Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.

Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 ?l to 1 ml from the dissolution vessels to wells of an external receptacle.

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.

Abstract: A microfluidic sensor formed by stacking a plurality of substantially non-electrically conductive layers, typically formed from thin polymer films. Certain layers may carry patterned electrodes that are arranged to permit their connection to an electrical interrogation circuit. Electrodes may be disposed in a 3-dimensional array in the sensor. A fluid path through the sensor includes an orifice sized to promote single-file travel of particles. The orifice may be defined by a tunnel passing through at least one layer. Particles entrained in an electrolytic carrier fluid may be detected, or otherwise characterized, by interrogation circuitry connected to certain embodiments of the sensor. Sensors generally include portions of a fluid path disposed parallel to the layers. Sensors may operate under the Coulter principle, and/or Stokes' shift phenomena. In certain embodiments, the sensor may be carried by a cartridge, which is adapted to couple with an interrogation platform.

Abstract: A particle quantifier includes a filter with a predetermined number of pores of a first predetermined size, a pump, and a fluid path from the pump to the filter. A pressure sensor is responsive to fluid pressure in the fluid path, and a processing module is responsive to the pressure sensor. The pressure increase of a sample fluid in the fluid path is determined as it is pumped through the filter and particles in the fluid are trapped by the filter. This pressure increase is compared with calibration data and an estimate is made concerning the concentration of particles greater than a second predetermined size present in the sample.

Abstract: Systems and methods are provided for monitoring a solid-liquid interface during a casting process. The systems and methods enable determination of the location of a solid-liquid interface during the casting process.

Abstract: A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position.

Abstract: A method and apparatus for measuring dissolved residue concentrations and particulate residue particle concentrations and size distribution in liquids, particularly colloidal suspensions. The method involves separating dissolved and particulate residues in liquids for subsequent analysis of the residue species. The method includes the steps of forming an aerosol from the liquid sample to be analyzed, evaporating the droplets in the aerosol to dryness, detecting and sizing the particles, and determining the liquid volumetric inspection rate. An apparatus for separating dissolved and particulate residues in liquids for determination of the concentrations of the two residue species as well as the size distribution of the particulate species is also disclosed. The apparatus includes a droplet former, a dryer communicatively connected to the droplet former, and a detector communicatively connected to the evaporator for detecting and sizing particles.

Abstract: A method for characterizing particles suspended in a liquid, in a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. The method characterizes particles in liquid and samples a small and accurate volume of liquid. The cartridge includes a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.

Abstract: An exemplary sensor system for a fuel transport vehicle can comprise a fuel marker sensor positioned between a fuel storage chamber of the vehicle and an access valve for the fuel storage chamber of the vehicle. The fuel marker sensor can be configured to measure one or more characteristics of one or more fuel markers present in the fuel adjacent the sensor, such as when the marked fuel is unloaded at a retail station. The one or more characteristics can comprise concentration and/or identity of the one or more fuel markers in the fuel. Based on the measured characteristics of the one or more fuel markers, the sensor system can identify the fuel and/or can determine whether the fuel has been adulterated after the marked fuel was last measured, such as when the marked fuel was loaded into the vehicle.

Abstract: A method of selecting pipetting parameters of a pipetting device for dispensing or pipetting a specific volume of a liquid sample, includes a fluid column of a fluid chamber of the pipetting device set into oscillation at the beginning of the aspiration, the pressure is monitored with the pressure transducer in the fluid chamber, and the pressure changes generated during aspiration into measuring signals are recorded. These measuring signals are processed by a computer or micro-processor and reproduced as a pressure curve, which is characteristic for the fluid column with the aspirated liquid sample, and which is compared with known pressure curves. Based on this comparison, pipetting parameters of the pipetting device are selected for the dispense or for pipetting a specific volume of the liquid sample. Selectable pipetting parameters include a speed of a movement of a pump piston of the pipetting device.

Abstract: The present invention relates a method for the detection of at least one mycotoxin contamination from bulk ware, an apparatus for taking a sample of particles from bulk ware as well as a method for taking particles from bulk ware using the apparatus according to the invention and the use of the apparatus according to the invention.

Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.

Abstract: An apparatus and a method for detection of wear particles in a lubricant are disclosed. The apparatus includes a microfluidic device including a microchannel sized for a lubricant containing wear particles to pass therethrough and first and second electrodes extending into the microchannel. A detection system is coupled with the electrodes for detection of wear particles passing through the microchannel, based on a change in capacitance of the electrodes.

Abstract: A method and an apparatus for measuring the depositability of particulate contaminants present in a pulp or paper mill fluid stream and evaluating interactions of such particulate contaminants with other contaminants collects the particulate contaminants on a suitable substrate, such as a plastic film coated with an adhesive or coated with organic contaminate, placed in contact with the pulp or paper mill fluid stream for at least five minutes up to several hours. The amount of contaminants collected on the substrate is quantified and evaluated by taking one or more scanned images of the substrate with a resolution of at least 2,000 dots per inch (DPI) and analyzing the scanned images with image analysis technique.

Abstract: Methods, systems, and apparatus for a gate valve including a body, a stem, and a sensing bore. A subassembly includes a body, a stem, and a sensing bore; a bonnet contacting the body; and at least one of a vein and a plug in the sensing bore.

Abstract: A method of focusing a plurality of discrete particles. The method comprises establishing a flow of a fluid medium carrying a plurality of discrete particles within a capillary having a plurality of separate walls and a longitudinal axis. The method further includes vibrating the plurality of separate walls to apply an acoustic field having a central axis substantially along the longitudinal axis to focus the plurality of discrete particles substantially along the longitudinal axis.

Abstract: The invention relates to a particle counter apparatus for counting particles in a fluid flowing in a pipe or a pipeline. The particle counter apparatus comprises a pipe portion through which the fluid flows, where the pipe portion is provided with a fluid sample outlet for withdrawal of a fluid sample. Furthermore the particle counter apparatus also comprises a first fluid transfer body extending from the fluid sample outlet to a particle counter, and a second fluid transfer body extending from the particle counter to a fluid return outlet mounted in the pipe portion downstream of the fluid sample outlet. In the pipe portion there is mounted a propeller unit comprising a propeller and a generator, with the result that particles are distributed uniformly in the fluid before the withdrawal of fluid samples, and electric power is provided for operation of the particle counter apparatus.

Abstract: The fluidic system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone to a waste container, in which the flow rate of the sheath fluid is different from the flow rate of the waste fluid thereby drawing a sample fluid from a sample container into the interrogation zone, a detection system that provides a data set of input signals from the sample fluid, an analysis engine that recognizes aggregate particle events in the data set, and a controller that automatically adjusts the flow rate of the sample fluid into the interrogation zone based on the recognition of aggregate particle events, by controlling at least one of the flow rates of the sheath fluid and the waste fluid.

Abstract: A method and device for determining the appropriate time to recharge hydraulic fluid in a work vehicle. The method preferably includes making a real time determination of the at least a quality parameter of hydraulic fluid in a work vehicle. The system includes comparing in real time, the quality parameter to a predetermined value for the hydraulic fluid. The method of the present invention also includes a system for comparing the determined values and communicating same to an operator. The method of the present invention also includes the capacity to control the output level of the work vehicle according to the level of contamination in the hydraulic fluid. The present invention also provides a device for real time monitoring and control of the hydraulic fluid.

Abstract: A biomedical microfluidic device for separating a sub-population of particles from a first fluid, particularly a biological fluid, has means for separation and/or filtration of the fluid, which include a first microfluidic path defined in a first body of the device, a first inlet for introduction of a first fluid in the first path and at least a first outlet for discharge from the first path of a sample of fluid enriched in the sub-population of particles.

Abstract: Methods and devices for detecting particles in a fluid within a medium, such the analyzing device includes: a source adapted to transmit signals into the medium; at least one detector adapted to detect signals transmitted from the source such that the at least one detector and the source are structured and arranged on opposite sides of the medium; at least one processing unit in communication with the at least one detector and adapted to produce a plurality of output signals representative of one of at least one particle characteristic or one or more particle property.

Abstract: The method of quantifying and of validation of activation status of a water treatment polymer in an aqueous sample comprises the following steps: supplying polymer (e.g. continuously) to the aqueous sample; monitoring electrical conductivity measurements in the aqueous sample; thoroughly mixing the aqueous sample; correlating the conductivity measurements with the polymer concentration and activation status; and suspending mixing once conductivity steady state is achieved upon the aqueous solution polymer becoming fully activated.

Abstract: The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1).

Abstract: A method for identifying an improved particle size distribution profile of a dispersion, the method including: (a) providing a dispersion comprising a liquid and particles dispersed in the liquid; (b) measuring a particle size distribution of the dispersion, resulting in a first particle size distribution profile; (c) adjusting at least one parameter associated with the dispersion; (d) measuring a dispersion characteristic, after adjustment of the at least one parameter; and (e) measuring the particle size distribution of the dispersion after adjustment of the at least one parameter, resulting in a second particle size distribution profile; wherein each of the first and second particle size distribution profiles comprises a plurality of data points of particle concentration values as a function of particle size.

Abstract: Disclosed is a device for measuring the concentration of the particles contained in a fluid. The device comprises a control volume body having a predetermined effective volume. An inlet path is formed at an end of the control volume body to feed the fluid into the control volume body therethrough. An outlet path is formed at another end of the control volume body to discharge the fluid from the control volume body therethrough. Measuring instruments are provided at the inlet path and the outlet path to emit electrical signals when the fine particles pass through the inlet path and the outlet path. A computing machine receives the electrical signals transmitted from the measuring instruments, and then computes the number and the concentration of fine particles contained in the control volume body. The device is easily integrated with Micro-TAS (Total analysis System).

Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.

Abstract: A method for the determination of the degree of contamination of an examination object, such as a system for filling liquid foodstuffs, or a component or subsection of a system, in particular a pipe, including measuring a property distribution of a first examination medium before and after passage through the examination object.

Abstract: A Nanomotion Sensor comprises a micromechanical device for the detection and characterization of specimen motions when they interact with one or an array of cantilevered sensors set in the path of the moving specimen. In particular, the present invention provides a method for direct sensing and characterization of motion, including position, torsion, magnitude and direction of velocity, acceleration, force, torque, as well as binding, which may include hydrogen bonding, electrostatic attractions, hydrophobic effects, dipole interactions, or through other forces through the deflection of a micromechanical cantilever sensor. The present invention is particularly useful for the detection and characterization of the motion of biological cells such as bacteria and sperm, biological systems including motor proteins, cilia of the hearing organ and the lining of the airways in asthmatics, and microfabricated systems.

Abstract: A method of determining an amount of impurities that a contaminating material contributes to high purity silicon comprises the step of partially encasing a sample of high purity silicon in the contaminating material. The sample encased in the contaminating material is heated within a furnace. A change in impurity content of the high purity silicon is determined after the step of heating, compared to an impurity content of the high purity silicon prior to the step of heating.

Abstract: A method for determining the quality of milk wherein a sample is examined and the type of at least one detected object is determined on the basis of at least one object recognition rule.

Abstract: Disclosed is a device for measuring the concentration of the particles contained in a fluid. The device comprises a control volume body having a predetermined effective volume. An inlet path is formed at an end of the control volume body to feed the fluid into the control volume body therethrough. An outlet path is formed at another end of the control volume body to discharge the fluid from the control volume body therethrough. Measuring instruments are provided at the inlet path and the outlet path to emit electrical signals when the fine particles pass through the inlet path and the outlet path. A computing machine receives the electrical signals transmitted from the measuring instruments, and then computes the number and the concentration of fine particles contained in the control volume body. The device is easily integrated with Micro-TAS (Total analysis System).

Abstract: A system and method for determining the atomization characteristics of fluids is disclosed. In one embodiment, a fluid is emitted through a nozzle at controlled conditions. Vibrations occurring within the nozzle are sensed while the fluid is being emitted. An atomization characteristic of the fluid is predicted using the sensed vibrations. In one embodiment, the sensed vibrations are converted into a spectral density that is used to calculate a vibration power spectrum. In one embodiment, the atomization characteristic is the droplet size of the fluid with respect to the controlled conditions, and the droplet size is predicted based on a relationship between a descriptive attribute of the fluid and the vibration power spectrum of the fluid. In one embodiment, the descriptive attribute is the volume median diameter of the fluid.

Abstract: This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry. The invention also provides for a portable device or kit for modifying an existing mass spectrometer.

Abstract: A method for assaying an intrinsic energy property of water and other liquids is disclosed, as well as a means for detecting water energizing environmental energy fields. The method is based on the dynamic nature of dissolving neutral red dye particles added to the liquid and the light induced motion of remaining un-dissolved neutral red dye particles. The intrinsic energy activity of the liquid is related to the alternative cellular energy (ACE) pathway, which can function in the prevention and therapy of various illnesses in plants, animals and humans.

Abstract: Methods comprising: placing particulates in a test column; adding a fluid medium comprising a salt solution to the test column; placing the column under test conditions, wherein the test conditions comprise target temperature and target pressure; maintaining test conditions for a target test duration; and, analyzing the particulates. Some methods also measure a permeability value of the column after placing particulates in a test column and before placing the column under test conditions; continuously flow the salt solution through the particulates during the test; measure a permeability value after maintaining the test conditions for the target test duration; and, calculate a retained permeability value.

Abstract: A method and apparatus for monitoring a fluid that is to be transported through a fluid conduit within a hydrocarbon exploration and production installation is described. A monitoring zone is established upstream of the fluid conduit configured such the fluid supply to the fluid conduit is introduced via the monitoring zone. The fluid supply within the monitoring zone is monitored for the occurrence of events detrimental to the flow of the fluid supply through the fluid conduit. Monitoring the fluid supply prior to entering the fluid conduit allows for the early detection of an event detrimental to the flow of the fluid supply e.g. a chemical reaction indicative of corrosion of the fluid conduit or the formation of a potential blockage within the fluid conduit. In this way the risk of costly blockages or structural failure occurring within the fluid conduit is reduced.

Abstract: Embodiments of the present invention relate to a method to determine formation measurements, the method comprising placing a sample in a reservoir, removing aliquots from the reservoir containing the sample or continuously monitoring the reservoir or headspace as the sample and reservoir equilibrate and analyzing the aliquots or readings sufficient to provide diffusion measurements.

Abstract: A particle detector including a chamber, a first aspirator, a sensor(s), a controller and clean air supply. The controller, when in a detecting mode, receives an indicative signal from the sensor and applies logic to the indicative signal to generate a further signal, and when in the purge mode controls substantial purging of the chamber of sample fluid with clean fluid from the clean fluid supply. The controller receives the indicative signal when the chamber is so purged and if necessary adjusts the logic in response thereto.

Abstract: The invention is comprised, in part, of a surface that contains more than one component or construct. Such heterogenous surface compositions and configurations, related systems and methods for sensing particle or analyte interaction therewith can selectively and/or differentially interact with a range of particles/analytes, in lieu of specific molecular sensor-analyte interactions for each particle. These interactions of various analytes or particles can differ sufficiently in strength and range between multiple analyte types or particles to effect a separation of analytes or particles mixtures, in a way that requires no sensing or detection. With incorporation of a sensing mechanism, discrimination/detection of different compounds within an analyte mixture can be accomplished.

Abstract: A method for wear analysis. The method includes introducing a lubricant sample into a tube. The lubricant sample includes debris, wear, or other particles of different sizes. The tube includes a number of filter patches, each of a predetermined pore size. The method further includes centrifuging the tube for displacing the lubricant sample, and the wear particles thereof, along a length of the tube. The filter patches impede passage of wear particles of a size larger than their pore size therethrough, thereby separating the wear particles according to the sizes of the wear particles. The tube is attached to a handler of a centrifuge for centrifugation by the centrifuge. Multiple tubes can be attached to multiple handlers of the centrifuge for simultaneous centrifugation by the centrifuge. Centrifugation tubes (or tubes) are also provided by the present disclosure.

Abstract: Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.

Abstract: A Coulter-style, microfluidic sensor formed by stacking a plurality of substantially non-electrically conductive layers, typically formed from thin polymer films. Certain layers carry patterned electrodes that are arranged to permit their connection to an electrical interrogation circuit. Electrodes may be disposed in a 3-dimensional array in the sensor. A fluid path through the sensor includes an orifice sized to promote single-file travel of particles. The orifice may be defined by a tunnel passing through at least one layer. Particles entrained in an electrolytic carrier fluid may be detected, or otherwise characterized, by interrogation circuitry connected to the sensor. Certain sensors may include portions of a fluid path disposed parallel to the layers. In certain preferred embodiments, the sensor is carried by a cartridge, which is adapted to couple with an interrogation platform.

Abstract: A method for determining a soot concentration in an engine oil of internal combustion engines, in which method a defined quantity of the engine oil is conducted with a defined flow speed along and/or through a measurement path. In a region of the measurement path, the engine oil is acted on with energy from at least one energy source in such a way that the soot particles contained in the engine oil at least partially absorb the energy. An energy quantity absorbed in the measurement path region is subsequently detected, and from this a soot concentration in the engine oil is determined. A device for determining the soot concentration in the engine oil of internal combustion engines is provided for performing the method.

Abstract: An apparatus for characterizing particles suspended in a liquid sample containing electrolyte including a sample chamber to hold the liquid sample and a collection chamber to hold an electrolyte solution. A wall separates the chambers and includes an aperture to allow passage of particles between the chambers; and a pair of electrodes are disposed on opposite sides of the aperture to induce a current through the aperture. A pressure source forces the sample to pass from the sample chamber into the collection chamber; and a processor measures a signal representative of electric resistance variation between the electrodes to enable determination of the size of the particle within the liquid passing through the aperture, wherein the processor is adapted to monitor two or more parameters characterizing the flow of particles through the aperture, and to detect a potential blockage of the aperture by detecting a change in any one of the parameters.

Abstract: A system for collecting a biological sample includes a collection device comprising a cylindrical body having a bore extending there through and a filter membrane disposed at one end thereof; a filter plug having an insert configured for insertion into the bore; a collar concentrically mounted about the exterior surface of the insert and configured for insertion into the bore; and a gasket disposed about the exterior surface of the insert, wherein an outer dimension of the gasket is variable in response to relative movement between the collar and the insert, and wherein the gasket has a cross section with two end portions and a mid portion that is located radially further away from the insert than the two end portions.

Abstract: The invention is comprised, in part, of a surface that contains more than one component or construct. Such heterogenous surface compositions and configurations, related systems and methods for sensing particle or analyte interaction therewith can selectively and/or differentially interact with a range of particles/analytes, in lieu of specific molecular sensor-analyte interactions for each particle. These interactions of various analytes or particles can differ sufficiently in strength and range between multiple analyte types or particles to effect a separation of analytes or particles mixtures, in a way that requires no sensing or detection. With incorporation of a sensing mechanism, discrimination/detection of different compounds within an analyte mixture can be accomplished.

Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

Abstract: A method for preparing a microemulsion is disclosed which employs a method based upon identification of the phase behavior of a plurality of components comprising the microemulsion. Further disclosed is a microemulsion composition comprising a first component, coupling agent, and surfactant.

Abstract: The invention relates to a waste water immersion probe (10) comprising a liquid-tight housing (11), a sensor (18) which is disposed in the housing (11) and a sensor window (20) formed on the housing (11). A wiper element (22) for cleaning the sensor window (20) is arranged on the outside of the sensor window (20), and the wiper element (22) is driven by a drive motor (24) which is arranged essentially in the housing (11). The housing is devoid of openings. A magnetic element (36, 37) is associated with the drive motor (24) and a magnetic element (34, 35) is associated with the wiper element (22) in such a manner that the magnetic drive motor element (36, 37) produces a magnetic field which transverses the housing wall and transmits a drive torque to the wiper element (22) without a shaft.