With Detail Of Sampling, Sample Handling, Or Sample Preparation Patents (Class 73/61.59)
  • Patent number: 10744501
    Abstract: A microchip is provided, which includes a substrate including a fluid channel structure. The fluid channel structure includes a first fluid introduction channel and a second fluid introduction channel configured to meet so as to allow merging of a first fluid introduced from the first fluid introduction channel and a second fluid introduced from the second fluid introduction channel. A tapered portion is configured to be positioned after merging the first fluid and the second fluid so as to suppress a spiral flow field generated after the merging.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: August 18, 2020
    Assignee: Sony Corporation
    Inventors: Tatsumi Ito, Shoji Akiyama, Masaya Kakuta, Takeshi Yamasaki
  • Patent number: 10488374
    Abstract: The present invention provides a preprocessing device of a more compact structure, and an analysis system provided with the same. A preprocessing device (1) includes a container holding section (12), a filtration port (30), and a transport arm (24). The container holding section (12) holds a separation container (50) and a collection container (54). The filtration port (30) separates a sample by applying pressure to a sample in the separation container (50). The transport arm (24) transports the separation container (50) and the collection container (54) held by the container holding section (12) from a predetermined transport position.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: November 26, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Nobuhiro Hanafusa, Shin Nakamura, Hiroshi Tanihata
  • Patent number: 10422278
    Abstract: A cleaning device for a pressure sensor associated with an engine system includes a one-way valve having an inlet side and an outlet side. The outlet side is in selective fluid communication with an inlet of the pressure sensor. The cleaning device also includes a compressed air source in selective fluid communication with the one-way valve. The cleaning device further includes a control module communicably coupled to each of the pressure sensor, the one-way valve, and the compressed air source. The control module is configured to control an operation of the one-way valve and the compressed air source to impart at least one of a long burst of modulated air and a short burst of modulated air on the inlet of the pressure sensor.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 24, 2019
    Assignee: Progress Rail Locomotive Inc.
    Inventors: Juan Carlos Marroquin, Jaldeep Niranjan Kansara, Arvindkumar Makasana
  • Patent number: 9255827
    Abstract: A method for estimating a fluid flow velocity may include receiving, with a processing device, a plurality of observations corresponding to a concentration of a constituent of a flowing fluid mixture, and computing a final estimate of an average velocity of the flowing fluid mixture based at least in part on the observations, wherein the constituent is undergoing a chemical reaction and the computing implements a reactive transport model.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: February 9, 2016
    Assignee: International Business Machines Corporation
    Inventors: Bradley Eck, Sergiy Zhuk
  • Publication number: 20150135807
    Abstract: A mobile sample collection system including housing enclosing a main influent peristaltic pump operatively connected to a main tubing line; a continuous flow centrifuge (CFC) operatively connected to the main tubing line, the CFC comprising a centrifuge bowl; and an elutriate collection tank receiving elutriate from the CFC. The main influent peristaltic pump is configured to continuously pump fluids from a liquid source through the main tubing line and into the CFC. The fluids, containing suspended solids and dissolved solids, are processed through the CFC so that the suspended solids are retained on the centrifuge bowl and the dissolved solids are pumped out of the CFC through the main tubing line and into the elutriate collection tank for sample collection and analysis. The elutriate collection tank includes a tank liner configured to prevent direct contact of pumped fluids with the tank. Excess fluids are returned to the liquid source.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 21, 2015
    Applicant: TIERRA SOLUTIONS, INC.
    Inventors: Clifford E. FIRSTENBERG, Alain P. Hebert, Diane L. Waldschmidt
  • Publication number: 20150114093
    Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.
    Type: Application
    Filed: June 18, 2014
    Publication date: April 30, 2015
    Applicant: PREMIUM GENETICS (UK) LTD.
    Inventors: David APPLEYARD, Jeff BETTHAUSER, Marjorie FAUST, John LARSEN, Guocheng SHAO, Zheng XIA, Yu ZHOU
  • Patent number: 9020766
    Abstract: This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: April 28, 2015
    Assignee: Mastinc.
    Inventors: Brian Von Herzen, Steven Van Fleet
  • Patent number: 9017611
    Abstract: A biochip including a chip body, a first electrode and a second electrode is provided. The body has a first accommodating cavity, a second accommodating cavity and a micro-fluid channel. The micro-fluid channel is connected with the first accommodating cavity and the second accommodating cavity. The first electrode has a first end and a second end. The first end is used for contacting a first probe of a detection apparatus. The second end is positioned in the first accommodating cavity. The second electrode has a third end and a forth end. The third end is used for contacting a second probe of the detection apparatus. The forth end is positioned in the second accommodating cavity.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: April 28, 2015
    Assignee: Wistron Corporation
    Inventors: Pai-Yang Lin, Yih-Far Chen, Chin-Kuan Lin, Hsiang-Chia Chen, Sheng-Hsiung Weng
  • Publication number: 20150096356
    Abstract: A method of pipetting samples is described using a pipetting device comprising more than one pipetting unit, wherein said pipetting units are independently movable in Y and Z direction and comprise at least one module arranged in a staggered manner compared to the adjacent pipetting unit.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 9, 2015
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Alessandro D'Amore, Urs Knecht, Rolf Schneebeli
  • Publication number: 20150090012
    Abstract: The safety and proper performance of jet aircraft engines requires that any contamination of jet fuel, for example by water or by improper contaminants, be filtered (removed) before delivery of the fuel, through hoses, to the fuel tanks of the aircraft. Coalescing devices and filters in the fuel delivery system are used to attain this result. A typical problem is that filter materials chemically react with surfactants, and this causes the filter subsequently to “disarm” or fail to perform its function of removing water, which can lead to delivery of fuel containing excessive water. A solution to this problem is to pre-test the fuel for such surfactants by feeding a small fuel sample that has been mixed with “challenge water” through a smaller ‘representative’ test filter and monitor the performance. Using a fluorescent dye in the “challenge water,” the amount of water that passes the test filter is detected, compared with a baseline data and fuel quality determination is made.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 2, 2015
    Applicant: D-2, INC.
    Inventor: Alan James Fougere
  • Publication number: 20150027208
    Abstract: The present invention relates to a method for stabilising fatty acids present in a sample such as bodily fluids. The present invention further relates to a solid medium which is capable of stabilising fatty acids applied thereto, and a method for preparing same. The present invention further relates to a method for determining the fatty acid composition of a sample.
    Type: Application
    Filed: January 11, 2013
    Publication date: January 29, 2015
    Inventors: Robert Gibson, Liu Ge
  • Patent number: 8920658
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 30, 2014
    Assignee: Spectra Analysis Instruments, Inc.
    Inventors: William W. Carson, Sidney Bourne
  • Patent number: 8920726
    Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: December 30, 2014
    Assignee: Sysmex Corporation
    Inventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
  • Patent number: 8924166
    Abstract: This invention encompasses embodiments for multi-modal integrated simultaneous measurement of various aspects of fluids contained in circulating systems such as automotive reciprocating engines and vehicle transmissions. These circulating systems perform constant internal lubrication, and heat and contaminant removal to protect the internal moving parts from the inherent friction and damage in normal operation. Most commonly this is achieved with fluids based on hydrocarbon and/or related synthetics, which, over time, can lose their protective properties, and vary in their performance or breakdown/decay due to internal and external events. Several components within the lubricant fluid can be measured and can provide insight into the efficacy of the system to perform its designed mission.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: December 30, 2014
    Assignee: MASTINC
    Inventors: Brian Von Herzen, Steven Van Fleet
  • Patent number: 8911512
    Abstract: Disclosed is a method for determining properties of hydrocarbonaceous samples including a component prepared from: 1) the thermo-catalytic conversion of biomass, or 2) the pyrolytic conversion of biomass with subsequent upgrading. The determination of the property(ies) is by use of a near-infrared spectra based correlation.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: December 16, 2014
    Assignee: KiOR, Inc.
    Inventors: Jorge Gonzalez, Leslie May, Vicente Sanchez
  • Publication number: 20140301952
    Abstract: The present invention relates generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system, wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system, wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventors: Bruce A. Molitoris, Exing Wang, Ruben M. Sandoval, JR.
  • Patent number: 8746047
    Abstract: Provided is a method for analyzing a dispersion made by dispersing a liquid or solid dispersoid into a liquid dispersion medium. The method includes the steps of: preparing a sample liquid from the dispersion by forming an agglomerate of the dispersoid in the dispersion medium; redispersing the dispersoid that forms the agglomerate in the sample liquid into the dispersion medium of the sample liquid; and measuring the amount of the dispersoid that has been redispersed from the agglomerate in the sample liquid.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: June 10, 2014
    Assignee: Pokka Corporation
    Inventors: Takashi Inoue, Joju Niida, Yasuki Matsumura, Kentaro Matsumiya
  • Patent number: 8712702
    Abstract: A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: April 29, 2014
    Assignee: ARKRAY, Inc.
    Inventors: Takeshi Takagi, Koji Okumura, Tatsuo Kamata
  • Patent number: 8695813
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: December 8, 2007
    Date of Patent: April 15, 2014
    Assignee: Spectra Analysis Instruments, Incorporated
    Inventors: William W. Carson, Sidney Bourne
  • Publication number: 20140083174
    Abstract: A device for generating a nebulized sample for detection of an analyte. The device includes a surface acoustic wave (SAW) transducer and a superstrate. The superstrate has a first surface for coupling with the SAW transducer and a second surface for receiving a fluid sample incorporating the analyte. The fluid sample is nebulized from the second surface. The superstrate is provided with an electrical connection extending from the second surface of the superstrate to provide a conducting path from a charge source to the second surface of the superstrate. The charge source may be the surface of the transducer or an external voltage source.
    Type: Application
    Filed: May 18, 2012
    Publication date: March 27, 2014
    Inventors: Julien Reboud, Robert Wilson, Jonathan Cooper
  • Publication number: 20140083173
    Abstract: A fluid transfer device transfers a fluid from a first fluid channel with a first cross-sectional area into a second fluid channel with a second cross-sectional area, larger than the first cross-sectional area. The fluid transfer device includes a fluid inlet interface at which the fluid is transferable from the first fluid channel into the fluid transfer device; an inlet branch configured to split the fluid from the first fluid channel into multiple inlet branch channels; multiple outlet branches, each of which is configured to split the fluid from the inlet branch channels into respective outlet branch channels; and a fluid outlet interface configured to transfer the fluid in the outlet branch channels into the second fluid channel. The inlet and output branches and branch channels are disposed such that the fluid exits from the fluid outlet interface, distributed in a two-dimensional manner across the second cross-sectional area.
    Type: Application
    Filed: August 23, 2013
    Publication date: March 27, 2014
    Inventor: Holger Rapp
  • Patent number: 8677844
    Abstract: The invention relates to an injection port for analysis appliances, said injection port (10), when fitted correctly on an analysis appliance, forming an access line which leads to an analysis chamber of the analysis appliance and through which it is possible to guide the cannula of a sample injector containing a sample to be analysed, characterized in that the injection port comprises at least one elastic valve element (24) which can be opened and closed in a controlled manner and by means of which the access line to the analysis chamber can be sealed off both in the absence of a cannula and also when a cannula is guided through the injection port. The invention further relates to an analysis appliance provided with a corresponding injection port, and to a device for actuating the injection port.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: March 25, 2014
    Assignee: Dimatec Analysentechnik GmbH
    Inventor: Christian Monsé
  • Patent number: 8650936
    Abstract: A liquid chromatography device includes a sample inlet valve to which a sample to be analyzed is introduced, and a trap valve fluid-communicating with a solid phase extraction column and a reverse phase liquid chromatography column. The device further includes a solvent dividing unit dividing flow of a solvent discharged from the sample inlet valve into the first solvent inlet port and the second solvent inlet port of the trap valve. The liquid chromatography device improves resolution and increases reproducibility by allowing the sample injecting direction and the sample eluting direction to be opposite to each other.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: February 18, 2014
    Assignee: Korea University Research and Business Foundation
    Inventors: Sang-Won Lee, Min-Sik Kim, Seok-Won Hyung
  • Publication number: 20140026648
    Abstract: A known metering system for automatically maintaining a predefinable concentration of a liquid corrosion inhibitor in the aqueous hydraulic liquid of a water-hydraulic hydraulic system is characterized in that the measuring circuit can be disconnected from the hydraulic system (controllable valves 14, 15), in that the measuring circuit can be short-circuited between the outlet line and the inlet line by means of controllable valves 16, 17 and can be connected to a source (cleaning tank 18) of a cleaning liquid for a cleaning circuit. As a result, a cleaning liquid for cleaning the concentration sensor can be circulated in the measuring circuit for a predefinable time. For the purpose of calibration, the metering system can be charged with a reference liquid with a known inhibitor concentration, in particular water, in particular water from the public supply. Further sensors (23-25) can be connected into the measuring circuit.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 30, 2014
    Applicant: TIEFENBACH CONTROL SYSTEMS GMBH
    Inventors: Ulrich Schmitz, Hans-Hermann Hunfeld
  • Publication number: 20140020456
    Abstract: A method of separating petroleum samples containing a hydrocarbon-soluble elemental species of interest to facilitate analysis of an elemental and/or isotopic signature. A petroleum sample is mixed with a demulsifier and separated, for example by centrifuging, into one or more intermediate organic fractions. The intermediate organic fraction(s) are mixed with a solvent such as water and a second demulsifier, then separated into one or more prepared organic fractions and one or more solvent-based fractions. Some or all of the resulting fractions are then stored for possible further processing. Optionally, the petroleum sample may be spiked with one or more of an organic standard and an inorganic standard, and the solvent may likewise be spiked with an inorganic internal standard, to facilitate later analysis.
    Type: Application
    Filed: November 2, 2011
    Publication date: January 23, 2014
    Inventors: Sebastien L. Dreyfus, Lloyd M. Wenger, JR., Holger K. Justwan
  • Patent number: 8603395
    Abstract: A self-propelled apparatus for analyzing a component contained in a fluid medium. The self-propelled apparatus uses kinetic energy of the apparatus to drive a fluid under analysis through the apparatus. This is accomplished by use of a conveyance system that is attached to the analytical system of the apparatus. A sensor system is used to analyze the component collected within the confines of an analysis chamber, a part of the analysis system. The invention also includes a method of using the analytical apparatus.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: December 10, 2013
    Assignee: University of South Florida
    Inventors: David P Fries, Michelle L Janowiak, George Steimle, Heather A Broadbent
  • Patent number: 8604425
    Abstract: The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: December 10, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Katsuhiro Kanda, Makoto Nogami, Izumi Waki
  • Publication number: 20130313483
    Abstract: A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
    Type: Application
    Filed: August 22, 2011
    Publication date: November 28, 2013
    Inventors: Charles R. Mace, Ozge Akbulut Halatci, Ashok A. Kumar, Nathan D. Shapiro, George M. Whitesides
  • Patent number: 8584513
    Abstract: Disclosed are methods of determining the effectiveness of an asphaltene deposition inhibitor in oilfield applications. Such methods typically comprising the steps of introducing an oil well fluid into a microfluidic/millifluidic system; introducing a mixture of an asphaltene deposition inhibitor and carrier into the microfluidic/millifluidic system; introducing a precipitating agent, typically comprising heptane, into the microfluidic/millifluidic system; and optionally introducing toluene into the microfluidic/millifluidic system; then observing the presence or absence of asphaltene aggregation within the microfluidic/millifluidic system.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: November 19, 2013
    Assignee: Rhodia Operations
    Inventors: Lawrence A. Hough, Jean-Christophe Castaing, Gary Woodward, Ruela Talingting Pabalan, Floryan De Campo
  • Publication number: 20130276521
    Abstract: The invention is directed to a mobile hand held miniature laboratory system in general, and to fluid testing apparatus for performing a parameter measurement in a fluid sample and methods of use thereof in particular. The apparatus comprising: A strip adapted to absorb a fluid sample and to produce a signal indicative of said parameter level in said sample; and an adaptor adapted to connect said strip to a smart phone to thereby allow delivery of the produced signal or a correlated signal to said smart phone for obtaining a measurement of said fluid parameter displayed on said smart phone, wherein said testing apparatus relies on said smart phone at least for power supply and display means.
    Type: Application
    Filed: May 8, 2011
    Publication date: October 24, 2013
    Applicant: LABSTYLE INNOVATION LTD.
    Inventors: Oren Fuerst, David Weintraub, Dov Oppenheim, Meir Plevinski, Eyal Cohen
  • Patent number: 8557183
    Abstract: A submersible, self-propelled apparatus for analyzing a component contained in a liquid medium. The submersible, self-propelled apparatus uses kinetic energy of the apparatus to drive a liquid under analysis through the apparatus. This is accomplished by use of a conveyance system that is attached to the analytical system of the apparatus. A sensor system is used to analyze the component collected within the confines of an analysis chamber, a part of the analysis system. The invention also includes a method of using the analytical apparatus.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: October 15, 2013
    Assignee: University of South Florida
    Inventors: David P Fries, Michelle L Janowiak, George Steimle, Heather A Broadbent
  • Patent number: 8555709
    Abstract: A liquid chromatographic system includes columns, column mounting fixtures to which the columns are mounted, a detector, a collector, a controller and a plurality of RFIDs. A first RFID communicates with the controller and cooperating RFIDs mounted to other components provide information such as the history of components, parameters and the like. They also receive information from sensors relating to the operation of the liquid chromatograph, store the information and transmit it. Moreover, the RFIDs may substitute for hard wiring in many applications and may enable a central computer to control several liquid chromatographic system.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 15, 2013
    Assignee: Teledyne Instruments, Inc.
    Inventors: Dale A. Davison, Dale L. Meyer, Daniel G. Jameson, Jack E. Silver, Jon L. Curran, Ruth A. Pipes
  • Publication number: 20130255361
    Abstract: In most cancers, a significant factor in a poor outcome for the individual cancer victim is metastatic disease, i.e., dissemination of tumour cells to other parts of the human body via the circulation, such as distant organs, and their subsequent proliferation therein to form multiple other cancer tumours. The presence of circulating tumour cells, or CTCs, represents a vital intermediate step in this process and variations of a few CTCs within blood samples containing tens of billions of cells may denote the outcome for a patient or impact the cancer treatment regimen. At present no low cost field deployable technique for filtering CTCs exists. According to embodiments of the invention micro-machined filters with high aspect ratio, with and without, functionalization are employed to perform multi-parameter filtering for CTCs based upon compatibility with low cost semiconductor processes within multiple materials including silicon, polymers and silicon carbide.
    Type: Application
    Filed: March 26, 2013
    Publication date: October 3, 2013
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventor: The Royal Institution for the Advancement of Learning / McGill University
  • Publication number: 20130247655
    Abstract: A soil analysis device and a method are disclosed for measuring characteristics of a soil sample. A mixing chamber combines a soil sample and an extractant into a liquid mixture. A filtration system receives and filters the liquid mixture. The filtered liquid mixture is transmitted to a measurement cell. The measurement cell is coupled to a light source so that light propagating from the light source is attenuated and/or reflected by the liquid mixture and is measured by one or more optical detectors that are also coupled to the measurement cell. The optical detector generates an attenuation spectrum and/or a reflection spectrum indicating light received by the one or more detectors at different wavelengths. The attenuation and/or reflection spectrum is used to determine the characteristics of the soil sample.
    Type: Application
    Filed: May 28, 2013
    Publication date: September 26, 2013
    Applicant: Solum, Inc.
    Inventors: Michael John Preiner, Nicholas Carleton Koshnick, Justin Stewart White, Bevan Gerber-Siff
  • Publication number: 20130239665
    Abstract: A fully automatic extraction and analysis system for biologically active samples significantly simplifies the analysis of, for example, DMS samples and has significant advantages over the manual technology and the partially automated technology (punching out). The described extraction system is the first economical alternative to conventional blood analysis and supports the spread of said time-, cost-, and animal-saving technology in pharmacology and toxicology.
    Type: Application
    Filed: November 21, 2011
    Publication date: September 19, 2013
    Applicant: CAMAG
    Inventors: Matthias Loppacher, Manuel Altmeyer, Christoph Fankhauser, Urs Schranz
  • Publication number: 20130226347
    Abstract: Various methods and systems are provided for monitoring and control of soil conditions. In one example, among others, a method includes obtaining aqueous samples from suction probes within a soil substrate and analyzing the aqueous samples to determine a chemical composition of the soil substrate. Amounts of an additive may be determined to adjust the chemical composition of the soil substrate. In another example, a method includes installing a suction probe within a soil substrate; drawing a vacuum to induce hydraulic conduction of aqueous solutions from the soil substrate; extracting an aqueous sample; and analyzing the aqueous sample to determine a chemical composition of the soil substrate. In another example, a method includes obtaining a composition of a fertilizer solution (FS) supplied to a soil substrate and a chemical composition within the soil substrate; determining nutrient utilization, and providing an amount of additive to produce a subsequent FS for supply.
    Type: Application
    Filed: October 18, 2012
    Publication date: August 29, 2013
    Applicant: LABS & TECHNOLOGICAL HOLDING SOLEA, S.L.
    Inventor: Labs & Technological Holding Solea, S.L.
  • Publication number: 20130175000
    Abstract: A visual indicator device and method for determining the presence of oily contaminants in an aqueous stream are provided. The device includes a filtration status chamber for receiving and discharging the aqueous stream, and a transparent wall enabling viewing of the chamber interior. A fluid-pervious filtration media within the chamber is infused with an absorption composition at which the contaminant on contact with the media is immobilized. The media has a surface viewable through a transparent wall of the filtration status chamber, and the stream flow path causes the stream to impinge at the media via the surface, whereby the contaminants collect selectively at the media surface and are highly visible through the transparent wall.
    Type: Application
    Filed: February 13, 2013
    Publication date: July 11, 2013
    Applicant: MYCELX TECHNOLOGIES CORPORATION
    Inventor: Mycelx Technologies Corporation
  • Patent number: 8476075
    Abstract: A method of estimating the amount of unreacted starting materials (glycerides, methyl esters, etc.) and the composition of a biodiesel using TLC in conjunction with a lipophilic dye, Nile Red is described herein. The dye based TLC method of the present invention is convenient and provides significant advantages over existing methods for estimating the purity of a biodiesel composition.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 2, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eva Deemer, Wen Yee Lee, Xiomara Carolina Chianelli
  • Patent number: 8453524
    Abstract: A solution feeding device for feeding a sample solution which is precisely adjusted in the mixed quantity of a standard solution is realized. The solution feeding device comprises: a mixing module (100) including a first passage (101), a second passage (102), and a third passage (103) for providing communications of the midways of those two passages with a higher passage resistance than those of the two passages; a first storage unit (10) communicating with one end side of the first passage for storing a sample solution; a suctioning nebulizer (20) communicating with the other end side of the first passage for sucking the sample solution; a second storage unit (30) communicating through an on-off valve (31) with one end side of the second passage for storing a standard solution; and a syringe pump (40) communicating with the other end side of the second passage for sucking and discharging the standard solution, respectively, in the open state and the closed state of the on-off valve.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: June 4, 2013
    Assignee: IAS Inc.
    Inventor: Katsuhiko Kawabata
  • Publication number: 20130118951
    Abstract: Disclosed herein is a method involving the steps of: (a) precipitating an amount of polyaromatic compounds from a liquid sample of a first hydrocarbon-containing feedstock having solvated polyaromatic compounds therein with one or more first solvents in a column; (b) determining one or more solubility characteristics of the precipitated polyaromatic compounds; (c) analyzing the one or more solubility characteristics of the precipitated polyaromatic compounds; and (d) correlating a measurement of catalyst activity performance for the first hydrocarbon-containing feedstock sample with a mathematical parameter derived from the results of analyzing the one or more solubility characteristics of the precipitated polyaromatic compounds to predict catalyst performance of a catalyst in a refinery operation of the hydrocarbon-containing feedstock.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 16, 2013
    Applicant: Chevron U.S.A. Inc.
    Inventors: Varut Komalarajun, Cesar Ovalles, Estrella Rogel
  • Publication number: 20130124106
    Abstract: Disclosed herein is a method of estimating sediment content of a hydroprocessed hydrocarbon-containing feedstock.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 16, 2013
    Applicant: CHEVRON U.S.A. INC.
    Inventors: Estrella Rogel, Cesar Ovalles, Pak Leung, Nan Chen
  • Publication number: 20130111978
    Abstract: A sample analyzer includes a first measurement unit, a second measurement unit, a detection section which detects information about an amount of a sample in a sample container before the first measurement unit aspirates the sample in the sample container, and a control section. Based on a detection result by the detection section and based on information about a predetermined sample amount necessary for performing both in the first measurement unit and the second measurement unit, when the control section has determined that the amount of the sample in the sample container is insufficient for the predetermined sample amount, the control section controls the first measurement unit and the second measurement unit so as not to aspirate the sample in the sample container.
    Type: Application
    Filed: January 2, 2013
    Publication date: May 9, 2013
    Applicants: ARKRAY, INC., SYSMEX CORPORATION
    Inventors: Sysmex Corporation, Arkray, Inc.
  • Publication number: 20130111979
    Abstract: A device for measuring blood alcohol concentration for detecting the alcohol concentration from the blood of the unconscious driver as well as the driver's breath, comprises a first body including a coupling recess into which the blood collection module is coupled and a heater for heating the coupled blood collection module, and a second body including a detection probe to penetrate the blood collection module to suck the alcohol gas in the blood collection module, and an alcohol detection sensor to detect the alcohol concentration through the alcohol gas introduced through the detection probe.
    Type: Application
    Filed: June 8, 2011
    Publication date: May 9, 2013
    Applicant: DATECH CO., LTD.
    Inventor: Kwang Hee Park
  • Publication number: 20130104632
    Abstract: A biochip including a chip body, a first electrode and a second electrode is provided. The body has a first accommodating cavity, a second accommodating cavity and a micro-fluid channel. The micro-fluid channel is connected with the first accommodating cavity and the second accommodating cavity. The first electrode has a first end and a second end. The first end is used for contacting a first probe of a detection apparatus. The second end is positioned in the first accommodating cavity. The second electrode has a third end and a forth end. The third end is used for contacting a second probe of the detection apparatus. The forth end is positioned in the second accommodating cavity.
    Type: Application
    Filed: March 27, 2012
    Publication date: May 2, 2013
    Applicant: WISTRON CORPORATION
    Inventors: Pai-Yang Lin, Yih-Far Chen, Chin-Kuan Lin, Hsiang-Chia Chen, Sheng-Hsiung Weng
  • Publication number: 20130104633
    Abstract: A system for determining an analyte in a water sample includes at least one stationary sampling site identification transmitter at a sampling site. The at least one stationary sampling site identification transmitter is configured to wirelessly transmit a sampling site identification. A mobile sample container is configured to take a sample at the sampling site. The mobile sample container comprises a transmitter and receiver device. The transmitter and receiver device comprises a memory for the sampling site identification and for a sampling time stamp. A time stamp generator comprises a time stamp transmitter configured to wirelessly transmit the sampling time stamp. A water analysis device comprises a receiver configured to wirelessly receive the sampling site identification and the sampling time stamp from the transmitter and receiver device.
    Type: Application
    Filed: May 31, 2011
    Publication date: May 2, 2013
    Applicant: HACH LANGE GMBH
    Inventors: Dietmar Zangenberg, Carsten Schulz
  • Patent number: 8418533
    Abstract: The present invention provides an analyzing system with which a serial analysis inclusive of a pretreatment can be easily performed in a liquid chromatograph, and even unskilled users can perform a desired analysis. The analyzing system according to the present invention includes: an edit screen display section 31 for displaying an edit screen for allowing a user to create a pretreatment program using an external variable; a batch table display section 32 for displaying a batch table used for serially executing a plurality of analyses, the batch table having an external-variable setting field for allowing the user to enter the aforementioned external variable; and a serial analysis execution section 33 for serially executing each of the analyses inclusive of a pretreatment operation of an auto-sampler according to the pretreatment program and the batch table.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: April 16, 2013
    Assignee: Shimadzu Corporation
    Inventor: Takafumi Nakamura
  • Publication number: 20130067998
    Abstract: A method of forming a colloidal dispersion includes providing a first continuous material flow, providing a second continuous material flow, combining the first and second continuous material flows, and moving a continuous flow of a colloidal dispersion in a direction downstream of the first and second continuous flows. The first continuous material flow includes one or more of a diluent (e.g., deionized water), a base, and an acid, and the second continuous material flow includes an abrasive particle solution. The first and second material flows are combined with a Reynolds number greater than about 4400 and less than about 25000 (e.g., about 7400 to about 25000). The colloidal dispersion includes the diluent, the base, the acid, and abrasive particles from the abrasive particle solution.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: Planar Solutions, LLC
    Inventors: Saeed H. Mohseni, Elizabeth K. Gramm, Deepak Mahulikar
  • Publication number: 20130040403
    Abstract: A method and apparatus for pretreatment of a desired sample in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 14, 2013
    Applicant: THERMO FISHER SCIENTIFIC OY
    Inventors: Sari TIKANOJA, Annu SUONIEMI-KÄHÄRÄ, Johan FINELL
  • Publication number: 20130036800
    Abstract: A method and device for generating an ongoing consistent velocity within a pipeline flow in order to achieve fluid homogeneity prior to oil water measurement. A recirculation flow loop withdraws flow from a first point in a pipeline, accelerates that flow with a pump, and reinjects the outflow from the pump through turbulence inducing outlets at a second point in the pipeline upstream of the first flow withdrawal point. The increased turbulence and mixing of the fluid flowing in the pipeline enhances the homogeneity of the oil/water suspension. The more homogeneous fluid recirculating in the flow loop passes through a measurement probe of an oil/water detector, thus increasing the accuracy of the oil/water measurement of the fluid.
    Type: Application
    Filed: July 17, 2012
    Publication date: February 14, 2013
    Applicant: Kam Controls, Inc.
    Inventor: Kam Mohajer
  • Publication number: 20130008240
    Abstract: A microchip is provided which includes a first introduction channel, second introduction channels arranged to sandwich the first introduction channel and merged with the first introduction channel from both sides, and a merge channel connected to the first introduction channel and the second introduction channels, where fluids fed from the first and the second introduction channels are merged and flow, wherein the merge channel has a tapered portion formed so that a channel width in a sandwiching direction along which the first introduction channel is sandwiched by the second introduction channels gradually increases along a fluid feeding direction.
    Type: Application
    Filed: February 18, 2011
    Publication date: January 10, 2013
    Applicant: SONY CORPORATION
    Inventors: Tatsumi Ito, Shoji Akiyama, Masaya Kakuta, Takeshi Yamasaki