Patents Assigned to Lexicon
  • Human proteases and polynucleotides encoding the same
    Patent number: 6743621
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 1, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Human proteases and polynucleotides encoding the same
    Patent number: 6734007
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: May 11, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Carl Johan Friddle, Erin Hilbun
  • Human kinases and polynucleotides encoding the same
    Patent number: 6734010
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: May 11, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Xuanchuan Yu, Qiongshu Xie, Alejandro Abuin, D. Wade Walke
  • Human kinases and polynucleotides encoding the same
    Patent number: 6734009
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 11, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Xuanchuan (Sean) Yu, Maricar Miranda, Carl Johan Friddle
  • Indexed library of cells containing genomic modifications and methods of making and utilizing the same
    Publication number: 20040072243
    Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
    Type: Application
    Filed: February 4, 2003
    Publication date: April 15, 2004
    Applicant: Lexicon Genetics Incorporated
    Inventors: Arthur Sands, Glenn Friedrich, Brian Zambrowicz, Allan Bradley
  • Human kinase protein and polynucleotides encoding the same
    Patent number: 6720173
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: April 13, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Brian Mathur, C. Alexander Turner, Jr., Alejandro Abuin, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human thrombospondin repeat proteins and polynucleotides encoding the same
    Patent number: 6720412
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: April 13, 2004
    Assignee: Lexicon Genetics Corporation
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human kinase proteins and polynucleotides encoding the same
    Patent number: 6716616
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: April 6, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
    Patent number: 6716614
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: April 6, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • PPAR-&ggr; agonists as agents for the treatment of type II diabetes
    Patent number: 6713514
    Abstract: N-(substituted)carbamoylaryl- and heteroaryl substituted aminopropanoic and butanoic acid compounds which are highly selective agonists for the PPAR-&ggr; receptor or prodrugs of agonists for the PPAR-&ggr; receptor, and are useful in the treatment of Type II diabetes (NIDDM).
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 30, 2004
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Gerard McGeehan, Zhi-Cai Shi, Laxma Reddy Kolla, Cullen Cavallaro
  • Novel seven transmembrane proteins and polynucleotides encoding the same
    Publication number: 20040048285
    Abstract: Nucleotide and amino acid sequences of several G protein coupled receptors are described.
    Type: Application
    Filed: May 9, 2003
    Publication date: March 11, 2004
    Applicant: Lexicon Genetics Incorporated
    Inventors: Yi Hu, Boris Nepomnichy, Xiaoming Wang, D. Wade Walke, Brenda Gerhardt, C. Alexander Turner
  • Polynucleotides encoding human transporter protein
    Patent number: 6703495
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: March 9, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: D. Wade Walke, John Scoville
  • Novel human seven-transmembrane receptors
    Publication number: 20040038345
    Abstract: The nucleotide and amino acid sequences of several novel human G protein coupled receptors are described.
    Type: Application
    Filed: March 17, 2003
    Publication date: February 26, 2004
    Applicant: Lexicon Genetics Incorporated
    Inventors: Michael Nehls, Frank Wattler
  • Human transferase proteins and polynucleotides encoding the same
    Patent number: 6692947
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: February 17, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: D. Wade Walke, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Isolated nucleic acid molecules encoding membrane polypeptides
    Publication number: 20030219868
    Abstract: The nucleotide and amino acid sequences of several novel G protein coupled receptors are described.
    Type: Application
    Filed: March 21, 2003
    Publication date: November 27, 2003
    Applicant: Lexicon Genetics Incorporated
    Inventors: D. Wade Walke, Xiaoming Wang, John Scoville
  • Human proteases and polynucleotides encoding the same
    Patent number: 6649399
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: November 18, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Glenn Friedrich, John Scoville, Brian Zambrowicz, Arthur T. Sands
  • One step synthesis of 1,2,3-triazole carboxylic acids
    Patent number: 6642390
    Abstract: Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a &bgr;-ketoester in the presence of a base.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: November 4, 2003
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Cullen Cavallaro, Zhi-Cai Shi, Alexander Gontcharov, Zhi-Min Wang, Paul F. Richardson, Ramanaiah C. Kanamarlapudi
  • Novel lipoxygenase proteins and polynucleotides encoding the same
    Publication number: 20030172391
    Abstract: The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
    Type: Application
    Filed: April 23, 2003
    Publication date: September 11, 2003
    Applicant: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Brian Zambrowicz, Michael Nehls, Glenn Friedrich, Arthur T. Sands
  • Human kinase proteins and polynucleotides encoding the same
    Patent number: 6617147
    Abstract: Novel human kinase polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: September 9, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: Yi Hu, Boris Nepomnichy, Xiaoming Wang, Gregory Donoho
  • Human kinases and polynucleotides encoding the same
    Patent number: 6610537
    Abstract: Human polynucleotide and polypeptide sequences for novel protein kinases are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: August 26, 2003
    Assignee: Lexicon Genetics Incorporated
    Inventors: C. Alexander Turner, Jr., Brian Mathur