Abstract: The invention describes a laser sensor or laser sensor module (100) using self-mixing interference for particle density detection, a related method of particle density detection and a corresponding computer program product. The invention further relates to devices comprising such a laser sensor or laser sensor module. It is a basic idea of the present invention to detect particles by means of self-mixing interference signals and determine a corresponding particle density. In addition at least a first parameter related to at least one velocity component of a velocity vector of the particles is determined in order to correct the particle density if there is the relative movement between a detection volume and the particles. Such a relative movement may for example be related to a velocity of a fluid transporting the particles (e.g. wind speed). Furthermore, it is possible to determine at least one velocity component of the velocity of the particles based on the self-mixing interference signals.

Abstract: Modeling, constructing, and designing conformal cellular structures with spatially variable and graded microstructures that have full geometric continuity is disclosed, which includes defining a global structural domain, where the microstructures are generated for a global mesh, defining a unit structure as a base cell using a level set function, which allows for beams, trusses, shells, and solids, transforming and mapping the base cell into each element of the global mesh using an isoparametric transformation, which creates a conformal cellular structure in accordance with a set of requirements on distribution of material and/or mechanical properties, and applying a global cutting function to guarantee geometric continuity in connections on the common face of any two neighboring cells of the structure. As a result, more complex geometric shapes and features can be generated at the cell level, while maintaining the specified geometric connectivity across the cells of the structure.

Abstract: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.

Abstract: An apparatus for estimating analytics and interactive exploration of big data, stored and/or streaming, using approximate query processing is presented. The apparatus comprises a model constructor and a sampler. The model constructor identifies important predictors variables in big data using feature selection, predictor variables, and outcome variables and partitions the important predictor variables into one or more stratifications based either the identified interactions or identified relationships. The sampler generates a subset of data by querying the big data using a query constructed based on at least one stratification. The subset of data can be fed into an analytics generator. The analytics generator generates analytics data for the outcome variables based on the subset of data and an analytics algorithm and a visualization, e.g. an interactive visualization, comprising the outcome variables, the important predictor variables, the stratification, the subset of data, and the analytics data.

Abstract: A physiological information processing method includes: acquiring electrocardiogram data of a subject; acquiring pulse wave data of the subject; measuring the heart rate based on the electrocardiogram data; measuring the pulse wave transit time based on the electrocardiogram data and the pulse wave data; calculating a cardiac output based on the pulse wave transit time and heart rate which have been measured; calculating the systemic vascular resistance; and correcting the calculated cardiac output based on the systemic vascular resistance.

Abstract: An example of a system for monitoring and treating a medical condition of a patient may include signal inputs to receive patient condition signals indicative of a state of inflammatory bowel disease (IBD), a signal processing circuit configured to process the patient condition signals and generate patient condition parameters indicative of the state of IBD using the processed patient condition signals, and a medical condition analyzer configured to analyze the patient condition parameters and determine the medical condition including the state of IBD using an outcome of the analysis. The patient condition parameters may include one or more physiological marker parameters each representative of a physiological marker of IBD and one or more quality of life parameters each being measure of quality of life of the patient.

Abstract: An apparatus for classifying an input includes a classifier and a feature extractor. The feature extractor is configured to generate a feature vector based on the input. The feature vector is also configured to set a number of elements of the feature vector to zero to produce a sparse feature vector. The sparse feature vector has the same dimensions as the feature vector generated by the feature extractor. However, the sparse feature vector includes fewer non-zero elements than the feature vector generated by the feature extractor. The feature vector is further configured to forward the sparse feature vector to the classifier to classify the input.

Abstract: A method, system, and computer program product for detecting data tampering with resilient watermarking is provided. The method accesses a first relational data set on a data repository. The first relational data set includes a plurality of data elements. The first relational data set is sorted to generate a first sorted list and a second sorted list of the plurality of data elements. The method generates a watermark from the first sorted list and the second sorted list. The watermark contains a hash corresponding to the first sorted list and the second sorted list of the plurality of data elements. In response to an access request for the first relational data set, the method verifies an integrity of the first relational data set based on the watermark.

Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donor's weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.

Abstract: A method for vascular assessment is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to produce a stenotic model over the vasculature, the stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature. The method, in some embodiments, further comprises obtaining a flow characteristic of the stenotic model, and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.

Abstract: A method for detecting and quantifying allergen components of a substance is described herein. A method can include obtaining an Ig sample derived from two or more individuals, and one or more capillaries comprising allergenic biologics adhered thereto. The Ig sample can be applied to the one or more capillaries and allergen component and molecules that has bound with the Ig sample, can be detected in the one or more capillaries. A molecular weight and/or frequency of appearance, an isoelectric charge and/or frequency of appearance, a molecular functional group and/or frequency of appearance or a combination thereof, of the allergen component can be recorded. Furthermore, methods for determining the minimum and maximum concentrations of the detected allergen components for pre-determined platforms, formulating an allergen product using the determined concentration ranges and applying the allergen product to result an effective assay are described.

Abstract: A system and associated method are provided for fulfillment of medication requisitions corresponding to contained medication units. Requisition fulfillment logic may be included to provide decision data to a patient care provider for use in selecting one of a plurality of different fulfillment sites to fill a given medication requisition. A requisition router may route the medication requisition to a selected one of the plurality of fulfillment sites. The fulfillment sites may provide medication requisition metadata (e.g., data relating to the preparation and handling of medication units) to a medication requisition database in corresponding relation to the corresponding medication requisitions fulfilled by the fulfillment sites. The medication requisition metadata may be stored in the medication requisition database and accessed to facilitate enhanced management functionalities in relation to medication units dispensed by patient care providers.

Abstract: A system and methods of capturing rapid changes in complex systems by examining the interaction of the various components within the system. A multivariate signal is decomposed into a dictionary of elements and a corresponding sparse mixing matrix Each dictionary element may provide a rank-1 estimation of a disjoint partition of time points of the signal that may permit estimation of the covariance of each partition using an outer-product of the corresponding dictionary element.

Abstract: The method presented herein includes acquiring a mass spectrum of a molecule that includes mass spectrum peaks corresponding to a precursor ion and fragment ions. The method also includes identifying at least a portion of the fragment ions in the mass spectrum as corresponding to one or more monomer subunit ion of the precursor ion by appending one or more of the fragment ions to an inferable constituent to produce a topology building block. The topology building block is then stored in a candidate pool as corresponding to one or more of the monomer subunit ion if the combined mass of the inferable constituent and one or more of the fragment ions satisfy a first user-defined mass tolerance. One or more candidate topology of the precursor ion is then obtained by combining a plurality of the topology building blocks that satisfy a second user-defined mass tolerance for the precursor ion.

Abstract: The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

Abstract: A method of displaying blood glucose information may include monitoring blood glucose levels of a user, where the blood glucose levels include at least a current blood glucose level and a historic blood glucose level. The method may also include presenting the current blood glucose level using a point indicator along an approximately horizontally centered axis based on a non-linear scale, and presenting the historic blood glucose level and a predicted future blood glucose level on the display as a single smoothed curve passing the point indicator.

Abstract: The invention provides computational methods for engineering, selecting, and/or identifying proteins with a desired activity. Further provided are automated computational design and screening methods to engineer proteins with desired functional activities including, but not limited to ligand binding, catalytic activity, substrate specificity, regioselectivity and/or stereoselectivity.

Abstract: Medical devices and related patient management systems and methods are provided. A method of monitoring a plurality of patients involves a computing device obtaining measurement data for the plurality of patients from a database, obtaining one or more prioritization rules from the database, generating a prioritized list of the plurality of patients based on the measurement data in accordance with the one or more prioritization rules, and providing a dashboard graphical user interface (GUI) display including the prioritized list. The prioritized list on the dashboard GUI display is dynamically updated in accordance with the prioritization rule(s) in response to updated measurement data in the database.

Abstract: In a biological simulation apparatus, an operation unit represents a structure domain where tissues of a biological organ exist by a structure mesh model based on a Lagrange description and a fluid domain where fluid inside the biological organ exists by an ALE fluid mesh model based on an ALE description method. In a fluid-structure interaction simulation, the operation unit deforms the structure mesh model, and then deforms the ALE fluid mesh model so as to form no gap on a first interface between a domain where a site other than a certain site of the biological organ in the structure domain exists and the fluid domain or no overlap with the structure domain. The operation unit captures a position of a second interface between a domain where the certain site exists and the fluid domain by using the ALE fluid mesh model as a reference.

Abstract: Disclosed herein are sensors for sensing analyte concentration values, and methods of operating such sensors. The sensors include a sensor probe comprising two electrodes; a voltage controller operably connected to the two electrodes of the probe, the voltage controller operable to apply multiple voltage pulses to one of the electrodes; a current sensor operable to measure a current response to the multiple voltage pulses; and a processor module operably connected to the current sensor, the processor module operable to calibrate the current sensor on the basis of the current response.

Abstract: A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an uploading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step.

Abstract: Method and system for storing and accessing genomic data. Genomic sequencing data are partitioned into access units of different types based on the predictability of the contained data. Access units are classified in different types and the structuring enables selective access and selective processing of genomic data.

Abstract: Embodiments of the present disclosure provide methods, systems, apparatuses, and computer program products that enable client devices to install integrations of a third party application that supports variable host address identification.

Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

Abstract: Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of cleavable probes capable of forming double-stranded structures, such as hairpin structures, which probes can be distinguished from one another on the basis of reporter signal, melt properties, or both.

Abstract: Various methods, systems, computer readable media, and graphical user interfaces (GUIs) are presented and described that enable a subject, doctor, or user to characterize or classify various types of cancer precisely. Additionally, described herein are methods, systems, computer readable media, and GUIs that enable more effective specification of treatment and improved outcomes for patients with identified types of cancer. Some embodiments of the methods, systems, computer readable media, and GUIs described herein comprise obtaining RNA expression data and/or whole exome sequencing (WES) data for a biological sample from a subject; determining a molecular-functional (MF) profile for the subject; identifying an MF profile cluster with which to associate the MF profile for the subject; and clustering the plurality of MF profiles to obtain the MF profile clusters.

Abstract: There is described a method for calculating a patient-specific hemodynamic parameter. The method comprises measuring at least one pressure measurement in an artery using an intravascular pressure measurement device, and taking at least one medical image of the artery from a medical imaging instrument, the at least one medical image of the artery being synchronous with the at least one pressure measurement. Both the pressure measurement and the medical image are fed to a computing system to calculate a flow from the at least one medical image, to calculate parameters of the artery from at least two artery pressure drops and corresponding flow components, and based on the flow and the parameters of the artery, to calculate a patient-specific hemodynamic parameter or a plurality thereof.

Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.

Abstract: Disclosed herein are systems, methods, and compositions useful for determining cellular pathway disruption comprising the use of RNA expression level information. This determined level of disruption can assist in the identification of genetic variants that alter pathway activity, to correlate these variants with disease state and disease progression, and to identify those therapeutics most likely to be effective and which should be avoided.

Abstract: In an example a method includes identifying, by a processor, in a data model of at least a portion of a three-dimensional object, an object property associated with a location in the three-dimensional object. A data model of a virtual build volume comprising at least a portion of the three-dimensional object may be generated in which an association with an object property is dispersed beyond the location.

Abstract: A system and method that takes in a data set comprising molecular structure data and properties of interest, e.g., ADMET, EC50, IC50, etc., and determines the substructures that cause or do not cause the property of interest. The substructures may then be used to filter out potentially harmful new proposed/generated molecules or create a new data set of known active/inactive substructures of a property of interest that may fulfill other obligations. The system comprises a substructure extraction module which further comprises a scaffold extraction module and a comparison module. A scaffold extraction module clusters, searches, and extracts substructures in question while a comparison module compares the bioactivity of each molecule with and without each substructure in question to determine the substructures effect on the property of interest.

Abstract: A system and method for generating a mesodermal outline nourishment program comprises a computing device configured to obtain an undifferentiated connective tissue workup as a function of a connective tissue system, determine a mesodermal outline as a function of the undifferentiated connective tissue workup, wherein determining comprises obtaining a mesodermal group as a function of a connective database, and determining the mesodermal outline as a function of the mesodermal group and undifferentiated connective tissue workup using a mesodermal machine-learning model, generate an outline signature as a function of the mesodermal outline, wherein generating comprises receiving a normal range as a function of a mesodermal guideline, and generating the outline signature as a function of the normal range and mesodermal outline using a signature machine-learning model, identify an edible as a function of the outline signature, and output a nourishment program as a function of the edible.

Abstract: Techniques are provided for replacing image assays using real world data and real word evidence RNA-seq analysis for assessing biologic pathways for identifying molecular subtypes. Systems of a methods diagnose HER2 status for a patient, by identifying discordant HER2 status result between the HER2 status from immunohistochemistry (IHC) and the HER2 status from fluorescence in-situ hybridization (FISH) and diagnosing HER2 status based gene expression data.

Abstract: There is provided a system for measuring a physiological parameter of a person indicative of physiological pathology, comprising: a plurality of remote non-contact sensors, each of a different type of sensing modality, at least one hardware processor executing a code for: simultaneously receiving over a time interval, from each of the plurality of remote non-contact sensors monitoring a person, a respective dataset, extracting, from each respective dataset, a respective sub-physiological parameter of a plurality of sub-physiological parameters, analyzing a combination of the plurality of sub-physiological parameters, and computing a physiological parameter indicative of physiological pathology according to the analysis, wherein an accuracy of the physiological parameter computed from the combination is higher than an accuracy of the physiological parameter independently computed using any one of the plurality of sub-physiological parameters.

Abstract: The present disclosure provides methods and reagents for the diagnosis, prognosis or the monitoring of breast cancer, including various subtypes of breast cancer including, for example, estrogen receptor (ER) negative breast cancer, ER positive breast cancer, triple negative breast cancer (TNBC) and other subtypes of breast cancer.

Abstract: According to one embodiment, a genotype estimation device includes: an acquirer configured to acquire a clustering strength of genotype data of a plurality of specimens including an unknown specimen whose genotype is not known and known specimens whose genotypes are known; and an estimator configured to estimate the genotype of the unknown specimen on the basis of the genotype data in response to the clustering strength being larger than a first threshold, and output an estimation result.

Abstract: A method of luminance lifetime imaging includes receiving incident photons at an integrated photodetector from luminescent molecules. The incident photons being received through one or more optical components of a point-of-care device. The method also includes detecting arrival times of the incident photons using the integrated photodetector. A method of analyzing blood glucose includes detecting luminance lifetime characteristics of tissue using, at least in part, an integrated circuit that detects arrival times of incident photons from the tissue. The method also includes analyzing blood glucose based upon the luminance lifetime characteristics.

Abstract: A system and method are disclosed for generating a teleconference space for two or more communication devices using a computer coupled with a database and comprising a processor and memory. The computer generates a teleconference space and transmits requests to join the teleconference space to the two or more communication devices. The computer stores in memory identification information for each of the two or more communication devices. Each of the two or more communication devices stores audiovisual data pertaining to one or more users associated with each of the two or more communication devices. Each communication device converts the audiovisual data into facial expressions data, generates emotions data from the facial expressions data, generates attention data from the emotions data, and transmits the attention data from the communication device to the computer. The computer displays the attention data.

Abstract: The present disclosure is directed to a method and system for automatically detecting a physiological condition from a medical image of a patient. The method may include receiving the medical image acquired by an imaging device. The method may further include detecting, by a processor, target objects and obtaining the corresponding target object patches from the received medical image. And the method may further include determining, by the processor, a first parameter using a first learning network for each target object patch. The first parameter represents the physiological condition level of the corresponding target object, and the first learning network is trained by adding one or more auxiliary classification layers. This method can quickly, accurately, and automatically predict target object level and/or image (patient) level physiological condition from a medical image of a patient by means of a learning network, such as 3D learning network.

Abstract: A video decoding method includes obtaining an encoded bitstream of an original video content; decoding the encoded bitstream based on a residual coding scheme and signaling information; and presenting the original video content. The decoding the encoded bitstream includes: obtaining encoded residual information associated with the encoded bitstream, wherein the residual information includes at least a remainder, and performing a decoding process on the encoded residual information to obtain a transform domain coefficient using a Markov decision process (MDP) based on a current state, a Rice parameter, and a next state.

Abstract: A system for generating an immune protocol including a computing device configured to receive an immune biomarker, retrieve an immune profile, assign the immune profile to an immune category, determine, using the immune category and the immune profile, an elimination plan, including identifying an effect on the immune profile for each nutrition element consumed by the user, determine at least a nutrition element that contributes to the immune category, create, using the elimination plan, a reintroduction phase, including identifying a frequency associated with the nutrition element determined in the elimination plan, and identifying a magnitude associated with the nutrition element determined in the elimination plan, identify a plurality of protocol elements, wherein each contains a nutrient amount intended to prevent autoimmune disease, and generate an immune protocol as a function of the elimination plan, the reintroduction phase, and the plurality of protocol elements.

Abstract: A dehydration amount prediction method for hemodialysis and an electronic device using the same are provided, and the method includes the following steps. Physiological data and hemodialysis treatment data of a first patient are obtained. The first patient is determined to belong to one of groups, wherein the groups are respectively associated with a plurality of prediction models. A target prediction model corresponding to the one of the groups is selected from the prediction models. The physiological data and the hemodialysis treatment data are provided to the target prediction model to generate a recommended dehydration amount by the target prediction model.

Abstract: The present disclosure relates to a method and system for object identification. A method for object identification is provided, comprising: acquiring a first image presenting at least a part of an object from a user; identifying a category of the object through a pre-established object identification model based on the first image, to obtain at least one result; searching a rule database containing at least one set of confusable object categories using the at least one result, to determine whether there is a confusable object category corresponding to the at least one result; and if there is a confusable object category corresponding to the at least one result in the rule database, returning the at least one result and the confusable object category corresponding thereto to the user.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: The purpose of the present invention is to provide an automatic analysis device capable of determining, through a simple processing, whether or not idle aspirate has occurred. The automatic analysis device according to the present invention determines whether or not idle aspirate has occurred, by calculating a parameter which specifies whether or not the length of a portion of a path through which the sample passes inside a dispensing probe is shorter than that during normal aspirate, the portion being actually filled with a sample (see FIG. 4).

Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.

Abstract: A medical condition based content filter mechanism is provided that analyzes patient information associated with a patient to identify medical condition(s) associated with the patient and correlating the medical condition(s) with one or more medical condition content indicator data structures specifying negative content indicators and/or positive content indicators. A user specific content indicator dictionary data structure (USCID) is generated based on the correlation and used to process received content to filter out portions of the content matching the negative content indicators or present portions of the content matching the positive content indicators, thereby generating modified content that is output to the patient via a content access application executing on a computing device associated with the patient.

Abstract: Systems and methods are provided for determining location data corresponding to a location of a user, retrieving candidate locations for pickup or drop-off locations based on the location data corresponding to the location of the user, and determining a safety score for each of the candidate locations. The systems and methods further select a best candidate location using the safety score associated with each of the candidate locations and provide a recommendation for a pickup or drop-off location comprising the best candidate location.

Abstract: Methods and systems for searching genomes for potential nucleotide-guided nuclease off-target sites are provided. Also provided are methods of searching genomes for potential off-target deadCas9 binding sites. In some embodiments, the methods include ranking the potential off-target sites based on the number and location of mismatches, insertions, and/or deletions in the DNA, RNA, or DNA/RNA guide sequence relative to the genomic DNA sequence at a putative target site in the genome, allowing the selection of better target sites and/or experimental confirmation of off-target sites.

Abstract: The present disclosure relates to a smart bottle holder and a daily water consumption monitoring method and system thereof. The smart bottle holder includes a bottle holder main body for accommodating a bottle, and a control unit provided in a bottom part of the bottle holder main body. The control unit includes a weighing module, for obtaining a total weight of the bottle and water therein; a controller; a communication module, for sending water consumption data to an external terminal; and a power module, for supplying power to the weighing module, controller, and communication module. Compared with the prior art, the present disclosure has stronger structural mobility and wider range of applications. Also, the present disclosure is more power-saving and environmentally friendly and can provide more accurate water consumption statistics.