Abstract: The invention relates to a dispensing device having a dispenser for dispensing a liquid containing at least one cell and/or at least one particle and an optical detection device for optically detecting at least a region of the dispenser, which has a light source for emitting an illuminating light for illuminating the region and a deflection device for deflecting a detection light emanating from the region. The dispensing device is characterised in that the deflection device deflects the detection light at least twice, in particular exactly twice.

Abstract: The present disclosure generally pertains to a biomimetic apparatus configured to simulate physiological conditions by, in part, providing for both barrier and transport interfaces. The presently disclosed apparatus may be used to: test therapeutics for different diseases; to study transport; form a substrate for any organ tissue with a barrier and/or transport function; provide a closed loop assembly for fluid flow; mimic underlying and enveloped tissue; and model external environmental conditions.

Abstract: A method for degrading an organism includes steps as follows. A composite structure is provided, wherein the composite structure includes a degradation activity donor and a supporter. The degradation activity donor has a piezoelectric property. The supporter carries the degradation activity donor, wherein the degradation activity donor is completely or partially covered by the supporter. A contacting step is conducted, wherein the composite structure is contacted with a medium. The medium includes at least one organism and water. A degrading step is conducted, wherein a mechanical perturbation is generated in the medium to polarize the degradation activity donor, and a separation of an electron-hole pair is generated for degrading the organism.

Abstract: The disclosure relates generally to a cell culture apparatus and a cell culture method. One aspect of the disclosure provides a perfusion cell culture bag comprising one or more polymer films, having edges bonded together to form edges around an undivided interior compartment of the bag; first and second ports each formed in an exterior surface of the bag; first and second liquid-permeable tubes each extending into and in fluid communication with the interior compartment of the bag and operatively coupled to a respective port; and a third port formed in an exterior surface of the bag, the third port being in fluid communication with the interior compartment of the bag; wherein the first tube comprises a first inner support structure defining a central lumen of the tube and a first outer filter layer surrounding the first inner support structure.

Abstract: It is described an orbital incubator shaker, which comprises an incubator housing (1) defining an incubation chamber (2), and an orbital shaker (3) configured to shake a shaking table (4). The orbital shaker (3) comprises a rotary direct drive motor (7, 8, 9, 10) comprising a stator (7, 8) and a rotor (9, 10) comprising a rotor shaft (9), and an eccentric bearing unit (11, 12, 14) mounted on the rotor shaft (9). The stator (7, 8) is located outside the incubation chamber (2) and the rotor shaft (9) extends from a space (22) outside the incubation chamber (2) towards the incubation chamber (2).

Abstract: A method and an apparatus are provided for cleaning, disinfecting, and/or sterilizing a device. The method comprises contacting an object with an obstructing substance such that the object is infiltrated with at least a portion of the obstructing substance. An absorptive and/or adsorptive capacity of the object is reduced by the obstructing substance. The object is contacted with a treatment agent after the capacity of the object is reduced. Infiltration of the object with the treatment agent is limited by the reduction of the capacity of the object.

Abstract: Systems and methods for monitoring and tracking the behavior of cells and tissues in a culturing medium, for example, in a cell culture medium or an in vivo tissue environment, using a tissue scaffold system having one or more sensor arrays. Such monitoring systems include a tissue scaffold system and one or more sensor arrays on the tissue scaffold system in vertically stackable configurations. The sensor array(s) are configured to monitor electrical impedance and/or electrophysiological activities of cells or tissues which may be provided to an external data acquisition system for production of a three-dimensional (3D) map.

Abstract: Provided herein are systems comprising multiple fluidically-coupled chamber volumes. In particular, provided herein are cell culture systems that incorporate fluid flow between multiple cell culture volumes, and method of use thereof for the culture of multiple related cell/tissue types.

Abstract: A system for culturing cells includes a bioreactor including a scaffold on which the cells tend to adhere. The system further includes a circulatory system that intermittently flows fluid over the scaffold.

Abstract: A disinfecting glove includes: a glove body that can be made of nitril rubber; a disinfecting pad that includes a pad body with a disinfecting agent applied and optionally an adhesive layer, a scrubbing portion, a cleaning portion, and dusting portions, such that the disinfecting pad can be detachably or permanently positioned on a palmar side of the glove body, such that the disinfecting glove can be used to clean and disinfect a surface. Also disclosed is a disinfecting glove system including a pair of glove assemblies, each including a glove container and a disinfecting glove; and a disinfecting system including a plurality of pairs of disinfecting gloves; and a plurality of disinfecting shoe covers, each including a shove cover body and a disinfecting pad.

Abstract: A body cube for culturing tissue that includes: an organ chip holder; and a body barrier chip and a first body organ chip disposed in the organ chip holder, the first body organ chip including a first cell culture chamber that receives cell culture medium and produces a first tissue in the first cell culture chamber, such that the organ chip holder receives cell culture medium and communicates the cell culture medium to the first cell culture chamber of the first body organ chip in response to rotation of the organ chip holder.

Abstract: It is described an orbital incubator shaker, which comprises an incubator housing (1) defining an incubation chamber (2), and an orbital shaker (3) configured to shake a shaking table (4). The orbital shaker (3) comprises a drive motor comprising a stator and a rotor (9), and an eccentric bearing mounted to the rotor (9). The orbital shaker (3) is fixed within the incubation chamber (2) or in a mobile version without fixing just being placed inside the incubation chamber (2). The orbital shaker (3) further comprises a bearing (16) configured to support the rotor (9) on a support structure. The rotor (9), the bearing (16) and the support structure are configured to seal the stator from the incubation chamber (2).

Abstract: A cell culture device includes a culture unit, a gas supply unit, a first pressure unit, at least one inspecting unit and a control unit. The culture unit contains a cell culture liquid. The gas supply unit, connected with the culture unit, is used for transmitting a culture gas into the culture unit. The first pressure unit, connected with the culture unit, is used for applying a pressure to the cell culture liquid in the culture unit. The at least one inspecting unit, connected with the culture unit, is used for receiving the cell culture liquid for inspection. The control unit, electrically coupled with the culture unit, the first pressure unit, the gas supply unit and the at least one inspecting unit, is used for monitoring corresponding condition parameters to determine respective operations. In addition, a cell culture method for the cell culture device is also provided.

Abstract: This application relates to an automated three-dimensional (3D) cell culture system. The system includes a first body including a cell culture space in which a scaffold, on which cells are cultured, is provided and the cells are cultured thereon, and a medium storage space which is partitioned from the cell culture space by a first partition wall, in which a medium is provided and stored, and which surrounds the cell culture space, wherein the first partition wall has a drain hole to communicate the medium storage space with the cell culture space. The system also includes a communication pipe provided at the first partition wall to drain the medium of the cell culture space to the outside by a siphon action. The system further includes a second body including a medium recovery space located under the first body and recovering and externally draining the medium drained through the communication pipe.

Abstract: In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.

Abstract: Methods, systems, and apparatuses involving disinfecting light subcomponents are provided. An example system comprises a substrate with one or more light emitters disposed on the substrate. The one or more light emitters may be configured to inactivate microorganisms on a surface by emitting light. The light may comprise a proportion of spectral energy of the light, measured in a 380 nanometers (nm) to 420 nm wavelength range, greater than 50%. The light may comprise a full width half max (FWHM) emission spectrum of less than 20 nm and centered at a wavelength of approximately 405 nm to concentrate a spectral energy of the light and minimize energy associated with wavelengths that bleed into an ultraviolet wavelength range. The light may comprise an irradiance at the surface sufficient to initiate inactivation of microorganisms on the surface.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample.

Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.

Abstract: The invention relates to methods of household waste management, in particular, to methods of disposing waste by plasma-chemical destruction method. The invention is directed to attaining a technical effect of broadening range of technical solutions by providing a method of destruction of household waste at low temperature of treatment that is comparable to environment temperature. This technical effect is attained by a destruction method, where household waste is fed into a reactor via an input opening, and entry of atmospheric air into the reactor is restricted. The reactor is a closed cavity, whose inner surface is made conductive entirely or partially and is grounded. An electrode protrudes into the reactor, and this electrode is isolated from the grounded surface. High-voltage pulses are supplied to the electrode. The pulses cause formation of corona discharge streamers in a gap between the electrode and the conductive surface of the reactor.

Abstract: A method of disinfecting using a light diffusing fiber includes optically coupling a light source to a light diffusing optical fiber having a core, a cladding surrounding the core, an outer surface, and a plurality of scattering structures positioned within the core, the cladding, or both the core and the cladding. The method further includes positioning the light diffusing optical fiber in optical engagement with a pathogen sample and directing light output by the light source into the light diffusing optical fiber for a first time interval. The scattering structures scatter light propagating along the light diffusing optical fiber toward the outer surface and a portion of the light diffuses through the outer surface thereby irradiating the pathogen sample with light having an average power density of about 5 mW/cm2 to about 30 mW/cm2 at a wavelength from about 380 nm to about 495 nm for an exposure time from about 2 hours to about 24 hours.