Abstract: Disclosed is a device including a substrate having a plurality of detection areas to receive at least a portion of a sample having an analyte or suspected of having an analyte and at least one reference marker adjacent to at least one of the detection areas, wherein each of the detection areas detects a specific analyte and the at least one reference marker defines a scale mark, a shape mark, a color mark, or a combination thereof. Also disclosed is an imaging system and method for using the device and imaging system.
Type:
Application
Filed:
November 9, 2020
Publication date:
December 22, 2022
Applicant:
Essenlix Corporation
Inventors:
Wei DING, Stephen Y. CHOU, Wu CHOU, Ji WANG, Chen JI
Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.
Type:
Application
Filed:
August 26, 2022
Publication date:
December 22, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Jun Tian, Wei Dong
Abstract: The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).
Type:
Grant
Filed:
February 16, 2018
Date of Patent:
December 13, 2022
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi
Abstract: Device, systems, and methods are provided that can be used to monitor, examine, and/or analyze hair conditions and make suggestions to improve the hair conditions.
Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.
Type:
Application
Filed:
June 22, 2020
Publication date:
November 10, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Ji QI, Jun TIAN, Wu CHOU, Hongbing LI
Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.
Type:
Application
Filed:
July 6, 2022
Publication date:
October 27, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Ji QI, Jun Tian, Wu Chou
Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.
Type:
Grant
Filed:
February 18, 2021
Date of Patent:
October 4, 2022
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Ji Qi, Jun Tian, Wei Dong
Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.
Type:
Application
Filed:
December 29, 2021
Publication date:
September 22, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Wu CHOU, Jun TIAN, Yuecheng ZHANG, Mingquan WU, Xing LI
Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.
Abstract: Among other things, the present disclosure provides devices and methods for improving a homogeneous assay, particularly in improving accuracy, reduce noises, none-perfect conditions, multiplexing, etc.
Abstract: Disclosed is a method for correlating a biomarker in a non-blood bodily fluid with the same biomarker in the blood of an individual, including: measuring, in a first period in time, the biomarker in non-blood bodily fluid and measuring the same biomarker in the blood of the same individual to establish an R ratio of [NBBF1]/[BB1], where [NBBF1] is the biomarker concentration in non-blood bodily fluid in the first period in time, and [BB1] is the biomarker concentration in the blood in the first period in time; storing the ratio in a memory; measuring, in a second period in time, the biomarker in non-blood bodily fluid to determine [NBBF2], where [NBBF2] is the biomarker concentration in the non-blood bodily fluid in the second period in time; and correlating the measured [NBBF2] with the R ratio to generate a correlated [BB2] biomarker concentration in the blood of the individual in the second period in time.
Abstract: The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.
Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between two plates.
Type:
Grant
Filed:
February 12, 2021
Date of Patent:
August 16, 2022
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou
Abstract: Provided herein is a method and device for performing a homogeneous nucleic acid detection assay. The device can contain a pair of plates where one of the plates comprises (i) surface amplification surface; and (ii) target-specific nucleic acid probes that are immobilized on said amplification surface and that specifically binds to a part of the target nucleic acid; and the second plate comprises a sample contact area comprising a reagent storage site that comprises target-specific nucleic acid detection agents that specifically binds to another part of the target nucleic acid. In some embodiments, the device can be read without a washing unbound label from the surface of the device.
Type:
Grant
Filed:
February 8, 2018
Date of Patent:
August 9, 2022
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang, Ji Li
Abstract: The present invention relates to the methods, devices, and systems that make bio/chemical sensing (including, not limited to, immunoassay, nucleic assay, electrolyte analysis, etc.) faster, more sensitive, less steps, easy to perform, smaller amount of samples required, less or reduced (or no) needs for professional assistance, and/or lower cost, than many current sensing methods and devices. The present invention also allows a test performed by a smartphone.
Type:
Application
Filed:
February 3, 2022
Publication date:
July 28, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. CHOU, Wei DING, Ji QI, Yufan ZHANG
Abstract: Devices and methods for authenticating medical tests, such as a saliva test is provided. The devices can simultaneously image at least one biometric identifier associated with an intended subject being tested so as to provides authentication of a medical test such as a saliva test. The present invention has useful and practical utility in health monitoring, mobile monitoring, and crime monitoring in the fields of insurance, health, and medication.
Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.
Abstract: Provided herein is a method and device for performing a homogeneous nucleic acid detection assay. The device can contain a pair of plates where one of the plates comprises (i) surface amplification surface; and (ii) target-specific nucleic acid probes that are immobilized on said amplification surface and that specifically binds to a part of the target nucleic acid; and the second plate comprises a sample contact area comprising a reagent storage site that comprises target-specific nucleic acid detection agents that specifically binds to another part of the target nucleic acid. In some embodiments, the device can be read without a washing unbound label from the surface of the device.
Type:
Application
Filed:
March 22, 2022
Publication date:
July 7, 2022
Applicant:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Ji Qi, Yufan Zhang, Ji Li
Abstract: The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.
Type:
Grant
Filed:
January 15, 2021
Date of Patent:
June 28, 2022
Assignee:
Essenlix Corporation
Inventors:
Stephen Y. Chou, Wei Ding, Yufan Zhang, Hua Tan