Abstract: One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.
Type:
Grant
Filed:
August 28, 2019
Date of Patent:
August 8, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Wu Chou, Jun Tian, Yuecheng Zhang, Mingquan Wu, Xing Li
Abstract: Among other thing, the present invention provides solution to the problem, particularly, the present invention certain surfaces and certain sample holder to improve the sensitivity, speed, and easy-to-use of an optical signal based assays, such as colorimetric assays or fluorescence assays.
Type:
Grant
Filed:
September 9, 2020
Date of Patent:
August 1, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi
Abstract: Disclosed are devices and methods for performing biological and chemical assays, such as immunoassays and nucleic acid assays, more particularly a homogeneous assay that does not use a wash step by using the aggregation and de-aggregation processes of microparticles or nanoparticles.
Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).
Type:
Application
Filed:
March 14, 2023
Publication date:
July 13, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Hua Tan, Yufan Zhang
Abstract: Device, systems, and methods are provided that can be used to monitor, examine, and/or analyze hair conditions and make suggestions to improve the hair conditions.
Abstract: The present invention provides diagnostic devices and methods for quantifying the amounts of an acute phase reactant (e.g., C-reactive protein (CRP) or serum amyloid A (SAA)) in a body fluid sample and/or white blood cell counts in blood sample. In particular, the present invention provides a rapid assay to detect CRP, SAA, and/or white blood cells in blood with high sensitivity and specificity.
Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.
Type:
Grant
Filed:
December 29, 2021
Date of Patent:
June 13, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Wu Chou, Jun Tian, Yuecheng Zhang, Mingquan Wu, Xing Li
Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.
Type:
Application
Filed:
January 24, 2023
Publication date:
June 1, 2023
Applicant:
Essenlix Corporation
Inventors:
Xing Li, Wu CHOU, Stephen Y. CHOU, Wei DING, Ji QI
Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).
Type:
Grant
Filed:
December 12, 2018
Date of Patent:
May 16, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Hua Tan, Yufan Zhang
Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, such as but not limited to assay related to analysis of white blood cells.
Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g., 0.5 ?L or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.
Abstract: The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).
Type:
Application
Filed:
November 3, 2022
Publication date:
March 16, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi
Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.
Abstract: A device and a method of using the device for improving sensitivity, speed, and easy-to-use of a colorimetric assay of a liquid sample are provided. The device includes a first plate and a second plate, spacers, and a textured surface. The two plates each have a sample contact surface and are movable relative to each other into an open configuration or a closed configuration. The sample is deposited on one or both plates in the open configuration. Thereafter, the closed configuration is formed where the plates compress at least part of the deposited sample into a continuous layer. The textured surface is disposed on the sample contact surface of the second plate and has a textured structure that scatters light, from which an optical signal such as a colorimetric or fluorescent signal can be obtained for analyzing the sample.
Type:
Grant
Filed:
February 9, 2018
Date of Patent:
March 14, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi
Abstract: Device, systems, and methods are provided that can be used to monitor, examine, and/or analyze hair conditions and make suggestions to improve the hair conditions.
Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.
Type:
Grant
Filed:
November 25, 2020
Date of Patent:
February 28, 2023
Assignee:
Essenlix Corporation
Inventors:
Xing Li, Wu Chou, Stephen Y. Chou, Wei Ding
Abstract: The disclosure provides a spacing-changeable device and a method using both lateral flow and compressed open flow for assaying a liquid sample. The device includes a first plate, a second plate, and an exterior liquid sample contact area. The spacing between the two plates are changeable to form different configurations including a first and second configurations. In the first configuration, the two plates face each other and form at least two gaps including a spacing-1 and a spacing-1?. The spacing height of the spacing-1? has a size that allows a liquid sample to flow into the spacing-1?. In the second configuration, the two plates are pressed, which changes spacing-1 and spacing-1? to spacing-2 and spacing-2?, respectively, and the spacing-2? has a spacing height larger than that of spacing-2. In the second configuration, the sample flows and spreads in areas of spacing-2 and spacing-2?.
Abstract: Among other things, the present disclosure is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly a homogeneous assay that does not use a wash step and that is fast (e.g., 60 seconds from dropping a sample to displaying results). The present disclosure is related to both competitive and non-competitive homogeneous assays.
Type:
Grant
Filed:
September 17, 2021
Date of Patent:
January 31, 2023
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
Abstract: The present invention is to provide methods and devices that monitoring health and diagnosing a disease by directly measuring the biomarkers inside a cell (intra-cellular detection) rapidly and easily.
Type:
Application
Filed:
January 13, 2021
Publication date:
January 19, 2023
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Susan Y. SUN, Shengjian CAI, Wei DING
Abstract: Devices and systems are provided herein relating to a novel and rapid assay for tissue staining. Methods for using the devices and systems for analyzing tissue samples are also disclosed.