Therapeutic Or Pharmaceutical Composition Patents (Class 977/915)
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Publication number: 20120045514Abstract: The present invention relates to a microparticle and its use. The microparticle has a width of at least about 1 micron. The microparticle includes a biocompatible polymer, a nanoparticle, and an anti-cancer agent.Type: ApplicationFiled: November 24, 2009Publication date: February 23, 2012Applicant: Agency for Science, Technology and ResearchInventors: Yin Win Khin, Enyi Ye, Mingyong Han
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Publication number: 20120039951Abstract: Provided are methods for enhancing exercise (e.g., intense, eccentric, elevated temperature, repetitive, aerobic, and high altitude) performance, comprising administering electrokinetically-altered aqueous fluids comprising an ionic aqueous solution of stably configured charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than 100 nanometers. In certain aspects, enhancing exercise performance comprises at least one of: reducing plasma inflammatory cytokines (e.g., IFN-alpha, ENA-78 and BDNF); ameliorating muscle/tendon damage or enhancing muscle/tendon recovery; reducing biomarkers of exercise-induced muscle injury (e.g., CK, plasma myoglobin); ameliorating exercise induced tendinosis, tendonitis, tenosynovitis, avulsion, and tendon strain associated with chronic repetitive movement or enhancing recovering therefrom; increasing VO2 max; decreasing RPE; reducing blood lactate; preserving muscle contractile function (e.g.Type: ApplicationFiled: May 6, 2011Publication date: February 16, 2012Applicant: REVALESIO CORPORATIONInventors: RICHARD L. WATSON, ANTHONY B. WOOD, GREGORY J. ARCHAMBEAU
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Publication number: 20120034156Abstract: The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, computer-implemented methods relating thereto, and associated computer program products.Type: ApplicationFiled: August 3, 2010Publication date: February 9, 2012Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Wayne A. Kindsvogel, Gary L. McKnight, Elizabeth A. Sweeney, Lowell L. Wood, JR.
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Publication number: 20120034162Abstract: A composition and method is described for intracellular delivery of fullerene containing peptides. The composition and method involve fullerene-substituted phenylalanine as part of a peptide based delivery system. The presence of a fullerene-substituted amino acid in a peptide is found to alter the intracellular transport properties of the peptide.Type: ApplicationFiled: March 30, 2007Publication date: February 9, 2012Applicant: William March Rice UniversityInventors: Andrew R. Barron, Jianzhong Yang, Jianhua Yang, Kuan Wang, Jonathan Driver
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Publication number: 20120027809Abstract: The present invention provides pharmaceutical compositions comprising water-soluble sulfonate-protected nanoparticles, more particularly, pharmaceutical compositions comprising water-soluble sulfonate-protected silver or gold nanoparticles. The pharmaceutical compositions of the invention are useful in prevention or treatment of infections or conditions or disorders caused by microorganisms capable of binding to heparan sulfate, e.g., herpes simplex viruses.Type: ApplicationFiled: June 21, 2011Publication date: February 2, 2012Applicant: Bar-llan UniversityInventors: Ronit Sarid, Aharon Gedanken, Dana Baram-Pinto
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Publication number: 20120027821Abstract: Disclosed are cyanoacrylate polymer particles which comprise an amino acid(s) and have an average particle diameter of less than 1000 nm. The amino acid-containing particles according to the present invention can kill cancer cells by inducing apoptosis-like cell death. The particles have an especially high affinity for cell lines derived from lymphomas such as T-cell lymphoma and B-cell lymphoma. The particles can also exhibit an antiproliferative effect against some kinds of pancreatic cancer-derived cell lines. Therefore, the particles according to the present invention are useful for prevention and/or treatment of cancers.Type: ApplicationFiled: March 3, 2010Publication date: February 2, 2012Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITYInventors: Shoichi Shirotake, Atsushi Yoshida, Shumpei Yokota, Itaru Endo
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Publication number: 20120021010Abstract: Disclosed herein are compositions and methods for inhibiting platelet aggregation in a patient in need thereof. The compositions and methods use superparamagnetic iron oxide nanoparticles (SPIONs), which are shown to inhibit aggregation of platelets. Such methods are useful in preventing blood clotting in diseases such as acute coronary syndrome. Also disclosed are in vitro methods of sensing platelet function using SPIONs.Type: ApplicationFiled: June 14, 2010Publication date: January 26, 2012Inventors: Suryyani Deb, Anjan Kr. Dasgupta
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Publication number: 20120021016Abstract: Compounds of general Formula (I), and cosmetic and pharmaceutical compositions containing such a compound are described.Type: ApplicationFiled: February 26, 2010Publication date: January 26, 2012Applicant: GALDERMA RESEARCH & DEVELOPMENTInventor: Cédric Poinsard
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Publication number: 20120021012Abstract: The present invention relates to SiC nanoparticles to be used in the context of cancer treatment, said nanoparticles preferably having a size less than 100 nm.Type: ApplicationFiled: October 16, 2009Publication date: January 26, 2012Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE CLAUDE BERNARD DE LYON (UCBL)Inventors: Volodymyr Lysenko, Alain Geloen, Barbara Mognetti
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Publication number: 20120015035Abstract: The present invention provides compositions and methods for treating ocular disorders such as myopia.Type: ApplicationFiled: January 11, 2010Publication date: January 19, 2012Inventors: Christine F. Wildsoet, James Su, Kevin E. Healy
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Publication number: 20120015004Abstract: Encapsulated nutrient salts including nutrient salt particles encapsulated with a water-insoluble chitosan-stearic acid complex are provided. A method for forming encapsulated nutrient salts is provided, including forming a water-in-oil micro-emulsion including an oil and an aqueous salt solution, adding chitosan and stearic acid to the water-in-oil micro-emulsion, where the chitosan and stearic acid form a complex, and collapsing the aqueous phase of the water-in-oil micro-emulsion to form the encapsulated salt particles.Type: ApplicationFiled: June 14, 2011Publication date: January 19, 2012Applicant: TROPICANA PRODUCTS, INC.Inventors: Maxim A. Mironov, Peter S. Given, Teodoro Rivera
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Publication number: 20120004293Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.Type: ApplicationFiled: May 17, 2011Publication date: January 5, 2012Inventors: Stephen E. Zale, Mir Mukkaram Ali
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Publication number: 20120004181Abstract: The present invention relates a targeted delivery system for siRNA or antisense technology. In one embodiment, the invention provides for a method of treating cancer by administering a therapeutically effective dosage of HerPBK10 combined with siRNA, resulting in the inhibition of Her2 expression and cell death. In another embodiment, a plurality of HerPBK10 combined with siRNA form a nanoparticle.Type: ApplicationFiled: July 22, 2011Publication date: January 5, 2012Applicant: CEDARS-SINAI MEDICAL CENTERInventor: Lali K. Medina-Kauwe
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Publication number: 20120004531Abstract: A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses.Type: ApplicationFiled: March 16, 2010Publication date: January 5, 2012Inventors: Zdravka Medarova, Anna Moore, Mehment Yigit
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Publication number: 20120004308Abstract: The invention provides a novel method for obtaining solid micro- or nanoparticles with a homogeneous structure. A method is provided for obtaining solid micro- or nanoparticles with a homogeneous structure having a particle size of less than 10 ?m where the processed solid compound has the natural, crystalline, amorphous, polymorphic and other features associated with the starting compound. In accordance with the invention a method which also makes it possible to obtain solid micro- or nanoparticles with a substantially spheroidal morphology is provided.Type: ApplicationFiled: November 6, 2009Publication date: January 5, 2012Applicants: CENTRO DE INVESTIGACION BIOMEDICA EN RED EN BIOINGENIERIA, BIOMATERIALES Y NANOM, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Nora Ventosa Rul, Jaume Veciana Miró, Mary Cano Sarabia, Santiago Sala Vergés
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Publication number: 20110311596Abstract: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.Type: ApplicationFiled: August 30, 2011Publication date: December 22, 2011Applicant: Abbott Cardiovascular Systems Inc.Inventors: Michael Huy Ngo, Mikael O. Trollsas, Thierry Glauser, Jinping Wan, Bozena Zofia Maslanka
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Publication number: 20110311647Abstract: The present invention provides novel compositions comprising: (a) protamine sulfate and (b) benzalkonium chloride or a silver containing particle; or (a) sodium metaperiodate and (b) 5-fluorouracil or chlorhexidine and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: ApplicationFiled: January 22, 2010Publication date: December 22, 2011Applicant: Kane Biotech Inc.Inventors: Purushottam V. Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich
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Publication number: 20110311613Abstract: Described herein, are topical formulations for treating a dermatological disease, disorder, or condition.Type: ApplicationFiled: December 21, 2009Publication date: December 22, 2011Applicant: AMIRA PHARMACEUTICAL, INC.Inventors: John Howard Hutchinson, Jillian F. Evans, Kevin Murray Schaab
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Publication number: 20110311505Abstract: This invention is related to preparation of photosensitive ruthenium based aminoacid monomers and oligomers, aminoacid monomer-protein cross-linking using photo sensitat ion and conjugation on micro and nano-structures by ruthenium-chelate based monomers. Its vast range biotechnolgy applications of multifunctional, biocompatible, stabilE and specific micro and nanobio-conjugates, which will stand-alone or simultaneously enable (i) both purification and determination, (ii) both targeting and imaging and theranostics and (iii) catalysis and determination. The construction and method of preparation is applicable to silica materials, superparamagnetic particles, QDs, CNTs, Ag/Au nanoparticles and Au surfaces and polymeric materials. The photosensitive aminoacid monomer linkers can react via chemically and biocompatible to a lot of different micro and nano-surface and then to the protein when they act as a single-step cross-linking reaction using irradiation.Type: ApplicationFiled: December 11, 2009Publication date: December 22, 2011Inventors: Arzu Ersoz, Deniz Hur, Filiz Yilmaz, Adil Denizli, Ayca Atilir Ozcan, Sibel Emir Diltemiz, Suzan Yazar, Ozlem Bicen, Sibel Buyuktiryaki, Rustem Kecili, Guner Saka, Tugba Findik
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Publication number: 20110305768Abstract: This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the thin film and provide protection to components encapsulated within. The invention further describes methods to incorporate bioactive components encapsulated within pH-sensitive polymeric microparticles into a quick-dissolving thin film strip while maintaining the bioactivity of the contained therapeutic agents during thin film formation and microencapsulation.Type: ApplicationFiled: December 24, 2008Publication date: December 15, 2011Applicant: The Johns Hopkins UniversityInventors: Hai-Quan Mao, Christopher Ku Yu, Vu Linh Truong, Yang Li, Dhanya Rangaraj, Xuesong Jiang, Sagar Ramesh Shah, Derek Sing
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Publication number: 20110293723Abstract: Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are not coupled to the synthetic nanocarriers, and a pharmaceutically acceptable excipient.Type: ApplicationFiled: May 26, 2011Publication date: December 1, 2011Applicant: Selecta Biosciences, Inc.Inventors: Robert L. Bratzler, Grayson B. Lipford, Lloyd Johnston, Charles Zepp
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Publication number: 20110293705Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.Type: ApplicationFiled: November 24, 2009Publication date: December 1, 2011Applicant: Massachusetts Institute of TechnologyInventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
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Publication number: 20110287069Abstract: A solid oral dosage pharmaceutical formulation of (R)-2-Amino-7-[4-fluoro-2-(6-methoxy-pyridin-2-yl)-phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one or its salt; and a surfactant or an acid.Type: ApplicationFiled: January 28, 2010Publication date: November 24, 2011Inventors: Daya Verma, Yue (Helen) Teng, Rajinder Singh, Dan Thompson
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Publication number: 20110274622Abstract: The invention relates to a nanocrystal formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase comprises a cosurfactant. The invention also relates to a method for the production of said formulation as well as uses within the fields of medical imaging, thermotherapy or phototherapy.Type: ApplicationFiled: August 14, 2009Publication date: November 10, 2011Applicant: Commissariat a L"energie atomique et aux energies alternativesInventors: Isabelle Texier-Nogues, Toufic Daou, Mathieu Goutayer
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Publication number: 20110274621Abstract: Nanoparticles, which are luminescent and/or electroactive and/or suitable for MRI (magnetic resonance imaging and/or PET (positron emission tomography) applications, comprise a micelle, which has a hydrophilic shell and an hydrophobic central portion, and a polysilicate core; the micelle comprises a plurality of molecules of a functionalized surfactant having the following structure: M1-Hydro1-Lipo-Hydro2-M2 wherein Lipo indicates a hydrophobic chain; Hydro1 ed Hydro2 indicate, each, a respective hydrophilic chain; M1 ed M2 represent respective recognition functionalities.Type: ApplicationFiled: July 31, 2009Publication date: November 10, 2011Applicant: ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNAInventors: Sara Bonacchi, Riccardo Juris, Marco Montalti, Luca Prodi, Enrico Rampazzo, Nelsi Zaccheroni
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Publication number: 20110275702Abstract: The present invention provides a ligand-nucleic acid nanostructure that promotes cell-cell interaction. Specially, the invention provides a ligand-nucleic acid nanostructure for treating tumor in a mammal. The methods of using and making the composition comprising a ligand-nucleic acid nanostructure are also provided.Type: ApplicationFiled: October 2, 2009Publication date: November 10, 2011Applicant: ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTINGInventors: Yung Chang, Hao Yan
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Publication number: 20110274759Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic)acid-poly(ethylene)glycol.Type: ApplicationFiled: May 17, 2011Publication date: November 10, 2011Inventors: Greg Troiano, Michael Figa, Abhimanyu Sabnis
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Publication number: 20110275686Abstract: Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for clinical use in photodynamic therapy comprising a hydrophobic photosensitizer, poly(lactic-co-glycolic) acid and stabilizing agents are provided. These nanoparticulate pharmaceutical formulations provide therapeutically effective amounts of photosensitizer for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers, whose efficacy and safety are enhanced by such nanoparticulate formulations. It also teaches the method of preparing PLGA-based nanoparticles under sterile conditions. In one of the preferred embodiments of the present invention PLGA-based nanoparticles have a mean particle size less than 500 nm and the photosensitizer is temoporfin, 5,10,15,20-tetrakis(3-hydroxyphenyl)-chlorin (mTHPC).Type: ApplicationFiled: November 8, 2010Publication date: November 10, 2011Inventors: Klaus Langer, Thomas Knobloch, Beate Röder, Annegret Preuß, Volker Albrecht, Susanna Gräfe, Arno Wiehe, Hagen von Briesen, Karin Löw, Sylvia Wagner
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Publication number: 20110269830Abstract: The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one 2-methyl-buta-2-ene unit, to nanoparticles of such a complex, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least one complex and/or nanoparticles such as previously defined. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of hyperlipemia and hypercholesterolemia.Type: ApplicationFiled: October 28, 2009Publication date: November 3, 2011Inventors: Patrick Couvreur, Didier Desmaele, Fat'ma Zouhiri, Reddy Harivardhan Lakkireddy
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Publication number: 20110268659Abstract: In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.Type: ApplicationFiled: April 8, 2011Publication date: November 3, 2011Applicant: H R D CorporationInventors: Abbas HASSAN, Rayford G. ANTHONY, Aziz HASSAN
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Publication number: 20110269731Abstract: The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to nanoparticles of said complexes, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least said complex and/or said nanoparticles. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of bacterial infections, in particular caused by strains that are sensitive to beta-lactams.Type: ApplicationFiled: October 28, 2009Publication date: November 3, 2011Inventors: Patrick Couvreur, Didier Demaele, Fatima Zouhiri
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Publication number: 20110262364Abstract: A core-shell nanoparticle having a core that includes a fluorophore and a first oxide of a first metal and a shell that includes a second oxide of a second metal such that the first oxide and the second oxide are different. Also disclosed are methods relating to the core-shell nanoparticle.Type: ApplicationFiled: April 4, 2011Publication date: October 27, 2011Inventors: Hua Wang, Denise Wingett, Kevin Feris, Mfadhusudan R. Kongara, Alex Punnoose
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Publication number: 20110262356Abstract: Luminescent and/or electroactive nanoparticles suitable for MRI (Magnetic Resonance Imaging) and/or PET (Positron Emission Tomography) are prepared by mixing luminescent or electroactive compounds and ethyl oxide/propyl oxide block-copolymers in an organic solvent, which is thereafter evaporated in order to obtain a residue; and by hydrolyzing-condensating tetraalkoxysilanes in an aqueous solution in the presence of the residue; the obtained nanoparticles show no or a negligible release of the luminescent or electroactive compounds and are useful for bio-analytic and bio-medic applications.Type: ApplicationFiled: July 31, 2009Publication date: October 27, 2011Applicants: CYANAGEN S.R.L., ALMA MASTER STUDIORUM-UNIVERSITA' DI BOLOGNAInventors: Sara Bonacchi, Ricarrdo Juris, Marco Montalti, Luca Prodi, Enrico Rampazzo, Nelsi Zaccheroni, Leopoldo Della Ciana, Serena Fabbroni, Stafano Grilli, Ettore Marzocchi
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Publication number: 20110263492Abstract: A method for preparing a formulation containing nanoparticles of a compound is described. The method includes forming the compound into nanoparticles and then delivering the nanoparticles directly to a collection media. The collection media is a desired component of the formulation.Type: ApplicationFiled: October 19, 2010Publication date: October 27, 2011Inventors: Nahed M. Mohsen, Thomas A. Armer
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Publication number: 20110262500Abstract: The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.Type: ApplicationFiled: December 15, 2009Publication date: October 27, 2011Applicants: FUNDACIÓ PRIVADA INSTITUT CATALÁ DE NANOTECNOLOGIA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU, UNIVERSITAT DE VALÉNCIA, UNIVERSIDADE DE SANTIAGO DE COMPOSTELAInventors: Victor Franco Puntes, Fernando Domìnguez Puente, Francisco Manuel Romero Martínez, Óscar Gallego Rubio
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Publication number: 20110263514Abstract: Provided are compositions and methods for delivery of therapeutic agents, such as chemically stabilized antisense oligonucleotides useful in RNA silencing. The compositions include interfering nanoparticles (iNOPs) associated with one or more agents. Several functional iNOP derivatives are provided which allow for targeted delivery of agents to specific cell types as well as exhibiting reduced cellular toxicity.Type: ApplicationFiled: March 16, 2011Publication date: October 27, 2011Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTEInventor: TARIQ M. RANA
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Publication number: 20110256225Abstract: Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and/or polymersomes comprising of poly(ethylene oxide)-block-poly(?-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(?-methyl ?-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties.Type: ApplicationFiled: April 19, 2011Publication date: October 20, 2011Applicant: Vindico NanoBio Technology Inc.Inventors: P. Peter Ghoroghchian, Eric Ostertag
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Publication number: 20110256183Abstract: Compositions and methods are provided for the manufacture and use of hydrogels with increased permeability to macromolecules with minimum loss of matrix mechanical strength and prepolymer viscosity for patternability. The hydrogels of the invention are formed from a prepolymer, which is polymerized in the presence of hydrophobic nanoparticles. In some embodiments of the invention cells are present during polymerization, and are encapsulated by the hydrogel. A high interfacial energy between the hydrophobic substrate and the aqueous polymerizing solution disrupts the hydrogel network structure, leading to network defects that increase permeability without loss of patternability.Type: ApplicationFiled: March 11, 2011Publication date: October 20, 2011Inventors: Curtis W. Frank, Won Jae Lee, Nam-Joon Cho, Jeffrey S. Glenn
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Publication number: 20110250259Abstract: Breast cancer is a common cancer in women. Early diagnosis and treatments are vital for better outcomes. This formula consists of a liquid anti-disease anti-cancer formula that can be delivered to the source where breast cancer begins. Method of treating breast disease, including cancer, with a formula and a means of delivery with a topical, intraductal, ductal, and/or intraductal infusion to prevent the formation of cancer or precursors to cancer or atypia or other form of abnormal breast tissue or to treat breast diseases of all kinds. May include homeopathic remedies to be used topically or inside the breast with a delivery method to those regions and may be processed with or without photonic programming or an ionic delivery system for greater effectiveness and use against degenerative diseases or cancerous or precancerous diseases, precursors of breast disease, inflammatory breast disease, or accumulation of toxins in the breast tissue.Type: ApplicationFiled: April 12, 2010Publication date: October 13, 2011Inventor: Kevin Buckman
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Publication number: 20110250237Abstract: The present application pertains to a composition, comprising (a) amphipathic peptides; (b) lipids and (c) at least one immunogenic species. Respective compositions are suitable for immunogenic species transport and delivery, for example for systemic or local delivery to a mammal. Also provided are pharmaceutical compositions, comprising respective compositions. Methods of forming the foregoing are also provided.Type: ApplicationFiled: July 15, 2009Publication date: October 13, 2011Inventors: Derek O'Hagan, Andrew Geall, Philip Dormitzer
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Publication number: 20110250278Abstract: Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing opioid-induced side effects in patients, and may be provided to chronic opioid users as well.Type: ApplicationFiled: June 15, 2009Publication date: October 13, 2011Applicant: University of ChicagoInventor: Chun-Su Yuan
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Publication number: 20110250243Abstract: Poly(ethylene carbonate) (PEC) nanoparticles comprising pharmacologically active substances, their production method and their use for sustained release of the pharmacologically active agent after application are described.Type: ApplicationFiled: December 14, 2009Publication date: October 13, 2011Inventors: Thomas Kissel, Holger Petersen
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Publication number: 20110237536Abstract: The present invention relates to the use of spicamycin derivatives for treatment and/or prevention of pain, including neuropathic pain. The invention further relates to pharmaceutical compositions of spicamycin derivatives suitable for treatment or prevention of pain.Type: ApplicationFiled: October 9, 2009Publication date: September 29, 2011Inventors: John R. Didsbury, Kenneth J. Ingold, Linda Goff Jet, Andrew Xian Chen, Hailiang Chen
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Publication number: 20110236430Abstract: The present invention provides a method for controlling toxicity of metallic particles and a low-toxicity composite of metallic nanoparticles and inorganic clay. The metallic nanoparticles are effective in preventing infection and in skinning over, and thus suitable for treating scalds/burns. In the composite, the weight ratio of metallic nanoparticles to inorganic clay preferably ranges 0.1/99.9 to 6.0/94.0 in a size of about 5 to 100 nm. Preferably, the metal is silver and the inorganic clay is nano silicate platelets.Type: ApplicationFiled: January 24, 2011Publication date: September 29, 2011Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Jiang-Jen Lin, Hong-Lin Su, Fu-Chuo Peng, Chia-Yu Chu, Ying-Fang Chiu, Pei-Ru Li, Hsi-Tai Sun
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Publication number: 20110229532Abstract: A process for nanomulsification of highly lipophillic polyphenols compounds using non-ionic surfactant and a non-ionic co-solvent with the help of sonar energy, to enhance the aqueous solubility is disclosed herein.Type: ApplicationFiled: November 17, 2009Publication date: September 22, 2011Inventors: Anitha Krishnan Nair, Ramchand Nanappan Chaniyilparampu, Kiran Bhupathiraju, Rama Raju Gokaraju, Ganga Raju Gokaraju, Trimurtulu Golakoti
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Publication number: 20110229577Abstract: The present invention relates to low-molar mass condensed derivatives of silicic acid of sub-nano particle size characterised by particular structure and specific biological activities. Preparation methods and applications are presented for the here disclosed sub-nano silicic acid (SNSA) which interact with bio-molecules and modify significantly their structure and biological function. Preferred field of application of the inventive silicic acid derivatives is to modulate the structure and biological function of proteins particularly of those involved in reversible phosphorylation within biological signal transduction or membrane transport processes. Structure of the substances, methods for the preparation and stabilization, as well as pharmaceutical compositions comprising the substances and methods of application in the prevention, diagnosis and therapy of diseases are disclosed.Type: ApplicationFiled: July 31, 2009Publication date: September 22, 2011Inventor: Franz Kerek
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Patent number: 8017147Abstract: A synergistic mixture (which may be utilized as a food or a drink or a supplement or a drug or a cosmetic or a hygienic product) that is formulated and is capable of improving a person's well being, lowering the risks of cardiovascular and/or Alzheimer's diseases and/or lowering blood sugar using natural and synthetic ingredients. Numerous ratios may be formulated for aroma, color, flavor, flow (viscosity), taste and uniformity. Moreover, ingredients for sugar substitutes, natural preservatives, nano-dispersion, nano-emulsion, nano-encapsulation of ingredients and apparatus for personalized nutrition are also described herein.Type: GrantFiled: October 2, 2009Date of Patent: September 13, 2011Inventors: Mohammad A. Mazed, Sayeeda Mazed
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Publication number: 20110212142Abstract: Aqueous ophthalmic compositions comprising natural or synthetic curcuminoids either alone or in combination, nonionic surfactant and co-solvent along with suitable ophthalmic excipients, effective in increasing the bioavailability of the active compounds when administered topically to the eye is disclosed herein.Type: ApplicationFiled: November 17, 2009Publication date: September 1, 2011Applicant: LAILA PHARMACEUTICALS PVT.LTD.Inventors: Ramchand Nanappan Chaniyilparampu, Anitha Krishnan Nair, Anuj Kapoor, Kavitha Parthasarathy, Kiran Bhupathiraju, Rama Raju Gokaraju, Ganga Raju Gokaraju, Trimurtulu Golakoti
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Publication number: 20110212157Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.Type: ApplicationFiled: June 26, 2009Publication date: September 1, 2011Applicant: ANTERIOS, INC.Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
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Patent number: 8008249Abstract: Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.Type: GrantFiled: January 15, 2010Date of Patent: August 30, 2011Assignee: Morehouse School of MedicineInventor: Byron D. Ford