inventors: Addison Shelley, Alexander Padmos, Angel Leung, Chun-Che Wang, Dominic Green, Edward Liu, Janet Donegan, Lauren Sutton, Lucy He, Sharang Phadke
  • Patent number: 10998083
    Abstract: Methods and apparatus to identify and quantify the microorganisms present in a sample. Sequence reads are classified using existing methods, but the classification results are corrected to account for the number of reads expected to be falsely classified as determined through simulation. With statistics on the expected number of reads misclassified, a linear least squares method (non-negative or otherwise) or other related technique can be used to adjust the number of reads that are classified to various taxonomic units (e.g., species) and to determine more accurate values for the quantities of those taxonomic units actually present in the sample, eliminating microorganisms in taxonomic units falsely determined to be present in the sample.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 4, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Henry Lin, Sitharthan Kamalakaran
  • Patent number: 10997218
    Abstract: A method and system for managing associations between entity records. The method includes: identifying a first plurality of entity records in at least one curated database, associations between the first plurality of entity records based on at least one entity attribute and associations between entity attributes of the first plurality of entity records; extracting data records from existing data sources, wherein the data records comprise entity names and entity attributes associated with the entity names; identifying the entity names, and entity attributes corresponding to each of the entity names in each of the extracted data records; clustering the entity names and corresponding entity attributes to create a second plurality of entity records; and identifying associations between the second plurality of entity records based on the identified associations between the first plurality of entity records and/or identified association between entity attributes of the first plurality of entity records.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 4, 2021
    Assignee: Innoplexus AG
    Inventors: Gaurav Tripathi, Vatsal Agarwal, Yannik T. H. Schelske, Mohit Mangal, Arpan Sheetal, Nikhil Vinod Fulzele
  • Patent number: 10998090
    Abstract: A terminal for analyzing a drug-disease relevance relation includes a transceiver and a processor. The transceiver is configured to receive drug information, disease information and drug-disease relevance relation information. The processor is configured to construct a pharmacodynamic relation model based on the drug information, the disease information and the drug-disease relevance relation information.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 4, 2021
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Zhenzhong Zhang, Hui Li, Chenyin Shen
  • Patent number: 10996223
    Abstract: Embodiments of the disclosure relate to a screening method for the diagnosis of haematological neoplasia. In the method, a first test step is performed to check whether a potential haematological neoplasia exists. At least a first haematogram is created with a blood sample in the first test step. Based on a first set of filter rules, it is checked whether the first haematogram differs from a desired state specified according to the first set of filter rules, and a second test step is performed to check for potential haematological neoplasia if the first test step reveals that there is potential haematological neoplasia. In addition, the disclosure relates to a system, a computer program product, and a computer-readable storage medium.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: May 4, 2021
    Assignee: Bioscientia Institut Für Medizinische Diagnostik GmbH
    Inventor: Wolfgang Kaminski
  • Patent number: 10997726
    Abstract: The invention provides for a medical instrument (100, 300, 400) comprising: a memory (110) for storing machine executable instructions (112) and a processor (106) for controlling the medical instrument.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: May 4, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Bernhard Gleich, Jorn Borgert, Jochen Keupp
  • Patent number: 10991450
    Abstract: The present invention provides methods and materials useful for determining metabolizer status. Embodiments of the present invention provide an approach using a genotyping panel and integration of genotypes of CYP3A4 and CYP3A5 to assess CYP3A metabolizer status, applicable to all CYP3A substrates, including approximately 40% of all drugs. Algorithms for CYP3A metabolizer status are described. Where the contribution ratios of CYP3A4 and CYP3A5 to overall drug levels or drug effects are known, the algorithm can be used to calculate optimal dosing. Where the contributory ratios to overall drug effects are not available, the contributory ratios can be calculated with use of the genotypes for use in drug development. Embodiments of the present invention can be used in optimizing drug treatments, selecting dose, designing therapeutics, and predicting efficacy.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: April 27, 2021
    Assignee: Ohio State Innovation Foundation
    Inventors: Wolfgang Sadee, Danxin Wang
  • Patent number: 10984081
    Abstract: An association management system for establishing, maintaining, and monitoring associations between a personal identifier and an electronic device, includes a provider subsystem in operable communication with at least one of the personal identifier and the electronic device. The provider subsystem is configured to provision a person associated with the personal identifier, authenticate both of the personal identifier and the electronic device, and establish an association of the authenticated personal identifier to the authenticated electronic device. The system further includes a certificate authority subsystem for issuing at least one digital certificate to verify an identity of one or more digital entities operating on the management system, and a digital distributed ledger including a plurality of a consensus pool of participating processors. The digital distributed ledger is configured to verify, using the at least one digital certificate, transaction events of the association management system.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 20, 2021
    Assignee: Cable Television Laboratories, Inc.
    Inventors: Steven John Goeringer, Brian Alexander Scriber
  • Patent number: 10980926
    Abstract: A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: April 20, 2021
    Assignee: HAEMONETICS CORPORATION
    Inventor: Michael Ragusa
  • Patent number: 10977794
    Abstract: Automated image analysis methods to identify and quantify tumor buds in a high resolution image of a section of a tumor that is stained using either pan-cytokeratin AE1/3 or hematoxylin and eosin (H&E) are disclosed. The methods may be used to aid and/or replace manual visual inspection for tumor buds and may be used to predict a clinically relevant outcome or treatment in some cases. The disclosed methods may be used for many different cancer types, such as colorectal cancer.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 13, 2021
    Assignee: Ohio State Innovation Foundation
    Inventors: Metin Gurcan, Wendy Frankel, Wei Chen, Mohammad Faizal Ahmad Fauzi
  • Patent number: 10975445
    Abstract: Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: April 13, 2021
    Assignee: Tempus Labs, Inc.
    Inventors: Aarti Venkat, Jerod Parsons, Joshua S K Bell, Catherine Igartua, Yilin Zhang, Ameen Salahudeen, Verónica Sánchez Freire, Robert Tell
  • Patent number: 10970504
    Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: April 6, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventor: David Opalsky
  • Patent number: 10957420
    Abstract: The amount of genomic data as well the sensitivity of the information carried necessitates the need to develop smart and efficient ways to transmit genomic data in a secure way. While encryption schemes exist, there is also the need to first reduce the amount of massive information and then apply an encoding and encryption method that will be effective both in the economic sense as well as for security of genomic data. In this invention, we discuss novel techniques to encode processed variant information and send it across to a remote site ensuring covert transmission. The protocols not only encode and encrypts the information; it condenses the information that needs to be transferred.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: March 23, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Vartika Agrawal, Nevenka Dimitrova, Raymond J. Krasinski
  • Patent number: 10957419
    Abstract: A structure-generating method for generating a structure candidate of a new material including: by a structure-generating processor: performing machine learning on a machine learning model, wherein the machine learning model is configured to provide a result based on a descriptor of a material, a physical property of the material, and a structure of the material; and generating a structure candidate of the new material based on the result of the machine learning, wherein the new material has a target physical property, and wherein the descriptor of the material, the physical property of the material, and the structure of the material are stored in a database.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: March 23, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jiho Yoo, Seokho Kang, Youngchun Kwon, Kyung doc Kim, Jaikwang Shin, Hyosug Lee, Younsuk Choi
  • Patent number: 10950424
    Abstract: The invention relates to a method for monitoring a quality of preparation workflows of analytical tissue sections for mass spectrometric imaging using a control sample to be processed and measured alongside the analytical tissue sections on the same sample support and ascertaining if characteristics of the control sample measurement fit into a range of characteristics of separate reference measurements from the same type of control sample.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: March 16, 2021
    Inventor: Sören-Oliver Deininger
  • Patent number: 10943686
    Abstract: An infusion map system includes a memory storing at least infusion mapping instructions, and a processor that executes the stored instructions. When the processor executes the infusion mapping instructions, the infusion map system performs a displaying function that displays at least a portion of an electronic medical record associated with a patient and a diagramming function that receives the electronic medical record and generates an infusion map showing all intravenous drugs being administered to the patient. For each of the drugs, the infusion map further illustrates a route of administration for the drug. An order administering function performed by the system allows a user to alter the infusion map, and a record updating function of annotating the electronic medical record to correspond to the altered infusion map.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 9, 2021
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Thomas Edward Dudar, Steven Clarence Jepson
  • Patent number: 10936626
    Abstract: Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: March 2, 2021
    Assignee: 23andMe, Inc.
    Inventors: Brian Thomas Naughton, Chuong Do, John Michael Macpherson
  • Patent number: 10937546
    Abstract: The present invention relates to a system for estimating a degree of distraction based on unconstrained bio-information. The present invention provides a system for estimating a degree of distraction based on unconstrained bio-information, the system comprising: a degree-of-distraction measurement chair comprising a seating unit, a message transmission unit, a pressure detection unit, and a support unit, which are formed in this order from the top to the bottom thereof, wherein the pressure detection unit formed on the support unit comprises a smart sensor including three load cells arranged at three vertices of a triangular shape on a plane; and a mobile smart terminal configured to receive information regarding the degree of distraction from the message transmission unit of the degree-of-distraction measurement chair through the Bluetooth communication.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: March 2, 2021
    Assignee: Dongseo University Industry-Academic Cooperation Foundation
    Inventors: Woo Jin Hwang, Do Un Jeong, Gi Hyun Hwang, Dae-Soo Cho
  • Patent number: 10934590
    Abstract: Described herein is the use of Agouti Signaling Protein (ASIP), in addition to certain other melanocortin signaling network (MSN) genes, as prognostic and predictive biomarkers for the progression of breast cancer. In particular, the novel biomarkers can be used to determine if a female breast cancer patient is at risk of progressing to metastatic disease and thus also be used to direct treatment of the patient.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: March 2, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: James Donald Shull
  • Patent number: 10935512
    Abstract: A system includes a circuit configured to detect a voltage corresponding to an electrical measurement of a nanopore. The system also includes a component configured to compare the voltage to another voltage. Based at least in part on the comparison, a one bit indicator is determined. The one bit indicator indicates whether the voltage indicates a change in a state of the nanopore. In the event it is determined that the voltage indicates the change in the state of the nanopore, a multiple bit signal is provided for output.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: March 2, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Santiago Fernandez-Gomez, Hui Tian, Bill Maney, Seung Shin
  • Patent number: 10931399
    Abstract: In one embodiment, a method comprises determining, by a network device in a wireless data network, that a prescribed Clear Channel Assessment (CCA) threshold is unsuitable for use on an identified wireless network channel among available wireless network channels, based on a determined variance of a corresponding channel transmit attempt failure rate for the identified wireless network channel, relative to an expected variance in channel transmit attempt failure rates that is determined across the respective available wireless network channels; and selectively adjusting the corresponding CCA threshold for the identified wireless network channel, until a second determined variance of the corresponding channel transmit attempt failure rate, at the identified wireless network channel, falls below a prescribed channel failure rate variance factor relative to the expected variance.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 23, 2021
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Lele Zhang, Huimin She, Chuanwei Li, Nan Yi
  • Patent number: 10929422
    Abstract: A method, performed by a computer, for event estimation, the method includes: executing a registering process that includes receiving a registration of a first word group including a plurality of words, each of which is associated with time, and storing the first word group into a memory; executing a calculating process that includes receiving a first time pointer that indicates a time point on a time axis, obtaining, among the plurality of words in the first word group, a first word associated with a time belonging to a predetermined range from the time point indicated by the first time pointer, and calculating, in accordance with the first word, an index value indicating likelihood of occurrence of a life event; and executing a display process that includes controlling display of the life event based on the index value.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: February 23, 2021
    Assignee: FUJITSU LIMITED
    Inventor: Wei Zhu
  • Patent number: 10921328
    Abstract: The invention relates to the use of novel biomarkers and biomarker combinations having utility in the early determination of an individual's critical and/or life threatening response to illness and/or in predicting outcome of said illness. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention have utility in making the determination of an individual's critical and/or life threatening response to illness. In some embodiments, the biomarker and biomarker combinations are agnostic and are independent of the pre-identification and/or determination of the cause or nature of the illness. In some embodiments, the biomarkers and biomarker combinations can be utilized to select treatment and/or monitor the effectiveness of treatment interventions for an individual who has a critical illness.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 16, 2021
    Assignee: FIO CORPORATION
    Inventors: Kevin Kain, W. Conrad Liles, Laura Erdman, Andrea Conroy
  • Patent number: 10914740
    Abstract: A method of detecting serous ovarian cancer, particularly early stage serous ovarian cancer is described. The method uses up to sixteen compounds found in the blood serum of a person, and determines that changes of some portion of these sixteen compounds can determine the presence of serous ovarian cancer in a women with up to 100% accuracy, specificity, and sensitivity.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: February 9, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: David Gaul, Facundo M. Fernandez, John Francis McDonald
  • Patent number: 10912522
    Abstract: Systems and methods for counting features in a motion signal are provided. An example method includes detecting a signal indicative of a motion of a human body, determining, by a controller communicatively coupled to the sensor, a period in the signal, determining a location and a value of a feature within the period of the signal, determining that the location and the value of the feature are valid for counting, and in response to the determination that the location and the value of the feature are valid for counting, increasing a counter for the feature. The feature may also include a global maximum of the signal within a positive phase of the period. Criteria for the validation depend on a current type of activity. The method includes automatically determining the current type of activity based on several preceding locations and values of the feature in the signal.
    Type: Grant
    Filed: January 25, 2020
    Date of Patent: February 9, 2021
    Assignee: AURA DEVICES, INC.
    Inventors: Alexey Dzyuba, Dmitrii Davydov
  • Patent number: 10913772
    Abstract: Provided is a peptide for preventing or treating inflammatory diseases and a use thereof. According to a novel dimeric peptide according to the present invention, it is possible to not only exhibit an excellent therapeutic effect through anti-inflammatory action but also have a very small-sized peptide, thereby minimizing side effects due to the administration of external substances and will be expected to be used as an active substance that can replace existing therapeutic agents for inflammatory diseases.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: February 9, 2021
    Assignee: KINE SCIENCES CO., LTD.
    Inventors: Dae Ho Cho, Kyung Eun Kim, Sun Young Park, Youn Kyung Houh
  • Patent number: 10913150
    Abstract: A processing system includes a robot including at least one arm each including a hand at an end of the at least one arm; a first position measurement sensor, which is to be grasped by the hand and moved by the at least one arm, and is configured to measure a position of a device to be used when the robot processes a processing target; and a robot control device configured to: cause the hand to grasp the first position measurement sensor; and cause the first position measurement sensor to measure the position of the device.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: February 9, 2021
    Assignee: KABUSHIKI KAISHA YASKAWA DENKI
    Inventors: Takuya Fukuda, Yukio Hashiguchi, Kenji Matsukuma, Makoto Umeno
  • Patent number: 10908093
    Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: February 2, 2021
    Assignee: Labrador Diagnostics, LLC
    Inventors: Ian Gibbons, Chengwang Wang, Shaunak Roy, Elizabeth A. Holmes
  • Patent number: 10898267
    Abstract: Stenosis information is obtained by obtaining photographic image data (302) from a displayed image of a blood vessel (103, 203) containing the stenosis. Contours of the blood vessel and the stenosis are detected and dimensions are estimated from the photographic image data. A blood vessel model is reconstructed and fractional flow reserve data is calculated using the blood vessel model.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: January 26, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Schmitt, Christian Haase, Hannes Nickisch, Sven Prevrhal
  • Patent number: 10898149
    Abstract: A method, system and computer program product for determining changes in breast density. A generative adversarial network is trained to predict an appearance of a mammogram image for a patient's current examination based on mammogram images assigned labels of a first type of density classification. An appearance of a mammogram image for a patient's current examination is predicted using the generative adversarial network based on a mammogram image(s) obtained from the patient's prior examination assigned labels of the first type of density classification. A comparison is made between the predicted and actual mammogram images for the patient's current examination to determine if there is a difference between scores assigned to the predicted and actual mammogram images, and if so, whether such difference can be attributed to the subjective assessment by different physicians or changes in the standards of density classification or is due to a real change in breast density.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: January 26, 2021
    Assignee: International Business Machines Corporation
    Inventors: Sun Young Park, Dusty Sargent
  • Patent number: 10896740
    Abstract: The clinical course of idiopathic pulmonary fibrosis (IPF) is difficult to predict. Described herein is a peripheral blood 52-gene expression signature useful to improve outcome prediction in IPF.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 19, 2021
    Assignee: Yale University
    Inventors: Naftali Kaminski, Jose D. Herazo-Maya
  • Patent number: 10891334
    Abstract: A learning graph is generated for documents according to a sequencing approach. The learning graph includes nodes corresponding to the documents and edges. Each edge connects two of the nodes and indicates a sequencing relationship between two of the documents to which the two of the nodes correspond that specifies an order in which the two of the documents are to be reviewed in satisfaction of the learning goal. The learning graph is a directed graph specifying a learning path through the documents to achieve a learning goal in relation to a subject.
    Type: Grant
    Filed: December 29, 2013
    Date of Patent: January 12, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Georgia Koutrika, Lei Liu, Jerry J. Liu, Steven J. Simske
  • Patent number: 10891550
    Abstract: Systems and methods are disclosed for receiving a target image corresponding to a target specimen, the target specimen comprising a tissue sample of a patient, applying a machine learning model to the target image to determine at least one characteristic of the target specimen and/or at least one characteristic of the target image, the machine learning model having been generated by processing a plurality of training images to predict at least one characteristic, the training images comprising images of human tissue and/or images that are algorithmically generated, and outputting the at least one characteristic of the target specimen and/or the at least one characteristic of the target image.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: January 12, 2021
    Assignee: PAIGE.AI, Inc.
    Inventors: Supriya Kapur, Christopher Kanan, Thomas Fuchs, Leo Grady
  • Patent number: 10884090
    Abstract: The present invention relates to methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: January 5, 2021
    Assignee: Oxford University Innovation Limited
    Inventors: Steven Chance, Rebecca McKavanagh, Mark Jenkinson, Karla Miller
  • Patent number: 10886115
    Abstract: The invention relates to the identification and visualization of the spatial distribution of particular tissue states in histological tissue sections from mass spectrometric signals acquired with spatial resolution. The invention proposes a method by means of which regions of the tissue with similar mass spectra are found automatically, and it is further proposed that mass spectra of these regions are summed in order to improve the spectral quality to such an extent that known markers for tissue degenerations can be identified with increased certainty. Regions of similar mass spectra can be interconnected on a large scale, but can also be isolated from each other on a small scale.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: January 5, 2021
    Inventors: Sören-Oliver Deininger, Martin Schürenberg
  • Patent number: 10885149
    Abstract: A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (STN). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures. A statistical shape model is applied for variation modes of the STN, or the corresponding regions of interest, and its predictors on high-quality training sets obtained from high-field, e.g., 7T, MR imaging. The partial least squares regression (PLSR) method is applied to induce the spatial relationship between the region to be predicted, e.g., STN, and its predictors. The prediction accuracy for validating the invention is evaluated by measuring the shape similarity and the errors in position, size, and orientation between manually segmented STN and its predicted one.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: January 5, 2021
    Assignee: Owl Navigation, Inc.
    Inventors: Guillermo Sapiro, Noam Harel, Yuval Duchin, Jin Young Kim
  • Patent number: 10878938
    Abstract: The invention provides methods for comparing one set of genetic sequences to another without discarding any information within either set. A set of genetic sequences is represented using a directed acyclic graph (DAG) avoiding any unwarranted reduction to a linear data structure. The invention provides a way to align one sequence DAG to another to produce an alignment that can itself be stored as a DAG. DAG-to-DAG alignment is a natural choice wherever a set of genomic information consisting of more than one string needs to be compared to any non-linear reference. For example, a subpopulation DAG could be compared to a population DAG in order to compare the genetic features of that subpopulation to those of the population.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: December 29, 2020
    Assignee: Seven Bridges Genomics Inc.
    Inventor: Deniz Kural
  • Patent number: 10878944
    Abstract: A method for generating a searchable small-molecule tandem mass spectrometry library comprises: (a) generating, by theoretical calculation and for each of a plurality of small-molecule compounds, a list of ion species, including fragment-ion species that are predicted, by the theoretical calculations, to be generated by tandem mass spectrometry (MSn) analyses, where n?2; (b) comparing at least a subset of the predicted ion species to entries in a database that includes a list of experimentally observed ion species; (c) matching a predicted mass-to-charge ratio (m/z) value of each of one or more of the predicted fragment-ion species to a respective experimentally measured m/z value of an experimentally observed fragment-ion species for which information is tabulated in the database; and (d) updating the predicted list of ion species based on information derived from the matched predicted and experimentally measured m/z values.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: December 29, 2020
    Assignees: Thermo Finnigan LLC, HighChem Ltd.
    Inventors: Ralf Tautenhahn, Timothy J. Stratton, Robert Mistrik