Abstract: A tone generating system 100 has a motion detection terminal 11 and a tone producing device. The Motion detection terminal 11 has a motion sensor MS which is attached to the back of a hand, and transmitting unit 11a. The Motion sensor MS detects a torsional motion of the hand to which it is attached. The Transmitting unit 11a transmits motion information on the torsional motion. A Tone producing device 10 receives the motion information, generates control information based on the motion information, and produces a tone on the basis of the control information.

Abstract: The present invention discloses combined therapies for treating hematologic malignancies, including B cell lymphomas and leukemias or solid non-hematologic tumors, comprising administration of anti-cytokine antibodies or antagonists to inhibit the activity of cytokines which play a role in perpetuating the activation of B cells. The administration of such antibodies and antagonists, particularly anti-IL10 antibodies and antagonists, is particularly useful for avoiding or decreasing the resistance of hematologic malignant cells or solid tumor cells to chemotherapeutic agents and anti-CD20 or anti-CD22 antibodies. The invention also provides combination therapies for solid tumors having B cell involvement comprising the administration of an anti-cytokine antibody and a B cell depleting antibody such as RITUXAN® (rituximab).

Abstract: A method of determining aberration of an optical imaging system comprises measuring at least one parameter, such as position of best-focus and/or lateral position, of an image formed by the imaging system. This is repeated for a plurality of different illumination settings of the imaging system, and from these measurements at least one coefficient, representative of aberration of said imaging system, is calculated.

Abstract: The present invention relates to methods for treating B cell lymphoma using CD80-specific antibodies.

Abstract: Sound radiating structure includes a plurality of pipes each defining an inner cavity along the length of the pipe. Each of the pipes has an end opening at one end and is closed at the other end with a closure. Each of the pipes also has a side opening in its one side portion. When a sound is input to the sound radiating structure, it re-radiates various sound waves through a number of the end and side openings together with reflected sound waves.

Abstract: A manure management system that removes a large percentage of solids from a manure slurry when the slurry is run across a series of sloped screen separators. The sloped screen on the separator has very small openings. In addition, the separator has a water line with spray heads formed across the sloped screen. The spray heads direct water under pressure onto the sloped screen. Further, the separator controls the air flow through the sloped screen.

Abstract: Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian cells, including cells of human origin, in vitro or in vivo. The inventive method involves the use of a pituitary tumor transforming gene carboxy-terminal peptide (PTTG-C), which has the ability to regulate endogenous pituitary, tumor transforming gene (PTTG) expression and/or function in a dominant negative manner. In some embodiments, the invention is directed to gene-based treatments that deliver PTTG-C-related polynucleotides to mammalian cells, whether in vitro or in vivo, to inhibit the endogenous expression of PTTG. Other embodiments are directed to peptide-based treatments that deliver PTTG-C peptide molecules to the cells, which inhibit endogenous PTTG expression and/or PTTG function. Additional embodiments directed to a method of inhibiting tumor angiogenesis, in vivo, are also disclosed.

Abstract: On an optical disk, video object sets (VTST_VOBS) to be reproduced and video title set information (VTSI) serving as management information on the video object sets have been stored. In each video object set (VTST_VOBS), many data cells, each containing video, audio, and sub-picture data, are arranged. Management information on programs chains, which are combinations of programs to be reproduced one after another, has been written in a video title set PGC table (VTS_PGCIT). By referring to the program chain table (VTS_PGCIT) according to the user's input, the playback order of the program chains can be changed, enabling the program chains to be reproduced one after another in various modes.

Abstract: A non-volatile memory device and a manufacturing method thereof are disclosed. The non-volatile memory device includes a gate insulating film formed on a semiconductor substrate, a floating gate formed on the gate insulating film, a dielectric film comprising a (TaO)1?x(TiO)xN film on the floating gate, and a control gate formed on the dielectric film. Thus, large charge capacitance values can be obtained compared to a similarly sized device using an ONO or Ta2O5 thin film dielectric while simultaneously simplifying the manufacturing process.

Abstract: A receiver medium for digital imaging comprises a substrate having a dye-receiving surface bearing a coating comprising a highly branched functionalised polymer of generally globular form, e.g. a dendrimer, dispersed in a host polymer. Functional groups at or near the surface of the branched polymer, may interact with and bind dye molecules having complementary functional groups, eg dyes as disclosed in WO 96/34766, e.g. by acid-base interaction, thus having the effect of chemically fixing the dye within the coating on the receiver medium. Because dye molecules can be chemically bound to the branched polymer in the receiver sheet, it is possible to use host polymer materials of lower Tg than generally required in the prior art, with the host polymer typically having a Tg of less that 50° C. This means that dye molecules can have significantly increased diffusivity through the coating, prior to interaction, resulting in a more even distribution of dye through the coating than has been possible hitherto.

Abstract: A flying insect trapping device configured to be used with a fuel supply containing combustible fuel. The device may include a supporting frame; an insect trap chamber carried on the supporting frame; and a combustion device which may also be carried on the supporting frame. The combustion device comprises an inlet port for connection with the fuel supply, an exhaust port, and a combustion chamber communicating the inlet port with the exhaust port. The inlet port enables the fuel from the fuel supply to flow into the combustion chamber for continuous combustion therein to create an exhaust gas within the combustion chamber. The combustion device further includes a catalyst element disposed within the combustion chamber. The catalyst element has a catalyst body with a plurality of essentially linear elongated conduits for enabling the exhaust gas created in the combustion chamber to flow therethrough towards the exhaust port.

Abstract: A disk drive of perpendicular magnetic recording method including a read head comprising a GMR element and a drive using a double-layered disk medium, is disclosed. In the magnetic field response characteristic of the GMR element, the relationship between the degree of nonlinearity and a pulse width at 50% threshold (PW50) of a differentiated read signal is used. The degree of nonlinearity of the GMR element is adjusted such that the PW50 is smaller than the maximum value. The read channel comprises a differentiation circuit for converting the read signal output from the GMR element into the differentiated read signal.

Abstract: A process for producing a polynucleotide encoding a restriction endonuclease with an altered specificity, which process comprises: (a) mutagenising a polynucleotide encoding a restriction endonuclease with specificity for a recognition sequence so as to produce one or more mutated polynucleotides; and (b) isolating therefrom a polynucleotide encoding a mutated restriction endonuclease with specificity for an altered recognition sequence by selecting a polynucleotide which expresses a restriction endonuclease with methylase specificity for the altered recognition sequence.

Abstract: An optical disk recording apparatus operates on an optical disk having circular tracks which are provisionally written with an index signal used for securing a constant linear velocity of the optical disk from an innermost circular track to an outermost circular track, and records data along the circular tracks at different linear densities on different annular zones of the optical disk. In the apparatus, a disk drive section rotates the optical disk while synchronizing the index signal successively read from the rotated optical disk with a predetermined reference clock signal to thereby maintain the constant linear velocity of the circular tracks. A clock generating section multiplies or divides the reference clock signal by different rates to generate different writing clock signals in correspondence to the different annular zones of the optical disk.

Abstract: Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practical utility in the treatment or prophylaxis of disease conditions wherein inhibition of induced IgE production is therapeutically desirable, including allergic conditions, autoimmune diseases and inflammatory diseases.

Abstract: A retractable rule assembly includes wear resistant structure formed of a wear resistant material. The wear resistant structure is mounted at each lateral side of a blade opening of the rule assembly's housing to substantially protect the plastics material at the lateral sides from wear by the lateral side edges of the blade. An alternative retractable rule assembly has rollers rotatably mounted at each lateral side of the blade opening.

Abstract: Disclosed is a method of access control for a disk drive whereby an access operation for, particularly, sequentially and alternately executing accesses is supported. A CPU of the present disk drive sequentially and alternately executes accesses to a plurality of data tracks on a disk in response to an access request generated from a host system. During the access operation, the CPU secures time for a look-ahead operation, the time corresponding to the difference between transfer rates. Thus, sequential and alternate access operation in which the number of seek operations can be reduced can be realized.

Abstract: The banknote processing apparatus has a receiving portion into which banknotes are inserted, a take-out roller for taking out banknotes from the receiving portion, a detector for discriminating “regular and defective” and “front and back” of taken-out banknotes, and first to fourth stacking and banding devices for classifying and stacking banknotes on the basis of discrimination results and banding each 100 banknotes. When the first stacking and banding device fails in a mode that the first and second stacking and banding devices stack front bills and the third and fourth stacking and banding devices stack back bills, in expectation of 100 front bills being stacked in the second stacking and banding device, in the timing that the 97th front bill passes the detector, the take-out roller is stopped. When the number of front bills is less than 100, the take-out roller rotates and takes out one banknote.