Abstract: The present invention disclosure relates to the use of a silicon substrate with a thin film membrane as a transparent substrate for the imaging of biological- and material-related specimens using a microscope such as a transmission electron microscope (TEM). More specifically, the present invention relates to an improved substrate design that incorporates the fabrication of a circular shape that allows easier insertion into traditional specimen holders used in TEMs. In addition to an improved shape, the present invention incorporates microscopic surface texture on the gripping surface that assists in handling. The invention also encompasses surface modification techniques for enhanced biocompatibility of the thin film membrane for biomedical applications.

Abstract: In an aspect of this invention, a closure for a well plate is provided which has a reservoir. The closure has openings through which acoustic ejection of fluid droplets can take place without removing the closure. The reservoirs in the closure may help to maintain acceptable levels of solvent in the wells of the well plate despite the evaporation which may occur during the course of ejection.

Abstract: A system and method for continuously monitoring the intake of a fresh water system to detect pathogens, chemicals, and other biological contaminants. The apparatus consists of a number of monitoring and containment facilities which are inserted into a fresh water intake pipe at various locations. The monitoring and containment facilities detect a hazard in the incoming water, send a signal to shut down the main intake pump, and collect samples of water immediately adjacent the monitoring and containment facility that detected the hazard. A signal may also be sent to a regulatory agency and to the Department of Homeland Security. The method consists of conducting a qualitative and quantitative analysis of water in a fresh water intake pipe; testing for hazards, and shutting down the main intake pump if a sufficient level of hazard is detected. The method also consists of collecting water samples for later analysis and of notifying the appropriate agencies.

Abstract: A fluid analysis apparatus for containing and analyzing a fluid sample includes a cell body assembly having a plurality of distinct portions in fluid communication with one another and with the distinct portions being hydraulically sealed to one another through the use of one or more resilient gaskets interposed between adjacent ones of the plurality of distinct portions of the cell body assembly. The one or more resilient gaskets enable both hydraulic sealing of adjacent distinct portions, as well as fluid coupling and routing through the fluid analysis apparatus.

Abstract: A sampling needle is disclosed that includes a sampling part that is inserted into a sample, and a sample holding part that holds the sample that is introduced through the sampling part. The sampling part and the sample holding part are arranged into a seamless structure, and the inner diameter of the sampling part and the inner diameter of the sample holding part are equal.

Abstract: The invention relates to a sample chamber of plastics with at least one receiving area for receiving a liquid, wherein the sample chamber comprises a hydrophilic and/or an oleophobic layer in a predetermined surface area.

Abstract: A gas sorption sample chamber contains a plurality of thin-film substrates and fluidly couple said substrates to a Sieverts' device or other gas sorption analyzer. The thin-film substrates are held in proximity to each other in the sample chamber in a columnar arrangement, either in a stacked or slightly spaced configuration, to reduce free-gas volume in the sample chamber, thereby improving sorption test accuracy. The interior geometry of the chamber is configured to provide a minimal clearance between the thin-film substrates and the internal surfaces of the chamber, so that essentially all of the chamber volume is occupied by thin-film sample material and inactive substrate material. To facilitate use in a glove box, the chamber may be configured with a removable sample cartridge in which thin-film substrates are placed so that all substrates may be loaded and unloaded as a group.

Abstract: An apparatus assembly for detecting an analyte in a sample of material includes a valve, a frame, and a plurality of housing segments. The valve may be actuated to adjust a flow path and flow rate through the housing segments.

Abstract: The invention relates to a sample receiving device (100), particularly for the cryoconservation of at least one sample, including a bundle (10) consisting of a plurality of hose-shaped flexible sample chambers (11, 12, . . . ) and a holding device (20) with which the bundle (10) of the sample chambers is joined. The holding device (20) has a plurality of holding frames (21, 22, . . . ) which are arranged in a longitudinal direction of the bundle (10).

Abstract: A sample carrier having a top wall, a base, and a support wall joining the top wall and the base. The top wall includes aligned, spaced-apart openings on at least one side of the support wall which are sized to receive sample tubes. Sleeves depending from the top wall and circumscribing each opening direct sample tubes into sample tube holding areas. The sample tube holding areas each include one or more retaining walls extending upward from the base opposite the support wall. Springs extending outward from the support wall bias sample tubes against the retaining walls. A drip shield comprising a cover plate, a pair of through-holes for accessing sample tubes in the sample carrier, and a depending fin which separates sample tubes on opposite sides of the support wall protects against cross-contamination between sample tubes held by the sample carrier.

Abstract: The invention relates to a composite structure of a sample carrier 20 and a sample holder 30 for use in a TEM, for example. The sample carrier is hereby separately embodied from the sample holder. Although such compositions are already known, the known compositions are very fragile constructions. The sample carrier according to the invention can be formed from a strip of metal, and is a simple and cheap element. Using resilient force, it clamps onto or into the sample holder. The portion of the sample holder to which the sample carrier couples also has a simple form. The sample carrier can couple to the sample holder in vacuum using a coupling tool.

Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

Abstract: A document sampler can be arranged to receive a document in an insertion area of the document sampler. With such arrangements, a document can be directly inserted into a document sampler without an extra step of swabbing a document with a sample collection device. By eliminating the extra step of swabbing a document, the efficiency of sample detection is improved, sample detection is performed more rapidly, and operating costs of sample detection are decreased.

Abstract: A cytocentrifuge sample chamber includes a sample receiving well to receive and hold a sample to be centrifuged and a sedimentation chamber adjacent a microscope slide upon which cells and/or other sediment material in the sample is to be deposited. A passage, such as a spillway, connects the sample receiving well and the sedimentation chamber, so that sample flows from the sample well under the influence of centrifugal force as centifugation begins into the sedimentation chamber where the sample is forced by centrifugal force against the microscope slide leaving a vacant space at the inner end of the sedimentation chamber. Sedimentation of the sample takes place against the microscope slide. When centrifugation ends, the liquid components of the sample flow back into the vacant space in the sedimentation chamber and can be removed from the vacant space at the inner end of the sedimentation chamber through a removal chamber.

Abstract: A modified syringe collects samples of a fluid without removing volatile compounds by forming a vacuum within a sample collection vial. A fluid sample is drawn into the collection vial by means of the applied vacuum.

Abstract: The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.

Abstract: A robotic system for handling components during chromatographic analysis of a sample includes a holder for positioning a sample within a separation pathway, the holder including a first opening having an internally tapered shape and a second opening having an externally tapered shape. An interior of the holder, between the first and second openings, defines the separation pathway. A hollow rigid member has an externally tapered shape, and a receiving portion has an internally tapered shape. The holder is positioned between the hollow rigid member and the receiving portion, wherein the externally tapered hollow rigid member engages the internally tapered first opening and the internally tapered receiving portion receives the externally tapered second opening to provide a sealed separation pathway extending from the hollow rigid member to the receiving portion.

Abstract: A bound materials core measuring device includes a tubular body to accommodate a core sample of road or pathway surfacing bound material. The tubular body has a plurality of graduated scales extending therealong at spaced intervals therearound to enable the core sample to be measured from a plurality of angles by reading from each of the plurality of graduated scales. The tubular body has, located therein, a supporting element for supporting the core sample with the supporting element being mounted for longitudinal movement relative to the tubular body. The tubular body also includes therein a device for effecting the longitudinal movement.

Abstract: A measuring system for calibrating a machine in which a base (10) is attachable to a surface of the machine and a housing (20) is mountable on the base, wherein at least one surface of the base and at least one surface of the housing are each provided with a complementary part of a mounting device, such that when the two parts of the mounting device are connected together, the housing may be aligned in any of a plurality of predetermined directions. The base includes a lifting mechanism (64) which when lowered allows the complementary parts of the mounting device (93, 95) of the housing (20) and the base (10) to be in contact and when raised causes them to at least partly break contact with one another. The level of the base (10) may be adjusted using a system of members and tapered rollers.

Abstract: The present invention provides plate spinner systems and devices, and methods of using such systems and devices. In preferred embodiments, the systems and devices contain one or more of the following features: a manual power generating component (e.g. a hand crank power supply); a rotor assembly composed of a rotor with brackets for securing a sample holding device such as a sample processing device or a micro-titer plate; a rotor hub that supports nearly all of the weight of the rotor assembly; a manually operated brake; and a kettle cover containing a rotor tachometer.

Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.

Abstract: Disclosed is a chemical reaction cartridge comprising: an elastic member as a component; a flow path and a plurality of chambers which are connected to each other by the flow path, the flow path or the chambers or both of the flow path and the chambers being partially blocked by applying external pressure to the elastic member from outside so that a fluid substance in the flow path or in the chambers is moved or blocked, and one of the chambers being a sample collecting chamber to temporarily retain a sample supplied from outside; an insert section to insert an injection needle to inject the sample into the sample collecting chamber; and a sealing member in which an opening to accept the injection needle inserted into the insert section is formed, and the opening is sealed to seal the insert section.

Abstract: The invention relates to a device for receiving a test sample, particularly sample holders for combined examination of the test sample by a test procedure combined with another test procedure, which differs from the first test procedure, with a planar preparation component (1) in a transparent material with a preparation surface on which the test sample can be prepared, wherein a test path for the introduction of a test facility for carrying out the test procedure is formed on one side of the preparation component (1) and another test path for the introduction of a test facility for carrying out the other test procedure on the test sample is formed on an opposite side of the preparation component (1), wherein a supporting and covering element (3a) which has an aperture (5) through which the test path is formed is pressed against the preparation component (1) on one side (FIG. 1).

Abstract: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.

Abstract: A core sample extraction system for extracting a plug from soil and removing the plug from the device so that the soil and any roots in the plug can be analyzed includes a boring tube including a top end and a bottom end. The bottom end is driven into soil to isolate a plug of the soil when the boring tube is struck by a mallet. An extraction assembly is positioned in the boring tube. The extraction assembly engages the plug in the boring tube and pushes the plug out of the bottom end when the extraction assembly is forced through the boring tube.

Abstract: Vials used for obtaining an aliquot of a biological sample are provided. Also provided are method of using the vials and instruments to obtain an aliquot of a biological sample.

Abstract: A device, process and system are provided for collecting and releasing a liquid sample, especially saliva. A defined saliva sample, i.e., a filtered, approximately homogeneously mixed saliva sample of a predetermined volume is made available in the simplest possible manner. A sampling tip (2) is provided made of a dimensionally stable and porous material, which is moved with its mouthpiece (4) in the mouth of a test subject for one to two minutes and takes up saliva based on the capillary action. A reagent liquid enters the pores of the sampling tip (2), mixes with the saliva there and is subsequently fed from a reagent depot by the action of pressure. The saliva and the reagent liquid are finally discharged as a droplet (40) in the filtered and mixed state, either into the cavity (10) of the sample collector or into a filter mixer.

Abstract: The device comprises a support in the form of a tray or the like, which is at the top and provided inside with first grooves for guiding first cards arranged parallel to each other, forming a single level for the cards and is characterised in that it has sets of grooves interposed between the first grooves, allowing a second level of cards to be placed at a level higher than the first cards.

Abstract: Disclosed herein is a microvolume sampling device that includes a chip and a UV-transmissive cell formed of fused silica. The chip has a plurality of wells, a receiving area extending therebetween, and a port extending through the chip to the receiving area. The cell, which preferably has a rectangular cross-section, is securingly positioned within the receiving area and extends into the wells. A chamber is defined by the cell, and a fluid sample can be drawn into the chamber from at least one of the wells by capillary force. The microvolume sampling device can be disposed upon a tray having an opening such that the port of the microvolume sampling device is in alignment with the opening to define an optical path for spectroscopic measurement of the fluid sample. The tray can be provided as a well plate for receiving a plurality of microvolume sampling devices.

Abstract: Disclosed herein is a coring tubular. The coring tubular has a body, at least one opening hole radially oriented in the tubular body and a parting line in the tubular body. Further disclosed herein is a method for reducing contamination of a core sample. The method includes installing a coring tubular having features set forth in the foregoing paragraph in a coring tubular, running the tubular to obtain a sample and retrieving the bore by prying the tubular open at an opening hole along the parting line.

Abstract: An adjustable device is disclosed comprising two relatively re-orientatable members each having a lockable universal joint, and a connecting member for connecting the two relatively re-orientatable members whereby when the two relatively re-orientatable members are connected the two joints are in mechanical communication via the connecting member. The two lockable joints may be locked and unlocked using an actuator, a lever, which may act on a compression device in order to render the lockable joints either mobile or locked. The compression device may cause a change in cross-sectional area of the tube over at least a part of its length. At least one of the lockable universal joints may provide for linear movement between the two relatively re-orientatable members. Also disclosed is an apparatus for the simulation of the orientation of a sample with respect to a cutting tool or scanning probe and method for aligning the adjustable device.

Abstract: A water quality evaluation method capable of evaluating quality of water to be evaluated with high precision and a substrate contacting apparatus used in the water quality evaluation method are provided. The substrate contacting apparatus 10 has a sealing performance keeping the interior at a vacuum degree lower than or equal to ?0.094 MPa. A substrate W is accommodated in the substrate contacting apparatus 10 and water to be evaluated is fed therein, after stopping feeding water, the interior of the substrate contacting apparatus 10 is sealed, and the substrate contacting apparatus 10 is sent to an analysis device with the substrate W accommodated therein.

Abstract: A pressure source material is loaded into a space having constraint device 1, which is formed partly by optically transparent material 1a, 1b, and is disrupted under volume constraint. Light energy is externally supplied to the pressure source material constrained in the space through the optically transparent material by employing the device to apply light energy. The disruption of atomic bonds in the pressure source material is induced by heating through the supplied energy. Exceptionally high pressures are generated in the space by the use of expansive forces arising from the disruption of atomic bonds. Such a configuration can implement ultrahigh pressure abilities that has not been achieved, so far.

Abstract: The invention, in various embodiments, provides systems, methods and devices relating to processing a sample. A vessel is described for containing a sample. The vessel includes a reversibly sealable chamber for containing the sample which has a flexible portion to allow the vessel to deform nondestructively in response to a mechanical impact to fragment the sample. In certain embodiments the vessel may include a port for reversibly engaging with a second vessel to enable transfer of material between the two vessels while maintaining a barrier between the sample and an external environment. The vessel may be exposed to mechanical impacts of various energies and at various temperatures, and the internal surface of the structural barrier of the vessel may be treated with various chemical agents to maintain integrity of the sample.

Abstract: The systems and methods of the invention provide for sample holders for centrifuges that include a channel structure having a sample channel and an overflow channel. The sample channel and the overflow channel are configured such that any excess sample flows into the overflow channel thereby maintaining a constant sample level in the sample channel. In other aspects, the invention provides for centrifuges comprising sample holders having a plurality of channel structures. In still other aspects, the invention provides for methods of using the sample holder and methods for detecting species in a sample using luminescence based measurement techniques.

Abstract: A method of preparing a sample for examination in a TEM, where the sample is attached to a probe tip point, uses a TEM sample holder form embodied in a TEM sample holder coupon. The probe-tip points and the TEM sample holder coupon are oriented with each other so that the sample is approximately centered in the TEM sample holder form. The probe-tip points are embedded in the TEM sample holder form by means of a press, simultaneously cutting off that portion of every probe-tip point outside the boundary of the TEM sample holder form and cutting the TEM sample holder free from the TEM sample holder coupon. The operation can be formed inside or outside of a focused ion-beam instrument.

Abstract: A method of using an aseptic sampling arrangement. The sampling arrangement includes a septum cartridge and a securing element for use with a fluid enclosure. A locking arrangement is provided to allow selective access to the septum cartridge and the securing element. The sampling arrangement further includes a needle, a tube, and a collection bag. The sampling arrangement can be used to monitor the quality of a fluid product. The method of monitoring includes obtaining a fluid product sample from the fluid enclosure within the collection bag. The collection bag is then incubated for a period of time during which oxygen permeates the bag to simulate post-pasteurizing conditions and/or pre-pasteurizing conditions of the fluid product. The method further includes monitoring the level of contamination detected within the fluid product sample.

Abstract: A sample handling apparatus identifies sample holders and their location in a sample holder carrier. This information may be used to determine the identity of sample holders based only on location in the carrier during subsequent processing of material contained in the sample holders. Sample holder identity may be automatically read, and placement of holders in a carrier may be automatically determined and correlated with the holder identity. Such information may be stored, e.g., in a memory in the carrier so that sample holders can be easily identified later.

Abstract: The present invention comprises a device and methods for dissolution or immersion testing and, in particular, a device and methods that improve the consistency of test results by limiting the ability of pharmaceutical or other dosage forms to move or reorient during testing.

Abstract: A soil sampling system is provided that allows headspace screening of soil samples at spaced intervals along a soil sample liner without disturbing the soil samples to be collected and shipped to a laboratory for further testing. The soil sample liner includes a plurality of cylindrical liner sections positioned end-to-end in a linear array, with each liner section having a sidewall and open ends. A shrink-wrap material covers the liner sections and holds the liner sections together as an assembled unit. Some of the liner sections have access openings formed in a sidewall thereof for providing access to the soil samples contained therein. The liner sections having access openings are interspersed between other liner sections that do not have access openings. The access openings are used by piercing the shrink-wrap material covering the access opening, and inserting a probe tip through the access opening into a headspace to measure contamination.

Abstract: A device for the axial and rotational movement of a sample is disclosed comprising a mount member for mounting the sample, which is rotatable about and movable along an axis, characterised in that the mount member has a helical screw thread which produces the movement along said axis simultaneously with the rotation. A sample may be scanned or machined whilst being axially and rotationally moved. The screw thread may be disengageable perphaps by relative movement of co-operating screw threads into and out of engagement with each other by a lever to allow movement of the mount member along the axis without rotation when desired. The screw thread on one of the members may be formed from a piece or layer of a deformable material, which deforms to form a mating screw thread upon being brought into engagement with the screw thread on the other member. Also desclosed is a method of scanning a sample.

Abstract: In one embodiment, a system for analytical testing comprises a test cartridge for use in conducting an analytical test including a test medium and an RFID device. An encoding device is provided adapted to preprogram the RFID with information relating to the test. An analytical detection device including a RFID transceiver adapted to transfer data to and from the RFID device is coupled to test detection instrumentation adapted to analyze the test medium in response to the information relating to the test.

Abstract: A soil sample containment device is provided which allows soil samples to be contained within individual sections of a soil sampler liner. The device includes first and second end caps for covering and sealing the respective ends of the soil sampler liner section. Each end cap has a structure for coupling with the opposite end cap for securing the end caps together. The coupling structure for each end cap includes a hook arm and an eye arm. The hook arm of the first end cap can be coupled with the eye arm of the second end cap to secure the end caps together over the ends of the liner section. A flexible sealing material is provided within each end cap for providing a compression seal between the end caps and the liner section. The liner sections can be formed of different lengths and different materials to accommodate different soil tests.

Abstract: A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

Abstract: An automatic sample loader is for use in association with a mass spectrometer and at least one vial containing a sample. The loader includes a vial block, an insertion head, an insertion tube, a mechanism for pushing the sample out of the vial and a mechanism for moving the insertion head relative to the vial. The vial block has at least one vial cavity and each vial cavity is adapted to receive a vial. The insertion head is adapted to be sealingly engageable in the vial cavity. The insertion tube is operably connected to the mass spectrometer through the insertion head, such that the tube extends into the vial when the insertion head is sealingly engaged in the vial cavity. The pushing mechanism is adapted to push the sample out of the vial and into the tube. The moving mechanism is adapted to move the insertion head relative to the vial block from an engaged position to a disengaged position.

Abstract: Embodiments of the present invention describe a MALDI (matrix-assisted laser desorption and ionization) sample plate body that includes a reusable sample plate and a sample plate adapter that are releasably coupled to one another. In one particular embodiment, the sample plate and the sample plate adapter are releasably coupled to one another to form the MALDI sample plate body by a latch formed by a spring-loaded hook within the sample plate adapter and a recess shaped to accept the hook within the sample plate. The MALDI sample plate body may be formed by aligning the sample plate with the sample plate adapter and coupling the sample plate to the sample plate adapter to releasably couple the sample plate to the sample plate adapter.

Abstract: An ion analyzing apparatus for analyzing the composition of an object includes a chamber maintained under a vacuum, a support for supporting a plurality of objects disposed in the chamber, and a drive unit that selects one of the supported objects and rotates the selected object. An ion generator irradiates the rotating object with primary ions. A detector detects secondary ions emitted from the rotating object. An analyzer analyzes the secondary ions. A transfer device is connected to the supporter. The transfer device rotates the support or moves the support linearly in a horizontal direction to place an object at a predetermined position at which the object is selected and rotated by the drive unit.

Abstract: A holder for materials for use in a measuring instrument includes a three-piece housing consisting of an upper housing member, an intermediate housing member and a lower housing member, the three-piece housing defining a first closed cavity and a second closed cavity. A first winding assembly is disposed within the first closed cavity, and a second winding assembly is disposed within the second closed cavity.

Abstract: A method of maintaining, tracking and identifying the integrity of a disposable specimen container comprising the steps of: writing to an RFID device attached to an individual specimen vial information including the date and a unique identification of the vial; putting sample in the specimen vial; writing to the RFID device attached to the specimen vial information including the time and the day; storing the vial in an environment to maintain its integrity; sending the vial to a laboratory for analysis; inventorying the vials by scanning the RFID attached to the individual vials; and separating the RFID device from the vial so that the RFID device may be re-used.

Abstract: An apparatus for collecting biological aerosols from an air sample is provided comprising an air intake assembly adapted to draw the air sample into the apparatus, a separation section coupled to the intake assembly and adapted to separate aerosol particles from the air sample, a capture section coupled to the separation section and adapted to transport the aerosol particles in a stream of liquid, and a hydrophobic membrane disposed between the separation section and the capture section and adapted to establish a controllable air/fluid boundary therebetween.