Chemical Property Analysis Patents (Class 702/30)
  • Patent number: 8452548
    Abstract: In one embodiment a method to determine at least one low temperature property of the lubricant oil is disclosed. This method comprises obtaining a base stock, generating a DSC curve of wax versus temperature using a heating curve for the base stock, correlating the heating curve of the base stock with a MRV for a formulated oil, and determining the MRV of the lubricant oil from the correlation of the base stock to the MRV of the corresponding desired base oil.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: May 28, 2013
    Assignee: Exxonmobil Research and Engineering Company
    Inventors: Ronald M. Gould, Eugine Choi
  • Patent number: 8447527
    Abstract: A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: May 21, 2013
    Assignee: Waters Technologies Corporation
    Inventors: Marc V. Gorenstein, Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li
  • Patent number: 8433723
    Abstract: In various embodiments, multiple heterogeneous documents are processed to identify structures, such as chemical structures, contained therein, including non-embedded structures. Also described is a graphical user interface that permits a user to search for a structure or substructure within a set of electronic documents, then displays the matching structures as well as the actual pages of the documents on which the matching structures are found. Display of the actual pages allows the user to verify the matches and provides helpful context for the user.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: April 30, 2013
    Assignee: Cambridgesoft Corporation
    Inventors: Robin Y. Smith, William B. Ballard, Scott G. Flicker, Sean G. Greenhow
  • Publication number: 20130096845
    Abstract: An apparatus comprising: a value receiver, configured to receive fluorescence values measured during a chemical reaction involving a test sample, each value pertaining to a respective physical parameter value, a difference calculator, configured to calculate differences, each difference being between respective one of the measured fluorescence values and one of reference fluorescence values of a reference sample, each reference fluorescence value pertaining to a respective physical parameter value, a cumulative index calculator, configured to calculate a cumulative index, by selecting a first difference among the calculated differences, and selecting and adding to the first difference differences, each one of the added differences being selected according to a proximity standard applied on each two differences selected in a sequence, the proximity standard being based on proximity of physical parameter values and difference size, and a similarity determiner, configured to determine similarity between the samp
    Type: Application
    Filed: October 14, 2011
    Publication date: April 18, 2013
    Inventor: Ze'ev RUSSAK
  • Publication number: 20130090865
    Abstract: Disclosed is a method for electronic residual spectroscopy for atomic-scaled surface and sub-surface information purification. The method comprises collecting at least one reference spectrum and a plurality of spectra under various conditions. The background of all the plurality of spectra is then subtracted and the plurality of spectra are normalized. Subtracting the reference spectrum from the normalized plurality of spectra will give atomic-scaled, meaningful information at selected zones.
    Type: Application
    Filed: June 18, 2010
    Publication date: April 11, 2013
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventor: Changqing Sun
  • Patent number: 8417467
    Abstract: According to one embodiment, a method for estimating an activity of one or more radio-nuclides includes receiving one or more templates, the one or more templates corresponding to one or more radio-nuclides which contribute to a probable solution, receiving one or more weighting factors, each weighting factor representing a contribution of one radio-nuclide to the probable solution, computing an effective areal density for each of the one more radio-nuclides, computing an effective atomic number (Z) for each of the one more radio-nuclides, computing an effective metric for each of the one or more radio-nuclides, and computing an estimated activity for each of the one or more radio-nuclides. In other embodiments, computer program products, systems, and other methods are presented for estimating an activity of one or more radio-nuclides.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: April 9, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventor: Karl Einar Nelson
  • Publication number: 20130073221
    Abstract: Techniques for identifying a composition of a target fluid using a set of vectors representing known residue patterns for a two or more fluids including said target fluid is provided. An exemplary method includes storing one or more digital measurements of residue for the target fluid, extracting one or more descriptive features from the measurements; and processing descriptive features to identify the composition of the target fluid. The processing includes using a machine learning algorithm trained with data linking residue morphology to fluid composition. A distance between a vector representing said one or more descriptive features and said set of vectors representing known residue patterns is determined, and a residue is assigned to one or more of the known residue patterns.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Inventors: Daniel Attinger, Frederic Zenhausern, Cedric Hurth, Shih-Fu Chang, Zhenguo Li
  • Patent number: 8386194
    Abstract: The condition of a bond surface is determined. A 3-D wettability tension curve is generated for the bond surface which represents a range of possible wettings of an adhesive on the bond surface that may result in a bond joint of acceptable quality. At least three surface energies on the bond surface are measured, and the wettability curve is used to determine whether the condition of the bond surface is acceptable based on the measured bonding surface energies.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: February 26, 2013
    Assignee: The Boeing Company
    Inventors: Joel P. Baldwin, Russell L. Keller, Eugene Dan-Jumbo
  • Publication number: 20130035873
    Abstract: A method for supervising a process for producing a metal alloy object with a known chemical composition. A resistivity of the metal alloy object is determined. A content of dissolved alloying elements in the metal alloy object is estimated based on the determined resistivity and the chemical composition of the metal alloy object. A content of precipitated alloying elements in the metal alloy object is estimated based on the determined resistivity and the chemical composition of the metal alloy object. The production process is supervised based on a ratio between the estimated content of dissolved alloying elements and the estimated content of precipitated alloying elements.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 7, 2013
    Applicant: ABB AB
    Inventors: Sten Linder, Lennart Thegel
  • Patent number: 8370082
    Abstract: A method for predicting a physical property of a residue obtainable from a crude oil by a process of distillation, wherein the conditions during the process are represented by a processing parameter, is disclosed. The method includes the steps of: a) using a spectroscopic technique to acquire a spectrum for the crude oil; and b) applying a predictive model based upon a correlation between the spectrum, the physical property and the processing parameter. The method may be used to predict the suitability of crude oil for bitumen production.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: February 5, 2013
    Assignee: Shell Oil Company
    Inventors: Peter De Peinder, Fred Adrianus Johannes Singelenberg, Tom Visser, Bert Marc Weckhuysen
  • Publication number: 20130030719
    Abstract: Methods and systems for identifying a quantitation cycle (Cq) for a PCR reaction that includes fitting a line having a plurality of line segments to data points associated with a PCR amplification reaction. The data points include a cycle value associated with a PCR cycle and a product value associated with a PCR product. A baseline is identified and reaction segment associated with an exponential region of the PCR reaction is also identified. The reaction segment includes a subset of the plurality of line segments having a slope not less than a steepness criterion. A reaction line is fit to the data points associated with the reaction segment. The Cq is identified by calculating the cycle value for a data point defining the intersection of the baseline and reaction line.
    Type: Application
    Filed: July 27, 2012
    Publication date: January 31, 2013
    Applicant: THERMO FISHER SCIENTIFIC OY
    Inventors: Jorma Mustola, Antti Koski
  • Patent number: 8364423
    Abstract: Chemical compositions in the blood may be selectively or preferentially excited by the application of scores comprising a series of at least four energy inputs to a blood vessel.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: January 29, 2013
    Assignee: The Invention Science Fund I, LLC
    Inventors: Muriel Y. Ishikawa, Edward K. Y. Jung, Nathan P. Myhrvold, Lowell L. Wood, Jr.
  • Patent number: 8364316
    Abstract: A method of modeling phase characteristics of thermodynamic systems utilizing pseudo-properties strategy and a reduced number of variables is disclosed herein. The method describes a means of determining the probability of phase splitting of mixtures of materials at a given temperature, pressure, and composition by characterizing the functions that describe the system via pseudo-properties, and also by describing the system in n?1 or fewer variables, where n represents the number of components in the system of interest. In an embodiment, a multi-component system is characterized in one variable, thereby providing simplified thermodynamic models in a time-efficient manner. In addition, the information generated by this reduced-variable calculation can further be used as a starting point for calculations of equations of state.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: January 29, 2013
    Assignee: Invensys Systems, Inc.
    Inventors: Gang Xu, David Bluck
  • Patent number: 8362415
    Abstract: A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: January 29, 2013
    Assignees: Lawrence Livermore National Security, LLC, Lawrence Berkeley National Laboratory
    Inventors: James S. Felton, Kuang Jen J. Wu, Mark G. Knize, Kristen S. Kulp, Joe W. Gray
  • Patent number: 8359168
    Abstract: The present invention relates to a fuel identification system and method normally applied to internal combustion engine vehicles of the flex-fuel type by means of which it is possible to identify the composition of the fuel used at each point in time, particularly the ratio used in a gasoline/ethanol blend or detect the presence of air or fuel in the vapor state in the fuel line, using the same device that heats the fuel.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: January 22, 2013
    Assignee: Robert Bosch Limitada
    Inventors: Fernando Lepsch, Marcos Melo Araujo, Hilton Rafael Spiler, Carlos Henrique De Oliveira Melo, Hans Hugo Eichel, Jr.
  • Patent number: 8357301
    Abstract: Herein is reported a method for determining whether a re-useable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-useable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 22, 2013
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Anton Belousov, Thomas Dams, Benjamin Gerwat
  • Publication number: 20130018593
    Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR process or other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.
    Type: Application
    Filed: September 24, 2012
    Publication date: January 17, 2013
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Bio-Rad Laboratories, Inc.
  • Publication number: 20130018599
    Abstract: A graphene nano-sensor with a suspended graphene flake electrically connected to metal electrodes. The graphene nano-sensor is capable of detecting single molecules in an atmosphere through a change in electrical conductance through the graphene flake.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 17, 2013
    Inventor: Haibing Peng
  • Publication number: 20130013218
    Abstract: According to various embodiments, package evaluation systems and methods are provided for evaluating the sustainability of packaging used in the shipment of goods. In particular, the package evaluation systems and methods are configured for performing package evaluations and managing and providing access to data resulting from package evaluations. The package evaluations are designed to assess, among other things, the ability of sample packages to prevent damage to their contents, the volumetric efficiency of sample packages, and the sustainability of the materials used to construct sample packages. In addition, the systems and methods are further configured for assigning a certification to an entity associated with the evaluated packages based on the results of the evaluation.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 10, 2013
    Applicant: UNITED PARCEL SERVICE OF AMERICA, INC.
    Inventors: Arnold Barlow, Dennis R. Estep, Andrew J. Gruber, Patrick McDavid, Quinto Marini, Nancy Parmer
  • Publication number: 20130009781
    Abstract: An Anti-Terrorism water quality monitoring system for continuously monitoring a potable water treatment system and related potable water distribution network that provides potable water to a municipality, city, housing development or other potable water consumer. The system includes the collection of data from the water distribution system and from the water treatment facility and from advanced separation processes which are integrated into analytical instruments. The data collected are stored in a remote database on a remote server computer or bank of computers and accessible by Homeland Security or its designated agency. Preferred parameters of monitoring include the turbidity and disinfectant such as chlorine, hypochlorous acid, sodium hypochlorite, calcium hypochloritc, ozone, chlorine dioxide, chloramines, hydrogen peroxide, peracetic acid.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: HACH COMPANY
    Inventor: Thomas D. Wolfe
  • Publication number: 20130008149
    Abstract: Systems and methods for estimating an efficiency of a catalyst placed in an exhaust path of a combustion engine are disclosed. In one example approach, a method comprises: ageing the catalyst consecutively at different temperatures for definite time periods; measuring the catalyst conversion efficiency after each ageing step; calculating the ageing factor for each step of the ageing procedure and the accumulative value of the ageing factors for all steps of the ageing procedure; estimating catalyst efficiency correlation factors related to the measured catalyst conversion efficiency for each temperature point and for all ageing conditions; determining a correlation between the catalyst efficiency correlation factors and the accumulative value of the ageing factors; and calculating the conversion efficiency of the aged catalyst based on a predetermined correlation between the accumulative ageing factor and the catalyst efficiency correlation factor.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 10, 2013
    Applicant: FORD GLOBAL TECHNOLOGIES, LLC
    Inventors: Robert Ukropec, Alexey A. Dubkov, Yasser Mohamed Sayed Yacoub, Albert N. Chigapov, Nina Shishkina, Brendan Patrick Carberry
  • Patent number: 8348843
    Abstract: A meter is provided that includes an improved user interface that enables the user to take a specific action, leading them directly to data input options. Such a user interface could be used to input first selected information, such as whether a test was premeal or postmeal, immediately after receiving a result. Optionally, the user interface may include the ability to add an additional comment after inputting the first selected information. Provision of such a user interface would facilitate simpler capture of the first selected information each time the user performs a test, leading to an enhanced understanding of a patient's level of glycemic control. Designing a user interface to enable first selected information to be entered by a user directly after receiving a result is more likely to engage a patient by making it easy and simple to enter important information. This may enable capture of the information thought to be most pertinent e.g.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: January 8, 2013
    Assignee: LifeScan Scotland Limited
    Inventors: Stanley Alan Young, David William Taylor, Allan Orr, Cheryl Neary, Nicola Canning, Marc Daniel Stern
  • Patent number: 8340921
    Abstract: A measuring arrangement of the invention includes: At least one measuring device, which generates, repeatedly during operation, measured values, especially digital, measured values, representing the at least one measured variable to be registered; as well as an electronic data processing system superordinated to the at least one measuring device, especially a data processing system which is spatially distributed and/or spatially remote from the measuring device. Measuring device and data processing system are connected together by means of at least two line-pairs, through each of which an electrical current flows, at least at times, during operation. According to the invention, the measuring device transmits the internally generated, measured values to the data processing system via both line-pairs. In this way, it is then possible to transmit a plurality of measured values simultaneously, when each of the two line-pairs is embodied as part of a two-conductor current-loop.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: December 25, 2012
    Assignee: Endress + Hauser Flowtec AG
    Inventors: Jiri Karbula, Robert Lalla, Gernot Engstler
  • Patent number: 8332162
    Abstract: A Method and apparatus to accurately measure and display various properties of hydrocarbons and petroleum factions for a small volume of sample in a short period of time in one test with less cost and energy for the analysis by the method of light refection. The refraction of light through the sample is measured and compared to the refraction f the light through vacuum by the apparatus. The method of the invention comprises a property estimation from the apparatus to output a property estimate value. The property estimation means is equipped with a property estimation model for evaluating the property estimate value outputted from the property estimation model. The method is incorporated into standard or otherwise any refractive index test apparatus or refractometer to provide accurate measure of the thermodynamic and transport properties of pure hydrocarbons and undefined multicomponent mixtures such as petroleum factions.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: December 11, 2012
    Assignee: Kuwait University
    Inventor: Tareq Abduljahl Abahri
  • Patent number: 8328719
    Abstract: A meter is provided that includes an improved user interface that enables the user to take a specific action, leading them directly to data input options. Such a user interface could be used to input first selected information, such as whether a test was premeal or postmeal, immediately after receiving a result. Optionally, the user interface may include the ability to add an additional comment after inputting the first selected information. Provision of such a user interface would facilitate simpler capture of the first selected information each time the user performs a test, leading to an enhanced understanding of a patient's level of glycemic control. Designing a user interface to enable first selected information to be entered by a user directly after receiving a result is more likely to engage a patient by making it easy and simple to enter important information. This may enable capture of the information thought to be most pertinent e.g.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: December 11, 2012
    Assignee: LifeScan Scotland Limited
    Inventors: Stanley Alan Young, David William Taylor, Allan Orr, Cheryl Neary, Nicola Canning, Marc Daniel Stern
  • Patent number: 8329103
    Abstract: An sample analyzer, which enables to confirm an analysis remaining time for each sample and a total analysis remaining time for all samples set in the analyzer, so that time management for both each sample and all samples can be easily performed, is disclosed. Specifically, an analyzing unit analyzes a sample by executing an analysis sequence including a predetermined number of analyzing steps, and an control device calculates an analysis remaining time for each sample based on the number of analyzing steps. Control device acquires a total analysis remaining time by calculating the analysis remaining time for the sample in which sample information is lastly inputted. The display member displays the analysis remaining time and the total analysis remaining time.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: December 11, 2012
    Assignee: Sysmex Corporation
    Inventors: Yuji Wakamiya, Tomohiro Okuzaki, Hisato Takehara
  • Publication number: 20120303291
    Abstract: A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.
    Type: Application
    Filed: April 25, 2012
    Publication date: November 29, 2012
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: Manoj K. Prasad, Neal J. Snyderman, Mark S. Rowland
  • Publication number: 20120303292
    Abstract: A method of scoring binding affinity of a proposed ligand molecule for a receptor molecule using computer analysis and computer data bases to accounts for the increase in energy required where docking disrupts or partially disrupts the ?-conjugated character of the ligand when bound to the receptor. The method uses data representing one or more proposed ligand molecules to be scored and data representing the receptor molecule. Computer analysis of the proposed ligand molecule data determines whether the ligand includes at least one ?-conjugated moiety having multiple possible geometries, one of those geometries being characterized by less delocalization of electrons across the ?-conjugated moiety than the delocalization of electrons characterizing another of those geometries. Computer analysis of the predicted ligand-receptor structure determines whether the ligand in the ligand-receptor structure adopts the geometry characterized by less delocalization.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 29, 2012
    Inventors: Richard A. Friesner, Robert Murphy
  • Publication number: 20120295278
    Abstract: Two or more kinds of fluorescent beads containing at least two kinds of basic fluorochromes different in fluorescence intensity, fluorescence wavelength, and fluorescence relaxation time from each other, wherein a content ratio between the at least two kinds of basic fluorochromes and absolute amounts of contents of the basic fluorochromes are set so as to be different between different kinds of fluorescent beads. The fluorescent beads are used in a flow cytometer for fluorescence detection. This makes it possible to identify a greater variety of beads than before with high accuracy in a single measurement.
    Type: Application
    Filed: January 19, 2011
    Publication date: November 22, 2012
    Applicant: MITSUI ENGINEERING & SHIPBUILDING CO.,LTD.
    Inventors: Hironori Hayashi, Shigeyuki Nakada
  • Patent number: 8315821
    Abstract: A method and system for determining a packing property of a particulate composition. The method includes: obtaining size information relating to the particulate material; determining neighbor information from the size information; determining contact information from the size information; and determining a packing property from the neighbor information and the contact information, thereby enabling determination of the characteristic properties of the particulate composition. The method can be executed by use of a computer system to execute computer software instructions applied to data obtained on the particulate composition to determine a variety of properties of the particulate composition.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: November 20, 2012
    Assignee: New York University
    Inventors: Jasna Brujic, Eric Corwin, Maxime Clusel
  • Publication number: 20120290224
    Abstract: A method for determining a cation which is stable to oxygen radical. Specifically, a lithium air cell which includes at least an air electrode, a negative electrode and a non-aqueous electrolyte that is interposed between the air electrode and the negative electrode. The lithium air cell is characterized in that the nonaqueous electrolyte contains an ionic liquid that does not contain atoms having a positive charge larger than that of a hydrogen atom and is composed of cations, which have an average of the charges carried by atoms other that hydrogen atoms of 0 or less, and counter anions of the cations.
    Type: Application
    Filed: January 18, 2010
    Publication date: November 15, 2012
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Hidetaka Nishikoori, Noriaki Nishino, Atsushi Shirasawa, Iwao Nitta, Fuminori Mizuno
  • Publication number: 20120280814
    Abstract: Devices, systems, and methods for sensing and derived information conveyance as disclosed. One electrical device includes an electronic circuit and executable instructions provided by at least one of: software stored in memory associated with the circuit or provided in firmware within the circuit, wherein the circuit receives raw sensor data from one or more sensors associated with the circuit, analyzes the data, and creates a report document that includes one or more features of the analysis of the data.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 8, 2012
    Applicant: PAKSENSE, INC.
    Inventors: Arthur G. Beale, Kevin C. Hess, Amy E. Childress, Thomas P. Jensen, Casimir E. Lawler, JR., Elias H. Roby, III
  • Publication number: 20120279824
    Abstract: The invention relates to improved bitumen recovery processes and systems. One process provides for operation of a bitumen froth treatment plant at optimum shear rates in the feed pipe carrying the bitumen froth to the froth settling unit. Another process provides for optimizing the design of a bitumen froth treatment plant by optimizing the diameter of the feed pipe to impart an optimum shear rate to the bitumen froth mixture and further optimizing the volume of the feed pipe to impart an optimum residence time for the bitumen froth stream in the feed pipe. An optimal plant design is also disclosed, the plant including optimal diameter and volume of the feed pipe.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 8, 2012
    Inventors: Arun K. Sharma, Michael F. Raterman
  • Patent number: 8298413
    Abstract: Systems and methods for separating charged molecules on the basis of their differential electrostatic binding to a charged stationary phase comprise controlling the creation of simultaneous independent or dependent pH and additive gradients.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: October 30, 2012
    Assignee: Cryobiophysica, Inc.
    Inventors: Latchezar Ivanov Tsonev, Allen Gene Hirsh
  • Patent number: 8301395
    Abstract: The present invention includes analyte measurement systems, analyte measurement meters, analyte testing devices, cartridges thereof and integrated circuits for use therewith, and further includes methods related to the use of the integrated circuits and, in certain embodiments, to the counting or tracking of parameters related to the cartridges and analyte test devices.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: October 30, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: William Matievich, Jr., Alexander G. Ghesquiere, Ting Chen
  • Patent number: 8301397
    Abstract: A method of determining physico-chemical properties of a petroleum sample from two-dimensional gas chromatography. The amounts of molecular compounds present in the sample are determined by means of two-dimensional gas chromatography. At least one physical property, such as the octane number, is then determined from these amounts. A previously calibrated relation connecting the physical property to the amounts is used to this end.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: October 30, 2012
    Assignee: IFP
    Inventors: Fabrice Bertoncini, Benoît Celse, Cyril Dartiguelongue
  • Patent number: 8285492
    Abstract: Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: October 9, 2012
    Assignee: Applied Biosystems, LLC
    Inventor: Stephen J. Gunstream
  • Patent number: 8285496
    Abstract: A method for providing a characteristic quantity for a state of an air system of a supercharged internal combustion engine includes: detecting a characteristic quantity measured value as characteristic quantity information with the aid of a sensor; providing a characteristic quantity model, using which a characteristic quantity model value is computed on the basis of one or more quantities different from the characteristic quantity measured value; and providing the characteristic quantity either based on the characteristic quantity measured value or on the characteristic quantity model value computed by the characteristic quantity model, as a function of a state of the air system.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: October 9, 2012
    Assignee: Robert Bosch GmbH
    Inventors: Matthias Heinkele, Patrick Menold, Michael Drung
  • Publication number: 20120253692
    Abstract: A pH measuring method includes: illuminating a medium solution, which includes: a first material; and a second material, with a plurality of light beams, which includes: a first light beam, a wavelength of which corresponds to a first absorption peak; a second light beam, a wavelength of which corresponds to a second absorption peak or a second convergence point; a third light beam, a wavelength of which corresponds to a third absorption peak or a third convergence point; and a fourth light beam, a wavelength of the fourth light beam at which an absorbance of at least one of the first and second materials is converged irrespective of a pH; receiving transmitted or reflected light beams of the first to fourth light beams; measuring absorbances at the wavelengths of the received light beams respectively; and calculating a pH of the medium solution based on the absorbances.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 4, 2012
    Inventors: Mitsuhiro OURA, Hirotsugu Kubo, Sunao Takeda, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20120244637
    Abstract: A method of determining one or more interaction parameters for the interaction between an analyte and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with a control analyte, C: registering the sensor response from binding of the control analyte to binding sites of the ligand, D: determining the control saturation response (RmaxC) for the interaction between the control analyte and the ligand, E: transforming the control saturation response (RmaxC) to an analyte saturation response (RmaxA) using the relative molar response contribution of the analyte and the control analyte.
    Type: Application
    Filed: November 29, 2010
    Publication date: September 27, 2012
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Olof Karlsson
  • Publication number: 20120239309
    Abstract: A computer implemented method for automatic chemical assay classification, the method comprising steps the computer is programmed to perform, the steps comprising: receiving a plurality of sets of parameters, each one of the received sets of parameters characterizing a respective assay of a chemical reaction, calculating a space enhancing proximity among points representative of assays of qualitatively identical chemical reactions, and representing each one of at least two of the received sets of parameters as a respective point in the calculated space, and dividing the points in the calculated space into a number of groups, according to proximity among the points in the calculated space, each group pertaining to a respective chemical reaction, thereby classifying the assays.
    Type: Application
    Filed: November 22, 2009
    Publication date: September 20, 2012
    Applicant: AZURE VAULT LTD.
    Inventor: Ze'ev Russak
  • Patent number: 8249817
    Abstract: A chromatograph analyzing device for automatically executing a base line setting process on an unseparated peak using preset base line conditions. The chromatograph analyzing device includes a separation unit for separating a component included in a sample, and a data processing device for identifying the component of the sample and the quantity of the component in the sample by using a chromatogram obtained from the separation.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: August 21, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Osamu Watabe, Masahito Ito
  • Publication number: 20120203472
    Abstract: The present invention provides a method to calibrate a NIR analyzer to measure monomer concentrations at one or more locations in a reactor system. The regression coefficients for the NIR analyzer are transferable between reactors using the same process (solution polymerization to solution polymerization) and may be used to control the reaction, or calibrate flow meters on line.
    Type: Application
    Filed: February 3, 2011
    Publication date: August 9, 2012
    Inventor: Yves Lacombe
  • Patent number: 8237108
    Abstract: The present invention provides, inter alia, methods of analyzing mass spectral data based on charge states of analyte ions. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a given compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: August 7, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: David M. Horn, Xiangdong Don Li
  • Patent number: 8224588
    Abstract: A method for determining the water conductivity of a multi-component mixture of gas and at least one liquid containing water in a pipe, the method comprising the following steps: a. electromagnetic measurements at least two measurement frequencies are performed in a pipe near the pipe wall at a first cross-sectional location where the mixture predominantly contains gas and at a second cross-sectional location where the mixture predominantly contains liquid, b. the temperature of the multi-component mixture is determined, and c. based on an empirically determined relationship between the measurements performed is step a and b and the conductivity of pure water, the conductivity of the water contained in the multi-component mixture is determined. An apparatus for performing the method is also disclosed.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: July 17, 2012
    Assignee: Multi Phase Meters AS
    Inventor: Arnstein Wee
  • Patent number: 8219327
    Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: July 10, 2012
    Assignee: Irori Technologies, Inc.
    Inventors: Michael P. Nova, Andrew E. Senyei, Zahra Parandoosh, Gary S. David, Xiao-Yi Xiao
  • Publication number: 20120173156
    Abstract: A method of analysis wherein molecular interactions at one or more sensing surface areas are detected and respective response curves representing the progress of each interaction with time are produced, and wherein a resulting set of response curves is subjected to a quality assessment procedure which comprises representing the response curves with one or more quality descriptors, applying a quality classification method to the descriptors to find outliers, and removing the outliers. The invention also relates to an analytical system including means for classifying the response curves with regard to quality, a computer program for performing the classification, and a computer program product containing the program.
    Type: Application
    Filed: March 14, 2012
    Publication date: July 5, 2012
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: KARL ANDERSSON, PETER BORG
  • Publication number: 20120160707
    Abstract: A method for characterizing refinery feedstocks according to their corrosivity is provided. The characterization is based on any of: dissociation of acids in the crude, breakup of naphthenic acid molecular associations, and/or dissociation of sulfur compounds in the feedstocks. In one embodiment, the characterization is done via vibrational spectroscopic measurements over a range of temperature, e.g., from ambient to 700° F. The method can be practiced in any of refinery, terminal, and laboratories. It can be used in conjunction with models and hardware to optimize the usage of refinery feedstocks in the blending and valuation of the feedstocks.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 28, 2012
    Inventors: Grzegorz Jan Kusinski, Thomas M. Devine
  • Publication number: 20120166100
    Abstract: An apparatus for identifying transition points in a chemical reaction, the apparatus comprising: a property value receiver, configured to receive a plurality of values of a physical property of the chemical reaction, a linear function calculator, associated with the property value receiver, configured to calculate a linear function connecting two of the received values, the two values pertaining to a start and end of a time period, a difference calculator, associated with the linear function calculator, configured to calculate a difference between the linear function and a plurality of the received values pertaining to the time period, and a transition point identifier, associated with the difference calculator, configured to identify at least one transition point of the chemical reaction, using the calculated difference.
    Type: Application
    Filed: September 12, 2009
    Publication date: June 28, 2012
    Applicant: AZURE VAULT LTD.
    Inventor: Ze'ev Russak
  • Patent number: 8209132
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: June 26, 2012
    Assignees: Momenta Pharmaceuticals, Inc., Massachusetts Institute of Technology
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram