Specific Signal Data Processing Patents (Class 702/32)
  • Patent number: 8489241
    Abstract: An exemplary method is disclosed for controlling on-line the steam output of a waste incineration plant that is fed with waste of varying composition. Process or system quantities (u2, u3, xGC, xLL, w0) can be measured repeatedly, at different times during operation of the plant, and a relation with linear parameters (?i) as coefficients of non-linear expressions (?i) of the process quantities can be established by evaluating the measurements. From this relation, an optimal waste feed rate to obtain a desired steam output ({dot over (M)}steam) can be determined and applied to a waste feed actuator of the waste incineration plant.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: July 16, 2013
    Assignee: ABB Technology AG
    Inventors: Silvia Bardi, Alessandro Astolfi
  • Patent number: 8489240
    Abstract: A control system for industrial water systems that utilizes multiple measurements of information and models to decide optimal control actions to maximize corrosion/scaling/fouling inhibition and particulate dispersancy performance and minimize cost of water and treatment chemicals. This system is capable of automatic operation for a wide range of process conditions, ensures multiple performance objectives, achieves robust operation under a variety or un-measurable disturbances and achieves the least costly solution delivery.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: July 16, 2013
    Assignee: General Electric Company
    Inventors: Zhaoyang Wan, Gary E. Geiger, Yong Zhang, Yu Zhang
  • Patent number: 8486268
    Abstract: A method that identifies common peaks among unidentified peaks in the data from different LC-MS or LC-MS/MS runs is provided. The method employs an algorithm, herein referred to as “Precision Peak Matching (PPM).” The different runs can be from different laboratories, instruments, and biological samples that result in a significant variability in the data. PPM allows estimation and control of precision, defined as the fraction of truly identical peptide pairs among all pairs retrieved, in the matching process. PPM finds the maximal number of peptide pairs at a prescribed precision, thereby allowing quantitative control over the trade off between the number of true pairs missed, and false pairs found. PPM finds common peptides from a database of LC-MS runs of heterogeneous origins, and at the specified precision. PPM fills a much-needed role in proteomics by extracting useful information from disparate LC-MS databases in a statistically rigorous and interpretable manner.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 16, 2013
    Assignee: International Business Machines Corporation
    Inventors: Peicheng Du, Frank Suits
  • Patent number: 8483974
    Abstract: A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: July 9, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Brian Edmond Connolly, Chad Harold Mace, Marc R. Lai
  • Patent number: 8478446
    Abstract: A method of configuration of combustion process control. The method includes providing a combustion system having a plurality of burner elements, a plurality of gas injection points and a controller. The gas injection points are configured to provide a support gas. One or more tasks for operation of the combustion system are determined. A plurality of groupings of the gas injection points are determined for each of the one or more tasks. An individual ranking for each of the plurality of groupings is determined in response to the one or more tasks. A composite ranking of injection points in response to the individual rankings and the controller is configured to operate the plurality of gas injection points in response to the composite ranking. A combustion system and a method for operating a combustion system are also disclosed.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: July 2, 2013
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Jeffrey William Kloosterman, Mark Daniel D'Agostini, Kevin Boyle Fogash
  • Patent number: 8452548
    Abstract: In one embodiment a method to determine at least one low temperature property of the lubricant oil is disclosed. This method comprises obtaining a base stock, generating a DSC curve of wax versus temperature using a heating curve for the base stock, correlating the heating curve of the base stock with a MRV for a formulated oil, and determining the MRV of the lubricant oil from the correlation of the base stock to the MRV of the corresponding desired base oil.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: May 28, 2013
    Assignee: Exxonmobil Research and Engineering Company
    Inventors: Ronald M. Gould, Eugine Choi
  • Patent number: 8452571
    Abstract: A real-time trigger figure-of-merit indicator for test and measurement instruments provides an indication of how close a signal-under-test is to satisfying a relevant trigger condition. The indicator includes a first marker that indicates a real-time trigger figure-of-merit that is calculated based on digital samples that represent the signal-under-test, and a second marker that indicates a level that the figure-of-merit must exceed in order for a trigger event detector to detect a trigger event and generate a trigger signal. Thus, by observing the indicator, a user may easily ascertain how close a signal-under-test is to satisfying the relevant trigger condition without requiring the instrument to actually trigger.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: May 28, 2013
    Assignee: Tektronix, Inc
    Inventor: John F. Turpin
  • Publication number: 20130131999
    Abstract: The method for predicting chloride-induced corrosion, particularly corrosion of steel embedded in concrete, is based on finite-element methods and implemented in a computational program that models and evaluates various durability aspects of concrete, such as concrete hardening (hydration), microstructure formation, corrosion and several associated phenomenon, over time from the casting of the concrete to a period of several months or years, thereafter. The program includes a main model and sub-models for acquisition of data, which is used to compute coupled temperature chloride induced corrosion of steel embedded in concrete under ambient temperature. Micro-cell corrosion is computed using electric potential and current of a corrosion cell obtained from ambient conditions. Using the Arrhenius law, the method numerically evaluates temperature dependency of corrosion rates concerning steel bars embedded in concrete affected by chloride.
    Type: Application
    Filed: November 23, 2011
    Publication date: May 23, 2013
    Applicant: KING SAUD UNIVERSITY
    Inventor: RAJA RIZWAN HUSSAIN
  • Patent number: 8447374
    Abstract: The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase filtering.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: May 21, 2013
    Assignee: Ceracor Laboratories, Inc.
    Inventor: Mohamed K. Diab
  • Publication number: 20130122596
    Abstract: An automatic analyzer includes sample vessels containing samples to be measured and reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
    Type: Application
    Filed: July 4, 2011
    Publication date: May 16, 2013
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Patent number: 8436298
    Abstract: LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: May 7, 2013
    Assignee: Waters Technologies Corporation
    Inventors: Scott J. Geromanos, Jeffrey Cruz Silva, Guo-Zhong Li, Marc Victor Gorenstein
  • Patent number: 8437966
    Abstract: A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: May 7, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Brian Edmond Connolly, Chad Harold Mace, Marc R. Lai
  • Patent number: 8433443
    Abstract: Generally, a method of monitoring a polymerization reaction in a fluid bed reactor to generate, in on-line fashion, data indicative of the imminent occurrence of a discontinuity event (for example, sheeting) and optionally also control the reaction to prevent the occurrence of the discontinuity event is provided. Typical embodiments include the steps of generating in on-line fashion at least one of bed static data indicative of static charge in the fluidized bed and carryover static data indicative of carryover static; and generating at least one of temperature data (in on-line fashion using at least one monitored reaction parameter) indicative of a first temperature and acoustic emission data indicative of resin stickiness in the reactor, where the first temperature is indicative of at least one of degree of resin stickiness in the reactor and a characteristic of melting behavior of polymer resin in the reactor in the presence of at least one diluent.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: April 30, 2013
    Assignee: Univation Technologies, LLC
    Inventors: Robert O. Hagerty, Ian D. Burdett, Marc L. DeChellis, F. David Hussein, Eric J. Markel, Michael E. Muhle, Richard B. Pannell, Daniel P. Zilker
  • Patent number: 8428888
    Abstract: A method for determining impedance includes receiving a time varying voltage signal from a biosensor and receiving a time varying current signal from the biosensor. The time varying voltage signal and the time varying current signal are transformed to a domain that represents complex values. The impedance representative of the biosensor based upon the transformed time varying voltage signal and the time varying current signal is calculated.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: April 23, 2013
    Assignee: Sharp Laboratories of America, Inc.
    Inventor: Dean Messing
  • Patent number: 8428889
    Abstract: There is provided a method of automatically identifying and characterizing spectral peaks of a spectrum generated by an analytical apparatus comprising the steps of: receiving the spectrum generated by the analytical apparatus; automatically subtracting a baseline from the spectrum so as to generate a baseline-corrected spectrum; automatically detecting and characterizing the spectral peaks in the baseline-corrected spectrum; reporting the detected and characterized spectral peaks to a user; receiving a list of adjustments to be made to the detecting and characterizing step from the user; and adjusting exit values used in the detecting and characterizing step, based on the list of adjustments.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: April 23, 2013
    Assignee: Thermo Finnigan LLC
    Inventor: David A. Wright
  • Patent number: 8386195
    Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: February 26, 2013
    Assignee: DAKO Denmark A/S
    Inventors: Gordon Feingold, Marc Key, Rosanne Welcher, John Favuzzi
  • Publication number: 20130041201
    Abstract: A method and apparatus for producing an effect of a chemical or biochemical agent on a system responsive to such agent, are disclosed. In practicing the method, a plurality of low-frequency time-domain signals of the agent are generated, each at a different at a different noise level within a selected noise level range. The signals are analyzed by producing spectral plots of the time-domain signals, and identifying an optimized agent-specific time-domain signal based on information in the spectral plots. A chemical or biological system responsive to the agent is exposed to the optimized time-domain signal by placing the system within the magnetic field of an electromagnetic transducer, and applying the signal to the transducer at a signal amplitude and for a period sufficient to produce in the system an agent-specific effect on the system.
    Type: Application
    Filed: July 20, 2012
    Publication date: February 14, 2013
    Applicant: NATIVIS, INC.
    Inventors: John T. Butters, Bennett M. Butters, Patrick Naughton, Miller Puckette
  • Publication number: 20130041595
    Abstract: Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.
    Type: Application
    Filed: August 14, 2012
    Publication date: February 14, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: Stephen J. GUNSTREAM
  • Patent number: 8372288
    Abstract: A method that identifies common peaks among unidentified peaks in the data from different LC-MS or LC-MS/MS runs is provided. The method employs an algorithm, herein referred to as “Precision Peak Matching (PPM).” The different runs can be from different laboratories, instruments, and biological samples that result in a significant variability in the data. PPM allows estimation and control of precision, defined as the fraction of truly identical peptide pairs among all pairs retrieved, in the matching process. PPM finds the maximal number of peptide pairs at a prescribed precision, thereby allowing quantitative control over the trade off between the number of true pairs missed, and false pairs found. PPM finds common peptides from a database of LC-MS runs of heterogeneous origins, and at the specified precision. PPM fills a much-needed role in proteomics by extracting useful information from disparate LC-MS databases in a statistically rigorous and interpretable manner.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: February 12, 2013
    Assignee: International Business Machines Corporation
    Inventors: Peicheng Du, Frank Suits
  • Patent number: 8374802
    Abstract: The invention relates to a method for photometrically investigating sample radiations of at least one sample, which are caused by the radiation of N emitter elements of at least one radiation element wherein said N emitter elements are emitting radiation during time periods which at least partially overlap, to detect the sample radiation of at least two samples as a sum signal during time periods which at least partially overlap and to evaluate the sample radiation of at least one individual sample from said sum signal.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 12, 2013
    Assignee: Eppendorf AG
    Inventors: Rainer Treptow, Gerd Joachim Eckert, Andreas Schirr, Rainer Schliesser, Norbert Wittschief
  • Patent number: 8362415
    Abstract: A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: January 29, 2013
    Assignees: Lawrence Livermore National Security, LLC, Lawrence Berkeley National Laboratory
    Inventors: James S. Felton, Kuang Jen J. Wu, Mark G. Knize, Kristen S. Kulp, Joe W. Gray
  • Publication number: 20130024134
    Abstract: As an elegant solution for minimizing false positives returned by a sensor tuned to an analyte molecule, filters constructed of carbon nanotubes are positioned relative to the sensor to limit the sensor to being exposed to molecules within a defined range of sizes, with too-big molecules being excluded from reaching the sensor by one filter, and too-small molecules being pumped out through another, finer filter before the sensor is operated.
    Type: Application
    Filed: April 6, 2012
    Publication date: January 24, 2013
    Inventor: Stephen J. Lukasik
  • Publication number: 20130018600
    Abstract: The present invention comprises a method and system for accurate estimation of the ion cyclotron resonance (ICR) parameters in Fourier-transform mass spectrometry (FTMS/FT-ICR MS). The parameters are essential to estimating the mass to charge ratio of an ion from FT-ICR MS data, the intended purpose of the instrument. Achieving greater accuracy in the parameters assists in greater accuracy of the mass to charge ratio of an ion, and obtaining an accurate estimation of the mass to charge ratio of an ion further aides in detecting mass with sub-ppm accuracy. Estimating mass in this manner enhances identification and characterization of large molecules. The inventive method and system thereby enhances the data obtained by conventional FTMS by accurately estimating ICR parameters. Ultimately, accurate estimates of the masses of molecules and detection and characterization of molecules from FT-ICR MS data are obtained.
    Type: Application
    Filed: July 18, 2012
    Publication date: January 17, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventor: Robert A. Grothe, JR.
  • Publication number: 20130013221
    Abstract: The present invention provides a system and method for automatically deriving unique surrogate response data from experiment results in which inherent data loss occurs in a sufficient number of the samples to disallow quantitative effects estimation at the experimenter's desired level of confidence for statistical significance. In part, the unique surrogate response data sets of the present invention have one or more of four primary characteristics including: each is numerically analyzable; each may be readily or directly obtained when inherent data loss occurs; each provides a response value for an experiment trial; and each provides information on the effect of a change made to the process or system that would have been obtainable if the experiment samples had had no inherent data loss.
    Type: Application
    Filed: July 9, 2012
    Publication date: January 10, 2013
    Applicant: S-MATRIX
    Inventor: Richard P. Verseput
  • Patent number: 8352198
    Abstract: A user, when measuring a sensing target substance in fluid using a crystal sensor (sensing sensor) using a crystal vibrator whose natural frequency is varied by an absorption of the sending target, is able to easily and accurately grasp information peculiar to the crystal sensor, for instance, information regarding a quality thereof. An IC chip in which the information peculiar to the crystal sensor is stored is provided to the crystal sensor, and the peculiar information is read out at a side of a concentration measuring device when the crystal sensor is inserted into the concentration measuring device, and then displayed.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: January 8, 2013
    Assignee: Nihon Dempa Kogyo Co., Ltd.
    Inventors: Shunichi Wakamatsu, Hiroyuki Kukita
  • Patent number: 8346487
    Abstract: There is provided a method of automatically identifying and characterizing spectral peaks of a spectrum generated by an analytical apparatus and reporting information relating to the spectral peaks to a user, comprising the steps of receiving the spectrum generated by the analytical apparatus; automatically subtracting a baseline from the spectrum so as to generate a baseline-corrected spectrum; automatically detecting and characterizing the spectral peaks in the baseline-corrected spectrum; and reporting at least one item of information relating to each detected and characterized spectral peak to a user. In embodiments, baseline model curve parameters or peak model curve parameters are neither input by nor exposed to the user prior to the reporting step.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: January 1, 2013
    Assignee: Thermo Finnigan LLC
    Inventors: David A. Wright, Robert A. Grothe, Jr.
  • Patent number: 8340824
    Abstract: A sootblowing control system that uses predictive models to bridge the gap between sootblower operation and boiler performance goals. The system uses predictive modeling and heuristics (rules) associated with different zones in a boiler to determine an optimal sequence of sootblower operations and achieve boiler performance targets. The system performs the sootblower optimization while observing any operational constraints placed on the sootblowers.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: December 25, 2012
    Assignee: NeuCo, Inc.
    Inventors: John Robert James, John McDermott, Stephen Piche, Fred Pickard, Neel J. Parikh
  • Publication number: 20120283962
    Abstract: An apparatus for identifying outliers among chemical reaction assays, the apparatus comprising a transition point finder, configured to find at least one transition point in a cumulative function, the cumulative function giving a quantitative indication based on a count of points in a calculated space as a function of distance from a function dividing the calculated space into at least two groups, each one of the points representing results of a respective assay of a chemical reaction. The apparatus further comprises an outlier identifier, in communication with the transition point finder, configured to use a distance of the found transition point from the function dividing the calculated space, as a threshold, for identifying an outlier among the chemical reaction assays.
    Type: Application
    Filed: May 2, 2011
    Publication date: November 8, 2012
    Inventor: Ze'ev RUSSAK
  • Patent number: 8306665
    Abstract: The present invention provides a control system for the conversion of carbonaceous feedstock into a gas. In particular, the control system is designed to be configurable for use in controlling one or more processes implemented in, and/or by, a gasification system for the conversion of such feedstock into a gas, which may be used for one or more downstream applications. Gasification processes controllable by different embodiments of the disclosed control system may include in various combinations, a converter, a residue conditioner, a recuperator and/or heat exchanger system, one or more gas conditioners, a gas homogenization system and one or more downstream applications. The control system operatively controls various local, regional and/or global processes related to the overall gasification process, and thereby adjusts various control parameters thereof adapted to affect these processes for a selected result.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: November 6, 2012
    Assignee: Plasco Energy Group Inc.
    Inventors: Andreas Tsangaris, Kenneth Craig Campbell, Douglas Michael Feasby, Alisdair Alan McLean
  • Patent number: 8306766
    Abstract: A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: November 6, 2012
    Assignee: Medtronic MiniMed, Inc.
    Inventors: John C. Mueller, Jr., Desmond Barry Keenan, Lu Wang, John J. Mastrototaro
  • Patent number: 8298413
    Abstract: Systems and methods for separating charged molecules on the basis of their differential electrostatic binding to a charged stationary phase comprise controlling the creation of simultaneous independent or dependent pH and additive gradients.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: October 30, 2012
    Assignee: Cryobiophysica, Inc.
    Inventors: Latchezar Ivanov Tsonev, Allen Gene Hirsh
  • Patent number: 8297135
    Abstract: The invention relates to a method for substance mixtures, particularly complex chemical and/or biochemical substance mixtures. According to said method, a substance mixture that is to be analyzed is fed to a separating device, the substances of the substance mixture that is to be analyzed are separated from each other in the separating device by means of a chemically and/or physically induced conveying process, and the separated substances are detected in an evaluation unit. The invention further relates to methods and devices for producing pulsed substance mixtures, particularly complex chemical and/or biochemical substance mixtures. In order to improve the analysis of substance mixtures especially regarding the duration of the analysis, the throughput, and the resolution, the substance mixture that is to be analyzed is fed to the separating device in pulses having an unique binary sequence.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: October 30, 2012
    Assignee: Studiengesellschaft Kohle mbH
    Inventor: Oliver Trapp
  • Patent number: 8296078
    Abstract: A method of multi-dimensional moment analysis for the characterization of signal peaks can be used to optimize the operation of an analytical system. With a two-dimensional Péclet analysis, the quality and signal fidelity of peaks in a two-dimensional experimental space can be analyzed and scored. This method is particularly useful in determining optimum operational parameters for an analytical system which requires the automated analysis of large numbers of analyte data peaks. For example, the method can be used to optimize analytical systems including an ion mobility spectrometer that uses a temperature stepped desorption technique for the detection of explosive mixtures.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: October 23, 2012
    Assignee: Sandia Corporation
    Inventors: Kent B. Pfeifer, William G. Yelton, Dayle R. Kerr, Francis A. Bouchier
  • Patent number: 8293084
    Abstract: The present invention relates to methods for the identification of compounds in carbohydrate mixture compositions as well as the determination of carbohydrate mixture composition patterns, based on e.g. orthogonal cross determining migration time (indices) using capillary gel electrophoresis-laser induced fluorescence and identifying said carbohydrate components based on comparing said migration time (indices) with standard migration time (indices) from a database which data are preferably also orthogonal cross determined. In a further aspect, the present invention relates to a method for carbohydrate mixture composition pattern profiling, like glycosylation pattern profiling using capillary gel electrophoresis-laser induced fluorescence (CGE-LIF). In another aspect, the present invention refers to a system for an automated determination and/or identification of carbohydrates and/or carbohydrate mixture composition patterns (e.g.: glycosylation patterns).
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: October 23, 2012
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Erdmann Rapp, Jana Schwarzer, Udo Reichl, Christian Bohne
  • Publication number: 20120259557
    Abstract: Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 11, 2012
    Inventors: Marc V. Gorenstein, Guo-Zhong Li
  • Patent number: 8285492
    Abstract: Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: October 9, 2012
    Assignee: Applied Biosystems, LLC
    Inventor: Stephen J. Gunstream
  • Patent number: 8285493
    Abstract: A method and system of monitoring for chemical or other toxic agents includes operating a plurality of first type sensors having a first level of sensitivity to an agent in a monitored area. Concurrently a second type sensor is operated having a second level of sensitivity to the agent in the monitored area, where the second level of sensitivity is at least ten times more sensitive than the first level of sensitivity. Input from the plurality of first type sensors and the second type sensor is received and analyzed, at a central location, in order to determine the presence of the agent in the monitored area.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: October 9, 2012
    Assignee: Smiths Detection Inc.
    Inventors: Steven A. Sunshine, Timothy E. Burch, Gregory Steinthal, Neil Plotkin, Chang-Meng Hsiung
  • Patent number: 8280661
    Abstract: Methods, systems and mediums are disclosed for aligning mass spectrometry data before the analysis of the mass spectrometry data. The mass spectrometry data may be received from a mass spectrometry machine, and re-sampled using a smooth warping function. To estimate the warping function, a synthetic signal is build using, for example, Gaussian pulses centered at a set of reference peaks. The reference peaks may be designated by users or calculated after observing a group of spectrograms. The synthetic signal is shifted and scaled so that the cross-correlation between the mass spectrometry data and the synthetic signal reaches its maximum value.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: October 2, 2012
    Assignee: The Mathworks, Inc.
    Inventor: Lucio Cetto
  • Patent number: 8277524
    Abstract: A method for determining an optimal combustion interval during start-up of a hydrocarbon catalytic reformer under various conditions of temperature, fuel type, and combustion fuel flow rate. An initial catalyst temperature is measured and an algorithm is used to calculate a rate of heating of the catalyst by combustion based upon heat content of the fuel, selected fuel flow rate, and heat capacity and mass of the catalyst and reformer passages. From the initial temperature and the heating gradient, an optimal combustion interval is inferred through the algorithm and used to terminate combustion, initiate a combustion quench interval, and change over the fuel flow rate and mixture from combustion to reforming.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: October 2, 2012
    Assignee: Delphi Technologies, Inc.
    Inventors: Kevin R. Keegan, Amanda M. Weiss, Charles R. DeJohn
  • Patent number: 8280554
    Abstract: A novel fail-safe temperature monitoring system that can distinguish excessive chemical adsorbent temperature from temperature sensing component failure is provided. This system prevents the gas purifier from shutting down as a result of temperature sensing component failure, and thereby prevents a false shutdown of a high-purity gas production plant.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: October 2, 2012
    Assignee: Praxair Technology, Inc.
    Inventors: Thomas John Bergman, Jr., Rick Boyer, Sandro Di Santo, Michael Henry Hawke, Keith Randall Pace, Thomas Robert Schulte, Brian Donald Warrick
  • Publication number: 20120239310
    Abstract: A method for characterising nature of a material, including: providing at least one sample of the material between an X-ray source and a detector; using the X-ray source to make N X-radiation spectra transmitted through the material, each for a time; calculating transmission function of the material as a function of energy or the detection channel; and in each of at least two energy zones, calculating the integral of the transmission function, thus forming at least a first transmission coefficient and a second transmission coefficient.
    Type: Application
    Filed: November 2, 2010
    Publication date: September 20, 2012
    Applicant: commissariat a l'energie atomique et aux energies alternatives
    Inventors: Patrice Ouvrier-Buffet, Guillaume Beldjoudi, Veronique Rebuffel, Jean Rinkel
  • Patent number: 8265883
    Abstract: Systems and methods are provided for calibrating emission data or other information signals collected during a polymerase chain reaction (PCR), amplification reaction, assay, process, or other reaction. Calibration of multiple detectable materials can be achieved during a single cycle or run, or during a plurality of runs of the reaction. A reading from every well, container, or other support region of a sample support does not have to be taken. Interpolation can be used to determine values for emission data or other information signals that were not taken, or are unknown, using detected emission data, or other detected information signals. By calibrating the detected emission data and the interpolated data, a more accurate reading of emission data or information signal can be obtained.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: September 11, 2012
    Assignee: Applied Biosystems, LLC
    Inventor: Stephen J. Gunstream
  • Patent number: 8260561
    Abstract: Techniques and systems for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples detected at a single point along the length of a channel as they move through the channel past that point can be displayed on a display device of a computer system as a series of bands, the bands being arranged to resemble output from an electrophoresis gel. The bands may be aligned using a marker included in each sample.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: September 4, 2012
    Assignee: Caliper Life Sciences, Inc.
    Inventor: Steven J. Gallagher
  • Patent number: 8249817
    Abstract: A chromatograph analyzing device for automatically executing a base line setting process on an unseparated peak using preset base line conditions. The chromatograph analyzing device includes a separation unit for separating a component included in a sample, and a data processing device for identifying the component of the sample and the quantity of the component in the sample by using a chromatogram obtained from the separation.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: August 21, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Osamu Watabe, Masahito Ito
  • Patent number: 8244481
    Abstract: Methods for predicting the performance risk of a paint component are disclosed. The methods include providing a proposed paint formulation, wherein the proposed paint formulation comprises at least one paint component, and identifying previous paint formulations comprising the paint component. The methods further include evaluating formulation similarities between the previous paint formulations and the proposed paint formulation, assigning formulation similarity scores based on the formulation similarities, and determining a paint component risk score for the paint component based on the formulation similarity scores. The proposed paint formulation may be utilized in a manufacturing application when the paint component risk score satisfies a manufacturing threshold value.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: August 14, 2012
    Assignee: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventors: Faye Ruth Zaski, Adam Nathan Deedler
  • Patent number: 8239171
    Abstract: The invention provides a system and a method of eliminating interference for impurities measurement in noble gases based on emission spectroscopy which provide very stable, sensitive and interference free results. The method mainly relies on the use of a combination of particularly designed means serially connected for cancelling interferences and proper means for correcting linearity issues. The proposed method is particularly advantageous since it offers long-term stability while providing very accurate and reliable results, even at sub-ppb and up to 10,000 ppm levels, whatever the surrounding conditions and the additional impurities that could be present in the gas under analysis.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: August 7, 2012
    Assignee: Panalytique Inc.
    Inventors: Yves Gamache, André Fortier
  • Publication number: 20120191372
    Abstract: Low-complexity, application-independent fixation of a chromatogram is achieved by a) determining a limit frequency under the assumption that the shape of the peaks in the chromatogram corresponds approximately to a Gaussian function having a standard deviation and the Fourier transform of the Gaussian function describes the frequency spectrum of a peak, at which limit frequency the Fourier transform has decreased to a predetermined limit value, b) determining the height, width, and retention time of each individual peak from the chromatogram, or a chromatogram taken previously under the same conditions, c) determining a constant factor based on a first predetermined relationship, d) determining the functional dependency of the limit frequency on the retention time as a variable quantity based on a second predetermined relationship, and e) filtering the chromatogram with the limit frequency depending on the retention time as the variable quantity using a low-pass filter.
    Type: Application
    Filed: July 29, 2010
    Publication date: July 26, 2012
    Applicant: Siemens Aktiengesellschaft
    Inventor: Frank Probst
  • Patent number: 8229684
    Abstract: The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from an interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: July 24, 2012
    Assignee: Accuri Cytometers, Inc.
    Inventors: Clement James Goebel, Collin A. Rich
  • Patent number: 8229707
    Abstract: A method of extracting and analyzing a data set from a flow cytometer system of the preferred embodiment comprises the steps of (1) running a sample and saving all collected raw data, (2) viewing raw (or “unmodified”) data, (3) modifying the raw data (e.g., scaling and/or culling the raw data), (4) reviewing and saving the modified data, and (5) exporting the saved data. Once the sample has been run and all collected data have been saved, the user can repeat the steps of modifying the raw data, saving the modified data, and exporting the saved data as many times as necessary and/or desirable.
    Type: Grant
    Filed: July 4, 2011
    Date of Patent: July 24, 2012
    Assignee: Accuri Cytometers, Inc.
    Inventors: David Olson, Collin A. Rich, Clement James Goebel, III
  • Patent number: 8224609
    Abstract: Systems, methods, and other embodiments associated with MRI excitation are described. One example method includes performing a calibration to determine a set of transmission parameters for a set of excitation pulses for transmission channels available on a multi-channel MRI transmitter. The set of excitation pulses are configured to produce a resulting nuclear magnetic resonance (NMR) signal from an object exposed to the set of excitation pulses. The resulting NMR signal comprises NMR signal associated with a first NMR resonance associated with the object and NMR signal associated with a second NMR resonance associated with the object.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: July 17, 2012
    Inventors: Mark A. Griswold, Jeremiah Heilman