With Capture Device Transporter Patents (Class 73/864.31)
  • Patent number: 11002642
    Abstract: Aspects of the disclosure relate to demarcation templates for demarcating a test area on a test surface and for providing visual guidance to a user to precisely and accurately swab the test surface in order to determine the presence and/or concentration of an analyte of interest on the test surface. In one aspect, the analyte of interest is a hazardous contaminant. Some templates can include alignment markings around the border demarcating the test area to provide such guidance to users, and can include graphical use instructions on a removable central portion of the template. The template can be adhesive to be securely fixed to the test surface for accurate demarcation of the test area throughout sampling.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: May 11, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Matthew Oshinski, Austin Jason Mckinnon
  • Patent number: 9842252
    Abstract: A method is provided for use in optimizing ethanol yield from agricultural products. The method includes imaging agricultural products to determine predicted ethanol yields for the agricultural products and assigning characterizations to the imaged agricultural products based on their predicted ethanol yields. An apparatus is provided for collecting, retaining, and/or transporting bulk quantities of agricultural products. The apparatus includes an analyzer configured to image the agricultural products for use in determining the predicted ethanol yields. And, a system is provided for tracking and/or monitoring agricultural products.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: December 12, 2017
    Assignee: MONSANTO TECHNOLOGY LLC
    Inventors: Michael D. Edgerton, Pradip K. Das, Troy W. Hobbs
  • Patent number: 9126773
    Abstract: The object of the present invention is to suction all powders and granular materials in a container such as a drum to transport them. The powders and granular materials have low flowability, since over time they have been compacted due to their own weight or vibrations from the outside or humidity. The machine (1) for suctioning powders and granular materials comprises movable tables (2, 3) that the container that stores the powders and granular materials is mounted on and that horizontally move, a device (8) for driving the tables, a double-layered suction nozzle (11) that is located above the tables and is connected to a suction source, a device (12) for moving the nozzle up and down in the container mounted on the tables, and a controller for controlling the devices, wherein, while moving the tables, the suction nozzle is inserted in proper positions in the container to suction the powders and granular materials.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: September 8, 2015
    Assignee: SINTOKOGIO, LTD.
    Inventors: Takehiko Hino, Harumitsu Asano, Hirofumi Asai
  • Patent number: 8925396
    Abstract: During the fabrication of microstructure devices, such as integrated circuits, particles may be analyzed by displacing or removing the particles from the device surface and subsequently performing an analysis process. Consequently, a well-defined measurement environment may be established after removal of the particles, which may be accomplished on the basis of nanoprobes and the like. Hence, even critical surface areas may be monitored with respect to contamination and the like on the basis of well-established analysis techniques.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: January 6, 2015
    Assignee: GLOBALFOUNDRIES Inc.
    Inventors: Petra Hetzer, Matthias Schaller, Dmytro Chumakov
  • Patent number: 8920752
    Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Biodot, Inc.
    Inventors: Thomas C Tisone, Holger Eickhoff
  • Patent number: 8596149
    Abstract: A sequential sampler for runoff water. The sampler includes a rail member installed to be sloped downward in one direction; a plurality of storage members that move to a downward direction of the rail member; a stopper installed at a middle portion of the rail member that intermits a movement of the storage members; a device of supplying runoff water and inducing drop of storage cylinder that drops runoff water inside of the storage member stood by at a front portion of the stopper and drops the storage cylinder of the storage member stored with the runoff water after elapsing a predetermined time; and an intake pump of runoff water.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: December 3, 2013
    Assignee: Korea Institute of Geoscience and Mineral Resources
    Inventors: Bong Joo Lee, Yong Je Kim
  • Patent number: 8293191
    Abstract: The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: October 23, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Yoshinobu Kohara, Masataka Shirai, Hideyuki Noda, Tomoyuki Sakai, Kenko Uchida
  • Publication number: 20120144936
    Abstract: A sequential sampler for runoff water. The sampler includes a rail member installed to be sloped downward in one direction; a plurality of storage members that move to a downward direction of the rail member; a stopper installed at a middle portion of the rail member that intermits a movement of the storage members; a device of supplying runoff water and inducing drop of storage cylinder that drops runoff water inside of the storage member stood by at a front portion of the stopper and drops the storage cylinder of the storage member stored with the runoff water after elapsing a predetermined time; and an intake pump of runoff water.
    Type: Application
    Filed: June 16, 2011
    Publication date: June 14, 2012
    Inventors: Bong Joo Lee, Yong Je Kim
  • Patent number: 8113068
    Abstract: In a micro-liquid transfer apparatus including two washing tanks (first washing tanks A and B), operations to transfer a sample are carried out using two pin tools (pin tools A and B) alternately. While one pin tool A is being mounted on a pin tool holder and is being used to transfer a liquid, the other pin tool B is waiting in a state where the lower end portions of their associated pins are immersed in the first washing tank B. While one pin tool A is being mounted on a pin tool holder and is being used to transfer a very small amount of liquid, the lower end portions of the respective pins of the other pin tool are washed, whereby the liquid transfer operations can be made in progress with no interruption and thus the generation of the operation waiting time can be prevented.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: February 14, 2012
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Akira Higuchi, Shirou Yamashita, Kouji Shimogawa
  • Patent number: 8113069
    Abstract: An aerodynamic sampler for sampling particles from a surface or a flowing gas stream is provided. The sampler can include an arcuate-shaped shroud having a first opening and a second opening, the first opening being directed in a first direction and the second opening oppositely disposed and spaced apart from the first opening. A gas nozzle having at least one gas outlet directed generally in the first direction can be included and may or may not be located at least partially within the shroud. The gas nozzle is operable to supply a gas jet to a surface that is proximate the first opening of the shroud. In addition, a suction device operable to pull or suck the gas proximate the first opening through the second opening and afford for the gas to enter a detector is provided. The arcuate-shaped shroud can be a bell-shaped shroud with the first opening located at a bottom of the bell-shape.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: February 14, 2012
    Assignee: The Penn State Research Foundation
    Inventor: Gary S. Settles
  • Publication number: 20110203393
    Abstract: A sampling device having an elongate member positioned in the connecting section of a swing type auger is provided. The member has a channel facing into a flow of particulate matter passing through the connecting section and an open end. The member is attached to a rotating shaft. When the auger system is in operation and particulate matter is flowing through the connecting section, the arm rotates perpendicularly through the flow of particulate material and a portion of this particulate material is collected in the channel of the rotating member. The rotation of the member causes the collected particulate material to move along the length of the rotating member until it is thrown out the open end of the member, where a sample can be collected through an aperture in the side of the connecting section.
    Type: Application
    Filed: September 11, 2007
    Publication date: August 25, 2011
    Applicant: WEST CENTRAL ROAD & RAIL LTD.
    Inventors: Glenn Byrnes, Bill Woods
  • Publication number: 20100229660
    Abstract: A pick-and-place module for test handlers includes a main body, and a kit. The main body has N-th vacuum paths (where N is plural). The kit has M-th pickers. The M-th pickers are provided so as respectively correspond to M-th vacuum path parts (where 1?M?N), which are formed to respectively correspond to all or some of the N-th vacuum paths formed in the main body, and holds semiconductor devices or releasing the held semiconductor devices using vacuum pressures. The kit is detachably mounted to the main body.
    Type: Application
    Filed: May 20, 2010
    Publication date: September 16, 2010
    Applicant: TECHWING CO., LTD.
    Inventors: Dong-Hyun YO, Hyun SONG
  • Publication number: 20100112583
    Abstract: Provided is a blood diagnosis method and a dialysis machine, using a diagnostic marker which is versatile and which can contribute to the improvements in dialysis treatment and the evaluation of clinical effects, the method including a step for collecting a blood sample from a dialysis patient before and after dialysis; and a step for making a diagnosis regarding the collected blood sample based on a biomarker, wherein the biomarker is identified in advance based on the correlation between the urea clear space (CS) or the cellular membrane clearance (Kc) and profiles of mRNA or proteins.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Applicants: Yokogawa Electric Corporation, Tohoku University
    Inventors: Eiichiro ICHIISHI, Taisuke Baba, Yumiko Ishizaki, Makoto Ishizaki, Kazuhisa Fukushima, Tsuneji Sawai
  • Patent number: 7681466
    Abstract: A method and a device for removing high priority samples from a primary conveyor and transferring such samples directly to an analyzer's sampling location even if other samples have been previously removed from the conveyor and are in a queue to be analyzed.
    Type: Grant
    Filed: May 1, 2007
    Date of Patent: March 23, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Kerry Lynn Miller, Peter Louis Gebrian
  • Publication number: 20100011889
    Abstract: Handheld solid powder sampling and dispensing devices and methods thereof are disclosed. The handheld device has an ergonomically contoured outer surface to be held by a user. Actuation of an outer member of the device causes a predetermined quantity of a powder to be loaded within the device. Actuation of a plunger mechanism causes the predetermined quantity of powder to be dispensed. The outer member and the plunger mechanism are independently operable. Advantageously, the target delivery quantity of powder can be varied by a device adjustment mechanism.
    Type: Application
    Filed: July 16, 2008
    Publication date: January 21, 2010
    Applicant: BIODOT, INC.
    Inventor: Anthony V. Lemmo
  • Publication number: 20090241699
    Abstract: In a micro-liquid transfer apparatus including two washing tanks (first washing tanks A and B), operations to transfer a sample are carried out using two pin tools (pin tools A and B) alternately. While one pin tool A is being mounted on a pin tool holder and is being used to transfer a liquid, the other pin tool B is waiting in a state where the lower end portions of their associated pins are immersed in the first washing tank B. While one pin tool A is being mounted on a pin tool holder and is being used to transfer a very small amount of liquid, the lower end portions of the respective pins of the other pin tool are washed, whereby the liquid transfer operations can be made in progress with no interruption and thus the generation of the operation waiting time can be prevented.
    Type: Application
    Filed: March 13, 2009
    Publication date: October 1, 2009
    Applicant: PANASONIC CORPORATION
    Inventors: Akira Higuchi, Shirou Yamashita, Kouji Shimogawa
  • Publication number: 20090188332
    Abstract: A system for sampling a bale of fibrous material is provided including a transportation mechanism for moving the bale from a first point to a second point and a first gripper for obtaining a sample from the bale when the bale is at a position between the first point and the second point. The gripper includes a movable finger for gripping the sample from the bale. An actuator comprising an actuating rod is provided for pushing the sample away from the movable finger.
    Type: Application
    Filed: January 26, 2009
    Publication date: July 30, 2009
    Inventor: Bradley P. Actis
  • Publication number: 20090071268
    Abstract: Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time.
    Type: Application
    Filed: November 5, 2008
    Publication date: March 19, 2009
    Applicant: SARYNA BIOTECHNOLOGIES LLC
    Inventor: ALEX OKUN
  • Patent number: 7467559
    Abstract: Apparatus and methods are described for isolating or manipulating a portion of a sample at non-ambient temperatures and pressures. One apparatus embodiment of the invention comprises a primary sample containment vessel defining a primary chamber, the vessel having a primary sample inlet and outlet; a secondary sample collection container defining a collection chamber fluidly connected to the primary containment vessel; and a sample probe comprising a distal end able to isolate a secondary sample in the primary chamber and transfer it to the collection chamber, the probe fluidly connected to the primary chamber via a seal allowing at least the distal end to be moved in 3-dimensions within the primary chamber. This abstract complies with rules requiring an abstract. It should not be used to limit the scope or meaning of the claims. 37 CFR 1.72(b).
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: December 23, 2008
    Assignee: Schlumberger Technology Corporation
    Inventors: Ahmed Hammami, Terry Sopkow, Shawn David Taylor, Scott Jacobs, Hussein Alboudwarej
  • Patent number: 7380615
    Abstract: A core sample extraction system for extracting a plug from soil and removing the plug from the device so that the soil and any roots in the plug can be analyzed includes a boring tube including a top end and a bottom end. The bottom end is driven into soil to isolate a plug of the soil when the boring tube is struck by a mallet. An extraction assembly is positioned in the boring tube. The extraction assembly engages the plug in the boring tube and pushes the plug out of the bottom end when the extraction assembly is forced through the boring tube.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 3, 2008
    Inventor: David L. Vanearden
  • Patent number: 7160511
    Abstract: A liquid pipetting apparatus for dispensing liquid of minute volume for use in a survey instruments of a hemanalysis machine, a genetic screening, and a pharmaceutical screening, etc., is disclosed. The liquid pipetting apparatus comprises a liquid holding member for holding the liquid, and capable of dispensing the liquid from one end, and a driving member for moving the liquid holding member forward and backward along the dispensing direction, the liquid holding member being moved by the driving means, thereby dispensing the liquid held on the liquid holding member.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: January 9, 2007
    Assignee: Olympus Corporation
    Inventors: Seiya Takahashi, Morinao Fukuoka
  • Patent number: 7127956
    Abstract: The invention relates to a method of sample delivery for a sample analyser, which has a delivery device for samples which can be loaded with exchangeable liners, which are tubular at least at the inlet end and hold the sample, the liners, on which there is respectively fitted at the gas inlet end a transporting head which holds the liner by means of a seal hereby having a friction fit, being arranged such that they are inserted at predetermined locations in a magazine and/or in sample containers, a changing device, which is equipped with a gripper for the transporting heads of the liners, being used and on the basis of a predetermined program, the changing device gripping the respective liner at a predetermined place on its transporting head and inserting it into the delivery device in a sealing manner, the sample delivery being performed and, subsequently, the liner being removed from the delivery device by the changing device, by gripping its transporting head, and also to a liner handling system for this.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 31, 2006
    Assignee: Gerstel Systemtechnik GmbH & Co. KG
    Inventors: Ralf Bremer, Bernhard Rose
  • Patent number: 7096749
    Abstract: A lightweight, economical, mass-producible, reusable airfoil can be deployed in an airspace while in or attached to any moving vehicle for the purpose of collecting air samples. A frame has an airfoil shape that provides pressure differentials that preferentially direct particulates and contaminants of differing size and mass to different areas of an absorbent media attached or integral to the frame. The absorbent media are readily detachable from the frame for sanitary and efficient transfer to facilities where the samples can be analyzed.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: August 29, 2006
    Assignee: Signature Science LLC
    Inventors: Brian J. Schimmoller, Matthew F. Bartlett
  • Patent number: 7052914
    Abstract: The invention relates to an automated method for carrying out reactions with high spatial resolution on libraries of different materials and for analysis of the products obtained using a simple robot system and an analyzer, for example a mass spectrometer.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: May 30, 2006
    Assignee: hte Aktiengesellschaft the high throughput experimentation company
    Inventors: Wilhelm Maier, Matthias Orschel, Jens Klein, Christian Lettmann, Hans Werner Schmidt
  • Patent number: 7047829
    Abstract: An apparatus is provided for detecting whether a person has handled explosives, narcotics or other substances of interest. The apparatus includes a metallic sample collection surface on which a person may place a finger. Upon removal of the finger, the metallic sample collection surface is moved to a desorber. The desorber heats the metallic surface sufficiently to vaporize residue transferred from the person. The vaporized residue then is transmitted to a detector for analysis. The detector also may include a fingerprint reading apparatus for reading the fingerprint of the person and comparing the fingerprint to known fingerprint data.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: May 23, 2006
    Assignee: General Electric Company
    Inventor: Joseph D. Napoli
  • Patent number: 6973846
    Abstract: The invention relates to a sample handling device for an analytical device, comprising a sampler provided with a holder, a movable holding arm for the holder and a support for the holder, said support being arranged in a stationary manner with respect to the holding arm, said holder being transferable between a suspended position on the support and a position located on the holding arm and being releasable from the holding arm by a pulling force exerted by the holding arm substantially perpendicular to the longitudinal direction of the latter.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: December 13, 2005
    Assignee: Gerstel Systemtechnik GmbH & Co.
    Inventors: Ralf Bremer, Bernhard Rose
  • Patent number: 6953552
    Abstract: The present invention relates to a spotting device for fabricating microarrays of biological materials and a spotting pin inserted therein. More particularly, the present invention is directed to a spotting device, which comprises several pins and pin-guiding holder that allows the pins to move accurately and rectilinearly toward up-down direction by guiding and supporting pins at several points, and spotting pins inserted therein.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: October 11, 2005
    Inventors: Park Han-Oh, Kim Hang-Rae, Ahn Jung-Wook, Song Gu-Young, Oh Gui-Hwan, Cho Yun-Seok, Choi Il-Kyu
  • Patent number: 6935198
    Abstract: A sampling apparatus is characterized by a sampler and a sample collection station. The sampler is stationary and periodically delivers discrete product samples to a stationary inlet to the sample collection station. The sample collection station includes a deck having a plurality of passages in linearly aligned spaced relationship, a plurality of sample collection containers, and inlets to the sample collection containers that are in communication with associated ones of the deck passages. The deck is linearly indexed in both directions of movement along the linear alignment of the deck passages to place selected ones of the deck passages into communication with the stationary inlet, so that product samples delivered by the sampler to the sample collection station are directed into selected ones of the sample collection containers.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: August 30, 2005
    Inventor: Ben E. Jaeger
  • Patent number: 6913934
    Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: July 5, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: G. Cameron Dales, Gary Diamond, Trevor G. Frank, J. Christopher Freitag, Kenneth S. Higashihara, Dave Huffman, Jonah R. Troth
  • Patent number: 6833113
    Abstract: A sample suction apparatus includes: first through third members; a drive source; and a suction needle provided on the third member. The drive source reduces a distance between the first member and the third member to perform: a first action of shifting the first member toward the third member to contact the first member with a portion of a specimen vessel; a second action of shifting the second member together with the third member toward the first member to contact the second member with another portion of the specimen vessel so that the specimen vessel is sandwiched between the first and second members; and a third action of shifting the third member toward the first member to bring the third member close to the second member so that the suction needle is inserted in the specimen vessel.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: December 21, 2004
    Assignee: Sysmex Corporation
    Inventor: Masayasu Sentoh
  • Publication number: 20040235155
    Abstract: Collecting rods are pre-greased for use with a rotorod sampler. Multiple collecting rods are molded in one piece with a header to form a group. The collecting rods are attached to the header by thin gates so that they can be easily broken off for use. Multiple groups are combined into an assembly that is adhered to a container lid and dipped into a pre-greasing suspension to pre-grease the collecting rods. The container lid is attached to the rest of the container to enclose the pre-greased collecting rods for shipment.
    Type: Application
    Filed: January 27, 2004
    Publication date: November 25, 2004
    Inventors: Jay C. Elander, Dennis E. Gebhard
  • Patent number: 6817227
    Abstract: An apparatus and method for sampling sub-surface soil gas samples and detection of distinctive chemical tracer compounds in the soil gas samples employing an aboveground sampling apparatus. The aboveground sampling apparatus does not include any device that penetrates the soil surface or man-made structures imposed upon the soil surface. Rather, the above-ground sampling apparatus evacuates soil gas samples through the soils surface or through mad-made structures imposed upon the soil surface, such as asphalt or concrete, and passes the soil gas sample through an adsorbent bed containing adsorbent material specific for the distinctive chemical tracer compounds.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: November 16, 2004
    Assignee: Praxair Technology, Inc.
    Inventors: Glenn M. Thompson, O. Daniel Evans
  • Patent number: 6796194
    Abstract: A sampling system includes a rocket body, and a first sampling vessel coupled to the rocket body, wherein, during operation, a propellant is discharged from the rocket body and causing the rocket body to be propelled towards a body of liquid. The sampling system may also include a deployment line coupled to the rocket body at a first point on the line, the deployment line also coupled proximate to a launching area at a second point on the line, wherein, subsequent to the discharge of the propellant, the rocket is retrieved by an operator using the deployment line.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: September 28, 2004
    Assignee: San Diego State University
    Inventor: John Ryan
  • Patent number: 6742405
    Abstract: A deep lysimeter including a hollow vessel having a chamber, a fill conduit extending into the chamber through apertures, a semi-permeable member mounted on the vessel and in fluid communication with the fill conduit, and a line connection for retrieving the lysimeter.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 1, 2004
    Assignee: Bechtel BWXT Idaho LLC
    Inventors: Joel M. Hubbell, James B. Sisson
  • Patent number: 6712161
    Abstract: A containment cartridge for extracting and preserving a soil sample comprises a cylindrical sampling barrel for insertion into the soil for collecting a soil sample.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: March 30, 2004
    Assignee: GD Air Testing, Inc.
    Inventor: Gesheng Dai
  • Patent number: 6696288
    Abstract: Collecting rods are pre-greased for use with a rotorod sampler. Multiple collecting rods are molded in one piece with a header to form a group. The collecting rods are attached to the header by thin gates so that they can be easily broken off for use. Multiple groups are combined into an assembly that is adhered to a container lid and dipped into a pre-greasing suspension to pre-grease the collecting rods. The container lid is attached to the rest of the container to enclose the pre-greased collecting rods for shipment.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: February 24, 2004
    Assignee: Surveillance Data, Inc.
    Inventors: Jay C. Elander, Dennis E. Gebhard
  • Patent number: 6620620
    Abstract: The drop-by-drop evaporation of a liquid or solution is controlled by monitoring the disappearance of each successive droplet and by actuating the deposition of the next droplet until the desired volume is deposited. In the case of a solution, non-volatile residue (NVR) is collected on a deposition surface plate as a relatively small mound. One of a variety of methods may be employed to measure the evaporative behavior of each droplet and to key the deposition procedure. The process is preferably carried out employing a clean deposition surface plate that is maintained at or below the boiling point of the particular liquid or solvent being deposited. The environment is preferably controlled so that inadvertent contamination is precluded from interfering, and thus the method permits the automatic, micro-processor controlled evaporation of liquids with the resultant deposition of non-volatile residues from solutions within relatively short periods of time.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 16, 2003
    Assignee: ERA Systems, Inc.
    Inventors: John Lynde Anderson, Ross F. Russell, David O. Hanon, James Nelson Edwards
  • Patent number: 6605257
    Abstract: A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a living body sample, a solution storing member 52 for taking in the solution from the tighter plate 12 and storing the solution therein, and a needle 51 which can be inserted into the solution storing member 52 to allow the solution stored in the solution storing member 52 to adhere onto each of the substrates by a given quantity, wherein the solution storing member 52 and needle 51 are moved in directions where they approach and part away from the substrates to thereby form spots on the substrates. And, the individual operations of the solution storing member 52 and needle 51 are carried out by single drive means 32.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: August 12, 2003
    Assignees: THK Co., LTD, Riken
    Inventors: Touji Nakazawa, Akihiro Iimura, Hideo Tashiro, Tokuji Kitsunai, Yoshihide Hayashizaki
  • Patent number: 6599479
    Abstract: A multi-channel dispensing head including a plurality of micropipettes, each micropipette having an electrically actuatable trigger device with a ground and signal terminal; and a shared carrier having a plurality of receptacles located in a one- or two-dimensional arrangement and sized and shaped to receive said micropipettes, each receptacle having a ground and signal contact, wherein the ground and signal contacts on the carrier are spaced apart in the direction of a longitudinal axis extending through the respective micropipettes and each of the ground and signal contacts on the carrier contacting the ground and signal terminals of the trigger devices, respectively.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: July 29, 2003
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Markus Kietzmann, Markus Kalkum, Thomas Przewieslik, Holger Eickhoff, Carsten Arold
  • Patent number: 6579499
    Abstract: A pin replicator is disclosed for dispensing minute volumes of liquid onto a substrate surface in an array in connection with drug discovery, diagnostic analysis, and other applications. The pin replicator comprises a base plate, a plurality of pins reciprocable through corresponding holes in the base plate, and a free floating weight plate resting on top of the upper ends of the pins. The weight plate biases the pins toward their fully extended lowered positions. A cover attaches to the base plate, encloses the pins and weight plate and guides the weight plate during vertical movement thereof. The pin replicator can be moved downwardly toward a first micro titer plate so that a lower end of each of the pins contacts the sample liquid in the corresponding well a sufficient amount to pick up and retain a small quantity of the sample liquid due to surface tension.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: June 17, 2003
    Assignee: Autosplice, Inc.
    Inventors: Craig M. Kennedy, Fernando J. Ramirez
  • Patent number: 6576477
    Abstract: After attaching a disposable pipette tip to an end of pipetting probe, which is held by a movable holder, humidity in the pipette tip is increased before a pipetting operation of a sample or a reagent. The pipette tip is transferred to a high humid chamber provided with a warmer, and high humid air is introduced into the pipette tip. Subsequently, the pipetting operation of the sample or the reagent is performed. Accordingly, an exact amount of the sample or the reagent can be supplied to a reaction vessel.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: June 10, 2003
    Assignee: Hitachi, Ltd.
    Inventors: Yukie Tokiwa, Shigeki Matsubara, Kyoko Imai
  • Patent number: 6551557
    Abstract: The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or “gravity” pin to draw or collect source fluid and “spot” or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: April 22, 2003
    Assignee: Cartesian Technologies, Inc.
    Inventors: Don Rose, Thomas C. Tisone
  • Patent number: 6551558
    Abstract: The invention concerns a liquid transfer device for an analysis apparatus with a liquid transfer cannula (5) and a capacitive liquid level detector to detect the immersion of the liquid transfer cannula (5) in an analysis liquid contained in a vessel. To reliably check if the liquid transfer cannula (5) is submerged in the analysis liquid or immersed for example in foam it is proposed additionally that resistance is measured by a measurement section (16) in the liquid transfer cannula (5).
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: April 22, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Karl-Heinz Mann, Stephan Sattler
  • Patent number: 6537818
    Abstract: Apparatus and methods for aspirating and dispensing reagents are provided. Aspirating of reagents is accomplished by a probe, a vial insert and reagent vial according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the vial insert. Dispensing of reagents is accomplished by a probe and a probe dispense and wash station according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the probe dispense and wash station.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: March 25, 2003
    Assignee: Ventana Medical Systems, Inc.
    Inventors: William Richards, Anthony Ford, Vince Rizzo, Darin McDaniel, Kurt Reinhardt, Wayne Showalter
  • Patent number: 6517779
    Abstract: The device serves for the transfer of microobjects, in particular of biological objects, from a current substrate (9) to a target substrate. In this case, use is made of a displaceable pipette system which is connected to a pressure generating device for aspirating in and flushing out the biological objects. The pipette system is disposed in a micromanipulator (3) and consists mainly of a substantially vertically disposed microcapillary (1) having a clear width of 1 &mgr;m to 50 &mgr;m.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: February 11, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Luttermann, Edgar Diessel, Markus Weidauer
  • Publication number: 20030017604
    Abstract: The present invention provides an improved apparatus and method for loading tips onto a pipettor. A means for applying removal force on the pipette tip box is provided so as to ensure that the box is dislodged from the pipette tips after the pipette tips have been forced onto the dispense head mandrels. In the preferred embodiment, the shuck arms are modified to incorporate springs such that when the engagement force is removed from the pipette tip box, the shuck arms are forced by the springs against the pipette tip box thereby displacing the pipette tip box from the pipette tips.
    Type: Application
    Filed: September 10, 2002
    Publication date: January 23, 2003
    Applicant: Beckman Coulter, Inc.
    Inventors: Jonn Hitch, Rick A. Spencer
  • Patent number: 6423548
    Abstract: A method and apparatus for capturing a sample of flowable material from a closed system inside a receptacle without exposing the sample to the ambient environment. The apparatus includes a housing having an opening at one end for receiving a receptacle and stopper. An end cap is removably mounted to the housing for opening and closing the opening. An inlet is provided in the housing for feeding a cleaning or sterilizing agent or the flowable material to be sampled into an interior of the housing. A clasp is provided to manipulate the receptacle to separate the receptacle and the stopper while the stopper and receptacle are inside of the housing. Once the receptacle and the stopper are separated, the flowable material is fed into the receptacle through the inlet. The clasp is then manipulated to reattach the receptacle and the stopper in order to capture the flowable material.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: July 23, 2002
    Assignee: NL Technologies, Ltd.
    Inventors: Douglas A. Newberg, Richard R. Newberg
  • Patent number: 6387330
    Abstract: A method and device for storing and dispensing specified subsets from a collection of tens, hundreds or thousands of different reagents to specified locations within microtitre trays or microarray substrates or the like. The reagents of interest are stored in racks of syringe-like dispensers. These dispensers and/or substrates and/or actuators are controllably moved by automated means to a dispensing position where a single action, vibration and weighing system transfers a controlled quantity to a specified location in a microtitre tray or the like. Deficits of the prior art, such as evaporation, cross-contamination, oxidation, waste of reagents and lab-ware, and human operator non-reliability are overcome.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: May 14, 2002
    Inventors: George Steven Bova, Stephen B. Leighton
  • Patent number: 6339966
    Abstract: A bulk sampling device for sampling mixtures of powder and semi-solid compositions. The sampling device comprises an apertured hollow outer tubular casing for receiving an inner receiving rod with adjacent non-communicating sample ports for holding sampled materials. The inner rod also contains removable partitions located between each sample port thereby forming non-communicating sample ports and diminishing the risk of leakage and contamination between each port. The removable partitions, located between the sample ports, are dimensioned and positioned within the partition receiving slots such that each partition remains trapped between the outer hollow tubular casing and the receiving rod when the device is assembled. The distal end of the device has a solid cone, and the proximate end has a handle to manipulate and rotate the inner receiving rod and sample ports to obtain volumetric sampling.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: January 22, 2002
    Inventor: Sanyasi R. Kalidindi
  • Patent number: 6318190
    Abstract: Instruments and processes according to the invention provide for the preparation of a fluid sample that has a substantially known concentration of a select particulate matter. In one aspect, the invention is understood as laboratory instruments for sample preparation. These instruments can include a filter that is submersible within a fluid suspension of particulate matter. To collect particulate matter from the fluid suspension, the instruments can cause a fluid flow that pulls fluid across the filter to trap particulate matter against one surface of the filter. The instruments can then remove the filter from the fluid suspension and dispose the filter above a collection vessel such that the side of the filter that is carrying particulate matter is positioned above the opening of the collection vessel.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: November 20, 2001
    Assignee: Cytyc Corporation
    Inventors: Gail E. Radcliffe, Daniel C. Lapen, Charles A. Festel