Plural Patents (Class 73/864.17)
  • Patent number: 8808644
    Abstract: Automated apparatus and methods for dispensing fluids into microplates utilizing microwell covers, the covers comprising open portions to allow a pipette access to one or more wells and impermeable portions which prevent the fluids from getting into wells shielded by the impermeable portion. The open portions and impermeable portions are preferably arranged and sized to align with alternating rows of wells in a particular microplate. Preferred covers are movably positioned on the microplate. Automated dispensing apparatus for use with microplates and microwell covers comprises a programmable controller, and suitable interfaces which allow the apparatus to be programmed, and which control a dispensing head such that pipettes are moved in the desired manner in order to take advantage of the protective features of the microwell covers. The apparatus also preferably comprises at least one transfer mechanism for moving a cover relative to a microplate at a dispensing station.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: August 19, 2014
    Assignee: Biochemical Diagnostics, Inc.
    Inventor: Allen I. Panetz
  • Patent number: 8802030
    Abstract: A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: August 12, 2014
    Assignee: Cybio AG
    Inventor: Adrian Siemers
  • Patent number: 8758705
    Abstract: The dispenser includes a dispensing head extending downward from a cylinder body section with a cylindrical inner space and having a dispensing cylinder with the diameter smaller than that of the inner space of the cylinder body section; a piston capable of being inserted from the inner space of the cylinder body section into the dispensing cylinder section and moving up and down between a dispensing start position located in an upper portion of the dispensing cylinder section and a dispensing end position in a lower portion of the dispensing cylinder section; and a sucking mechanism sucking a liquid from a dripping port at a tip of the dispensing cylinder section up to a position above the dispensing start position inside the inner space of the cylinder body section. The piston is always at the dispensing start position under a liquid surface whenever the dispensing operation is started.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 24, 2014
    Assignee: Medicatec Kabushiki-Kaisha
    Inventor: Hiroyasu Tsukioka
  • Patent number: 8685342
    Abstract: A device for receiving and dispensing liquids has a plurality of piston-cylinder units (1, 1?, 1?) which are respectively arranged on a piston plate (2) and a cylinder plate (3). The liquid is received and dispensed by displacing the pistons (1?) in the cylinders (1?) by changing the distance between the plates (2, 3), perpendicularly to the plate planes, by means of a drive mechanism (6) and a plate guiding system. The volume can be determined by an upper abutment (4) and a lower abutment (5), at least one of said abutments being regulatable by a regulating means (8). The device is suitable for handling precise volumes of a larger number of piston-cylinder units (1, 1?, 1?) in a technically simple manner.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: April 1, 2014
    Inventors: Bernd Steinbrenner, Roger Steinbrenner
  • Patent number: 8616076
    Abstract: Testing the reliability of flexible separators arranged under conditions enabling the cycling rate of testing to be accelerated. According to the invention, two separators are enclosed in two rigid chambers, each defining a liquid capacity and a gas capacity. The two gas capacities communicate with each other, and each of the liquid capacities communicates with means for causing the volume of each of them to vary in alternation.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: December 31, 2013
    Assignee: Olaer Industries
    Inventor: Alain Houssais
  • Patent number: 8529848
    Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 10, 2013
    Inventors: Ronald Danehy, Jorge Fonseca, Jayanthi Prasad
  • Patent number: 8518345
    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: August 27, 2013
    Assignee: Integra Biosciences Corp.
    Inventors: David E. Butz, Gregory Mathus, Richard Cote, George P. Kalmakis
  • Patent number: 8420027
    Abstract: A dosing device for liquids, with a distributor rail and a plurality of dosing units for the liquid that are hydraulically connected to the replaceable distributor rail. Each dosing unit has a valve unit, preferably a suction valve, a discharge valve and a discharge cannula. A piston-cylinder unit is detachably arranged on each valve unit for drawing in and measured discharging of the liquid. Each valve unit has a hydraulic connection element for detachable hydraulic connection to the distributor rail. The distributor rail has an elongate fluid supply line, a supply connection for the liquid being provided on an end of the distributor rail and dosing unit connections being distributed laterally along the length of the rail. Each of the dosing unit connections are detachably coupled to the hydraulic connection elements of the dosing units. The distributor rail is a replaceable part made of a preferably recyclable, injection-moldable plastic.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: April 16, 2013
    Assignee: Brand GmbH + Co KG
    Inventors: Peter H. Mahler, Thomas Stricker, Harry Siebert, Eberhard Albrecht
  • Patent number: 8371181
    Abstract: A continuous flow syringe pump includes a first syringe configured for at least one of loading or dispensing at least one fluid, a second syringe configured for at least one of loading or dispensing the at least one fluid, and a first valve connected to the first syringe and the second syringe. The continuous flow syringe pump also includes a second valve connected to the first valve. The continuous flow syringe pump further includes at least one outlet connected to the first valve. The at least one outlet is configured to alternate output of the at least one fluid between the first syringe and the second syringe in a substantially continuous operation.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: February 12, 2013
    Assignee: Elemental Scientific, Inc.
    Inventor: Daniel R. Wiederin
  • Patent number: 8245586
    Abstract: For aspiration and dispensation of a metering fluid, a pipetting apparatus comprises a work fluid which differs from the former, the work fluid being accommodated in a work space with a variable volume which extends along a channel axis and, with reference to the latter, is formed by a piston-cylinder system at least along an axial section of the channel axis, having a cylinder which delimits the work space along a cylinder section in the radial direction and a piston which delimits the work space in a first axial direction, the cylinder and the piston being arranged so that they can move with respect to each other such that the piston-cylinder system has an axial longitudinal end region for metering, which is open for aspiration and dispensation, and an axial longitudinal end region for work which is closed by the piston, the piston being designed as an outer piston and surrounding the cylinder on the outside in the longitudinal end region for work of the piston-cylinder system.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: August 21, 2012
    Assignee: Hamilton Bonaduz AG
    Inventors: Armin Panzer, Patrick Schelling
  • Patent number: 8201466
    Abstract: A device for use in a multi-channel pipetting system is provided. The device includes a body, a plurality of modules mounted to the body, a plurality of pistons mounted to a piston holder for simultaneous movement of the plurality of pistons in a first direction, and a guidance assembly. Each module includes an orifice connecting to an intake chamber. A piston extends into the intake chamber for movement in the first direction. The guidance assembly includes a first rotating element, a second rotating element, a shaft connecting the first rotating element to the second rotating element, and a first track and a second track extending parallel to the first direction. The shaft extends in a second direction orthogonal to the first direction. The first rotating element is mounted to roll along the first track, and the second rotating element is mounted to roll along the second track simultaneously with the plurality of pistons.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 19, 2012
    Assignee: Gilson S. A. S.
    Inventor: Bernard Roussel
  • Patent number: 8128892
    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: March 6, 2012
    Assignee: Integra Biosciences Corp.
    Inventors: David E. Butz, Gregory Mathus, Richard Cote, George P. Kalmakis
  • Patent number: 8088342
    Abstract: The invention provides hand-held pipettor in accordance with an embodiment that includes a piston that is received in one end of a cylinder, a pipettor tip that is removably secured to an opposite end of said cylinder, a manually driven unit that reciprocates the piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from the pipettor tip, a mechanism including a stepper motor responsive to control signals for adjusting a range of the stroke, and a voice recognition system that decodes verbal commands and outputs the result to a central processing unit, which in turn generates the control signals.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: January 3, 2012
    Assignee: Matrix Technologies Corporation
    Inventors: Richard Cote, Robert Henry Zier
  • Patent number: 8029742
    Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: October 4, 2011
    Assignee: Integra Biosciences Corp.
    Inventors: David E. Butz, Gregory Mathus, Richard Cote, George P. Kalmakis
  • Patent number: 8011257
    Abstract: A multichannel pipette, including a grip part defining a longitudinal axis and including a piston-driving device movable axially thereon, a displacement part rotating about the axis and having cylinder and piston arrangements, and a connection device for detachably connecting the grip part to the displacement part and permitting a rotation of the displacement about the longitudinal axis. The connection device includes threaded connection elements engaged with one another. The pistons move axially to the cylinders via a piston-driving device. A connection part of the threaded elements is axially connected with the cylinders and includes a clearance for a rotary bearing provided therein. Form-fit configurations on the support and connection parts are engaged to prevent a reverse rotation of the connection part relative to the support part. By a manual release action, the form-fit configurations disengage, such that the connection part rotates in a reverse rotation relative to the support part.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: September 6, 2011
    Assignee: Brand GmbH + Co KG
    Inventors: Ottmar Kneucker, Michael Ertl
  • Patent number: 7947512
    Abstract: The invention relates to a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, and aims at providing a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, with high quantitativity and capable of suppressing the scale of the device and efficiently utilizing working space, despite the relatively large volumes of fluid handled. The construction comprises: a small diameter section, a large diameter section which communicates with the small diameter section and is capable of holding fluids, a sliding section provided in a slidable manner within the large diameter section which enables fluid to be sucked and discharged to and from the large diameter section through the small diameter section, and a connection section which connects the sliding section in a detachable manner to a suction and discharge mechanism which drives the sliding section.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: May 24, 2011
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Yoshinao Hirahara
  • Patent number: 7943393
    Abstract: The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the method involves adjusting the head pressure of the column during the process, or otherwise controlling or regulating the head pressure.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: May 17, 2011
    Assignee: PhyNexus, Inc.
    Inventors: Douglas T. Gjerde, Ronald Jones, Allen Burge
  • Publication number: 20110088493
    Abstract: Syringe for use with a metering device comprising a centring element with an axial through-passage in a receiver for a syringe cylinder and an axially displaceable piston receiver for a syringe piston, comprising syringe cylinder syringe piston, the syringe cylinder comprising an outlet at the bottom, centring flange at the top on the external periphery for inserting into the receiver, cylindrical piston movement area connected to the outlet, with a first internal diameter, in which the syringe piston is sealingly guided, and at least at a distance of at least 3 mm from the upper end of the syringe cylinder a centring region for inserting the centring element, which has a second internal diameter, which exceeds the first internal diameter and is at least 16.2 mm, the syringe piston at the upper end has a coupling piece for inserting into the piston receiver.
    Type: Application
    Filed: July 26, 2010
    Publication date: April 21, 2011
    Applicant: EPPENDORF AG
    Inventors: Michael Blumentritt, Juergen Loehn
  • Patent number: 7727478
    Abstract: A system including an inspection chip equipped with at least a pump connection having a flow path opening for interconnecting to a micro-pump, a flow path through which a fluid flows, and a fluid mixing section for joining and mixing two or more fluids, and including a system body equipped with at least a base body, a chip connection having a flow path opening for interconnecting to the inspection chip, a micro-pump unit in the base body including micro-pumps in substantially the same shape, a detection processor and a controller for controlling at least the functions of the micro-pump unit and the detection processor, and the joining amount ratio is adjusted to set the mixing ratio of two fluids to be joined in the fluid mixing section to be approximately m:n (not 1:1) by making the drive voltages of the micro-pumps substantially equal to each other.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: June 1, 2010
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Kusunoki Higashino, Akihisa Nakajima, Yasuhiro Sando
  • Patent number: 7727476
    Abstract: A device for aspirating and dispensing liquid samples comprising a pump that comprises a cylindrical chamber, a piston movable in this cylindrical chamber, and a piston drive that engages the piston. The device further comprises a tip connected to the cylindrical chamber with a line, and a channel system that discharges into the cylindrical chamber for flushing or rinsing the latter. The device is characterized in that the piston entirely seals this cylindrical chamber from the channel system, if the piston is positioned in the cylindrical chamber in such a way that a free piston end comes to rest between the channel system and the line. Preferably, the cylindrical chamber is located in a cylinder block, which comprises two parts that are separated by and enclosing an intermediate channel system. The channel system most preferably is implemented as a coherent cavity. According to a first embodiment, the cylindrical chamber is implemented as a sleeve that is inserted in a boring located in a cylinder block.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: June 1, 2010
    Assignee: Tecan Trading AG
    Inventors: Nikolaus Ingenhoven, Noa Schmid, Stefano Fornito
  • Patent number: 7709268
    Abstract: A positive displacement type substance sampling and dispensing device comprises a central plunger formed from a first material. A plunger housing is formed from a second material having a melting point lower than the first material, the housing being formed by molding and setting the second material on to the surface of the plunger so that the plunger can slide in the housing to draw a substance into it.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: May 4, 2010
    Assignee: TTP Labtech Limited
    Inventors: Thomas Richard Kerby Edwards, John Cassells, Nicholas Ian Mounteney, Gerald Avison
  • Patent number: 7687033
    Abstract: A tip mounting position, an aliquoting position, a dispensing position, and a tip casting position are circumferentially arranged around a rotating shaft, and a plurality of aliquoting/dispensing mechanisms are circumferentially arranged corresponding to the plurality of operating positions around the rotating shaft. Each aliquoting/dispensing mechanism is provided with a nozzle lift mechanism and a nozzle mechanism that includes a nozzle lift mechanism and a nozzle portion. The rotating shaft is intermittently rotated to locate the aliquoting/dispensing mechanisms individually in the positions whereupon tip mounting, aliquoting, dispensing, and tip casting operations are performed continuously.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 30, 2010
    Assignee: IDS Co., Ltd.
    Inventor: Teruaki Itoh
  • Patent number: 7655187
    Abstract: The present invention provides systems for isolating toxins and collecting an eluate from a sampling column for subsequent testing and to methods of extracting and collecting an eluate using the same systems. Preferably, the systems comprise a sample holder such as an immuno-affinity column for holding the sample and a self-contained fluid delivery system that can deliver liquid, e.g., reagents, and gaseous fluids, e.g., compressed air. More preferably, the fluid control system of the fluid delivery system provides some amount of pressurized gas continuously to the headspace of the column even when a fluid is not being forced through the resin gel in the column.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: February 2, 2010
    Assignee: Waters Technologies Corporation
    Inventors: Dennis E. Jackson, Nancy Zabe
  • Patent number: 7536926
    Abstract: A self contained dispensing head apparatus wherein a modified pipette tip box tray carrier is utilized to furnish pipette tips, carried in a standard pipette tip box, by a pipette tip box tray carrier to the head apparatus and wherein means are provided to engage the pipette tip box tray carrier in a manner whereby the pipette tips are loaded into corresponding internal cylinders formed in the dispense block head. The dispense block head comprises a solid block of material having a plurality of internal cylinders to engage the pipette tips in a sealing arrangement. The pipette tips are modified from the conventional design in that a disk-shaped ring portion is interposed adjacent one end of the pipette tip, a tapered end of the tip allowing a seal to be formed with the dispense block head internal cylinders.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 26, 2009
    Assignee: PerkinElmer LAS, Inc.
    Inventor: Richard A. Carl
  • Patent number: 7470402
    Abstract: The invention relates to an automatic precision pipetting device. The inventive device comprises at least two cylinder/piston-type pumping units (1, 2), the rods of which are rotated by means of a common motor unit (MP). Moreover, the pumping chamber of each of the pumping units (1, 2) is connected to a circuit comprising, successively, a conduit that opens into a container of rinsing liquid (RL), three successive solenoid valves (EV1, EV2, EV3) and a portion of circuit which connects the second solenoid valve (EV2) with the pipetting means (AP). The larger pumping chamber is connected in the part of the circuit that provides the connection between the two solenoid valves (EV1, EV2) while the second pumping chamber is connected to the above-mentioned portion of circuit by means of a connector, said portion of circuit comprising a solenoid valve (EV3) which is disposed between said connector and the aforementioned pipetting means.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: December 30, 2008
    Assignee: Stago Instrument
    Inventors: Khaled Abou Saleh, Alain Rousseau
  • Patent number: 7270789
    Abstract: In a preferred embodiment, a pipettor head, including: a body; one or more solenoid valves disposed in the body; each one or more solenoid valves having an outlet at a lower end and an inlet at an upper end; each one or more solenoid valves having an outlet attached to a dispensing passageway; each one or more solenoid valves having its inlet attached to a standpipe; and the standpipe having an open top communicating with an interior of a closed vacuum/pressure chamber defined in the pipettor head, the closed vacuum/pressure chamber being arranged such that vacuum or pressure may be selectively applied to the closed vacuum/pressure chamber. A method of using the pipettor head is also provided.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: September 18, 2007
    Inventor: Thomas W. Astle
  • Patent number: 7223370
    Abstract: Device for automatically implementing the SPE method, with a two-dimensional needle arrangement which is suitable for removing substances from different two-dimensional specimen vessel arrangements and dispensing them under pressure into a two-dimensional cartridge arrangement.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: May 29, 2007
    Assignee: CyBio AG
    Inventors: Thomas Moore, Uwe Naumann, Wolfgang Kraemer, Peter Zimmermann, Sebastian Pobering, Holger Licht, Gerd Ebert, Ralf Thiericke, Ingrid Schmid
  • Patent number: 6953552
    Abstract: The present invention relates to a spotting device for fabricating microarrays of biological materials and a spotting pin inserted therein. More particularly, the present invention is directed to a spotting device, which comprises several pins and pin-guiding holder that allows the pins to move accurately and rectilinearly toward up-down direction by guiding and supporting pins at several points, and spotting pins inserted therein.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: October 11, 2005
    Inventors: Park Han-Oh, Kim Hang-Rae, Ahn Jung-Wook, Song Gu-Young, Oh Gui-Hwan, Cho Yun-Seok, Choi Il-Kyu
  • Patent number: 6931948
    Abstract: A multiple pipette (X) comprising a first pipette (1) and a second pipette (2), wherein the first pipette (1) allows a liquid stored in a liquid storing section (17a) to be delivered a plurality of times by a fixed amount each and the second pipette (2) allows a liquid drawn in from outside to be delivered all at a time. The first pipette (1) is designed to deliver a liquid a plurality of times by a fixed amount each, e.g., by utilizing a ratchet mechanism (12d, 13a). The first pipette (1) preferably has a cap (19) removably attached to the front end thereof.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: August 23, 2005
    Assignee: Arkray, Inc.
    Inventors: Shigeru Doi, Naoki Nokoshimatsu, Hideki Nishimura
  • Patent number: 6869571
    Abstract: A device (1) for aspirating and dispensing liquid samples having a pump (2), which comprises a cylindrical chamber (3), a piston (4) movable in this cylindrical chamber, and a piston drive (5) engaging on the piston. The device additionally comprises a pulse generator (6), which effects dispensing of samples from a liquid by generating pressure waves in this liquid and a tip (8) connected via a line (7) with the cylindrical chamber (3), with the piston drive (5) comprising a first drive (9) and a second drive (10), implemented as a pulse generator (6). Such a device comprises a channel (27) for rinsing or flushing the cylindrical chamber (3), with the channel (27) discharging into the cylindrical chamber (3). Furthermore, the invention also concerns systems with, for example, 384 or more such devices that are arranged in an array.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: March 22, 2005
    Assignee: Tecan Trading AG
    Inventors: Nikolaus Ingenhoven, Noa Schmid, Stefano Fornito
  • Patent number: 6846680
    Abstract: The present invention provides a liquid handling system capable of automated dispensing and reformatting operations by virtue of a quick-release cannula array mounting system that permits cannula arrays to be changed automatically by the system or manually by a user. Automated changing of the cannula array is carried out by relative movement of the dispensing head and the sample support surface to deliver the attached cannula array to a storage location, releasing the array from the dispensing head, and attaching a new cannula array. Relative movement between the dispensing head and sample support surface in at least two dimensions increases flexibility of the system and makes self-loading of the cannula array practical. The system provides advantages in time and accuracy of cannula array changeover procedures. The automated cannula array changeover capability permits automated wellplate reformatting procedures, which can be performed quickly and accurately.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: January 25, 2005
    Assignee: Caliper Life Sciences, Inc.
    Inventors: David R. Friswell, Raymond Dunlap, George Grubner, Enrique Bernal
  • Publication number: 20040231438
    Abstract: An air-filled pipette for accurately metering small and large volumes of fluid samples is provided. The pipette has dual resolution capability such that the pipette can accurately aspirate a wide range of sample volumes and deliver them contact-free (touchless). The pipette may include an extension mandrel that reduces air space in a disposable tip within the pipette. The dual resolution capability and/or the extension mandrel a minimize errors associated with the compressibility of air. Multiple pipettes may also be arranged to form a pipetting module for the metering of multiple sample volumes simultaneously and automatically. The pipette includes a channel block having at least one cylindrical passage, that slides up and down over a rod, and a cylinder, with an axially extending passage therethrough, that is sized, shaped and aligned to fit into the cylindrical passage in a dynamic sealing relationship. A method for mixing multiple fluid samples within a pipette tip is also provided.
    Type: Application
    Filed: October 24, 2003
    Publication date: November 25, 2004
    Applicant: DRD Dilutor Corporation
    Inventor: H. Donald Schwartz
  • Publication number: 20040226389
    Abstract: A pipette control arrangement consists of a housing assembly adapted for operatively housing a pump assembly and for operatively connecting a pipette to the pump assembly via a flexible air tube. The pump assembly is adapted to independently accommodate a plurality of volume specific removable cylinder-plunger systems. The pipette control arrangement may further include a quick release trigger operated mechanism for rapidly and or in large volumes dispensing liquid from an attached pipette.
    Type: Application
    Filed: May 12, 2003
    Publication date: November 18, 2004
    Inventors: Paul Thom, Douglas W. Harrison, Francis Gomes, David Landsberger
  • Patent number: 6780648
    Abstract: A method comprises positively displacing a first candidate luminescence material precursor from a dispenser to a first position of an array, displacing a second candidate luminescence material precursor from a dispenser mechanism to a second position of an array and simultaneously reacting the first and second candidates to produce a library of luminescence materials. A combinatorial high throughput screening liquid dispenser assembly comprises a battery of positive displacement driven dispensers for dispensing solutions of precursor luminescence materials, an array plate with wells to receive dispensed solution from the dispenser, a robotic positioning table supporting the array plate to position wells beneath respective dispensers and a controller to control dispensing of the solutions and positioning of the plate.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: August 24, 2004
    Assignee: General Electric Company
    Inventor: Xiao-Dong Sun
  • Publication number: 20040123681
    Abstract: An automatic fluid sampler includes a substantially watertight housing and a structure for drawing fluid from outside the housing, wherein the fluid drawing structure is powered by stored potential energy within the housing. A method of automatic fluid sampling employs such samplers, and a fluid sampling system includes a plurality of interconnected samplers.
    Type: Application
    Filed: July 18, 2003
    Publication date: July 1, 2004
    Inventors: Ray Gerald Thomas, Jonathan Bowman Martin, Kevin Martin Hartl
  • Patent number: 6659142
    Abstract: A system and method for preparing and dispensing fluid mixtures is provided. Fluid wells are positioned below a plurality of fluid dispensing devices, such as syringes configured to dispense fluid into the individual fluid wells. The fluid dispensing devices are configured to be positionable relative the fluid wells to enable different fluid dispensers to be sequentially positionable over a particular fluid well. A controller controls the relative movement between fluid wells and the fluid dispensing devices. In a preferred embodiment, the controller selectively moves multi-well vessels in one direction and moves the fluid dispensing devices in a second direction so that when directed by the controller, a selected fluid dispensing device is enabled to deposit a determined quantity of a fluid into a selected individual well of the multi-well vessels.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 9, 2003
    Assignee: IRM, LLC
    Inventors: Robert Charles Downs, Mark Richard Weselak
  • Patent number: 6644364
    Abstract: A multi-channel fluid dispenser includes a reservoir (106) with multiple internal chambers (844) with ports (850) to fill each chamber (844), a multi-channel liquid dispensing head, a plurality of fluid-delivery conduits, and support and positioning elements.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: November 11, 2003
    Assignee: Pharmacopeia, Inc.
    Inventor: Ilya Feygin
  • Patent number: 6627157
    Abstract: A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: September 30, 2003
    Assignee: UT-Battelle, LLC
    Inventors: Mitchel J. Doktycz, William Louis Bryan, Reid Kress
  • Patent number: 6627160
    Abstract: A multiple channel pipetting device and pipette shaft, in which each pipette shaft has a circumferential seal receptacle inside, at its upper end in which the circumferential plunger seal is positioned and in which the circumferential plunger seal, at least in the case of a pulled back pipette plunger, definitely remains in the seal receptacle when the pipetted shaft is removed from the shaft carrier.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: September 30, 2003
    Assignee: Brand GmbH + Co. KG
    Inventor: Jurgen Wanner
  • Patent number: 6607662
    Abstract: The present invention provides an apparatus for purifying nucleic acids such as DNA and RNA or proteins such as enzymes and antibodies from microorganisms such as viruses and bacteria or animal and plant tissues, the apparatus being capable of fast processing of a plurality of samples.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: August 19, 2003
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Katsunori Ikeda, Yoshiaki Nishiya, Masahiro Kusumoto, Masahiro Suzuki, Yoshihisa Kawamura
  • Patent number: 6582664
    Abstract: The invention provides multichannel pipette heads and autopipettors for loading, measuring, transporting and dispensing, particularly from one micro-plate to another. An exemplary multichannel pipette head comprises a pump housing, pistons, a drive plate, an aspiration drive and bearing rails, wherein the pump housing comprises chambers adapted to receive the pistons, the pistons each comprise a shaft, the drive plate retains the pistons and translocates the piston shafts through the chambers, the aspiration drive translocates the drive plate along the bearing rails which pass through the drive plate and attach to the pump housing.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: June 24, 2003
    Assignee: Incyte Genomics, Inc.
    Inventors: JoeBen Bevirt, Josh Guyot
  • Patent number: 6569687
    Abstract: A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: May 27, 2003
    Assignee: UT-Battelle, LLC
    Inventors: Mitchel J. Doktycz, William Louis Bryan, Reid Kress
  • Patent number: 6544480
    Abstract: A device and related method for dispensing liquid. The device includes a housing configured to contain a plurality of liquid dispensing members containing a liquid and configured to contain a receiving member in a receiving position to receive the liquid from the plurality of liquid dispensing members. The housing defines a first pressure chamber and a second pressure chamber. The first pressure chamber is capable of being sealed relative to the second pressure chamber. The device also includes a differential pressure generator operably connected to one of the first and second pressure chambers. The generator is capable of generating a pressure differential between the first and second pressure chambers to cause the plurality of liquid dispensing members to dispense liquid onto the receiving member.
    Type: Grant
    Filed: October 26, 1999
    Date of Patent: April 8, 2003
    Assignee: Tibotec BVBA
    Inventors: Franck Velghe, Werner De Beukeleer, Chris Roelant, Rudi Pauwels
  • Patent number: 6544479
    Abstract: In a preferred embodiment, a small volume pipettor, including: a plurality of pistons; a plurality of liquid delivery needles; motive means to cause one of the pistons to move axially within one of the needles to cause a liquid to be selectively drawn into and discharged from the needle; sealing apparatus disposed around the pistons to effect sealing of upper ends of the needles; assembly apparatus in which the needles and the sealing apparatus are disposed; and apparatus to permit the assembly apparatus to be removed from the pipettor as a one-piece unit. Further provided are novel apparatus to seal upper ends of the needles around the pistons.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: April 8, 2003
    Inventor: Thomas W. Astle
  • Patent number: 6506611
    Abstract: A freely traversable metering head with numerous metering devices, wherein the metering devices are each provided individually or block-by-block with an activating device, and wherein a controller traversable with the metering head is designed for the independent operation of one or more activating devices. Metering devices for such a metering head and procedures for their use are also disclosed.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: January 14, 2003
    Assignee: Deutsches Resourcenzentrum fur Genomforschung GmbH
    Inventors: Klaus Bienert, Andreas Vente, Heiko Kraack, Rolf Zettl
  • Patent number: 6499363
    Abstract: A nozzle 33 is formed on a distal end side of a cylinder 3. The nozzle 33 has an intermediate portion 3b formed such that a tip 7 is freely attachable thereto and detachable therefrom. The intermediate portion 3b of the nozzle 33 is formed with an annular projection 3e for retaining the tip 7. The tip 7 has a thick portion 7a provided in a root portion thereof and formed larger in diameter than a root portion 3a of the nozzle 33 to be abuttable against a tip releasing member 11. Along an inner periphery of the root portion of the tip 7, an annular projection 7b is formed to contact with the annular projection 3e of the nozzle 33 thereby providing a seal with the nozzle 33. Both the annular projections 3e and 7b of the nozzle 33 and the tip 7 are arranged to reach a position where a sound of abutment is produced between the root end surface of the tip 7 and the shoulder of the nozzle 33 at the completion of fitting of the tip 7 onto the nozzle 33.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: December 31, 2002
    Assignee: The Sailor Pen Co., Ltd.
    Inventors: Ichiro Morimoto, Kiyoto Shigematsu, Isao Shimada, Eiji Hishinuma, Isao Inagaki
  • Patent number: 6455006
    Abstract: It has been hard to suck the high viscosity sample by using the syringe and to stop the suction of the sample. A sample sucking-discharging device in the invention comprises an injector provided with a cylinder and a piston installed in the cylinder so as to move up and down; a main body for holding the cylinder of the injector; a gear or a pair of gears held in the main body so as to rotate on an axis right-angled to the moving direction of the piston; a first rack, of which one end is connected with the piston, for moving with meshing to the gear or the pair of gears; and, a second rack held in the main body so as to move in the direction opposite to or crossing with the moving direction of the first rack.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: September 24, 2002
    Assignee: Kyoto Electronics Manufacturing Co., Ltd.
    Inventor: Hisataka Mukai
  • Publication number: 20020104389
    Abstract: An improvement on the standard bi-directional liquid sample handling system mechanism is provided. The improvement comprises a mechanism for sealing 24 pipettes arranged in a row. When the industry went from 12 wells to 24 wells, the construction of the pipettes, plungers and seals and the means for locating the pipettes had to be changed. This improvement comprises stainless steel plungers and pipettes that are much smaller in diameter, as well as an external sealing mechanism comprising an O-ring, a flange, and a biasing spring. Another improvement comprises replacing the rack-and-pinion table drive mechanism with a belt and pulley mechanism for more precisely locating the 24 pipettes over the corresponding 24 microtitre wells.
    Type: Application
    Filed: February 8, 2001
    Publication date: August 8, 2002
    Inventor: Scott A. Hovey
  • Patent number: 6399024
    Abstract: The invention provides multichannel pipette heads and autopipettors for loading, measuring, transporting and dispensing, particularly from one micro-plate to another. An exemplary multichannel pipette head comprises a pump housing, pistons, a drive plate, an aspiration drive and bearing rails, wherein the pump housing comprises chambers adapted to receive the pistons, the pistons each comprise a shaft, the drive plate retains the pistons and translocates the piston shafts through chambers, the aspiration drive translocates the drive plate along the bearing rails which pass through the drive plate and attach to the pump housing.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: June 4, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: JoeBen Bevirt, Josh Guyot
  • Patent number: 6387330
    Abstract: A method and device for storing and dispensing specified subsets from a collection of tens, hundreds or thousands of different reagents to specified locations within microtitre trays or microarray substrates or the like. The reagents of interest are stored in racks of syringe-like dispensers. These dispensers and/or substrates and/or actuators are controllably moved by automated means to a dispensing position where a single action, vibration and weighing system transfers a controlled quantity to a specified location in a microtitre tray or the like. Deficits of the prior art, such as evaporation, cross-contamination, oxidation, waste of reagents and lab-ware, and human operator non-reliability are overcome.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: May 14, 2002
    Inventors: George Steven Bova, Stephen B. Leighton