Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
January 28, 2004
Date of Patent:
April 19, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in industrial, therapeutic, diagnostic, and pharmacogenomic applications.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
September 14, 2001
Date of Patent:
March 15, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
C. Alexander Turner, Jr., Brian Mathur, Gregory Donoho
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
April 4, 2002
Date of Patent:
March 8, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Xuanchuan Yu, Maricar Miranda, Carl Johan Friddle
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
March 18, 2004
Date of Patent:
March 1, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
D. Wade Walke, John Scoville, Carl Johan Friddle
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
May 11, 2004
Date of Patent:
March 1, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Xuanchuan Yu, Maricar Miranda, Carl Johan Friddle
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
November 13, 2001
Date of Patent:
February 22, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
D. Wade Walke, Erin Hilbun, Gregory Donoho, C. Alexander Turner, Jr., Gwenn Hansen, Hector BeltrandelRio, Isaac Van Sligtenhorst
Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the gene of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
Type:
Grant
Filed:
August 15, 2000
Date of Patent:
February 15, 2005
Assignee:
Lexicon Genetics Inc.
Inventors:
Arthur T. Sands, Glenn A. Friedrich, Brian Zambrowicz, Allan Bradley
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
December 19, 2001
Date of Patent:
February 8, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Xuanchuan (Sean) Yu, Maricar Miranda, C. Alexander Turner, Jr.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
April 17, 2003
Date of Patent:
February 8, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Gregory Donoho, C. Alexander Turner, Jr., Glenn Friedrich, John Scoville, Brian Zambrowicz, Arthur T. Sands
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
May 11, 2004
Date of Patent:
February 8, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Xuanchuan Yu, John Scoville, Nathaniel L. Wilganowski, Nghi D. Nguyen
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenmic applications.
Type:
Grant
Filed:
June 13, 2002
Date of Patent:
January 11, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
Yi Hu, Nathaniel L. Wilganowski, Carl Johan Friddle, D. Wade Walke
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
August 12, 2002
Date of Patent:
January 4, 2005
Assignee:
Lexicon Genetics Incorporated
Inventors:
D. Wade Walke, Nathaniel L. Wilganowski, C. Alexander Turner, Jr.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
November 25, 2002
Date of Patent:
December 28, 2004
Assignee:
Lexicon Genetics Incorporated
Inventors:
Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
Abstract: Novel vectors are described that incorporate, inter alia, a novel 3′ gene trap cassette that does not encode a marker conferring antibiotic resistance and which can be used to efficiently trap, mutagenize, and identify previously unknown cellular genes. Vectors incorporating the presently described 3′ gene trap cassette find particular application in gene discovery, and the production of mutated cells and animals.
Type:
Application
Filed:
March 9, 2004
Publication date:
December 23, 2004
Applicant:
Lexicon Genetics Inc.
Inventors:
Brian Zambrowicz, Glenn A. Friedrich, Stan Lilleberg, Arthur T. Sands
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
May 8, 2003
Date of Patent:
November 9, 2004
Assignee:
Lexicon Genetics Incorporated
Inventors:
Carl Johan Friddle, Erin Hilbun, Brian Mathur, C. Alexander Turner, Jr.
Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Type:
Grant
Filed:
March 20, 2001
Date of Patent:
November 9, 2004
Assignee:
Lexicon Genetics Incorporated
Inventors:
D. Wade Walke, Nathaniel L. Wilganowski, C. Alexander Turner, Jr., Erin Hilbun, Xiaoming Wang, Gregory Donoho, John Scoville