Patents Assigned to GE Healthcare Limited
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Patent number: 10201625Abstract: Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).Type: GrantFiled: March 1, 2012Date of Patent: February 12, 2019Assignees: IMPERIAL COLLEGE, GE HEALTHCARE LIMITEDInventors: Sajinker Kaur Luthra, Julius Leyton, Eric Ofori Aboagye, Lisa Iddon, Bard Indrevoll, Matthias Eberhard Glaser, Alan Cuthbertson
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Patent number: 10134496Abstract: Methods and devices for directing a waste fluid from a radiopharmaceutical synthesis system to a waste vessel are provided. In one example, the method includes serially connecting a primary waste vessel to a secondary waste vessel with a fluid conduit, including a waste valve connected to the fluid conduit extending between the primary waste vessel and secondary waste vessel; opening the waste valve so as to allow fluid communication between cavities of the primary and secondary waste vessels; drawing a low pressure in both waste vessels; closing the waste valve so as to fluidically isolate the secondary waste vessel from the primary waste vessel, discharging the waste fluid through a pump valve into the primary waste vessel, and opening the waste valve to evacuate the waste fluid from the primary waste vessel into the secondary waste vessel.Type: GrantFiled: December 19, 2014Date of Patent: November 20, 2018Assignee: GE Healthcare Limited CompanyInventors: Nigel John Osborn, Julian Grigg, Eric Horn, Jonathan Robert Shales
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Patent number: 10087141Abstract: [18F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [18F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [18F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.Type: GrantFiled: August 21, 2014Date of Patent: October 2, 2018Assignee: GE HEALTHCARE LIMITEDInventors: Matthias Eberhard Glaser, Sajinder Luthra, Jane Brown, Robert James Nairne
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Patent number: 10067249Abstract: Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.Type: GrantFiled: December 20, 2013Date of Patent: September 4, 2018Assignee: GE Healthcare LimitedInventors: Alok M. Srivastava, Victor Samper, Stefan Riese
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Patent number: 10029228Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).Type: GrantFiled: September 24, 2012Date of Patent: July 24, 2018Assignee: GE Healthcare LimitedInventors: Torgrim Engell, Julian Grigg, Ingvil Gausemel, Knut Dyrstad, Jonathan R. Shales
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Patent number: 10023525Abstract: The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: June 6, 2016Date of Patent: July 17, 2018Assignee: GE Healthcare LimitedInventors: Anders Svadberg, Olav Ryan, Roger Smeets
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Publication number: 20180193490Abstract: The present invention relates to a method of in vivo imaging and in particular to a method for the evaluation of in vivo images of beta amyloid (A?) distribution in the brain of a subject suspected of having Alzheimer's disease (AD). The method of the present invention provides more detailed information to the clinician as compared with prior art methods, facilitating identification of those subjects who will benefit most from disease modifying therapies.Type: ApplicationFiled: July 7, 2016Publication date: July 12, 2018Applicant: GE HEALTHCARE LIMITEDInventors: Christopher John Buckley, Adrian Smith
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Publication number: 20180177900Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.Type: ApplicationFiled: February 20, 2018Publication date: June 28, 2018Applicant: GE HEALTHCARE LIMITEDInventor: Torild Wickstrom
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Patent number: 10000518Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: GrantFiled: November 18, 2005Date of Patent: June 19, 2018Assignees: GE HEALTHCARE LIMITED, GE HEALTHCARE ASInventors: Lill Torild Wickstrom, Dirk-Jan in't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
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Patent number: 9999692Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.Type: GrantFiled: March 28, 2014Date of Patent: June 19, 2018Assignee: GE Healthcare LimitedInventor: Torild Wickstrom
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Patent number: 9987382Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.Type: GrantFiled: October 7, 2015Date of Patent: June 5, 2018Assignee: GE HEALTHCARE LIMITEDInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
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Publication number: 20180147304Abstract: The present invention relates to a method of in vivo imaging with meta-[123I]iodobenzylguanidine ([123I]mIBG) and more particularly wherein said method is used to stratify a defined subset of subjects with heart failure into particular treatment regimens.Type: ApplicationFiled: May 23, 2016Publication date: May 31, 2018Applicant: GE HEALTHCARE LIMITEDInventors: Jean-Claude Provost, Paul Alexander Jones, Etienne Montagut, Jay Chahal, Meridith Keating Johnson
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Publication number: 20180147305Abstract: The present invention relates to a method of in vivo imaging with meta-[123I]iodobenzylguanidine ([123I]mIBG) and more particularly wherein said method is used to stratify a defined subset of subjects with heart failure into particular treatment regimens.Type: ApplicationFiled: May 23, 2016Publication date: May 31, 2018Applicant: GE HEALTHCARE LIMITEDInventors: Jean-Claude Provost, Paul Alexander Jones, Etienne Montagut, Jay Chahal, Meridith Keating Johnson
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Patent number: 9969761Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: GrantFiled: April 22, 2014Date of Patent: May 15, 2018Assignees: GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Dirk-Jan In't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
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Patent number: 9956303Abstract: The present invention relates to methods useful in the selection of cancer patients suitable for treatment with therapies directed at c-Met. The method employs imaging agents which comprise 18F-radiolabelled c-Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. Also disclosed are methods of treatment, methods of monitoring therapy directed atc-Met and the use of the imaging agents and peptides in the methods of the invention.Type: GrantFiled: December 19, 2012Date of Patent: May 1, 2018Assignee: GE HEALTHCARE LIMITEDInventors: Grethe Tang Dalsgaard, Ian Andrew Wilson
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Patent number: 9951011Abstract: The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known TSPO-binding radiotracers. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said precursor compound. Other aspects of the invention include a method for the synthesis of the in vivo imaging agent of the invention comprising use of the precursor compound of the invention, a kit for carrying out said method, and a cassette for carrying out an automated version of said method. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.Type: GrantFiled: September 19, 2014Date of Patent: April 24, 2018Assignee: GE HEALTHCARE LIMITEDInventors: William John Trigg, Paul Alexander Jones
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Publication number: 20180021750Abstract: The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.Type: ApplicationFiled: March 16, 2016Publication date: January 25, 2018Applicant: GE Healthcare LimitedInventor: Philippe Dumont
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Publication number: 20180008950Abstract: The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.Type: ApplicationFiled: March 16, 2016Publication date: January 11, 2018Applicant: GE Healthcare LimitedInventor: Philippe Dumont
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Publication number: 20180008949Abstract: The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.Type: ApplicationFiled: March 10, 2016Publication date: January 11, 2018Applicant: GE Healthcare LimitedInventors: Xavier Franci, Philippe Dumont, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Publication number: 20170360943Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.Type: ApplicationFiled: December 4, 2015Publication date: December 21, 2017Applicant: GE Healthcare LimitedInventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje