Abstract: A sampling apparatus is characterized by a sampler and a sample collection station. The sampler is stationary and periodically delivers discrete product samples to a stationary inlet to the sample collection station. The sample collection station includes a deck having a plurality of passages in linearly aligned spaced relationship, a plurality of sample collection containers, and inlets to the sample collection containers that are in communication with associated ones of the deck passages. The deck is linearly indexed in both directions of movement along the linear alignment of the deck passages to place selected ones of the deck passages into communication with the stationary inlet, so that product samples delivered by the sampler to the sample collection station are directed into selected ones of the sample collection containers.

Abstract: A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

Abstract: The invention relates to a device for detecting and locating fire sources or gas impurities in one or several monitoring chambers. Said device comprises a (main) detector for detecting a fire characteristic value or a gas impurity, into which a part of the ambient air in said monitoring chambers is continuously injected by means of an intake unit through a line, arranged in each monitoring chamber and provided with intake ports. Said invention also relates to a method for individually detecting fire sources or gas impurities. The aim of the invention is to provide a device and a method, which combine, in a simple and economic manner, the advantages of gas inlet systems, such as an active intake and a concealed assembly, with the advantage of the localization of each intake port as well as the detection of a precise fire source or a precise gas impurity.

Abstract: Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure.

Abstract: The object of this invention is to provide a gas sampling system of taking discreet samples from a continuous flow of gas or fluid. Said apparatus offers a frame (1) and mounting components in the form of a fixed chuck (4) and a spring-loaded chuck with a sampled container (5) mounted therebetween. The sampling container has self-sealing end cap valve assemblies (76) that automatically open when the sample container (5) communicates with the fixed chuck (4) and the spring loaded chuck (6) and the end cap valve assembly automatically closes when the sample container is removed. A value system allows the gas flow to be directed from one sample container to the other alternatively opening and closing a gas flow path. A sample extraction assembly (14) allows the efficient removal of samples from the sample containers. An extension rod pressurized (117) in conjunction with the end cap value assembly, such as first end cap valve assembly (76) allow the sample to be pressurized to facilitate easy sample removal.

Abstract: Embodiments of the present invention are directed to an improved chemical synthesis apparatus for performing chemical synthesis such as nuclei acid synthesis in a plurality of reaction wells or cells in an efficient manner. The apparatus employs dispenser heads that each include a cluster of nozzles which are fluidicly coupled to a plurality of reagent sources for dispensing different reagents through the single dispenser head. Because each dispenser head is capable of dispensing a plurality of different reagents, the apparatus can perform simultaneous synthesis in a plurality of cells at a high throughput without complex and elaborate control of movement of the dispenser heads relative to the cells.

Abstract: The invention provides a method of performing one- and two-dimensional electrophoresis with or without gel in an automated way. The two dimensional electrophoresis can be performed either separately or continuously. Both electrokinetic and hydrodynamic forces can be used to facilitate sample transfer from the first to the second dimension. The samples can be detected on-line by using common detectors like UV-Vis, laser induced fluorescence (LIF), and mass spectrometry (MS).

Abstract: A coring device includes a base portion that receives an arrayed plurality of samples, the base portion including a plurality of vertically oriented slider rods. A coring portion including an arrayed plurality of coring tubes aligned with the arrayed plurality of samples is slidable along the vertically oriented slider rods between a retracted position and an actuated position where cores are taken from the samples. An extraction portion including arrayed plurality of extraction pins aligned with the arrayed plurality of coring tubes for insertion therein is also slidable along the vertically oriented slider rods between a retracted position and an actuated position where the extraction pins eject cores from the coring tubes. A coring drive mechanism is provided to mechanically move the coring portion between the retracted position and the actuated position.

Abstract: Improved sampler apparatus and methods for dissolution testing include a controller that determines whether several different dissolution testing methods can be performed concurrently by the sampler and controls the sampler in response to the determination; fluid delivery apparatus adapted to pierce a septum and to deliver fluid to or from a collection receptacle through a first aperture, and to permit air flow to or from the collection receptacle through a second aperture; a syringe pump including a distributor having apertures through which fluid flows into and out of the pump chamber, the piston of the syringe pump being moveable adjacent the apertures; and/or a leak sensor responsive to the presence of spilled fluids.

Abstract: A filter removal apparatus for removal of microporous filter membranes from multi-well filtration plate comprises a removal device and a pusher having defined therein a plurality of vertical pushpins. The pusher has a leading pushing surface to which elongated pushpins are secured each having a flat face to deliver an even pressure onto the filter membrane. The removal device comprises a stationary base plate with end wall and side walls holding a pivotal cylindrical bar which rotates in eccentric manner along its longitudinal axis. Rotation of cylindrical bar using attached handle approximately 180 degrees around the longitudinal center-line of pivot shafts causes the cylindrical bar to rotate in an eccentric motion, thus imparting a linear force to a moving plate which forces the pusher into the filter plate and causing removal of filter membranes and their flattening onto adhesive film for retention.

Abstract: A device for transferring small drops of liquid from one or more liquid holders to one or more liquid destinations is disclosed. The device includes a support member and a plurality of fluid transfer members extending from the support member. Each fluid transfer member includes a flexible liquid transfer end.

Abstract: A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

Abstract: Several pin transfer assemblies are disclosed that utilize the surface tension of liquids for picking up and dispensing minute volumes of liquid from wells in a first well plate to a flat substrate surface or into wells in a second well plate. In one embodiment, a plurality of pins reciprocate through complementary arrays of holes in a base plate and an overlying spring plate biased apart by coil springs located around the periphery of the base plate. A foam layer sits on top of the spring plate and a weight plate sits on top of the foam layer. A single coil spring is positioned between a center of the weight plate and the cover to push the weight plate downwardly. The periphery of the cover guides the vertical movement of the weight plate and is connected to the periphery of the base plate. The periphery of the base plate is supported by a frame used to register the pin assembly in a receptacle of a manual or automated liquid transfer apparatus.

Abstract: Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure.

Abstract: A liquid dispenser characterized by a dispensing head which is movable upward and downward as a whole and comprises a plurality of plungers supported by a plunger plate, drive means for moving the plunger plate upward and downward, a plurality of cylinders in which the plungers slidably fit, and a plurality of nozzles arranged at the lower ends of the cylinders and having configurations adapted to engage airtightly with holes for holding specific dispensing tips, the plurality of nozzles being supported by a single nozzle holder, which is built to be detachable from said dispensing head. According to the invention, only the nozzle holder that support nozzles has to be replaced with another holder conforming to dispensing tips of different dimensions. The arrangement facilitates the replacement and make the dispenser available at lower cost.

Abstract: A pin replicator is disclosed for dispensing minute volumes of liquid onto a substrate surface in an array in connection with drug discovery, diagnostic analysis, and other applications. The pin replicator comprises a base plate, a plurality of pins reciprocable through corresponding holes in the base plate, and a free floating weight plate resting on top of the upper ends of the pins. The weight plate biases the pins toward their fully extended lowered positions. A cover attaches to the base plate, encloses the pins and weight plate and guides the weight plate during vertical movement thereof. The pin replicator can be moved downwardly toward a first micro titer plate so that a lower end of each of the pins contacts the sample liquid in the corresponding well a sufficient amount to pick up and retain a small quantity of the sample liquid due to surface tension.

Abstract: Serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface are provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. Also provided are tools that allow the parallel development of a sample array. To this end, the tool can be understood as an assembly of vesicle elements, or pins, where each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Each of the pins can fit inside a housing that forms an interior chamber. The interior chamber can be connected to a pressure source that will control the pressure within the interior chamber to regulate the flow of fluid within the interior chamber of the pins. The prepared sample arrays can then be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.

Abstract: An integrated mesopump-sensor suitable for disposition in two- and three-dimensional arrays having small dimensions is disclosed. One mesopump is formed of an electrostatically attractable flexible diaphragm disposed through cavities or pumping chambers formed between two opposing electrostatically chargeable material layers. Fluid is pumped through the chambers by sequentially moving the diaphragm toward the first chargeable layer, then towards the second chargeable layer, which can pull and push the fluid through a series of chambers, and past the sensor. One group of sensors utilizes multiple and varied chemoresistive sensors which can vary in resistance differently in response to the presence of various analytes. Another group of sensors utilizes chemo-fluorescent sensors that fluoresce in the presence of particular analytes.

Abstract: A capillary for introduction of whole blood into an analysis device. The capillary has a variable volume along its length, which allows the liquid sample to be drawn into the interior of the cartridge, away from the inlet, reducing the risk of contamination of the sample from the outside.

Abstract: The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or “gravity” pin to draw or collect source fluid and “spot” or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach.

Abstract: A port structure is disclosed that may be placed at differing height intervals in the side of the on-farm or smaller grain storage bin. The port is sealed with the sealing apparatus to prevent the introduction of unwanted moisture or insects into the storage cavity of the grain bin. A standard sharp pointed probe available in the industry is utilized with the invention. Once the sealed cap is removed, the probe is inserted through the port horizontally into the stored grain to obtain grain samples at whatever intervals are provided by the standard probe mechanism. Also disclosed is a method for sampling from a horizontal cross section of a particulate matter storage bin.

Abstract: A housing is described for use in preparing a sample for chemical analysis, the housing having a sample entrance, a sample exit, and a passageway therebetween; the housing further comprising at least three ridges, the ridges integral with the housing, depending into the passageway, and defining a supporting profile for holding a sorbent retaining member.

Abstract: An apparatus and method for determining the content or measuring the quantity of constituents, of a plurality of samples (12) is provided, being particularly useful for measuring the amount of CO2 released by soil samples (12). The apparatus includes a first plate (10) having a plurality of wells (11), each well (11) being intended to contain a sample (12), and a second plate (20) also having a plurality of wells (21), each well (21) of the second plate (20) being intended to contain an indicating means such as a gel with a PH indicator (22). A third plate (30) may be provided to connect the wells (11) of the first plate (10) to the second plate (20) such that at least one well (11) of the first plate (10) communicates with at least one well (21) of the second plate (20).

Abstract: A unit for sampling aldehydes and ketones contained in diluted exhaust gases from thermal combustion engines has a specific trapping circuit and a simulation circuit that simulates the specific trapping circuit. The specific trapping circuit and the simulation circuit are arranged in parallel so that the diluted gases can be passed for some time in the simulation circuit (5) before they are passed into the specific trapping circuit wherein aldehydes and ketones are trapped.

Abstract: A common liquid measuring device for a plurality of similar fluids, soluble within each other, which, depending on the required fluid, are connected by means of an arrangement of valves to the corresponding supply line between supply tank and fuel dispenser. A screw spindle arrangement is selected as liquid measuring device.

Abstract: An apparatus for controllably varying the sample volume for each of a plurality of sample lines used with air monitoring equipment is disclosed. The sample volume is varied depending on the compound or compounds of interest sampled through each line. The flow volume from each sample line is determined and controlled by proportional time that an electrically actuated valve is open for that sampling line.

Abstract: A sampling system for capturing samples of trace elements in ambient air comprises a multi-port valve coupled to a plurality of sorbent tubes. Each tube is connected to the multi-port valve by means of pairs of the valve ports. The multi-port valve is constructed and operated in a predetermined sequence to create a flow path through the multi-port valve. The flow path directs an air sample to only one connected sorbent tube at a given time and for a given time interval.

Abstract: An air monitoring system is disclosed having an air monitoring unit with at least one sensor for measuring data of an air quality parameter and a computer for storing the air quality parameter data received from the sensor. The air monitoring unit may use an installed or a portable system, or a combination of both, for measuring the air quality parameters of interest. A remote data center may be provided, and the data may be uploaded to the data center from the unit by a communications media such as the Internet. Information or instructions may also be downloaded from the data center to the unit via the communications media for controlling or modifying the function of the unit. An expert system may be provided with the air monitoring system for controlling the unit. The information or instructions downloaded to the unit may be generated by the expert system.

Abstract: In an apparatus for providing a continuous integrity test for suction driven filtering membrane assemblies 10, a monitoring line 32 diverts a portion of permeate to a monitoring device 30 (e.g. a turbidimeter). Both ends 34, 36 of the monitoring line are connected to the permeate pipe 20 upstream from the permeate pump 26 and at points of relatively higher and lower pressures respectively, to cause fluid to flow through the monitoring line. The relatively higher and lower pressures may be caused by a source of head loss 38 (e.g. a valve) in the permeate line. The source of head loss may be adjusted to provide a required flow through the monitoring device by a control 43 communicating with a flow meter 42 in the monitoring line. Membrane assemblies may be individually monitored although many of them may be connected to a common permeate pump (FIG. 2).

Abstract: An method of, and an apparatus for, collecting a sample of a substance of interest, utilizes an apparatus having a device for collecting a vapor sample and a device for retaining a substrate. A substrate, having a working portion and a mounting portion, is mounted by the mounting portion of the substrate, whereby the working portion of the substrate is exposed for use. The apparatus so that the working portion of the substrate traverses surfaces of interest, to collect a particulate sample. A device for sampling vapor is operated to obtain a vapor sample. The vapor and particulate samples collected are analyzed.

Abstract: A water quality meter is composed of a plurality of water quality monitoring meters including analyzing units for analyzing water samples introduced from a water distribution pipe, each analyzing unit analyzing the water samples and a measuring cell, and a liquid introducing unit integrated with the analyzing units, which is composed of a single member in which a plurality of fluid flow paths for feeding various types of liquid including the water sample into the analyzing unit are formed. Furthermore, the cells and the plurality of three-dimensional fluid flow paths formed in the single member are fabricated by a micro-fabrication technique using photo-curing resin.

Abstract: A flow rate detector mechanism using variable Venturi therein, comprising: a variable flow rate generator, comprising: a core 11; and a variable Venturi 12; wherein a throat (flow passage) cross-sectional area defined between the core and the venturi is able to be changed by shifting relative positions of the core and the venturi in a direction of axes thereof, and further comprising a flow rate calculation processing portion 30 for calculating a flow rate based on the relative positions in the direction of the axes thereof and for outputting the calculated flow rate, thereby continuously changing the constant flow rate, without occurrence of any disturbance therein.

Abstract: An apparatus and method for transferring one or more liquid samples from a depot member uses a receiving member that supports at least one receptacle and has a plurality of orifices in fluid communication with the receptacle. The depot member has a plurality of wells. Each well has an opening at one surface of a depot member, through which the liquid sample is displaced. The liquid sample takes the form of a droplet having a convex meniscus at the surface of the depot member over the opening when displaced. The receiving member is lowered to a height above the surface such that the receiving member compresses the droplet until the droplet contacts the orifices of the receptacle. Thereafter, back pressure is activated to load the compressed droplet through the contacted orifices. The apparatus and method reduce the sensitivity to positioning errors since the compressed droplet contacts all of the orifices of the receptacle prior to loading into the receiving member.

Abstract: Methods and apparatus for depositing a high density biological or chemical array onto a solid support. Specifically, the apparatus is made up of a plurality of open ended channels collectively forming a matrix. The matrix has been redrawn and cut such that the pitch of the channels on the loading end is larger than the pitch of the channels on the liquid delivery end. The upper portion of each channel serves as a reservoir, while the opposing end, which has been formed by the redrawing process, is diametrically sized such that liquid in the reservoir is retained by capillary pressure at the delivery end. At any point along the height of the capillary reservoir device, all cross-sectional dimensions and areas are uniformly reduced. In other words, the on-center orientation of any two channels, also referred to as the pitch between 2 channels, measured as a function of the diameter of any cross section, is constant throughout the structure.

Abstract: Installation for analyzing the level of at least one element, from at least two initial gas sources (S1, S2, . . . ) in a sampling procedure, using at least one analyzer (A1, A2, . . . ) capable of analyzing the element, including: at least two sources (S1, S2, . . . ) of initial gases to be analyzed; at least two tapping lines (Lp1, Lp2, . . . ), each line being connected in its upstream part to one of the initial gas sources, and in its downstream part to a respective flow-directing component (V1, V2. . . ); at least two discharge lines (LE1, LE2, . . . ), each discharge line being connected in its upstream part to one of the directing components and in its downstream part to a discharge or to a storage point (E1, E2, . . . ); at least two secondary lines (Ls1, Ls2, . . .

Abstract: The invention relates to the transfer and distribution, notably in a biological or chemical analysis, of a small amount of liquid. The invention relates notably to a method which consists of providing a transfer tool (18) having at least one rod (10) whose lower surface (12) of pre-determined cross section is wettable and of which at least one side surface (14) is non-wettable; immersing the rod (10) into a reservoir containing a liquid, for a pre-determined period of time and at a pre-determined depth; removing the rod (10) from the reservoir so that a liquid drop is retained on the lower surface (12) of the rod (10); positioning the rod (10) over a receptor medium; and placing the drop in contact with a surface of a receptor medium. The invention also relates to the transfer tool (18) which has in its structure at least one rod (10) and to a method for making the transfer tool (18).

Abstract: A water quality meter is composed of a plurality of analyzing units for analyzing water samples introduced from a water distribution pipe, each analyzing unit including a reagent mixing cell and a measuring cell, and a liquid introducing unit integrated with the analyzing units, which is composed of a single member in which a plurality of fluid flow paths for feeding various types of liquid including the water sample into the analyzing unit are formed. Furthermore, the cells and the plurality of three-dimensional fluid flow paths formed in the single member are fabricated by a micro-fabrication technique using photo-curing resin.

Abstract: The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated.

Abstract: A fluid sampling device including a manifold having inputs, common purge and sampling pathways, valves disposed to couple and decouple a first set of the inputs to the common purge pathway and a second set of the inputs to the common sampling pathway, and a differential sensor coupled to the pathways. A controller connected to the valves produces control signals that enable the valves to couple and decouple the inputs to the common sensor and purge pathways. In addition, a method for operating a fluid sampling system that is connected to a set of sample zones that includes the steps of sampling fluid from first and second sample zones in respective first and second sample locations, isolating third and fourth sample zones from the first and second sample locations, and measuring a differential parameter across the sample locations.

Abstract: A sampling cell of flow-through type and use of such a sampling cell. The sampling cell is preferably manufactured by etching of silicon wafers. It is especially useful for continuous picovolume sampling in an analytical flow. The pressure pulse generator (9) generates pulses directly into a flow channel (3). The flow channel (3) is preferably formed by a first basin (4) in a first structure (1) and a second basin (5) in a second structure (2). In a first embodiment the pressure pulse generator (9) comprises at least one piezo-ceramic disc and/or devices acting by way of magnetostrictive, electrostatical or electromechanical forces and/or devices acting by way of thermal expansion. Method of directing samples from a flow-through sampling cell by establishing a difference in electrical potential between the liquid in the flow-through sampling cell and the object to which the samples are to be directed.

Abstract: A gas sampling system includes a sample trapping module having a gas pump and a power supply, and a removable magazine that fits within a port of the trapping module. The magazine contains a non-volatile electronic memory, which controls operation of the trapping module, and has a rotating carousel for holding sample tubes. Individual sample tubes are sealed at each end by a cap that has a needle-pierceable septum, and contain a solid collector material to trap chemical and biological contaminants in a gas sample drawn through the sample tube. Individual sample tubes are moved into and out of a sampling location by incremental rotation of the carousel and, while at the sampling location, a pair of hollow bore needles are inserted through the sample tube end caps to allow the drawing of a gas sample through the tube.