Patents Assigned to GE Healthcare Limited
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Patent number: 11964020Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.Type: GrantFiled: June 13, 2022Date of Patent: April 23, 2024Assignee: GE Healthcare LimitedInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
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Patent number: 11615882Abstract: Systems and methods for tracking and management of a distributed ledger including information for a batch of radiopharmaceutical material are disclosed. Certain examples provide a computer-implemented method of managing radiopharmaceutical material including tracking, using at least one processor, a status of a batch of radiopharmaceutical material, the status to include a type, a quantity, and a timestamp associated with the batch of radiopharmaceutical material; generating a record in a first copy of a distributed ledger using the type, quantity, and timestamp associated with the batch of radiopharmaceutical material; updating the record based on at least one of usage of the batch of radiopharmaceutical material, resale of at least a portion of the batch of radiopharmaceutical material, and decay of the batch of radiopharmaceutical material; and sharing the record with a second copy of the distributed ledger.Type: GrantFiled: November 7, 2018Date of Patent: March 28, 2023Assignee: GE HEALTHCARE LIMITEDInventors: Jan Wolber, Scott Lagona
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Patent number: 11565257Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).Type: GrantFiled: March 29, 2019Date of Patent: January 31, 2023Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Alexander Jackson, Imtiaz Ahmed Khan, Alan Peter Clarke, Graeme McRobbie, Julian Grigg
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Publication number: 20230022430Abstract: The present invention provides a cassette for determining optimised solid phase extraction (SPE) purification conditions, wherein said cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves oriented along said flowpath, wherein each of said plurality of valves is selectively fluidly connected to one of a number of components, wherein said components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line.Type: ApplicationFiled: December 17, 2020Publication date: January 26, 2023Applicant: GE HEALTHCARE LIMITEDInventors: Graeme Walter MCROBBIE, Imtiaz Ahmed Khan, Jonathan Robert SHALES
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Patent number: 11534494Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: August 19, 2020Date of Patent: December 27, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam, Kristine Romoren, Olav Ryan
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Patent number: 11504430Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: December 21, 2011Date of Patent: November 22, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Anders Svadberg, Ole Kristian Hjelstuen, Dag M Evje, Liane Ochsenfeld
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Patent number: 11488282Abstract: An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.Type: GrantFiled: April 6, 2020Date of Patent: November 1, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Roger Lundqvist, Nils Lennart Thurfjell, Johan Lilja
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Patent number: 11389538Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.Type: GrantFiled: April 15, 2020Date of Patent: July 19, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
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Patent number: 11311636Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.Type: GrantFiled: April 4, 2019Date of Patent: April 26, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Graeme McRobbie, Robert James Nairne
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Patent number: 11135322Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.Type: GrantFiled: January 22, 2013Date of Patent: October 5, 2021Assignees: GE Healthcare Limited, University of SouthamptonInventors: Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
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Patent number: 11094424Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.Type: GrantFiled: August 29, 2019Date of Patent: August 17, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Lange
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Patent number: 11077216Abstract: The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.Type: GrantFiled: June 30, 2015Date of Patent: August 3, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam
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Patent number: 11051777Abstract: A method of imaging to permit calculation of left:right striatum uptake ratios is provided, and the degree of asymmetry used to assist in the diagnosis of neurological diseases. Also provided are a method of diagnosis, method of patient selection, and method of therapy monitoring using the imaging method, and software tools for use in the method.Type: GrantFiled: July 25, 2014Date of Patent: July 6, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Mark Rosser, Jan Wolber
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Patent number: 10984894Abstract: An image quality control system is disclosed. The example system includes an artificial intelligence modeler to process image data and metadata from patient data to generate first feature(s) from the image data and to parse the metadata to identify study information. The example system includes a computer vision processor to identify second feature(s) in the image data. The example system includes a results evaluator to compare the first feature(s) and second feature(s) to generate a comparison and to evaluate the comparison, first feature(s), and second feature(s) with respect to the study information to generate an evaluation. The example system includes a quality controller to compare the evaluation to quality criterion(-ia) to produce an approval or rejection of the patient data, the approval to trigger release of the patient data and the rejection to deny release of the patient data.Type: GrantFiled: December 27, 2018Date of Patent: April 20, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Christopher Foley, Pal Tezges, Laszlo Rusko
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Patent number: 10980899Abstract: The present application provides a means for differential diagnosis of Parkinson's disease and the clinically similar Parkinsonian disorders multiple system atrophy with predominantly Parkinsonian features (MSA-P) and progressive supranuclear palsy (PSP).Type: GrantFiled: December 20, 2017Date of Patent: April 20, 2021Assignees: GE HEALTHCARE LIMITED, ACADEMIC MEDICAL CENTER, VU UNIVERSITY MEDICAL CENTERInventors: Paul Alexander Jones, Jan Booij, Chris Vriend
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Patent number: 10894779Abstract: The present invention provides a process to enhance the productivity such as yield of radioactive fluorine labeled flutemetamol. Provided is a process for producing a radioactive fluorine labeled flutemetamol, which comprises: (a) a step of allowing a labeling precursor represented by the predetermined general formula to react with a radioactive fluoride ion in a presence of a solvent to obtain a radioactive fluorine labeled intermediate represented by the predetermined general formula, and (b) a step of removing the protecting groups from the radioactive fluorine labeled intermediate to obtain a radioactive fluorine labeled flutemetamol, in which the above step (a) is carried out at an internal temperature of reaction solution of 140° C. or higher.Type: GrantFiled: February 22, 2018Date of Patent: January 19, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami, Kei Akama
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Patent number: 10759747Abstract: The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.Type: GrantFiled: May 2, 2017Date of Patent: September 1, 2020Assignees: GE HEALTHCARE LIMITED, KINGS COLLEGE LONDONInventors: Imtiaz Khan, Graeme McRobbie, Anna Kirjavainen
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Patent number: 10758887Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).Type: GrantFiled: July 23, 2018Date of Patent: September 1, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
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Patent number: 10709798Abstract: A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent.Type: GrantFiled: November 28, 2013Date of Patent: July 14, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Sondre Nilsen, Srinath Balaji Aralikatti Prahladachar Balaji, Umamaheshwar P. Mokkapati, Afsal Mohammed Kadavilpparampu Mohamed
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Patent number: 10703771Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for the trapping of [18F]fluoride and recovery of [18O]water.Type: GrantFiled: November 12, 2015Date of Patent: July 7, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge