Patents Assigned to GE Healthcare Limited
  • Multi-vial dispensing
    Patent number: 9433556
    Abstract: A multi-vial dispensing cassette provides serial dispensement of radiopharmaceutical fluid into a plurality of dispense vials connected in series. Needle holders may be provided for one or more vials in the cassette and at clip may be incorporated into the needle holder. Each dispense vial has a body and a cap with a fill needle and a withdrawal needle. The withdrawal needle of one vial is connected to the fill needle of an adjacent vial.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: September 6, 2016
    Assignee: GE Healthcare Limited
    Inventors: Nigel J Osborn, Roger Pettitt
  • Flow cell for radiation detector
    Patent number: 9383456
    Abstract: The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 5, 2016
    Assignee: GE Healthcare Limited
    Inventors: Alan Peter Clarke, Thanushan Rajanayagam, Roger Paul Pettitt, Robert F. Chisholm
  • RADIOLABELLING METHOD
    Publication number: 20160166717
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule with the radioisotope 18F. The invention provides a method of preparation of lyophilised compositions of aminooxy-functionalised biomolecules, as well as radiolabelling methods using the purified materials. Also provided are lyophilised compositions and cassettes comprising such purified compositions. The invention is particularly suitable for use with an automated synthesizer apparatus.
    Type: Application
    Filed: August 20, 2014
    Publication date: June 16, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Willy Skjold, Bard Indrevoll
  • Preparation of F-fluciclovine
    Patent number: 9359288
    Abstract: The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis apparatus.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: June 7, 2016
    Assignee: GE Healthcare Limited
    Inventors: Anders Svadberg, Olav Ryan, Roger Smeets
  • Purification method
    Patent number: 9346771
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of ?-amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: May 24, 2016
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • In vivo imaging method for cancer
    Patent number: 9314541
    Abstract: The present invention provides a method useful in the diagnosis and monitoring of cancer wherein there is an abnormal expression of PBR. The method of the invention is particularly useful in evaluating the severity of the cancer, e.g. PBR expression correlates with cell proliferation rates, metastatic potential, tumor aggressiveness, malignancy progression. The method of the invention can therefore be applied in the determination of likely disease progression and in making an associated prognosis. Furthermore, the method of the invention can find use in determining the likely success of certain therapeutic approaches, or in the evaluation of the efficacy of certain proposed new treatments.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: April 19, 2016
    Assignee: GE Healthcare Limited
    Inventor: Paul Alexander Jones
  • Preparation of pet precursor
    Patent number: 9278916
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: March 8, 2016
    Assignee: GE Healthcare Limited
    Inventors: Tom Christian Berg, Anne Nilsen
  • Radiolabelling Process
    Publication number: 20160051710
    Abstract: The present invention relates to a novel composition comprising 1-amino-3[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 25, 2016
    Applicant: GE Healthcare Limited
    Inventor: Torild Wickstrom
  • Technetium labelled peptides
    Patent number: 9259496
    Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 16, 2016
    Assignee: GE Healthcare Limited
    Inventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
  • Hyperpolarized lactate contrast agent for determination of LDH activity
    Patent number: 9259490
    Abstract: A hyperpolarized MR imaging medium and a method of 13C-MR detection using a hyperpolarized MR imaging medium for the determination of lactate dehydrogenase (LDH) activity. The contrast media comprises hyperpolarized [13C, 2H]lactate.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: February 16, 2016
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Kevin Brindle, Mikko Iivari Kettunen, Brett W.C. Kennedy
  • SYNTHON COMPOSITION
    Publication number: 20160022845
    Abstract: The present invention relates to an improved [18F]labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F]labelled synthon. The resultant purified [18F]label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Application
    Filed: March 28, 2013
    Publication date: January 28, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: RAJIV BHALLA, ALEXANDER JACKSON, GARETH SMITH
  • Radiotracer Compositions
    Publication number: 20160022847
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Application
    Filed: October 7, 2015
    Publication date: January 28, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative
    Patent number: 9242924
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET agent, ensuring that the reaction efficiently goes to completion.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: January 26, 2016
    Assignee: GE Healthcare Limited
    Inventors: Steven Michael Fairway, Marit Rolandsgard
  • Process simplification for precursor compound
    Patent number: 9238596
    Abstract: The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3-fluorocyclobutanecarboxylic acid ([18F] FACBC) PET tracer.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: January 19, 2016
    Assignee: GE Healthcare Limited
    Inventor: Tom Christian Berg
  • Indole derivatives
    Patent number: 9220795
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: December 29, 2015
    Assignee: GE Healthcare Limited
    Inventors: Harry John Wadsworth, Dennis O'Shea, Joanna Passmore, William Trigg, Amanda Eewan, Bo Shan
  • Zinc Halide Mediated Cyclization Process Leading to Tricyclic Indoles
    Publication number: 20150336891
    Abstract: The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.
    Type: Application
    Filed: November 29, 2013
    Publication date: November 26, 2015
    Applicant: GE Healthcare Limited
    Inventors: Sondre Nilsen, Umamaheshwar P. Mokkapati
  • Fluorination Process
    Publication number: 20150328344
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Application
    Filed: July 27, 2015
    Publication date: November 19, 2015
    Applicants: GE HEALTHCARE AS, GE HEALTHCARE LIMITED
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Aryloxyanilide imaging agents
    Patent number: 9186424
    Abstract: The present invention provides a novel radiolabelled aryloxyalinine derivative suitable for in vivo imaging. In comparison to known aryloxyalinine derivative in vivo imaging agents, the in vivo imaging agent of the present invention has better properties for in vivo imaging. The in vivo imaging agent of the present invention demonstrates good selective binding to the peripheral benzodiazepine receptor (PBR), in combination with good brain uptake and in vivo kinetics following administration to a subject.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: November 17, 2015
    Assignee: GE Healthcare Limited
    Inventors: Harry John Wadsworth, Dennis O'Shea
  • Radioiodinated Fatty Acids
    Publication number: 20150320891
    Abstract: The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids.
    Type: Application
    Filed: July 20, 2015
    Publication date: November 12, 2015
    Applicant: GE HEALTHCARE LIMITED
    Inventors: MICHELLE E. AVORY, HARRY JOHN WADSWORTH, ROBERT JAMES DOMETT NAIRNE
  • Radiotracer compositions
    Patent number: 9180213
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: November 10, 2015
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas