Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments, the errors are random. One aspect of the present invention is to overcome the random errors or imperfections of an assay device or the operation of the assay device by measuring, in addition to measuring the analyte in a sample to generate an analyte test result, the trustworthiness of the analyte test result. The analyte test result will be reported, only when the trustworthiness meets a predetermined threshold, otherwise the analyte test result will be discarded. Various of parameter variation have been used for test trustworthy determination.
Type:
Application
Filed:
October 8, 2021
Publication date:
December 21, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Wu CHOU, Xing LI, Mingquan WU
Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.
Type:
Grant
Filed:
July 6, 2022
Date of Patent:
December 19, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou
Abstract: One aspect of the present invention is to provide the device and methods for performing an assay that uses the multiplexing of sample thicknesses on the same plate. The sample thickness multiplexing can offer many information that is unavailable in using a single sample thickness.
Type:
Application
Filed:
August 15, 2023
Publication date:
December 14, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Ji Qi, Yufan Zhang
Abstract: The present invention is to provide methods and devices that monitoring health and diagnosing a disease by directly measuring the biomarkers inside a cell (intra-cellular detection) rapidly and easily.
Type:
Application
Filed:
December 21, 2020
Publication date:
December 14, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Susan Y. SUN, Shengjian CAI, Wei DING
Abstract: One aspect of the present invention is to provide the device and methods for performing an assay that uses the multiplexing of sample thicknesses on the same plate. The sample thickness multiplexing can offer many information that are unavailable in using a single sample thickness.
Type:
Grant
Filed:
August 16, 2019
Date of Patent:
November 7, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang
Abstract: Disclosed is an apparatus and method for imaging: a side-view of a object on a surface, a Contact Angle of a liquid object, the color of an object, or combinations thereof.
Type:
Application
Filed:
July 6, 2023
Publication date:
November 2, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Wu CHOU, Ji QI, Jun TIAN, Yuecheng ZHANG, Mingquan WU
Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.
Type:
Application
Filed:
June 28, 2023
Publication date:
October 26, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wu CHOU, Xing LI, Hongbing LI, Yuecheng Zhang, Mingquan WU, Wei DING, Jun TIAN
Abstract: A multiplex assay device including: a separation structure on a first plate; and a sample contact area on the surface of the first plate. Also disclosed is a method for fabricating a multiplex assay, including: making a reagent into a non-liquid reagent particle; creating a well on a sample contact area of a plate of a Q-card two plate sample card; and dropping one or more of the non-liquid reagent particles into at least one well.
Abstract: The present invention relates to the methods, devices, and systems that make bio/chemical sensing (including, not limited to, immunoassay, nucleic assay, electrolyte analysis, etc.) faster, more sensitive, less steps, easy to perform, smaller amount of samples required, less or reduced (or no) needs for professional assistance, and/or lower cost, than many current sensing methods and devices. The present invention also allows a test performed by a smartphone.
Type:
Grant
Filed:
February 3, 2022
Date of Patent:
October 24, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang
Abstract: One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.
Type:
Application
Filed:
June 1, 2023
Publication date:
October 12, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Wu CHOU, Jun TIAN, Yuecheng ZHANG, Mingquan WU, Xing LI
Abstract: Among other things, the present disclosure is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly a homogeneous assay that does not use a wash step and that is fast (e.g., 60 seconds from dropping a sample to displaying results). The present disclosure is related to both competitive and non-competitive homogeneous assays.
Type:
Application
Filed:
December 27, 2022
Publication date:
September 21, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Ji LI, Yufan ZHANG
Abstract: The present invention provides diagnostic devices and methods for quantifying the amounts of an acute phase reactant (e.g., C-reactive protein (CRP) or serum amyloid A (SAA)) in a body fluid sample and/or white blood cell counts in blood sample. In particular, the present invention provides a rapid assay to detect CRP, SAA, and/or white blood cells in blood with high sensitivity and specificity.
Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.
Type:
Grant
Filed:
April 6, 2020
Date of Patent:
August 22, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wu Chou, Xing Li, Hongbing Li, Yuecheng Zhang, Mingquan Wu, Wei Ding, Jun Tian
Abstract: Disclosed is an apparatus and method for imaging: a side-view of a object on a surface, a Contact Angle of a liquid object, the color of an object, or combinations thereof.
Type:
Grant
Filed:
August 16, 2019
Date of Patent:
August 22, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Wu Chou, Ji Qi, Jun Tian, Yuecheng Zhang, Mingquan Wu