For Measuring Solid Components (e.g., Particles) Patents (Class 73/61.71)
  • Patent number: 10950376
    Abstract: The invention relates to a process for moving a droplet from a first location to a second location, which droplet comprises a magnetic material disposed in an aqueous medium. The invention also relates to a droplet assembly comprising a droplet, which droplet comprises a magnetic material disposed in an aqueous medium. Various uses of the droplet assembly are also described.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 16, 2021
    Assignee: Oxford University Innovation Limited
    Inventors: John Hagan Pryce Bayley, Kunwar Tanuj Sapra, Tobias Wauer, Holger Gerlach, Shiksha Mantri, Jamie Hill
  • Patent number: 10870110
    Abstract: A device and method for separating serum or plasma from blood cells in a whole blood specimen. The present invention uses a cap with a reservoir, such that blood cells are packed into the cap when the specimen container is centrifuged. When the cap is removed, the blood cells are also removed, and the serum or plasma is left in the specimen tube where it can be readily extracted by a pipette which is able to reach all the way to the bottom of the specimen tube minimizing the dead volume.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: December 22, 2020
    Assignee: Babson Diagnostics, Inc.
    Inventor: Eric Olson
  • Patent number: 10794797
    Abstract: A device for sampling, preparing and analysing a sample, for example a suspension, comprises: a sampling device adapted to sampling a fluid sample, at least one sample preparation unit adapted to prepare the sample, and at least one analysing unit. By adapting the device for sampling and analysing a sample for placement in direct vicinity to a process pipe and adapting the sampling device to sample a fluid sample directly from a gate, a compact and cost-efficient device is provided, which also provides fast feedback to a process to be controlled.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: October 6, 2020
    Inventors: Niclas Andersson, Bengt Anders Skålén, Stig Norder
  • Patent number: 10613051
    Abstract: The present disclosure provides a particle analyzer and a particle test control method and device thereof. A method comprises, after acquiring a diluted sample, preserving a part of the diluted sample, and monitoring whether a pore blocking event occurs during a counting process; when the pore blocking event occurs, suspending the test of the sample, and performing an unblocking operation; and after the unblocking operation is completed, controlling a liquid addition system to again acquire the preserved part of the sample from a reaction cell or a tube of the liquid addition system and inject it into a counting cell, and then re-counting the sample in the counting cell by an impedance method.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: April 7, 2020
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Tao Shen, Huilin Shi, Jin Teng, Wenheng Guo
  • Patent number: 10533934
    Abstract: According to one embodiment, a particle inspection system includes a voltage driving circuit which applies a driving voltage for a particle inspection to a particle inspection chip, a current-voltage conversion circuit which converts, into a voltage signal, a current signal output from the particle inspection chip when the driving voltage is applied to the particle inspection chip, a detection circuit which detects, based on the voltage signal, whether the sample liquid is introduced into a detection region of the particle inspection chip, and an analysis circuit which analyzes the fine particle, in the sample liquid based on the voltage signal. The voltage driving circuit varies the driving voltage based on the detection result of the detection circuit.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: January 14, 2020
    Inventors: Michihiko Nishigaki, Hiroshi Hamasaki, Naofumi Nakamura, Kentaro Kobayashi, Hiroko Miki
  • Patent number: 10352954
    Abstract: A sensing tip including a pipette tip having a cavity which communicates with an external environment of the pipette tip through an aperture located at a distal end of the pipette tip, and an impedance sensor having a sensing area including at least two electrodes located respectively outside and inside the pipette tip, wherein the sensing area is arranged within the aperture.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 16, 2019
    Inventors: David Vincent Bonzon, Georges Henri Muller, Philippe Renaud, Yann Barrandon
  • Patent number: 10302567
    Abstract: Use of high throughput methods to analyze samples for toxic elements originating from industrial hygiene and environmental sampling are described. These methods utilize optical detection methods using plates with arrays and microwells. Methods to fabricate samples in such plates are described. The invention is particularly illustrated by demonstrating its applicability for analysis of beryllium by fluorescence and uranium by phosphorescence. This invention also discloses the use of improved filtration method and use of reagents with low background signals.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: May 28, 2019
    Assignee: Berylliant, Inc.
    Inventors: Anoop Agrawal, Juan Carlos L. Tonazzi, Lori L. Adams, John P. Cronin
  • Patent number: 10244729
    Abstract: A milk sampling device includes a housing forming an inner space, an inlet opening to the inner space, a deflector member with an upper surface mounted in the inner space of the housing in a position vertically below the inlet opening, a flow passage formed between a periphery edge portion of the deflector member and an inner surface of the housing, and a milk sampling passage provided with an opening which constitutes a part of the flow passage. The upper surface of the deflector member comprises a plurality of a upwardly extending members arranged at a distance from each other in the vicinity of the periphery edge portion of the deflector member such that flow channels are formed between adjacent upwardly extending members.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: April 2, 2019
    Inventors: Christoffer Hagglund, Gunvor Nilsson, Torbjorn Petterson
  • Patent number: 10197824
    Abstract: A method of obtaining or maintaining optical transference into deaerated liquid in contact with a light transference medium is disclosed. The method comprises applying ultrasonic energy at a wavelength (?) into deaerated liquid in contact with a light transference medium. The ultrasonic energy at wavelength (?) originates at a distance (d) from an optical signal transmitted into the light transference medium. The distance (d) may be defined by a formula based on the wavelength (?) of the ultrasonic energy.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: February 5, 2019
    Assignee: ECOLAB USA INC.
    Inventors: Peter D. Hicks, Hui Li, Michael E. Bradley, Michael J. Murcia, Joe L. Schwartz
  • Patent number: 10067150
    Abstract: A method and particle analyzer for measuring a low concentration particles sample disclosed.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: September 4, 2018
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Wenheng Guo, Baohua Yan, Tao Shen
  • Patent number: 10066161
    Abstract: Disclosed are highly luminescent nanostructures, particularly highly luminescent quantum dots, comprising a nanocrystal core of InP and shell layers of GaP and AlP. The nanostructures may have an additional shell layer. Also provided are methods of preparing the nanostructures, films comprising the nanostructure and devices comprising the nanostructures.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: September 4, 2018
    Assignee: Nanosys, Inc.
    Inventors: John J. Curley, Chunming Wang
  • Patent number: 9874471
    Abstract: Disclosed are methods adapted to calibrate a liquid transfer system. The methods include providing a probe having a fluidly-coupled pressure sensor, the pressure sensor adapted to sense an aspiration pressure associated with the probe, performing one or more air aspirations and taking one or more pressure readings with the pressure sensor, and using one or more of the pressure readings to calibrate the pressure sensor. A novel liquid transfer system is also disclosed, as are other aspects.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: January 23, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jianfang Wang, Mark H. Sprenkle, Jingjing Zhang, John M. Shrewsbury
  • Patent number: 9581569
    Abstract: Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: February 28, 2017
    Assignee: Affinity Biosensors, LLC
    Inventors: Kenneth Babcock, Scott R. Manalis
  • Patent number: 9404839
    Abstract: Apparatus and methods for testing sediment submerged in liquid and manufacturing the apparatus. The apparatus and methods of the present embodiment can provide for nano/micro characterization of mechanical properties of materials submerged in liquid, facilitating specimen preparation and installation, and can provide hydrated materials. The apparatus can include cell walls with optical magnifying lenses so that the materials can be viewed without the aid of a microscope.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 2, 2016
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Allen Hagerman Reed, Hang Yin, David C. Young, Guoping Zhang
  • Patent number: 9021868
    Abstract: A sensor controller is for a particulate matter detection sensor that includes a pair of opposed electrodes spaced from each other and disposed on an attachment portion. The sensor controller includes a calculation portion configured to calculate an amount of particulate matter attached to the particulate matter detection sensor based on a detection value from the particulate matter detection sensor, and a determination portion configured to determine whether water exists in the exhaust passage based on the detection value. Thus, it is possible to accurately determine whether water exists in the exhaust passage.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Denso Corporation
    Inventors: Yuuki Sakamoto, Mikiyasu Matsuoka, Yuuzou Matsumoto
  • Publication number: 20150114094
    Abstract: The invention concerns a method and system for analyzing a liquid sample containing solid matter. The method comprises fractionating the sample according to particle sizes and/or masses of the solid matter so as to produce sample fractions, and measuring at least one physical or chemical property of at least one of said sample fractions. According to the invention the sample is conducted to a disintegration channel having one or more depressions, and a liquid flow having a non-constant temporal velocity profile is applied through the disintegration channel, in order to gradually take solid matter of the sample with the liquid flow from said one or more depressions for providing said sample fractions. The invention allows for efficient fractionation of samples, which cannot be fractionated using conventional field flow fractionation, for example.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 30, 2015
    Applicant: Kemira Oyj
    Inventors: Lari Vähäsalo, Eija Saari, Iiris Joensuu, Marjatta Piironen
  • Publication number: 20150105469
    Abstract: The present disclosure provides novel methods for determining an effective dosage of a PAA prodrug and for treating a UCD that incorporate body surface area and urinary PAGN concentration. The disclosure further provides novel methods for assessing compliance with PAA prodrug administration that incorporate urinary PAGN concentration, and the subject's current dosing regimen, BSA, or age. The disclosure further provides novel methods of treating a UCD in a subject in need thereof that incorporate urinary PAGN concentration, and the subject's current dosing regimen, BSA, and/or age.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 16, 2015
    Inventors: Bruce SCHARSCHMIDT, Masoud MOKHTARANI
  • Patent number: 9003869
    Abstract: This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to calculate a DNA content carried by the cell.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: April 14, 2015
    Assignee: 1087 Systems, Inc.
    Inventors: Matthias Wagner, John Heanue
  • Publication number: 20150096357
    Abstract: The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 42:4 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.
    Type: Application
    Filed: December 12, 2014
    Publication date: April 9, 2015
    Inventors: Francois-Pierre Martin, Ivan Montoliu Roura, Philippe Alexandre Guy, Serge Andre Dominique Rezzi
  • Publication number: 20150090015
    Abstract: A system for characterizing a water retention device may include a test pipe including a mount section for holding the water retention device to be tested; an injector to inject, upstream of the mount section, an air flow loaded with at least one of dust and droplets of water; at least one sensor for determining a distribution of sizes of the at least one of the dust and water particles, and a quantity of water retained in the mount section; and a calculator receiving the measured distribution of dust and water particles delivered by the at least one sensor to determine therefrom a dust and water retention level in the water retention device.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 2, 2015
    Inventor: Philippe Claudon
  • Patent number: 8984946
    Abstract: Methods, systems, and computer program products for determining a property of construction material. According to one aspect, a material property gauge operable to determine a property of construction material is disclosed. The gauge may include an electromagnetic sensor operable to measure a response of construction material to an electromagnetic field. Further, the electromagnetic sensor may be operable to produce a signal representing the measured response by the construction material to the electromagnetic field. An acoustic detector may be operable to detect a response of the construction material to the acoustical energy. Further, the acoustic detector may be operable to produce a signal representing the detected response by the construction material to the acoustical energy. A material property calculation function may be configured to calculate a property value associated with the construction material based upon the signals produced by the electromagnetic sensor and the acoustic detector.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: March 24, 2015
    Assignee: Troxler Electronic Laboratories, Inc.
    Inventor: Robert Ernest Troxler
  • Patent number: 8978449
    Abstract: A composition comprising a fluid, and a material dispersed in the fluid, the material made up of particles having a complex three dimensional surface area such as a sharp blade-like surface, the particles having an aspect ratio larger than 0.7 for promoting kinetic boundary layer mixing in a non-linear-viscosity zone. The composition may further include an additive dispersed in the fluid. The fluid may be a thermopolymer material. A method of extruding the fluid includes feeding the fluid into an extruder, feeding additives into the extruder, feeding a material into the extruder, passing the material through a mixing zone in the extruder to disperse the material within the fluid wherein the material migrates to a boundary layer of the fluid to promote kinetic mixing of the additives within the fluid, the kinetic mixing taking place in a non-linear viscosity zone.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: March 17, 2015
    Assignee: Ecopuro, LLC
    Inventor: William L. Johnson, Sr.
  • Publication number: 20150059452
    Abstract: The present invention reports a novel microfluidic analyzer for the high-throughput, label-free measurement of particles suspended in a fluid. The present invention employs the resistive pulse technique (RPT) which affords very high electrical bandwidth for the device, which surpasses that of currently available systems and devices. Further, devices in accordance with the present invention are fabricated with very simple microfabrication technologies, making the present invention more cost efficient and easier to manufacture than currently available devices.
    Type: Application
    Filed: October 30, 2014
    Publication date: March 5, 2015
    Inventors: Jean-Luc Fraikin, Andrew N. Cleland
  • Patent number: 8959985
    Abstract: A microparticle detecting apparatus is disclosed and includes at least one detection unit, each of which includes: a first sieve having at least a first mesh, a separator stacked on one side of the first sieve and having a separator hole, and a second sieve stacked on one side of the separator and having several second meshes. The diameter of the second mesh is smaller than that of the first mesh, and the first and second meshes are misaligned with each other in a vertical direction of the first and second sieves. The detection unit further includes at least a sensor aligned with the first or second mesh for detecting microparticles trapping into the first mesh or passing through the second mesh. Therefore, the microparticle detecting apparatus is suitably used for detecting or counting any microparticles with different size, to effectively shorten the detection processes of sample fluids.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: February 24, 2015
    Assignee: National Applied Research Laboratories
    Inventors: Chun-ming Huang, Chen-chia Chen, Chi-sheng Lin, Chien-ming Wu
  • Patent number: 8904853
    Abstract: Methods comprising: placing particulates in a test column; adding a fluid medium comprising a salt solution to the test column; placing the column under test conditions, wherein the test conditions comprise target temperature and target pressure; maintaining test conditions for a target test duration; and, analyzing the particulates. Some methods also measure a permeability value of the column after placing particulates in a test column and before placing the column under test conditions; continuously flow the salt solution through the particulates during the test; measure a permeability value after maintaining the test conditions for the target test duration; and, calculate a retained permeability value.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: December 9, 2014
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Enrique A. Reyes, Jimmie D. Weaver, Richard D. Rickman, Hongyu Luo
  • Patent number: 8899102
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: December 2, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Manalis, Andrea K. Bryan, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Publication number: 20140345863
    Abstract: Electromagnetically active slurries comprising stabilized fluids and methods of using the stabilized, electromagnetically active slurries in fluid flow control and detection. Also, methods, fluids, equipment and/or systems for treating a subterranean formation penetrated by a wellbore, relating to treatment fluids based on the stabilized, electromagnetically active slurries.
    Type: Application
    Filed: May 21, 2013
    Publication date: November 27, 2014
    Applicant: Schlumberger Technology Corporation
    Inventors: Hemant K. J. Ladva, Yiyan Chen, Anthony Loiseau, Dmitriy Ivanovich Potapenko
  • Patent number: 8877458
    Abstract: Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically translucent window can be held within another variant of the sample holder. Still alternatively, platelet storage bags having one or more tubes detachably appended to the bag can be used. A sample is drawn off into an appended tube for placement directly into the sample holder. This method provides a number of related, non-invasive techniques for detecting whether bacteria has contaminated a platelet concentrate. Contamination indicators include a population of particles different from platelets, microparticles or proteins, bad-quality platelets, i.e. low DLS score, and very high or very low scattering intensity.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 4, 2014
    Assignee: Canadian Blood Services
    Inventor: Elisabeth Maurer
  • Publication number: 20140302490
    Abstract: Method and device (1b) for performing the optical analysis of particles (2) contained in suspension in a fluid (3) arranged inside a microfluidic device (4) which maintains it at a temperature significantly lower than the ambient temperature; the formation of humidity on the outer surface (8) of the cover of the microfluidic device is avoided by applying a thermal flow (F) which determines an increase in the temperature of the outer surface (8) of the cover to above the condensation temperature (Td), or a reduction in the ambient temperature (and/or humidity) in the vicinity of the cover (8), so as to bring the condensation temperature (Td) (dew point) to below the temperature of the surface (8) of the cover determined by the internal operating temperature.
    Type: Application
    Filed: October 29, 2012
    Publication date: October 9, 2014
    Inventors: Gianni Medoro, Alex Calanca, Nicolò Manaresi
  • Patent number: 8833145
    Abstract: A method for determining a soot concentration in an engine oil of internal combustion engines, in which method a defined quantity of the engine oil is conducted with a defined flow speed along and/or through a measurement path. In a region of the measurement path, the engine oil is acted on with energy from at least one energy source in such a way that the soot particles contained in the engine oil at least partially absorb the energy. An energy quantity absorbed in the measurement path region is subsequently detected, and from this a soot concentration in the engine oil is determined. A device for determining the soot concentration in the engine oil of internal combustion engines is provided for performing the method.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: September 16, 2014
    Assignee: MAN Truck & Bus AG
    Inventors: Felix Fischer, Harald Beck
  • Publication number: 20140251879
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicant: CYTONOME/ST, LLC
    Inventors: Manish Deshpande, John R. Gilbert
  • Patent number: 8807879
    Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 19, 2014
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, Dino Dicarlo, Jon F. Edd, Daniel Irimia
  • Patent number: 8805594
    Abstract: A control system for remotely controlling the operation of a water distribution system is disclosed. The control system comprises a communication interface to enable communication between the control system and the water distribution system such that communication includes receiving from the water distribution system payment for dispensing of water, data on the working of its various components and data on the quality of the water dispensed by it. The control system further comprises a control processor configured to analyze data received from the water distribution system to determine if the quality of the water at the water distribution system satisfies a predetermined quality standard and to determine if the components of the water distribution system are functioning within a predetermined range.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: August 12, 2014
    Assignee: Piramal Enterprises Limited
    Inventors: Anand Shah, Naman Shah, Sameer Kalwani
  • Patent number: 8771484
    Abstract: The present invention discloses a device for detecting blood cells and a microscopic hole sensor assembly thereof. The device includes a microscopic hole sensor assembly positioned between a front pool and a back pool. The microscopic hole sensor assembly further includes a microscopic hole plate with a microscopic hole positioned thereon for communicating the front pool and the back pool. The end surface of the inlet is a flow-guiding surface gradually narrowing from the front pool to the back pool. The end surface of the outlet is a downstream surface gradually distending and extending towards the back pool. A straight effective orifice area is formed connecting the ends of the flow-guiding surface and the downstream surface.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: July 8, 2014
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Tianfeng Zhao, An Li, Huaming Xu
  • Patent number: 8770047
    Abstract: A method for wear analysis. The method includes introducing a lubricant sample into a tube. The lubricant sample includes debris, wear, or other particles of different sizes. The tube includes a number of filter patches, each of a predetermined pore size. The method further includes centrifuging the tube for displacing the lubricant sample, and the wear particles thereof, along a length of the tube. The filter patches impede passage of wear particles of a size larger than their pore size therethrough, thereby separating the wear particles according to the sizes of the wear particles. The tube is attached to a handler of a centrifuge for centrifugation by the centrifuge. Multiple tubes can be attached to multiple handlers of the centrifuge for simultaneous centrifugation by the centrifuge. Centrifugation tubes (or tubes) are also provided by the present disclosure.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: July 8, 2014
    Assignees: The Thailand Research Fund, King Mongkut's University of Technology North Bangkok
    Inventor: Surapol Raadnui
  • Patent number: 8746047
    Abstract: Provided is a method for analyzing a dispersion made by dispersing a liquid or solid dispersoid into a liquid dispersion medium. The method includes the steps of: preparing a sample liquid from the dispersion by forming an agglomerate of the dispersoid in the dispersion medium; redispersing the dispersoid that forms the agglomerate in the sample liquid into the dispersion medium of the sample liquid; and measuring the amount of the dispersoid that has been redispersed from the agglomerate in the sample liquid.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: June 10, 2014
    Assignee: Pokka Corporation
    Inventors: Takashi Inoue, Joju Niida, Yasuki Matsumura, Kentaro Matsumiya
  • Publication number: 20140144216
    Abstract: An apparatus for detecting wear particles in a fluid includes an inlet channel and an outlet channel. An ultrasonic transducer creating an acoustic wave that defines an acoustic focal zone is located between the inlet and outlet channels. A flow path located between the inlet and outlet channel is shaped to restrict the flow of the fluid to be within the acoustic focal zone. An inductive pulse sensor includes a plurality of flow channels receiving the fluid and a plurality of planar coils wound around the flow channels. The inductive pulse sensor includes a detection system for the detection of wear particles passing through the flow channels based on a change in an electrical property of the planar coils. A single combined excitation signal is sent to all the planar coils at once and the detection system measures one single output measurement for the plurality of flow channels.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 29, 2014
    Inventors: Jiang Zhe, Li Du
  • Publication number: 20140123737
    Abstract: An apparatus for detecting particles in a fluid is provided including a substrate, a plurality of channel through holes extending through the substrate, wherein the channel through holes are configured to carry the fluid, a plurality of circuits monolithically integrated with the substrate, wherein each circuit of the plurality of circuitries is arranged adjacent a respectively assigned channel through hole, each circuit including a detection electrode and an control circuit coupled to the detection electrode and configured to control access to the detection electrode, wherein each detection electrode is positioned relative to the respectively assigned channel through hole such at least one electrical property of the fluid flowing through the channel through hole can be detected.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 8, 2014
    Applicant: Agency for Science, Technology and Research
    Inventors: Tze Sian Pui, Abdur Rub Abdur Rahman
  • Patent number: 8713996
    Abstract: The Invention relates to a method for determining the filterability of beer, said method having the following steps: a) taking a wort or beer sample, b) filtering the sample on a plurality of filters of varying pore size, c) determining the size of the particles on the filter surfaces of the filters, d) qualitative analysis of the particles on the filter surfaces and assigning the measured particles to certain substances or groups of substances present in beer or the wort, wherein evidence on the filterability can be obtained from the size of the particles of different substances or groups of substances of individual fractions.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: May 6, 2014
    Assignee: Krones AG
    Inventor: Ralph Schneid
  • Patent number: 8701470
    Abstract: A method and system for determining particle size distribution and/or filterable solids in bitumen-containing fluid is described. A sample of bitumen-containing fluid, such as bitumen-froth feed, bitumen-froth solvent or paraffinic-froth-treated (PFT) bitumen-solvent is obtained. An optimized diluent combination is determined, comprising an aromatic or cycloaliphatic solvent such as toluene, benzene, naphthalene, xylene, anthracene, or cyclohexane together with a C3 to C12 paraffinic solvent. The combination is considered optimized when diluting the sample with the combination maintains substantially the same level of deasphalting in the diluted sample as in the undiluted sample. Upon dilution of the sample with optimized diluent combination, particle size distribution can be accurately determined using optical instrumentation, laser diffraction instrumentation, electrical counting instrumentation, or ultrasonic instrumentation.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: April 22, 2014
    Assignee: ExxonMobil Upstream Research Company
    Inventors: Joseph L. Feimer, Ken N. Sury
  • Publication number: 20140083175
    Abstract: The apparatus includes a levelling mechanism having an upwardly directed reference surface adjustably mounted on a frame for supporting the base of liquid sample containers in substantially level orientation. The apparatus further includes a container positioning member having a horizontally extending main body formed with a plurality of substantially vertical container-receiving sockets. These sockets are each open at their bottom ends, so as to allow the bases of liquid sample containers to project therethrough while held within the sockets adjacent their top rims. In this manner, when the container positioning member is placed down upon the levelling mechanism, the bases of the sample containers come to rest in contact with the reference surface. Such action levels the containers to facilitate accurate automated volume measurements of liquid samples within the containers to be taken, which accuracy, in turn, increases the accuracy of automated particle counts subsequently made with the liquid samples.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 27, 2014
    Applicant: CINRG SYSTEMS INC.
    Inventor: Alistair Geach
  • Publication number: 20140076036
    Abstract: The present invention relates to dabigatran etexilate and related substances and use of the substances as reference standards and markers. There are also provided processes of detecting the substances in samples of dabigatran etexilate, or pharmaceutically acceptable salts or solvates thereof, and also for analyzing the purity of samples of dabigatran etexilate, or pharmaceutically acceptable salts or solvates thereof. There are still further provided processes of preparing dabigatran etexilate and related substances, and pharmaceutical compositions containing the same.
    Type: Application
    Filed: May 10, 2012
    Publication date: March 20, 2014
    Applicant: Medichem S.A.
    Inventors: Judit Serra Miralles, Ernesto Durán López, Lingxiang Rao
  • Publication number: 20140080115
    Abstract: A device for monitoring particulates includes a means for correlating measurements of pressure across at least one filter, flow rate of a sample through the filter, or a combination thereof to the properties of particulates in a solution. More particularly, the device can be used for monitoring particulates in a reacting system to provide signals to the user or control input to the reacting system to alter the course of the reaction according to a desired path.
    Type: Application
    Filed: February 14, 2012
    Publication date: March 20, 2014
    Inventor: Wayne F. Reed
  • Publication number: 20140033806
    Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.
    Type: Application
    Filed: May 29, 2013
    Publication date: February 6, 2014
    Inventors: Russell McMAHEN, Mark Tengler, Michael Sloane, Daniel Lockhart
  • Publication number: 20140033807
    Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.
    Type: Application
    Filed: July 25, 2013
    Publication date: February 6, 2014
    Applicant: Sotax Coporation
    Inventors: Colin B. Kennedy, Syed Husain, Dale von Behren, Rick Bernal
  • Patent number: 8631685
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: January 21, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Manalis, Andrea K. Bryan, Michel Godin, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Patent number: 8616048
    Abstract: A microfluidic sensor formed by stacking a plurality of substantially non-electrically conductive layers, typically formed from thin polymer films. Certain layers may carry patterned electrodes that are arranged to permit their connection to an electrical interrogation circuit. Electrodes may be disposed in a 3-dimensional array in the sensor. A fluid path through the sensor includes an orifice sized to promote single-file travel of particles. The orifice may be defined by a tunnel passing through at least one layer. Particles entrained in an electrolytic carrier fluid may be detected, or otherwise characterized, by interrogation circuitry connected to certain embodiments of the sensor. Sensors generally include portions of a fluid path disposed parallel to the layers. Sensors may operate under the Coulter principle, and/or Stokes' shift phenomena. In certain embodiments, the sensor may be carried by a cartridge, which is adapted to couple with an interrogation platform.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: December 31, 2013
    Assignee: E I Spectra, LLC
    Inventor: Harold E. Ayliffe
  • Publication number: 20130333450
    Abstract: Systems and methods are provided for monitoring a solid-liquid interface during a casting process. The systems and methods enable determination of the location of a solid-liquid interface during the casting process.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 19, 2013
    Inventors: Nathan G. Stoddard, Monte A. Lewis, Roger F. Clark
  • Publication number: 20130333449
    Abstract: A particle quantifier includes a filter with a predetermined number of pores of a first predetermined size, a pump, and a fluid path from the pump to the filter. A pressure sensor is responsive to fluid pressure in the fluid path, and a processing module is responsive to the pressure sensor. The pressure increase of a sample fluid in the fluid path is determined as it is pumped through the filter and particles in the fluid are trapped by the filter. This pressure increase is compared with calibration data and an estimate is made concerning the concentration of particles greater than a second predetermined size present in the sample.
    Type: Application
    Filed: June 19, 2012
    Publication date: December 19, 2013
    Inventors: Thomas G. Barraclough, Stephen D. Lawrence
  • Publication number: 20130309763
    Abstract: A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position.
    Type: Application
    Filed: May 6, 2013
    Publication date: November 21, 2013
    Applicant: Sony Corporation
    Inventors: Gakuji Hashimoto, Takayuki Kato