Piston And Cylinder Patents (Class 73/864.16)
  • Patent number: 10168343
    Abstract: A processing system for processing experiment of biochemistry, biology and/or biotechnology includes a manual pipette which includes a piston and suctions and discharges liquid when the piston of the manual pipette is moved by external drive force, an automatic pipette which includes a piston and a built-in actuator and suctions and discharges liquid when the piston of the automatic pipette is moved by the actuator, a robot including a robotic arm which selects and grasps the manual or automatic pipette based on an operation command, and a robotic arm control device including circuitry which controls the robot such that the robotic arm selects and grasps the manual or automatic pipette based on the operation command. The operation command includes a collection of jobs that controls processes for processing a processing target in an experiment of biochemistry, biology and/or biotechnology and a container containing the processing target in a processing order.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: January 1, 2019
    Assignee: KABUSHIKI KAISHA YASKAWA DENKI
    Inventors: Kohei Miyauchi, Makoto Umeno, Jiro Muraoka
  • Patent number: 9421327
    Abstract: A dosing unit for an infusion pump device is disclosed having a piston pump with a pump cylinder and a plunger arranged within said cylinder, coaxially arranged along a longitudinal axis. The plunger has a shaft with a thread and the cylinder has a threaded sleeve part with a thread. The two threads engaging with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in an additional linear displacement of the plunger along said longitudinal axis. A separate bias force element biases the two threads in regard to each other along the longitudinal axis, such that the threaded engagement of inner thread and outer thread is free of play independent of a direction of a rotational movement and linear displacement of the plunger in regard to the cylinder.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 23, 2016
    Assignee: Roche Diagnostics International AG
    Inventors: Hanspeter Niklaus, David Teutsch, Ulrich Haueter
  • Patent number: 9352319
    Abstract: A droplet dispensing apparatus has a piston rod driven by a solenoid, the rod for connection to a piston of a droplet dispensing syringe, in which the output member from the solenoid is directly connected to the rod through the entire impulse produced by the solenoid.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: May 31, 2016
    Assignee: TTP LabTech Limited
    Inventors: Anthony Douglas, Gary Cochrane
  • Patent number: 9295986
    Abstract: A pipette for use with pipette tips in which a set metering volume is secured in that the locking body is arranged on the circumference of the annular cylindrical locking element when it is in the locking position. Through this, the transmission part which the locking element comprises on the outer circumference is held fast. The annular cylindrical locking element can be formed separately from a toothed ring for driving a counter mechanism. Thus, it is possible to perform the locking in arbitrary positions or in more selectable rotational positions than in the conventional locking equipment, where a locking element engages into the toothed ring for driving the counter mechanism.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 29, 2016
    Assignee: EPPENDORF AG
    Inventors: Jens Wilmer, Ingo Winter
  • Publication number: 20150128685
    Abstract: The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 14, 2015
    Inventors: Adolf SATZINGER, Hermann HOCHGRAEBER, Thomas Armin Alexander EICHHORN
  • Publication number: 20150013476
    Abstract: An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, wherein the user interface comprises at least one touch screen for operating the pipetting operations of the pipette, which touch screen comprises at least one touching or pressing area for operating the pipetting operations of the pipette. The invention also relates to a method for operating an electronic pipette and a use of a touch screen as a part of a user interface of an electronic pipette for operating the pipetting operations of the pipette.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 15, 2015
    Inventors: Juha Telimaa, Mikael Lind
  • Patent number: 8900526
    Abstract: The present invention relates to a device for manually metering liquids, for example a pipette or a metering button. The device comprises a joint forming a seal between a hollow cylinder and a piston housed inside the cylinder, the piston being moved vertically so as to suck in or expel the liquid. During the metering operation, the joint remains fixed with respect to the movement of the piston and comprises parts formed by portions having dedicated geometric and mechanical characteristics which make it possible to locally optimize the functions of sliding, sealing and fastening in the cylinder.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: December 2, 2014
    Assignee: Socorex Isba S.A.
    Inventor: Jean-Pierre Uldry
  • Publication number: 20140331794
    Abstract: An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, wherein the user interface comprises features for defining at least one dilution variable for pipetting operations based on input pipetting operation variables of which one is dilution ratio.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 13, 2014
    Applicant: Thermo Fisher Scientific Oy
    Inventors: Suvi Berghall, Juha Telimaa, Mikael Lind
  • Patent number: 8839685
    Abstract: A syringe for use with a dosing device with a receiver for a syringe cylinder and an axially displaceable plunger receiver for a syringe plunger with a syringe cylinder, which has a floor with an outlet on the bottom, a cylindrical plunger run area on the inside and has means for being held in the receiver on the top, a syringe plunger, which has a circumferential plunger seal for sealing on the plunger run area on the perimeter and a coupling piece for insertion into the plunger receiver on the top and stop means between the syringe cylinder and the syringe plunger, which restrict the displacement of the syringe plunger towards the floor so that the syringe plunger with the plunger seal can only approach to a certain distance from the floor.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: September 23, 2014
    Assignee: Eppendorf AG
    Inventor: Jürgen Löhn
  • Patent number: 8802030
    Abstract: A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: August 12, 2014
    Assignee: Cybio AG
    Inventor: Adrian Siemers
  • Patent number: 8758705
    Abstract: The dispenser includes a dispensing head extending downward from a cylinder body section with a cylindrical inner space and having a dispensing cylinder with the diameter smaller than that of the inner space of the cylinder body section; a piston capable of being inserted from the inner space of the cylinder body section into the dispensing cylinder section and moving up and down between a dispensing start position located in an upper portion of the dispensing cylinder section and a dispensing end position in a lower portion of the dispensing cylinder section; and a sucking mechanism sucking a liquid from a dripping port at a tip of the dispensing cylinder section up to a position above the dispensing start position inside the inner space of the cylinder body section. The piston is always at the dispensing start position under a liquid surface whenever the dispensing operation is started.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 24, 2014
    Assignee: Medicatec Kabushiki-Kaisha
    Inventor: Hiroyasu Tsukioka
  • Publication number: 20140137672
    Abstract: A piston-operated pipette with a drive unit with a piston drive and a displacement unit mounted on the drive unit, the displacement unit being dismountable from the drive unit, the drive unit having an actuating drive for the piston drive and a receiving section for the displacement unit. The displacement unit has a fastening section which fits the receiving section of the drive unit, there being a first detachable mechanical connection between the actuating drive and the piston drive and there being a second detachable mechanical connection between the receiving section of the drive unit and the fastening section of the displacement unit. The second detachable mechanical connection is made as a magnetic connection. A mechanical arrangement for breaking the magnetic connection is provided between the receiving section and the fastening section, the magnetic connection being releasable by actuating the arrangement for breaking the magnetic connection.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 22, 2014
    Applicant: BRAND GMBH + CO KG
    Inventors: Steffen Gehrig, Günter Hochholzer, Burkard Schaub
  • Patent number: 8728408
    Abstract: The nozzle (3) is in its lower part formed respectively for receiving a pipette exchangeable tip (19) and is in its upper part releasably connected with the holder (2). In the holder (2) a pressure sleeve (6) is placed as being slidably borne in the holder (2). The pressure sleeve (6) is via a pressure sub-assembly seated in the holder (2) pressed to the sealing means placed between the pressure sleeve (6) and the nozzle (3). The plunger (1) is slidably borne in the pressure sleeve (6) and in the pressure sub-assembly. Due to this, leakproofness of the plunger (1) in the nozzle (3), which is indispensable for a correct and reliable pipette operation, is provided in PIPETTING, ADJUSTMENT or CALIBRATION MODES of the pipette. Simultaneously, in MAINTENANCE MODE of the pipette the sealing means automatically slide out from an abutting surface (2c) of the holder (2).
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: May 20, 2014
    Assignee: PZ HTL SPOLKA AKCYJNA
    Inventor: Tomasz Strzelczyk
  • Patent number: 8685342
    Abstract: A device for receiving and dispensing liquids has a plurality of piston-cylinder units (1, 1?, 1?) which are respectively arranged on a piston plate (2) and a cylinder plate (3). The liquid is received and dispensed by displacing the pistons (1?) in the cylinders (1?) by changing the distance between the plates (2, 3), perpendicularly to the plate planes, by means of a drive mechanism (6) and a plate guiding system. The volume can be determined by an upper abutment (4) and a lower abutment (5), at least one of said abutments being regulatable by a regulating means (8). The device is suitable for handling precise volumes of a larger number of piston-cylinder units (1, 1?, 1?) in a technically simple manner.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: April 1, 2014
    Inventors: Bernd Steinbrenner, Roger Steinbrenner
  • Patent number: 8679421
    Abstract: A dispensing device and an analyzer capable of improving dispensing accuracy as well as improving jamming detection accuracy can be realized by having a short distance between a syringe and a suction tip. The dispensing device 10 includes an upper fixed unit 10A, a lower movable unit 10B which is connected to the upper fixed unit 10A, the movable unit being relatively movable with respect to the upper fixed unit 10A, and a Z-axis movement mechanism 55Z which moves the upper fixed unit to and fro. A syringe 4 and a plunger 13 are held by the upper fixed unit 10A. A tip nozzle 8 is attached to the lower movable unit 10B. An interior space of the syringe 4 and an interior space of the tip nozzle 8 are connected with each other by a connection tube 1 having flexibility.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: March 25, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Minoru Sano, Kazutoshi Onuki, Yoshiyuki Shoji, Isao Yamazaki
  • Patent number: 8661920
    Abstract: A handheld pipetting apparatus for metering liquids, with a handleable pipette housing, at least one accommodation for a fastening portion of a syringe cylinder of a syringe, at least one plunger accommodation in an accommodation body for a plunger fastening portion of a syringe plunger of the syringe, syringe and plunger gripping levers for detachably holding the fastening portion in the accommodation and the plunger fastening portion in the plunger accommodation, at least one displacement device with a displacement chamber and a shiftable chamber wall limiting the same, for displacing a fluid; at least one seat for detachably holding a pipette point, a channel, connecting a hole in the seat with a displacement chamber, and at least one drive device, which is connected to couplable with the accommodation body the and/or the chamber wall, for shifting the accommodation body with respect to the accommodation, the and/or the chamber wall with respect to the displacement chamber.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: March 4, 2014
    Assignee: Eppendorf AG
    Inventors: Peter Molitor, Karl-Friedrich Andres, Steffen Hofmann, Heinz-Gerhard Köhn
  • Patent number: 8656792
    Abstract: A pipette device including a metering liquid receptacle designed to be filled, at least in part, with working fluid and which has a pipette opening as a first tapering of cross-section of flow, a pressure change device which is designed to change the pressure of the working fluid in the metering liquid receptacle, and a throttle point in a pipette duct designed to be filled with working fluid as a further tapering of cross-section of flow. The throttle point is arranged fluid-mechanically between the metering liquid receptacle and the pressure change device and is dimensioned in such a way that a ratio of a flow resistance of the pipette opening for dispensed metering liquid to a flow resistance of the throttle point for working fluid, which flows through the throttle point when the metering fluid is dispensed, is less than 0.5.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: February 25, 2014
    Assignee: Hamilton Bonaduz AG
    Inventors: Vinzenz Kirste, Helmut Knapp, Urs Lendenmann, Noa Schmid, Tobias Seiler, Fabian Winter
  • Patent number: 8652418
    Abstract: A pipette for a pipette system comprising a pipette and a syringe. The pipette housing has a longitudinal axis. A syringe to be handled with the pipette is insertable with its fastening portion and plunger head into the pipette housing and is removable or discardable from said pipette housing in the direction of the longitudinal axis of the pipette housing, i.e., axially. The syringe has as cylinder and a plunger with a plunger head which projects out of the end of the cylinder even when the plunger has been completely inserted into the cylinder. A pipette housing comprises an axially accessible plunger gripping device for the plunger head of the syringe. An actuating device for the plunger gripping device is mounted on the plunger displacing device and is axially displaceable with said adjusting device.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: February 18, 2014
    Assignee: Brand GmbH + Co KG
    Inventors: Renate Rempt, Dieter Böhm, Steffen Gehrig, Ottmar Kneucker
  • Patent number: 8623641
    Abstract: In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: January 7, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Nun Chen, Chun-Jen Liao, Chin-Yu Lin, Chin-Fu Chen, Yung-chih Wu
  • Patent number: 8616076
    Abstract: Testing the reliability of flexible separators arranged under conditions enabling the cycling rate of testing to be accelerated. According to the invention, two separators are enclosed in two rigid chambers, each defining a liquid capacity and a gas capacity. The two gas capacities communicate with each other, and each of the liquid capacities communicates with means for causing the volume of each of them to vary in alternation.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: December 31, 2013
    Assignee: Olaer Industries
    Inventor: Alain Houssais
  • Publication number: 20130283884
    Abstract: A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 31, 2013
    Applicant: The Regents of the University of Michigan
    Inventors: Justin Douglas Beroz, Anastasios John Hart
  • Patent number: 8570029
    Abstract: A metering apparatus for liquids and a method for metering liquids which facilitate the operation of a further metering after detaching the pipette point or syringe.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: October 29, 2013
    Assignee: Eppendorf AG
    Inventors: Karl-Friedrich Andres, Peter Molitor, Peter Schmidt
  • Patent number: 8557200
    Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter thus reducing the injuries resulting in repetitive stress injury to the thumb and hand. The new ergonomic pipette tip incorporates a separate sealing member constructed from an elastomer that is coupled to the more rigid and chemically inert elongated tubular member that becomes the receptacle for transferring the fluid sample aspirated by the pipetter. The new elastomeric sealing member allows for greater sealing capability or squeeze between the pipetter barrel and the new pipette tip while lowering the coefficient of friction between the mating parts, thus decreasing the axial ejection forces require to overcome the breakaway friction between the new ergonomic pipette tip and the pipetter.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: October 15, 2013
    Inventor: James C. Smith
  • Publication number: 20130239667
    Abstract: A syringe with a syringe cylinder and a syringe, with a seat for the syringe cylinder and an axially displaceable piston seat for the syringe piston, comprising an encoding on the syringe cylinder with encoding elements as protrusions and deepenings at seven encoding positions, checking elements in the form of further protrusions and further deepenings at seven checking positions, each being disposed between two encoding positions, wherein the encoding elements and the checking elements have six protrusions in total, and a guiding structure to align the syringe on a further guiding structure with each encoding element and with each checking element to a sensing element, said further guiding structure being disposed in the seat of the metering device and having a certain position with respect to an annular sensing device for sensing the encoding by sensing elements of the metering device that are across the circumference.
    Type: Application
    Filed: September 13, 2012
    Publication date: September 19, 2013
    Applicant: EPPENDORF AG
    Inventor: Jürgen Löhn
  • Patent number: 8529848
    Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 10, 2013
    Inventors: Ronald Danehy, Jorge Fonseca, Jayanthi Prasad
  • Patent number: 8524170
    Abstract: A sealing pipette tip includes features to seal the tip directly against the piston in an air displacement pipette, avoiding the need for a piston seal within the pipette. This configuration reduces potential points of failure, allows the pipette-tip interface to be optimized, and improves liquid handling characteristics of the pipette.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: September 3, 2013
    Assignee: Rainin Instrument, LLC
    Inventor: James S. Petrek
  • Patent number: 8475741
    Abstract: Provided is a droplet discharging device that can precisely dispense large flow rate of droplets and small flow rate of droplets selectively. The droplet discharging device according to the present invention includes a pneumatic discharger for discharging a droplet having a first flow rate, and an electronic pipette for discharging or sucking a droplet having a second flow rate equal to or smaller than the first flow rate. The pneumatic discharger includes, i) a storage chamber for storing a liquid, ii) an air tank connected to the storage chamber through a first air pipe and supplying compressed air to the storage chamber to push the liquid of the storage chamber outside, and iii) a first nozzle connected to the storage chamber through the liquid pipe and receiving the liquid pushed out of the storage chamber to discharge droplets.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: July 2, 2013
    Assignee: Postech Academy-Industry Foundation
    Inventors: Seongjin Cho, Geunbae Lim, Intae Kim
  • Patent number: 8408079
    Abstract: A pipette with a pipette housing, in which are arranged an accommodation for the fastening portion of a syringe cylinder of a syringe, a plunger accommodation in an accommodation body for a syringe plunger of the syringe, fastening devices for reversibly fixing the fastening portion and the syringe plunger in the accommodations, and plunger setting devices for shifting the accommodation body in the pipette housing, with a pull-up member for removing the accommodation body from the accommodation, and an actuation member for drawing the accommodation body near to the accommodation.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: April 2, 2013
    Assignee: Eppendorf AG
    Inventors: Burkhardt Reichmuth, Herbert Belgardt, Klaus Schuerbrock
  • Patent number: 8398934
    Abstract: A magnetic coupling system may be used in a fluid displacement apparatus to magnetically couple a drive shaft to a piston. The magnetic coupling system may include first and second magnetic couplers at the ends of the drive shaft and piston, respectively. The first magnetic coupler and second magnetic coupler may be configured to exert an attractive force. A bearing between the magnetic couplers reduces friction and side loading.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: March 19, 2013
    Assignee: Ivek Corporation
    Inventor: Douglas S. Bensley
  • Patent number: 8322577
    Abstract: A plunger for a syringe used to inject gas and liquid chromatography samples has an end portion surrounded by a flexible sleeve. The sleeve forms a seal in the bore of a barrel traversed by the plunger, the bore being in fluid communication with a cannula attached to the end of the barrel. The plunger has an end surface that is exposed and is flush with an annular end surface of the sleeve. The plunger end surface, and not the sleeve, contacts the cannula upon injection and avoids imposing cyclical hoop stresses on the barrel which tend to crack the barrel after a finite number of cycles. In a further embodiment, a thin layer of sleeve material covers the end surface of the plunger. The thin layer avoids inducing significant barrel stress.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: December 4, 2012
    Assignee: Agilent Technologies, Inc.
    Inventor: Ponna Pa
  • Publication number: 20120255378
    Abstract: The dispenser includes a dispensing head extending downward from a cylinder body section with a cylindrical inner space and having a dispensing cylinder with the diameter smaller than that of the inner space of the cylinder body section; a piston capable of being inserted from the inner space of the cylinder body section into the dispensing cylinder section and moving up and down between a dispensing start position located in an upper portion of the dispensing cylinder section and a dispensing end position in a lower portion of the dispensing cylinder section; and a sucking mechanism sucking a liquid from a dripping port at a tip of the dispensing cylinder section up to a position above the dispensing start position inside the inner space of the cylinder body section. The piston is always at the dispensing start position under a liquid surface whenever the dispensing operation is started.
    Type: Application
    Filed: August 30, 2011
    Publication date: October 11, 2012
    Applicant: MEDICATEC KABUSHIKI-KAISHA
    Inventor: Hiroyasu TSUKIOKA
  • Patent number: 8147773
    Abstract: A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: April 3, 2012
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Charles D. Lemme, Vincent R. Rizzo, Jr., Bobbi Druyor-Sanchez, Anthony Ford, Bronwen Heilman, Darin McDaniel, Brian McGraw, Stephen Mead, William Richards, Wayne Showalter
  • Patent number: 8133453
    Abstract: A plunger stroke pipette for replaceable pipette points with a seat for the detachable mounting of a pipette point, a plunger, a cylinder in which the plunger is movably arranged, a connection channel connecting the cylinder with an opening in the seat, a driving equipment, coupled to the plunger for displacing the plunger in the cylinder, an upper stopper and a lower stopper and at least one counter-stopper of the driving equipment and/or the plunger for limiting the stroke of the plunger, a holder, holding the lower stopper, an overstroke spring between the upper stopper and the holder, an adjustment equipment for adjusting the position of the holder with respect to the cylinder, and an indicating equipment for indicating the position of the holder.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: March 13, 2012
    Assignee: Eppendorf AG
    Inventor: Peter Molitor
  • Patent number: 8122779
    Abstract: A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: February 28, 2012
    Assignee: Integra Biosciences Corp.
    Inventors: Gary E. Nelson, George P. Kalmakis, R. Laurence Keene, Joel Novak, Kenneth Steiner, Jonathon Finger, Gregory Mathus, Richard Cote
  • Patent number: 8117927
    Abstract: A pipette is provided. The pipette includes a body, a piston, and a valve. The body includes a nozzle, a first chamber, a second chamber, and a channel formed in the nozzle. The first chamber is isolated from the second chamber, and the channel is isolated from the first chamber and the second chamber. The piston is mounted to slide within the first chamber and the second chamber so that movement of the piston simultaneously increases a first volume of the first chamber and decreases a second volume of the second chamber. The valve is in communication with the first chamber, the second chamber, the channel, and an exterior of the body to selectively provide a communication between the first chamber and the channel, between the second chamber and the channel, between the first chamber and the exterior of the body, and between the second chamber and the exterior of the body.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: February 21, 2012
    Assignee: Gilson SAS
    Inventors: Frédéric Millet, Hervé Malvoisin
  • Patent number: 8117928
    Abstract: This invention relates to a method for selecting a plunger-cylinder tip of a pipette and a device for carrying out the method. In the method, the dose size is entered into the control electronics of the pipetting device; the dose size is stored in the control electronics; the amount of doses is entered; and on the basis of the dose size and the amount of doses, the control electronics indicates suitable available interchangeable components on the display.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: February 21, 2012
    Assignee: Biohit Oyj
    Inventors: Osmo Suovaniemi, Erkki Vesanen
  • Publication number: 20120017704
    Abstract: Pipette device (10), at least for dispensing metering liquid by increasing the pressure of a working fluid, comprising a metering liquid receptacle (38) which is filled, at least in part, with working fluid and has a pipette opening (36) as a first tapering of cross-section of flow, through which metering liquid can be dispensed from the metering liquid receptacle (38) as a function of the pressure of the working fluid, and comprising a pressure change device (40) which is designed to change the pressure of the working fluid in the metering liquid receptacle (38), wherein the pipette device (10) comprises a throttle point (42) in a pipette duct (12) filled with working fluid during normal operation as a further tapering of cross-section of flow, said throttle point being arranged fluid-mechanically between the metering liquid receptacle (38) and the pressure change device (40) and being dimensioned in such a way that a ratio of a flow resistance (R1) of the pipette opening (36) for dispensed metering liquid t
    Type: Application
    Filed: July 26, 2011
    Publication date: January 26, 2012
    Applicant: Hamilton Bonaduz AG
    Inventors: Vinzenz KIRSTE, Helmut Knapp, Urs Lendenmann, Noa Schmid, Tobias Seiler, Fabian Winter
  • Patent number: 8088342
    Abstract: The invention provides hand-held pipettor in accordance with an embodiment that includes a piston that is received in one end of a cylinder, a pipettor tip that is removably secured to an opposite end of said cylinder, a manually driven unit that reciprocates the piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from the pipettor tip, a mechanism including a stepper motor responsive to control signals for adjusting a range of the stroke, and a voice recognition system that decodes verbal commands and outputs the result to a central processing unit, which in turn generates the control signals.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: January 3, 2012
    Assignee: Matrix Technologies Corporation
    Inventors: Richard Cote, Robert Henry Zier
  • Patent number: 8028591
    Abstract: Systems and methods are provided that can include a storage and retrieval robot operating under program control to extract a selective number of support beads from a storage or retainment region, for dispensing to titer wells or other vessels for assays and other purposes. According to various embodiments, the storage and retrieval robot can position a capture device over any one or more storage wells containing oligonucleotide or other material support beads, and withdraw or extract those support beads into a collection tube under vacuum pressure or other force. According to various embodiments, a selected number of support beads can be extracted, using a linear motor piston to limit available space for support bead insertion. According to various embodiments, the collected support beads can be dispensed into one or more destination tubes, wells, or other containers, surfaces, vessels, receptacles or mixture containment region, for use in assays or other purposes.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: October 4, 2011
    Assignee: Applied Biosystems LLC
    Inventor: Charles S. Vann
  • Patent number: 8028592
    Abstract: An electronic metering apparatus for metering liquids, with a longitudinal, handleable housing, a drive, arranged in the housing, with an electric motor, at least one displacer device, arranged in the housing or being capable to be arranged on the same, with a displacer element, which is connected to the drive and/or connectable to the same, at least one holding device on the bottom end of the housing for holding a pipette point or a syringe, at least one electric operational control in or on the housing, at least one electric information device in or on the housing, an electric control unit arranged in the housing, which is connected to the electric motor, the electric operational control and the electric information device, and which controls the information device depending on the position and/or previous changes of the position of the displacer element, in order to put out an information concerning the next reasonable dislocation of the displacer element, and an electric power supply.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: October 4, 2011
    Assignee: Eppendorf AG
    Inventors: Peter Molitor, Karl-Friedrich Andres, Peter Schmidt
  • Patent number: 8030063
    Abstract: An apparatus for vitrifying a biological specimen includes a cap member, a tubular plunger, and a specimen chamber. The cap member includes a stem portion integrally formed with a receiving portion. The receiving portion has a disc-like shape and includes an outer surface. The outer surface includes a first skirt member comprised of a heat-sealable material. The first skirt member is attached along a circumferential portion of the outer surface. The specimen chamber has an open first end portion, a closed second end portion, and a cavity extending between the first and second end portions. The cavity is defined by oppositely disposed inner and outer surfaces. The specimen chamber further includes a second skirt member comprised of heat-sealable material. The second skirt member is attached along a circumferential portion of the outer surface.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 4, 2011
    Assignee: The Cleveland Clinic Foundation
    Inventors: Amr Farouk Abdel Kader, Tomasso Falcone, Helmuth Kotschi
  • Publication number: 20110181272
    Abstract: A metering apparatus for liquids and a method for metering liquids which facilitate the operation of a further metering after detaching the pipette point or syringe
    Type: Application
    Filed: October 28, 2010
    Publication date: July 28, 2011
    Applicant: EPPENDORF AG
    Inventors: Karl-Friedrich Andres, Peter Molitor, Peter Schmidt
  • Patent number: 7947234
    Abstract: A handheld multichannel pipette includes multiple fluid-handling nozzles and a rotary adjustment mechanism for adjusting the width of a pattern of nozzles while maintaining equal spacing between pairs of nozzles. Embodiments of the adjustable-spacing multichannel pipette include an adjustable stop mechanism.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: May 24, 2011
    Assignee: Rainin Instrument, LLC
    Inventors: Kenneth P. O'Connell, Nicholas R. Vitale
  • Patent number: 7947512
    Abstract: The invention relates to a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, and aims at providing a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, with high quantitativity and capable of suppressing the scale of the device and efficiently utilizing working space, despite the relatively large volumes of fluid handled. The construction comprises: a small diameter section, a large diameter section which communicates with the small diameter section and is capable of holding fluids, a sliding section provided in a slidable manner within the large diameter section which enables fluid to be sucked and discharged to and from the large diameter section through the small diameter section, and a connection section which connects the sliding section in a detachable manner to a suction and discharge mechanism which drives the sliding section.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: May 24, 2011
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Yoshinao Hirahara
  • Patent number: 7914462
    Abstract: A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: March 29, 2011
    Assignee: Cytyc Corporation
    Inventors: Timothy Hutchins, Hal Watts, Steven Scampini, Eric Grimes, Andrew H. Fischer
  • Patent number: 7819030
    Abstract: A hybrid manual-electronic pipette combines a manually driven piston with real-time electronic measurement of liquid volume and piston displacement while compensating for both pipette-specific and pipette model-specific variations. The hybrid nature of the pipette facilitates increased accuracy and improved ease of use, and enables additional functionalities not practicable with traditional manual pipettes.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: October 26, 2010
    Assignee: Rainin Instrument, LLC
    Inventors: Haakon T. Magnussen, James S. Petrek, William D. Homberg
  • Publication number: 20100266454
    Abstract: A metering device for utilisation with a syringe, which features on a syringe cylinder a fastening portion with at least one axially directed sensing surface projecting from the upside, and at least one alignment nose projecting from the outer perimeter of the fastening portion, and a plunger with a plunger rod, the metering device having an accommodation for the fastening portion of the syringe cylinder, the accommodation having an axial opening for axially inserting the fastening portion into a fastening position, a sensing device disposed in the accommodation with at least one sensing means projecting from a basis surface of the sensing device facing the axial opening, for sensing the at least one sensing surface of a fastening portion inserted in a fastening position.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 21, 2010
    Applicant: EPPENDORF AG
    Inventor: Burkhardt REICHMUTH
  • Patent number: 7788986
    Abstract: A hybrid manual-electronic pipette combines a manually driven piston with real-time electronic measurement of liquid volume and piston displacement while compensating for both pipette-specific and pipette model-specific variations. The hybrid nature of the pipette facilitates increased accuracy and improved ease of use, and enables additional functionalities not practicable with traditional manual pipettes.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: September 7, 2010
    Assignee: Rainin Instrument, LLC
    Inventors: Haakon T. Magnussen, James S. Petrek, William D. Homberg, Christian K. Apple
  • Publication number: 20100199789
    Abstract: A hybrid manual-electronic pipette combines a manually driven piston with real-time electronic measurement of liquid volume and piston displacement while compensating for both pipette-specific and pipette model-specific variations. The hybrid nature of the pipette facilitates increased accuracy and improved ease of use, and enables additional functionalities not practicable with traditional manual pipettes.
    Type: Application
    Filed: April 26, 2010
    Publication date: August 12, 2010
    Applicant: RAININ INSTRUMENT, LLC
    Inventors: Haakon T. Magnussen, Andrew Vainshtein, James S. Petrek, William D. Homberg
  • Patent number: 7727478
    Abstract: A system including an inspection chip equipped with at least a pump connection having a flow path opening for interconnecting to a micro-pump, a flow path through which a fluid flows, and a fluid mixing section for joining and mixing two or more fluids, and including a system body equipped with at least a base body, a chip connection having a flow path opening for interconnecting to the inspection chip, a micro-pump unit in the base body including micro-pumps in substantially the same shape, a detection processor and a controller for controlling at least the functions of the micro-pump unit and the detection processor, and the joining amount ratio is adjusted to set the mixing ratio of two fluids to be joined in the fluid mixing section to be approximately m:n (not 1:1) by making the drive voltages of the micro-pumps substantially equal to each other.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: June 1, 2010
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Kusunoki Higashino, Akihisa Nakajima, Yasuhiro Sando