Patents Assigned to GE Healthcare Limited
  • Method for removing acetaldehyde
    Patent number: 10660966
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 26, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • HER2 polypeptides useful for imaging and monitoring tumors and cancers
    Patent number: 10646600
    Abstract: A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is described. The method is for monitoring the response to HSP90 inhibition and comprises the use of the isolated polypeptide conjugated with 18F. The application also describes the use of an isolated polypeptide conjugated with 18F, wherein the isolated polypeptide binds specifically to HER2 or variants thereof, as an imaging agent to monitor uptake thereof to measure HSP90 inhibition.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: May 12, 2020
    Assignees: IMPERIAL INNOVATIONS LIMITED, GE HEALTHCARE LIMITED
    Inventors: Duncan Robert R. Hiscock, Eric Aboagye, Peter Iveson, Quang-De Nguyen, Susan Hoppmann, Sebastian Trousil, Maciej Kaliszczak, Giampaolo Tomasi
  • Pierce and fill device
    Patent number: 10625095
    Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: April 21, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Xavier Franci, Philippe Dumont, Svein-Erik Lindgaard
  • Methods of spatial normalization of positron emission tomography images
    Patent number: 10614547
    Abstract: An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: April 7, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Roger Lundqvist, Nils Lennart Thurfjell, Johan Lilja
  • Dual run cassette for the synthesis of 18F-labelled compounds
    Patent number: 10584078
    Abstract: The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: March 10, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Xavier Franci
  • NON-INVASIVE METHOD FOR PRESSURE MEASUREMENT
    Publication number: 20200046313
    Abstract: The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 13, 2020
    Applicants: THOMAS JEFFERSON UNIVERSITY, GE HEALTHCARE LIMITED
    Inventors: Flemming Forsberg, David Mills, John R. Eisenbrey, Kirk Wallace, Ipshita Gupta
  • Radiolabelling method
    Patent number: 10548995
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule with the radioisotope 18F. The invention provides a method of preparation of lyophilised compositions of aminooxy-functionalised biomolecules, as well as radiolabelling methods using the purified materials. Also provided are lyophilised compositions and cassettes comprising such purified compositions. The invention is particularly suitable for use with an automated synthesizer apparatus.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: February 4, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Willy Skjold, Bard Indrevoll
  • Heatseal
    Patent number: 10532115
    Abstract: The present invention relates to systems and methods to facilitate replacement between runs of a kit or cassette from an automated radiosynthesis device located in a hot cell. The method and apparatus of the invention enable automated disconnection of the outlet line by sealing the tubing hermetically by means of heat and by cutting the tubing where it is sealed in such a way that there is no risk of environmental contamination with radioactive material. The invention enables disconnection of the outlet line without manual intervention before opening the shielded enclosure.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 14, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Christoph Mosdzianowski, Philippe Dumont, Sali Kuci
  • Piercing device
    Patent number: 10525435
    Abstract: The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: January 7, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Xavier Franci, Philippe Dumont, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
  • Method for producing [F]flutemetamol
    Patent number: 10472338
    Abstract: Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18F labeling compound; after the above step, purifying the 18F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [18F]flutemetamol.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: November 12, 2019
    Assignees: GE HEALTHCARE LIMITED, NIHON MEDI-PHYSICS CO., LTD.
    Inventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami
  • Disconnector device
    Patent number: 10427127
    Abstract: The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: October 1, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Philippe Dumont
  • Shielding device
    Patent number: 10403411
    Abstract: The present invention relates to the field of radioactive substances and in particular to a method to facilitate handling of radioactive solutions. Provided by the present invention is a device that enables preparation of capsules filled with radioactivity. More particularly, the radioactivity is suitable for use in certain radiopharmaceutical procedures. The present invention provides improved accuracy and uniformity of patient doses. Furthermore, the potential for spills and needle stick injuries is reduced and the radiation burden is reduced.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: September 3, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Nanno Schreuder, Gerard Swiers, Maikel Herbrink
  • Synthesizer diagnostic cassette simulator
    Patent number: 10402508
    Abstract: The present invention relates to a diagnostic device (400) for measuring component performance on an automated radiopharmaceutical synthesis device (50).
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: September 3, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Robert F. Chisholm
  • Radiopharmaceutical products
    Patent number: 10328164
    Abstract: The present invention relates to improved radiopharmaceutical compositions in sealed containers, where the container closure has an ETFE (ethylene-tetrafluoroethylene copolymer) coating. Also disclosed are kits for radiopharmaceutical preparation using the sealed containers, as well as methods of preparation of radiopharmaceuticals using the sealed containers.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: June 25, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Stig Hemstad
  • Radiosynthesiser add-on device
    Patent number: 10315179
    Abstract: The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 11, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventor: Philippe Dumont
  • Radiotracer compositions and methods
    Patent number: 10300156
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 28, 2019
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Robert James Nairne, Graeme McRobbie
  • Shielding Device
    Publication number: 20190080808
    Abstract: The present invention relates to the field of radioactive substances and in particular to a method to facilitate handling of radioactive solutions. Provided by the present invention is a device that enables preparation of capsules filled with radioactivity. More particularly, the radioactivity is suitable for use in certain radiopharmaceutical procedures. The present invention provides improved accuracy and uniformity of patient doses. Furthermore, the potential for spills and needle stick injuries is reduced and the radiation burden is reduced.
    Type: Application
    Filed: October 28, 2016
    Publication date: March 14, 2019
    Applicant: GE Healthcare Limited
    Inventors: Nanno Schreuder, Gerard Swiers, Maikel Herbrink
  • Radiolabelling method
    Patent number: 10220105
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to automated methods for the preparation and purification of 18F-labelled tau imaging radiotracers. Also provided are interchangeable cassettes useful in the methods, and the use of automated synthesizers and cassettes in the methods.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: March 5, 2019
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Duncan George Wynn, Steven Michael Fairway, Matthias Eberhard Glaser, Ian Newington, Gareth Edwin Smith, Imtiaz Ahmed Khan, Julian Grigg
  • Method for Producing Flutemetamol
    Publication number: 20190055207
    Abstract: Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18F labeling compound; after the above step, purifying the 18F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [18F]flutemetamol.
    Type: Application
    Filed: October 17, 2016
    Publication date: February 21, 2019
    Applicants: GE Healthcare Limited, Nihon Medi-Physics Co., Ltd.
    Inventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami
  • Radiosynthesis device
    Patent number: D845506
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: April 9, 2019
    Assignee: GE Healthcare Limited
    Inventors: Jean-Michel Marteau, Philippe Dumont, Sali Kuci