Abstract: Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining an antihistamine with a nanoparticulate corticosteroid in a single formulation results in improved efficacy.

Abstract: Methods and mixtures for providing a composition of interest to a plant cell are provided. Methods using a mixture of particles are provided, wherein the mixture includes at least one nanoparticle associated with a microparticle via a lipid compound. Methods include methods for plant cell transformation, methods to increase transformation frequency, methods to increase gene targeting, and methods for plastid transformation. The nanoparticle comprises at least one composition of interest. Also provided are transformed plant cells, plants, and seeds produced using the methods and mixtures described herein. Further provided are the methods of making and using the mixtures of particles.

Abstract: The present invention relates to cationic lipids capable of forming complexes with nucleic acids and the use thereof for the transfection of eukaryotic cells. The cationic lipids according to the invention have general formulas (I) and (Ia): (see formulas (I) and (Ia), wherein E is a heteroaryl; R1 and R2 are selected from H, —R7—NH2, alkyl; R7 is selected from alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R3 and R4 are selected from: H, —R8—SH, R8—NH—NH2/—R8—CO—R9 or —R8—NH2; R8 is selected from: alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl-(C0-C20) alkyl; R9 is selected from: H, alkyl; R5 and R6 are selected from: H, alkyl, alkenyl, aryl, (C1-C20) alkyl-aryl.

Abstract: A method. A first copolymer is provided. A substrate is provided having an energetically neutral surface layer with at least one trough integrally disposed thereon with sidewalls. A first film of the first copolymer is coated inside the trough. Line-forming microdomains are assembled of the first copolymer forming first self-assembled structures within the first film normal to the sidewalls and parallel to the surface layer. The first and second polymer blocks are removed from the first film and oriented structures remain in the trough normal to the sidewalls and parallel to the surface layer. A second film of a second copolymer is coated inside the trough. Line-forming microdomains are assembled of the second copolymer, and form second self-assembled structures within the second film oriented normal to the oriented structures and parallel to the sidewalls. The third and fourth polymer blocks are removed, and at least one second oriented structure remains.

Abstract: This invention relates generally to capacitors comprising organized assemblies of carbon and non-carbon compounds. This invention further relates to methods of making such organized structures. It also relates to devices containing such structures. In preferred embodiments, the organized structures of the instant invention take the form of nanorods or their aggregate forms. More preferably, a nanorod is made up of a carbon nanotube filled, coated, or both filled and coated by a non-carbon material. In particular, the present invention is directed to a capacitor electrode comprising a carbon nanotube filled with one or more non-carbon materials comprising titanium, a titanium compound, manganese, a manganese compound, cobalt, nickel, palladium, platinum, bromine, iodine, an interhalogen compound, or the combination thereof.

Abstract: A conductive pattern forming ink for forming a conductive pattern on a substrate by a droplet discharge method includes: metal particles; an aqueous dispersion medium in which the metal particles are dispersed; inositol; and a polyglycerol compound having a polyglycerol skeleton. In the ink, H shown in the following formula (I) is 0.050 to 0.

Abstract: A conductive pattern forming ink for forming a conductive pattern on a substrate by a droplet discharge method includes: metal particles; an aqueous dispersion medium in which the metal particles are dispersed; galactitol; and a polyglycerol compound having a polyglycerol skeleton. In the ink, H shown in the following formula (I) is 0.10 to 0.

Abstract: A method of producing a polymer latex drag reducer. The method begins by forming an aqueous solution comprising a surfactant, a buffer and water. The method then forms an organic solution comprising a monomer and a co-stabilizer. The aqueous solution and the organic solution are mixed to form an emulsion. The emulsion is then subjecting to a high shear device to produce a miniemulsion, wherein the monomers are broken into small droplets followed by polymerizing the miniemulsion with the addition of an initiator, wherein a nucleation occurs in the small monomer droplets.

Abstract: This invention relates to a pharmaceutical dosage form for the site specific delivery of more than one active pharmaceutical ingredient to different sites in the human or animal body in the gastrointestinal tract. The dosage form has an outer polymeric layer incorporating a first active pharmaceutical ingredient which reacts to stimuli specific in the stomach, degrades, and releases the first active pharmaceutical ingredient in the stomach for absorption. The dosage form also has at least one inner polymeric layer incorporating a second active pharmaceutical ingredient which, once the outer layer has degraded, passes into the intestine where the polymers of the second layer degrade to release the second active pharmaceutical ingredient. The dosage form may have additional layers each incorporating active pharmaceutical ingredients for release in different portions of the intestine depending on the nature of the polymers.

Abstract: This invention relates to an orally administrable, gastroretentive pharmaceutical dosage form which contains at least one pharmaceutically active ingredient and at least one polymeric adjuvant. The adjuvant serves to retain the dosage form in a selected region of the gastrointestinal tract for sufficient time for the pharmaceutically active ingredient to be released and absorbed. Ideally the dosage form will contain two or more pharmaceutically active ingredients which are delivered to different regions of the gastrointestinal tract.

Abstract: The present invention describes a novel elastomeric biodegradable photoluminescent polymer (BPLP). The BPLPs of the present invention possess great processability and tunable fluorescence emission characteristics and are cell-compatible and biodegradable. The BPLPs of the present invention can serve as both implant materials and bioimaging probes.

Abstract: An agglomerate or capsule capable of being prepared by freeze-drying a first agglomerate or capsule, said first agglomerate comprising a solvent, nanoobjects or nanostructures coated with macromolecules of polysaccharides being homogeneously distributed in said agglomerate or said capsule, and said macromolecules forming in at least one portion of the first agglomerate, a gel by crosslinking with positive ions. A nanocomposite material comprising this agglomerate. A method for preparing this agglomerate and this nanocomposite material.

Abstract: A composite structure, for marking biomolecules in a biological, biochemical or medicinal system, comprises: at least one nano particle and at least one dendritic macromolecule, which has an inner region with branched, especially perfectly branched to highly branched, structures and a periphery, which comprises surface groups of the dendritic macromolecule, wherein a plurality, especially more than 50%, of the surface groups have in the periphery of the dendritic macromolecule, in each case, at least one functional group of first type, wherein the functional group of first type comprises at least one monosaccharide-, oligosaccharide- and/or polysaccharide unit, and wherein the dendritic macromolecule stabilizes the nano particle.

Abstract: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Abstract: Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labeled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labeled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labeled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.

Abstract: Polyurethane nanocomposites are provided which include a polyurethane and surface modified silica nanoparticles covalently bound into the polyurethane. High loadings in excess of 30% may be achieved. In some embodiments, the silica nanoparticles are covalently bound to the polyurethane polymer through a linkage derived from a surface-modifying compound comprising a silane functional group and a polyol segment. In some embodiments the polyurethane nanocomposite may be provided as a tape or film. In addition, precursors for a polyurethane nanocomposites are provided comprising: a first polyol and surface modified silica nanoparticles dispersed within the first polyol. In some embodiments, the silica nanoparticles are surface-modified by reaction with a surface-modifying compound comprising a silane functional group and a polyol segment derived from a second polyol, which may be the same or different from the first polyol.

Abstract: The invention at hand provides hydrolytically degradable ionic copolymers. These ionic copolymerizates are composed of one cyclic ketene acetal A, one anionic or cationic methacrylic acid derivative B, selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylene-allyloxy)]ethanesulfonate, [2-(2-methyl-1-methylene-allyloxy)ethyl]phosphonate or a quaternary amine of the N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and, optionally, a neutral methacrylic acid derivative C. The hydrolytically degradable anionic copolymers according to the present invention are produced by polymerizing the components A, B and C in the presence of a radical initiator under inert gas atmosphere and subsequent purification. All copolymers according to the present invention are hydrolytically degradable. Copolymers comprising a maximum of 40 mol-% of ester groups in the backbone are additionally biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% of quaternized DMAEMA is allowed to be available.

Abstract: The present invention is directed to compositions comprising an acylanilide, such as bicalutamide, having improved solubility in water. The bicalutamide particles of the composition have an effective average particle size of less than about 2000 nm, and are useful in the treatment of prostate cancer.

Abstract: Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a sampling member slideably engaged with a base that contains a lateral flow strip adapted to detect specific analytes of interest. The sampling member defines a solvent reservoir that stores an elution solvent in a fluid-tight manner before the device is used to sample and test environmental surfaces. During slideable withdrawal of the sampling member from the base, the elution solvent stored in the reservoir is automatically released to a wick assembly of the sampling member. The wick assembly includes a wick adapted to receive, distribute, and retain the elution solvent. After a user samples an environmental surface for an analyte of interest with the elution solvent wetted wick, the sampling member is returned to the base where the wick contacts the lateral flow strip contained in the base.

Abstract: Nicotinamide and/or a compound which is chemically combined with nicotinamide may be used as a carbon nanotube (“CNT”) n-doping material. CNTs n-doped with the CNT n-doping material may have long-lasting doping stability in the air without de-doping. Further, CNT n-doping state may be easily controlled when using the CNT n-doping material. The CNT n-doping material and/or CNTs n-doped with the CNT n-doping material may be used for various applications.

Abstract: A resin composition comprises a carbon-based nanofiller (A), a modified polyolefin-based polymer (B), and two or more resins (C) other than the modified polyolefin-based polymer (B), the resin composition comprising a dispersed phase formed from a resin (Caff) which has a highest affinity for the carbon-based nanofiller (A) among the two or more resins (C), and a continuous phase formed from the remaining one or more resins (C1), wherein at least part of the modified polyolefin-based polymer (B) is present at an interface between the dispersed phase and the continuous phase, and the carbon-based nanofiller (A) is present in the dispersed phase.

Abstract: The invention provides a process comprising heating a polyamic acid fiber to a temperature in the range of a first temperature and a second temperature for a period of time in the range of 5 seconds to 5 minutes to form a polyimide fiber, wherein the first temperature is the imidization temperature of the polyamic acid and the second temperature is the decomposition temperature of the polyimide

Abstract: Polyurethane gels are produced by converting a polyurethane system comprising (A1) one or more polyether alcohols of hydroxyl number 28 to 90 mg KOH/g produced primarily from propylene oxide added to a starter molecule of hydroxyl functionality between 2 and 4, (A2) one or more polyether alcohols of hydroxyl number 240 to 850 mg KOH/g produced primarily from propylene oxide added to a starter molecule of hydroxyl functionality between 2 and 4, (b1) one or more diisocyanates, (B2) one or more triisocyanates preferably produced by trimerisizing diisocyanates, (A3) at least one additive material fulfilling a prescribed function, and (A4) at least one additive material having a particle size in the range from 1 to 650 nm in the presence of one or more catalysts (A5) for forming polyurethane.

Abstract: A copolymer of formula 1 in which M1 is a unit obtainable from ring opening metathesis polymerization (ROMP); R is an alkyl, ether, ester or aryl unit; M2 and M3 are independently selected from units obtainable by reversible addition fragmentation chain transfer polymerization (RAFT); X is a terminal unit selected from the group consisting of dithioester, trithiocarbonate, xanthate; and m is an integer from 2 to 1 million, n is an integer from 2 to 500,000 and k is an integer from 2 to 500,000.

Abstract: There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.

Abstract: The present invention provides a process for the controlled gasification of a carbonaceous feedstock, including: pyrolizing the feedstock to produce a gas product and a solid product, wherein the gas product includes methane and noxious chemicals and the solid product includes carbon; and controlling the pyrolizing step using feedback related to constituents of the gas product. The present invention also provides a system for the controlled gasification of a carbonaceous feedstock, including: a pyrolysis unit including a heater and a conveyor for transporting the feedstock through the heater; a resultant chamber disposed downstream of the pyrolysis unit for separating gas products and solid products; means for adjusting the temperature of the solid products; and a filter for sequestering noxious materials from the gas products, wherein the filter uses at least some of the solid products to filter at least a portion of the gas products.

Abstract: There are provided compositions and methods to disperse mucin and/or actin using nanoparticles wherein the average diameter of the nanoparticles is less than about 1000 nm.

Abstract: Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance.

Abstract: Compositions comprising a fluorinated polymer and related methods.

Abstract: Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive agents are also provided.

Abstract: A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterised in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.

Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.

Abstract: Disclosed is a long fiber-reinforced colored pellet. The long fiber-reinforced colored pellet may include a thermoplastic polymer resin, a fiber reinforced material having a length of about 5 to 50 mm, and a pigment. In this instance, the thermoplastic polymer resin has a melt index (MI) of about 0.1 to 80 g/10 min at about 230° C. and under about 2.16 kg load, and a surface hardness of the pigment is about 5 or less.

Abstract: This invention concerns a manufacturing process for nanoparticles composted of biodegradable polymers and active ingredients with therapeutic, cosmetic, veterinary, and alimentary applications, and a composition which contains said nanoparticles, which are used in products for animals, including humans. The process consists of emulsifying the hydrosoluble substances to form a w/o emulsion; dissolving the non-emulsionable substances, liposoluble polymer or polymer/compounds in organic solvents; mixing the w/o emulsion and the organic solution of the hydrophobics to form a pre-emulsioned mixture; adding the pre-emulsioned mixture, with the assistance of an injector system, to an aqueous emulsifier solution under ultradispersion to form the final emulsion; leading the final emulsion to evaporation, then centrifuge, freeze, and lyophilize.

Abstract: Casting compound suitable for casting an electronic module, in particular a large-volume coil such as a gradient coil, which is composed of a support material forming a matrix, one or more fillers made of inorganic microparticles, and at least one filler made of polymer nanoparticles.

Abstract: A graft copolymer based on a component a) consisting of silica which has been reacted with an unsaturated silane, and a polymer component b) containing sulphonic acid is proposed. The silica used is preferably a nanosilica and the unsaturated silane is an ethylenically unsaturated alkoxysilane. The component b) is represented by a copolymer based on AMPS and a further ethylenically unsaturated monomer. The polymer according to the invention, which as a rule is a nanocomposite, is outstandingly suitable as an additive in construction chemistry applications and in the development, exploitation and completion of underground mineral oil and natural gas deposits, its effect as a water retention agent being particularly advantageous at high salinities and increased temperatures.

Abstract: The invention relates to a polymerizable composition containing: a) acrylates and/or methacrylates which have a glass transition temperature Tg of 0° C. or less, b) from 0.5 to 70% by weight of SiO2 particles which have an average particle size of from 1 to 150 nm and have polymerizable groups on the surface and are present in dispersed form in the acrylates and/or methacrylates, with at least 50% of the SiO2 particles being individual unaggregated or unagglomerated primary particles, where the composition contains not more than 2% by weight of crosslinker molecules.

Abstract: A method for covalently binding target molecules to carbon nanoparticles via at least one bridge molecule includes converting carbon nanoparticles to acyl carbon nanoparticles using a carbonyl compound of the at least one bridge molecule in the presence of a Lewis acid under Friedel-Crafts conditionsm, where the acyl carbon nanoparticles include a nucleofuge in the omega position. The target molecule is covalently bound to the acyl carbon nanoparticles via nucleophilic substitution of the nucleofuge in the omega position.

Abstract: Single-core and multi-core microcapsules are provided, having multiple shells, at least one of which is formed of a complex coacervate of two components of shell materials. The complex coacervate may be the same or different for each shell. Also provided are methods for making the microcapsules.

Abstract: Polyhydroxyfullerenes (PHFs) having enhanced electron scavenging capabilities have a ratio of non-hydroxyl functional groups to hydroxyl functional groups that is less than or equal to 0.3. When combined with a semiconductor photocatalyst, such as titanium dioxide nanoparticles, the PHFs provide a photocatalyst for degradation of chemical and biological contaminates with an efficiency of at least twice that of titanium dioxide nanoparticles free of PHFs. The PRFs are included in these catalysts at a weight ratio to titanium dioxide of about 0.001 to about 0.003, whereas significantly lower and higher ratios do not achieve the highly improved photodegradation capability. PHFs outside of the desired structure are shown to be of little value for photodegradation, and can be inhibiting to the photocatalytic activity of TiO2. The enhanced electron scavenging PHFs can be employed as a component of materials for solar cells, field effect transistors, and radical scavengers.

Abstract: The invention relates to a method for preparing an aqueous suspension of nanocapsules comprising an oily core surrounded by a polymeric shell, in which method the following phases are mixed: a) a first phase, called an oily phase, comprising: a hydrophobic polymer, an oil or a mixture of oils, at least one active ingredient, and a surfactant TA1, this oily phase being brought to a temperature T1 higher than the melting point of the hydrophobic polymer, the hydrophobic polymer being miscible, at this temperature T1, with the mixture of the surfactant TA1 and the oil or mixture of oils, and the active ingredient being miscible, soluble or solubilized in the mixture of the surfactant TA1 and the oil or mixture of oils; b) a second phase, called a polar phase, comprising a hydrophilic polymer in the form of a hydrogel in an aqueous solution containing a surfactant TA2, in such a way as to obtain the formation of the nanocapsules in an aqueous suspension.

Abstract: The present invention concerns a composition comprising vesicles and encapsulated within the vesicles, an antibody, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of delivering the above compositions into cells are also described.

Abstract: Processes and methods of making and preparing, compositions and structural products therefrom are provided, whereby the surface area of alumino-silicate based powders is greatly increased and rendered chemically active so that when the functionalized powders are mixed with water poly-condensation reactions occur between the surfaces binding the powders together to form a structural material with negligible emission of carbon compounds. In another embodiment, the surface functionalized powders can be mixed with an additive; a dry aggregate, such as sand and water to make a slurry that can be poured or cast into any desired shape and rapidly cured to a hardened shape suitable for use as a structural material with the mechanical strength equivalent to Portland-cement based concrete products.

Abstract: A nanostructured particulate material, which includes a redox active luminescent organic and/or ionic compound, is provided herein. The nanostructured particulate material may be used for determining the presence of an analyte of interest in a sample by detecting the emitted electromagnetic radiation generated by exposing a reagent mixture, which includes the nanostructured material and the target analyte, to chemical or electrochemical energy.

Abstract: A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated-benzimidazolone compound; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles.

Abstract: The presently-disclosed subject matter provides microfluidic devices comprised of two or more carbon nanotube membranes disposed at predetermined intervals within a microchannel. Further provided are methods of using the same for the electrokinetic separation of one or more molecules of interest from a sample.

Abstract: A catalyst for producing a carbon nanofiber is obtained by dissolving or dispersing [I] a compound containing Fe element; [II] a compound containing Co element; [III] a compound containing at least one element selected from the group consisting of Ti, V, Cr, and Mn; and [IV] a compound containing at least one element selected from the group consisting of W and Mo in a solvent to obtain a solution or the fluid dispersion, and then impregnating a particulate carrier with the solution or the fluid dispersion. A carbon nanofiber is obtained by bringing a carbon element-containing compound into contact with the catalyst in a vapor phase at a temperature of 300 degrees C. to 500 degrees C.

Abstract: A microwave-sensitive thermoplastic composition that includes a microwave-receptive additive; and a thermoplastic polymer; wherein the microwave-receptive additive is selected from the group consisting of sepiolite clay, molecular sieves formed from ammonium ion salts or hydrogen ion salts, aluminophosphates, silicoaluminophasphates, silicotitanates, organo-modified clays, molecular sieves or zeolites having a caged organic microwave receptive material, and combinations thereof.

Abstract: The present invention relates to novel composites that incorporate carbon nanospheres into a polymeric material. The polymeric material can be any polymer or polymerizable material compatible with graphitic materials. The carbon nanospheres are hollow, graphitic nanoparticles. The carbon nanospheres can be manufactured from a carbon precursor using templating catalytic nanoparticles. The unique size, shape, and electrical properties of the carbon nanospheres impart beneficial properties to the composites incorporating these nanomaterials.

Abstract: Toughened curable compositions are described. The curable compositions include a curable resin, surface-modified nanoparticles, and rubber nano-domains. Both core-shell rubber nano-domains, and nano-rubber domains arising from self-assembled block co-polymers are disclosed. Toughened, cured resin compositions, and articles comprising such cured compositions are also discussed.