Biological Or Biochemical Patents (Class 703/11)
  • Patent number: 10255387
    Abstract: A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: April 9, 2019
    Assignee: CLEARAG, INC.
    Inventors: John J. Mewes, Dustin M. Salentiny, Dane T. Kuper, Dustin C. Balsley
  • Patent number: 10255391
    Abstract: A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: April 9, 2019
    Assignee: CLEARAG, INC.
    Inventors: John J. Mewes, Dustin M. Salentiny
  • Patent number: 10236083
    Abstract: A visualization apparatus includes a memory unit and a computing unit. The memory unit stores a circulation model in which a vascular network, of an organ, having a diameter equal to or smaller than a predetermined value is defined on a two-dimensional plane, and a simulation result of a blood flow in the vascular network of the circulation model. The computing unit transforms the circulation model into a three-dimensional structure including the vascular network located on a cylindrical surface of a cylinder, and displays the simulation result on the three-dimensional structure.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: March 19, 2019
    Assignees: FUJITSU LIMITED, THE UNIVERSITY OF TOKYO
    Inventors: Masahiro Watanabe, Yoshimasa Kadooka, Toshiaki Hisada, Seiryo Sugiura, Takumi Washio, Jun-Ichi Okada
  • Patent number: 10229499
    Abstract: A dermoscopic lesion area is identified by: Obtaining a dermoscopic image and running a convolutional neural network image classifier on the dermoscopic image to obtain pixelwise lesion prediction scores. Segmenting the dermoscopic image into super-pixels, and computing for each super-pixel an average of the pixelwise prediction scores for pixels within that super-pixel. Computing a mean prediction score across the plurality of super-pixels. Assigning a confidence indicator of “1” to each super-pixel with a prediction score equal or greater than the mean prediction score, and a confidence indicator of “0” to each super-pixel with a prediction score less than the mean prediction score.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 12, 2019
    Assignee: International Business Machines Corporation
    Inventors: Seyedbehzad Bozorgtabar, Rahil Garnavi, Pallab Roy, Suman Sedai
  • Patent number: 10223788
    Abstract: A dermoscopic lesion area is identified by: Obtaining a dermoscopic image and running a convolutional neural network image classifier on the dermoscopic image to obtain pixelwise lesion prediction scores. Segmenting the dermoscopic image into super-pixels, and computing for each super-pixel an average of the pixelwise prediction scores for pixels within that super-pixel. Computing a mean prediction score across the plurality of super-pixels. Assigning a confidence indicator of “1” to each super-pixel with a prediction score equal or greater than the mean prediction score, and a confidence indicator of “0” to each super-pixel with a prediction score less than the mean prediction score.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 5, 2019
    Assignee: International Business Machines Corporation
    Inventors: Seyedbehzad Bozorgtabar, Rahil Garnavi, Pallab Roy, Suman Sedai
  • Patent number: 10219704
    Abstract: An automated measurement device and method for coronary artery disease scoring is disclosed. An example device includes a vascular tree reconstructor configured to receive vascular image data of a plurality of vascular segments of a patient and create a computerized model of the plurality of vascular segments by combining the vascular image data. The example device also includes a stenosis determiner configured to analyze the model to determine locations of potential lesions. The example device further includes a vascular state score calculator configured to, for each potential lesion, determine a first vascular state scoring tool “VSST”) subscore based on a size of the potential lesion and a second VSST subscore based on a distance of the potential lesion from a branch point in the plurality of vascular segment. The vascular state score calculator calculates a total VSST score by combining the first VSST subscore and the second VSST subscore.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: March 5, 2019
    Assignee: CathWorks Ltd.
    Inventors: Guy Lavi, Uri Merhav
  • Patent number: 10223893
    Abstract: A method for using a meter and a meter (10) adapted to determine an analyte concentration reading, the meter comprising a display (12) adapted to display information to a user of the meter, the display including information directed to a post-meal test-time alarm (22?) that is adapted to remind the user to obtain a post-meal analyte concentration reading, and at least one user input mechanism (15) adapted to allow the user to activate the post-meal test-time alarm.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: March 5, 2019
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Barry D. Power, Jeffrey A. Culver
  • Patent number: 10201153
    Abstract: Aspects for utilizing a seawater fluid to optimize egg-production characteristics are disclosed. In one aspect, a method is provided, which includes identifying a desired optimization, determining a corresponding seawater to non-seawater ratio, and generating a seawater fluid according to the ratio. An egg-cultivation method is also provided, which includes ascertaining a desired optimization, selecting a corresponding seawater to non-seawater ratio, and providing a seawater fluid comprising the ratio to a hen. In another egg-cultivation method, hens are provided with a mixed feed comprising a feed to seawater-mineralized produce ratio selected according to a desired optimization. A method to grow produce is also provided, which includes mineralizing soil with a seawater fluid comprising a seawater to non-seawater ratio corresponding to a preferred optimization.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: February 12, 2019
    Assignee: Luberski, Inc.
    Inventor: Timothy E. Luberski
  • Patent number: 10192642
    Abstract: A system and a method for determining an association of at least one biological feature with a medical condition, in particularly, but not exclusively, a system and a method of determining an association of at least one biological feature in form of a gene expression with cancer or a subtype of cancer that can include the generation of a simplified protein-protein interaction network based on processed biological data. The system and respective method is especially suitable for analysis of high dimensional and low sample size biological datasets such as in cancer research.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: January 29, 2019
    Assignee: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yong Liang, Hua Chai, Xiao-Ying Liu
  • Patent number: 10185790
    Abstract: A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: January 22, 2019
    Assignee: CLEARAG, INC.
    Inventors: John J. Mewes, Dustin M. Salentiny, Dane T. Kuper, Dustin C. Balsley
  • Patent number: 10179030
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: January 15, 2019
    Assignee: HEARTFLOW, INC.
    Inventors: Charles A. Taylor, Timothy A. Fonte
  • Patent number: 10180998
    Abstract: A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyses.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: January 15, 2019
    Assignee: CLEARAG, INC.
    Inventors: John J. Mewes, Dustin M. Salentiny, Dane T. Kuper, Dustin C. Balsley
  • Patent number: 10176280
    Abstract: A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyses.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: January 8, 2019
    Assignee: CLEARAG, INC.
    Inventors: John J. Mewes, Dustin M. Salentiny, Dane T. Kuper, Dustin C. Balsley
  • Patent number: 10146852
    Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving user input associated with a resource of a plurality of resources, storing the user input as a factor associating the resource with a user, receiving a search query, the search query identifying the user, processing data based on the search query and the factor to generate one or more search results, the one or more search results including an indicator associated with the resource, the indicator indicating that the one or more search results are associated with the user, and transmitting the one or more search results for display on a computing device.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: December 4, 2018
    Assignee: Google LLC
    Inventors: Justin Chu, David Nachum, Gregory M. Marra, Richard P. Klau
  • Patent number: 10140745
    Abstract: A computer-implemented method simulates a shape of a musculoskeletal system comprising a skeletal subsystem and a soft-tissue subsystem. The method comprises: simulating, by the computer system, an evolution of a skeletal subsystem model over a series of time steps to thereby determine rigid body variables representative of the shapes of the one or more rigid bodies in a physical space at each time step; and simulating, by the computer system, an evolution of a soft-tissue subsystem model over the series of time steps to thereby determine, for each of the one or more soft tissue objects, a soft-tissue object representation in an Eulerian space and an associated Eulerian representation for each vertex in the Eulerian space at each time step, the associated Eulerian representation, for each vertex and for each time step, specifying which one or more material space coordinates for the soft-tissue object correspond to the vertex at the time step.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: November 27, 2018
    Assignee: Vital Mechanics Research Inc.
    Inventors: Dinesh Kochikar Pai, Ye Fan
  • Patent number: 10102349
    Abstract: The present invention relates to a molecular orbital similarity deviation evaluation method comprising: a) a step for selecting two subject molecular orbitals, the molecular orbital similarity of which is to be compared, then obtaining Nx multi-block spectrums (MBS) having different block sizes, and subsequently combining Nx MBS pairs having the same block size; b) a step for calculating a TSS(m) score for each MBS pair (m being the number of the MBS and being from 1 to Nx) by carrying out a multi-step uniformity evaluation on the Nx MBS pairs; and c) a step for calculating the standard deviation of the TSS(m) scores for the Nx MBS pairs and using same to quantitatively evaluate the molecular orbital similarity deviation.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: October 16, 2018
    Assignee: LG Chem, Ltd.
    Inventors: Seungyup Lee, Hyesung Cho
  • Patent number: 10100375
    Abstract: Method, systems and apparatus to determine the suitability of parts or protocols to perform unit operations in the context of a biological process, comprising recording of a user score associated with an instance of use of a protocol or part, wherein the context of the use is recorded along with the rating, and wherein the context is defined as the value of factors that may affect the performance of the unit operation in which the part or protocol was used. The method may be implemented as a web service.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: October 16, 2018
    Assignee: SYNTHACE LIMITED
    Inventors: Markus Christian Gershater, Sean Michael Ward, Michael Ian Sadowski, Christopher Richard Grant
  • Patent number: 10081136
    Abstract: Systems and methods in accordance with embodiments of the invention implement additive manufacturing techniques that employ different sets of deposition characteristics and/or material formation characteristics during the additive manufacture of an object so as to strategically build up the object. In many embodiments, material used to build up an object is deposited at different deposition rates during the additive manufacture of the object, and the object is thereby strategically built up. In one embodiment, a method of additively manufacturing an object includes: depositing material onto a surface at a first deposition rate so as to define a first region of the object to be additively manufactured; and depositing material onto a surface at a second deposition rate so as to define a second region of the object to be additively manufactured; where the second deposition rate is different from the first deposition rate.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 25, 2018
    Assignee: California Institute of Technology
    Inventors: Douglas C. Hofmann, John Paul C. Borgonia
  • Patent number: 10068054
    Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. In various instances, each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform one or more steps a variant call operation.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 4, 2018
    Assignee: EDICO GENOME, CORP.
    Inventors: Pieter Van Rooyen, Michael Ruehle, Robert J. Mcmillen, Mark Hahm
  • Patent number: 10069573
    Abstract: A method implemented by an optical circuit, including beam splitter, phase shifters and cross-phase modulators, for solving Ising-model using quantum annealing discretizes a continuous time-dependent Hamiltonian function over a time period T, into a plurality of smaller portions; implements each of said smaller portions with a non-linear optical medium, and iterates over said smaller portions to output a solution of the Ising Hamiltonian problem, using the optical components.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 4, 2018
    Assignee: RAYTHEON BBN TECHNOLOGIES CORP.
    Inventors: Hari Kiran Krovi, Saikat Guha
  • Patent number: 10031580
    Abstract: One illustrative system disclosed herein includes a processor configured to receive a sensor signal from a neural interface configured to detect an electrical signal associated with a nervous system. The processor is also configured to determine an interaction in with a virtual object in a virtual environment based on the sensor signal. The processor is also configured to determine a haptic effect based at least in part on the interaction with the virtual object in the virtual environment. The processor is also configured to transmit a haptic signal associated with the haptic effect. The illustrative system further includes a haptic output device configured to receive the haptic signal and output the haptic effect.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: July 24, 2018
    Assignee: Immersion Corporation
    Inventor: Juan Manuel Cruz-Hernandez
  • Patent number: 10016169
    Abstract: A device obtains a series of measurements of a physiological parameter of one or more patients. The device displays a monitoring workflow home screen when the device is operating within a monitoring workflow. The device displays a non-monitoring workflow home screen when the device is operating within a non-monitoring workflow. The device displays a continuous workflow home screen when the device is operating within a continuous workflow. The monitoring workflow home screen, the non-monitoring workflow home screen, and the continuous workflow home screen are each different.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: July 10, 2018
    Assignee: Welch Allyn, Inc.
    Inventors: Daniel Thomas Meador, Janalee Esler, Michele Marie Donovan
  • Patent number: 10019800
    Abstract: The success of the positioning of devices for deployment inside an aneurysm, for example, is reliant on processes, which take place within an intervention procedure. For example, the position, orientation, or trajectory of the intervention device can affect the final position of a device for deployment deployed on the intervention device. Therefore, it is useful to predict the deployment position of a device for deployment based on a current localization of only the intervention device within an object of interest.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: July 10, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Raoul Florent, Odile Bonnefous, Hernan Guillermo Morales Varela
  • Patent number: 10013526
    Abstract: Analysis system and computer implemented method for analyzing biological samples are disclosed. The system has at least one analyzer for performing an analysis and a decision unit being operable to determine in response to the receipt of the analysis request whether results obtained from performing the analysis on the sample indicated in the analysis request are valid. This determination is executed by retrieving the meta information assigned to the sample and by applying the at least one condition on the meta information and wherein the at least one applied condition has at least a condition on whether the sample allows a valid analysis on the sample, and wherein the decision unit returns the decision that the analysis exercised on the indicated sample will return a valid result in case the conditions of the condition set are met by the sample.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: July 3, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Lars Oeltjen
  • Patent number: 9984197
    Abstract: A method of simulating the activity of the human nervous system includes providing a networked server for access by a user of a general purpose computer, with a database having predetermined data on human nervous system activity being in communication with the networked server. User information is input into the general purpose computer which is correlated with data in the networked database to determine what part of the human nervous system is impacted by the user information input. The general purpose computer displays a simulated image of a portion of the human nervous system and animates the impacted part of the human nervous system determined in the correlation.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: May 29, 2018
    Inventor: Ronald Marks
  • Patent number: 9916332
    Abstract: An example process for selecting chart scalings for plotting two time-series datasets includes determining a first log difference between a logarithm of a maximum value of a first dataset and a logarithm of a minimum value of the first dataset. The process also includes determining a second log difference between a logarithm of a maximum value of a second dataset and a logarithm of a minimum value of the second dataset. The process also includes selecting, based at least in part on the first and second log differences, between a linear chart scaling and a logarithmic chart scaling for the first dataset. The process also includes selecting, based at least in part on the first and second log differences, between a linear chart scaling and a logarithmic chart scaling for the second dataset.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: March 13, 2018
    Assignee: EntIT Software LLC
    Inventors: Luba Tsirulnik, Gabriel Dayan, Elad Kadosh
  • Patent number: 9908945
    Abstract: The invention provides methods of using sequence based analysis and rational strategies to modify and improve the structural and biophysical properties of single chain antibodies (scFvs), including stability, solubility, and antigen binding affinity. These methods and strategies can be used individually or in combination. The methods of the present invention also include the use of a database comprising scFv sequences from an experimentally screened scFv library of antibodies that have been selected to have superior solubility and stability. The invention also provides methods of using the properties found for these selected antibodies in a general approach for reshaping scFv antibodies to improve stability and solubility properties of a single chain antibody fragment.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: March 6, 2018
    Assignee: Esbatech, An Alcon Biomedical Research Unit LLC
    Inventors: David Urech, Leonardo Borras
  • Patent number: 9891044
    Abstract: Deviations of blood pressure due to stenosis caused by plaque pose a health risk. The deviation, often expressed in a fractional flow reserve, may be calculated on a per-location basis using deviations of the local cross-sectional area or local diameter from a reference value representing a healthy vessel. The reference value may be obtained by means of linear or higher order interpolation or linear regression techniques. Together with the flow velocity of a fluid through the vessel, a value of local deviation of a vessel geometry compared to a reference value allows for accurate, fast and efficient calculation of the fractional flow reserve for every location of the vessel for which geometry data is available. The reference value as well as actual data obtained by measurements may be represented or approximated by functions, allowing accurate and efficient calculation of data over a continuous region of the segment under scrutiny.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: February 13, 2018
    Assignee: MEDIS ASSOCIATED B.V.
    Inventors: Shengxian Tu, Johan Hendrikus Christiaan Reiber, Yingguang Li
  • Patent number: 9881349
    Abstract: Apparatus and methods for identification of a coded pattern visible to a computerized imaging apparatus while invisible or inconspicuous to human eyes. A pattern and/or marking may serve to indicate identity of an object, and/or the relative position of the pattern to a viewer. While some solutions exist for identifying patterns (for example, QR codes), they may be visually obtrusive to a human observer due to visual clutter. In exemplary implementations, apparatus and methods are capable of generating patterns with sufficient structure to be used for either discrimination or some aspect of localization, while incorporating spectral properties that are more aesthetically acceptable such as being: a) imperceptible or subtle to the human observer and/or b) aligned to an existing acceptable visual form, such as a logo. In one variant, a viewer comprises an imaging system comprised as a processor and laser scanner, or camera, or moving photodiode.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: January 30, 2018
    Assignee: GOPRO, INC.
    Inventors: Philip Meier, Dimitry Fisher, Chance Roth, Steven Hypnarowski
  • Patent number: 9873903
    Abstract: A method performed by a computer or microprocessor to determine the fermentation progress of an organic material, contained in a container and capable of generating fermentation gas, includes the steps of measuring the amount of gas actually generated over time by the material and determining the state of fermentation progress by comparing said amount with an estimate of the total gas producible by material throughout its fermentation.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: January 23, 2018
    Assignee: NOFORM SRL
    Inventor: Remo Crosato
  • Patent number: 9864840
    Abstract: Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 9, 2018
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Gilwoo Choi, Charles A. Taylor, Christopher K. Zarins
  • Patent number: 9864431
    Abstract: Computer systems, methods, and storage media for changing the state of an application by detecting neurological user intent data associated with a particular operation of a particular application state, and changing the application state so as to enable execution of the particular operation as intended by the user. The application state is automatically changed to align with the intended operation, as determined by received neurological user intent data, so that the intended operation is performed. Some embodiments relate to a computer system creating or updating a state machine, through a training process, to change the state of an application according to detected neurological data.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: January 9, 2018
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Cem Keskin, David Kim, Bill Chau, Jaeyoun Kim, Kazuhito Koishida, Khuram Shahid
  • Patent number: 9845349
    Abstract: Provided are antibodies capable of binding to a particular epitope or specifically binding to LF or LTx and enhancing the activity of the LF or LTx relative to the LF or LTx absent the antibody binding.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: December 19, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jason Marc Goldstein, Conrad P. Quinn, Dennis A. Bagarozzi, Jr.
  • Patent number: 9818231
    Abstract: A computer-implemented medical visualization method includes identifying a three-dimensional model of an anatomical item of a particular mammal; automatically identifying an open path in three-dimensional space through the anatomical item; fitting a smooth curve to the open path; and displaying the anatomical item and a visual representation of the smooth curve to a user on a three-dimensional imaging system.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: November 14, 2017
    Assignees: Boston Scientific Scimed, Inc., Regents of the University of Minnesota
    Inventors: Dane Coffey, Daniel F. Keefe, Arthur G. Erdman, Benjamin J. Bidne, Gregory Ernest Ostenson, David M. Flynn, Kenneth Matthew Merdan
  • Patent number: 9811640
    Abstract: A modeling and simulation environment enables a user to create a model of a stiff chemical or biological system. The stiff chemical or biological system refers to a system that includes at least two or more different time scales of the chemical or biochemical reactions. The modeling and simulation environment also enables the user to solve the stiff chemical or biological system using a leaping algorithm. The leaping algorithm may leap over simulation of the reactions occurring in the time interval to accelerate the simulation of the chemical or biological system. The algorithm maximizes the size of the time interval by adjusting the size of the time interval using a bracketing algorithm.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: November 7, 2017
    Assignee: The MathWorks, Inc.
    Inventor: Shrikant Vitthal Savant
  • Patent number: 9805255
    Abstract: A multimodal sensing system includes various devices that work together to automatically classify an action. A video camera captures a sequence of digital images. At least one other sensor device captures other sensed data (e.g., motion data). The system will extract video features from the digital images so that each extracted image feature is associated with a time period. It will extract other features from the other sensed data so that each extracted other feature is associated with a time period. The system will fuse a group of the extracted video features and a group of the extracted other features to create a fused feature representation for a time period. It will then analyze the fused feature representation to identify a class, access a data store of classes and actions to identify an action that is associated with the class, and save the identified action to a memory device.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 31, 2017
    Assignee: Conduent Business Services, LLC
    Inventors: Xitong Yang, Edgar A. Bernal, Sriganesh Madhvanath, Raja Bala, Palghat S. Ramesh, Qun Li, Jayant Kumar
  • Patent number: 9783774
    Abstract: A cell culture control system includes a controller configured to control parameters of a culture fluid which exists in a processor in accordance with a control value which is preliminarily set, a generator configured to generate time-series data by using a concentration value of the metabolic substances in the culture fluid, the concentration value of the metabolic substances being detected by a sensor, an extractor configured to extract a characteristic point of the time-series data generated by the generator, and a control value setter configured to change the control value in accordance with the characteristic point extracted by the extractor.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: October 10, 2017
    Assignee: Yokogawa Electric Corporation
    Inventors: Tetsushi Namatame, Souichirou Shimoda, Yasuyuki Suzuki, Fumiaki Izaki
  • Patent number: 9744001
    Abstract: A method includes to receive, via a computing device, data representing a plurality of teeth, identify data indicating which of the plurality of teeth are unerupted or erupting, predict at least one characteristic of a tooth of the unerupted or erupting teeth after they have fully erupted using one or more tooth eruption prediction factors, generate new data representing the unerupted or erupting teeth in multiple states of eruption based upon the predicted at least one characteristic of the fully erupted teeth, and generate a series of incremental tooth arrangements with the new data to define a proposed orthodontic treatment based on the new data representing the unerupted or erupting teeth in multiple states of eruption.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: August 29, 2017
    Assignee: Align Technology, Inc.
    Inventors: Jeeyoung Choi, Chunhua Li, John Morton, Bastien Pesenti, Vadim Matov, Alexander Beliaev, Petr Ushanov, Roman A. Roschin
  • Patent number: 9737369
    Abstract: A computer assisted surgery method and apparatus for determining a change in a property of a joint of a patient caused by an arthroplasty procedure is described. The relative position of a first bone and a second bone of the joint is determined with the joint in a first position. The position of a pre-operative center of motion of the joint relative to the first bone is determined. The position of the second bone relative to the pre-operative center of motion is determined using the relative position of the first and second bones. The position of a post-operative center of motion resulting from a prosthetic component to be used in the joint is determined. The position of the second bone relative to the post-operative center of motion is determined. Any change in the property of the joint. is determined from the difference between the position of the second bone relative to the pre-operative center of motion and the position of the second bone relative to the post-operative center of motion.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: August 22, 2017
    Assignee: DePuy International Ltd.
    Inventors: Thorsten Burger, Frank Foley, Michal Slomczykowski
  • Patent number: 9719842
    Abstract: A method for diagnosing or predicting the risk of shock, the method incorporating an algorithmic combination of optical, electromagnetic, and other sensors, along with their anatomic and temporal patterns. A method for developing the algorithms through iterative optimization using machine learning.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 1, 2017
    Inventor: Norman A. Paradis
  • Patent number: 9706925
    Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: July 18, 2017
    Assignee: HEARTFLOW, INC.
    Inventor: Charles A. Taylor
  • Patent number: 9694060
    Abstract: Peptides and vaccine compositions comprising peptides based upon EGFRvIII and lacking a glycine at the splice junction are disclosed. The vaccines can induce immune responses against EGFRvIII. Methods of inhibiting formation or growth of EGFvIII tumors, methods of inducing regression of EGFvIII tumors, methods of immunizing against EGFvIII tumors and methods of treating a subjects who have EGFvIII tumors are disclosed.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: July 4, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Albert J. Wong
  • Patent number: 9693831
    Abstract: According to the invention, the process includes the steps of: a) taking a sagittal preoperative x-ray of the vertebral column of the patient to be treated, extending from the cervical vertebrae to the femoral heads; b) on that x-ray, identifying points on S1, S2, T12 et C7; c) depicting, on the said x-ray, curved segments beginning at the center of the plate of S1 et going to the center of the plate of C7; e) identifying, on that x-ray, the correction(s) to be made to the vertebral column, including the identification of posterior osteotomies to make; f) pivoting portions of said x-ray relative to other portions of that x-ray, according to osteotomies to be made; g) performing, on said x-ray, a displacement of the sagittal curvature segment extending over the vertebral segment to be corrected; h) from a straight vertebral rod (TV), producing the curvature of that rod according to the shape of said sagittal curvature segment in said displacement position.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: July 4, 2017
    Assignee: MEDICREA International
    Inventors: Thomas Mosnier, David Ryan
  • Patent number: 9697327
    Abstract: A “dynamic” reference is presented that utilizes population level information to improve reference-based alignment to detect novel, deleterious, or functional variants in clinical sequencing applications. An automatically updated database of known genetic variants is provided to a memory connected with an integrated circuit configured for genetic sequence data with the dynamic reference and reference variants.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: July 4, 2017
    Assignee: Edico Genome Corporation
    Inventors: Robert McMillen, Michael Ruehle, John Cooper Roddey
  • Patent number: 9672615
    Abstract: Systems and methods are disclosed for assessing the quality of medical images of at least a portion of a patient's anatomy, using a computer system. One method includes receiving one or more images of at least a portion of the patient's anatomy; determining, using a processor of the computer system, one or more image properties of the received images; performing, using a processor of the computer system, anatomic localization or modeling of at least a portion of the patient's anatomy based on the received images; obtaining an identification of one or more image characteristics associated with an anatomic feature of the patient's anatomy based on the anatomic localization or modeling; and calculating, using a processor of the computer system, an image quality score based on the one or more image properties and the one or more image characteristics.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: June 6, 2017
    Assignee: Heartflow, Inc.
    Inventors: Timothy A. Fonte, Leo J. Grady, Zhongle Wu, Michiel Schaap, Stanley C. Hunley, Souma Sengupta
  • Patent number: 9652596
    Abstract: Illustrative embodiments of systems and methods for the deductive multiscale simulation of macromolecules are disclosed. In one illustrative embodiment, a deductive multiscale simulation method may include (i) constructing a set of order parameters that model one or more structural characteristics of a macromolecule, (ii) simulating an ensemble of atomistic configurations for the macromolecule using instantaneous values of the set of order parameters, (iii) simulating thermal-average forces and diffusivities for the ensemble of atomistic configurations, and (iv) evolving the set of order parameters via Langevin dynamics using the thermal-average forces and diffusivities.
    Type: Grant
    Filed: January 7, 2012
    Date of Patent: May 16, 2017
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Peter J. Ortoleva
  • Patent number: 9619624
    Abstract: The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile comprising the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: April 11, 2017
    Assignee: MOLECULAR HEALTH GMBH
    Inventors: David B. Jackson, Theodoros Soldatos, Guillaume Taglang, Alexander Zien, Stephan Brock
  • Patent number: 9597374
    Abstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: March 21, 2017
    Assignee: MannKind Corporation
    Inventors: Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
  • Patent number: 9585609
    Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: March 7, 2017
    Assignee: DexCom, Inc.
    Inventors: Naresh C. Bhavaraju, Arturo Garcia, Hari Hampapuram, Apurv Ullas Kamath, Aarthi Mahalingam, Dmytro Sokolovskyy, Stephen J. Vanslyke
  • Patent number: 9529427
    Abstract: A method of rendering an image based upon a first stereoscopic image comprising a pair of images is provided. The method includes generating a virtual three-dimensional model of the scene depicted in the first stereoscopic image responsive to distances derived from the first stereoscopic image, detecting one or more free edges in the three dimensional model, and generating one or more textures for the virtual three-dimensional model from at least one of the pair of images of the first stereoscopic image. The method also includes applying at least one texture to a respective part of the three dimensional model, and rendering the virtual three dimensional model from a different viewpoint to that of the first stereoscopic image. Rendering the virtual three dimensional model comprises modifying a transparency of rendered pixels of an applied texture as a function of the pixel's distance from that free edge.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: December 27, 2016
    Assignee: Sony Computer Entertainment Europe Limited
    Inventors: Sharwin Winesh Raghoebardayal, Simon Mark Benson, Ian Henry Bickerstaff