Abstract: A device for preserving a predetermined dose of liquid-based substance, notably animal semen or a preservation medium containing embryos or tissue samples, comprises a tube (11) made of a weldable plastics material. The tube allows a service state in which a receiving portion (21) intended to contain the said predetermined dose has a circular cross-section whereas a sealing portion (22) comprises a welded pinch (19) and a transition zone (23). Over at least part of the sealing portion a differentiating edge region (28) gives the external surface of the tube a visual appearance different from the visual appearance of the external surface of the tube outside of the differentiating edge region. A range comprises such a device and a similar device but without the differentiating edge region.

Abstract: Provided is a bioreactor system and a fermentation process employing continuous inline medium dilution in which concentrated medium and nutrients are blended with water or buffer and fed to the cell culture vessel of a bioreactor system, e.g. for production of antibodies and other recombinant proteins by mammalian cells.

Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.

Abstract: Single-use devices configured to sanitize accessible surfaces of luer access devices (e.g., needleless medical valves) at risk of contamination with infectious agents are described, as are methods for making and using such devices. In particularly preferred embodiments, such devices include a container (e.g., laminated foil pouches or packets) that contain a sanitizing component that includes a substrate with a cleaning port or recess, a cleansing matrix associated with the substrate, and a sanitizing reagent dispersed in the cleansing matrix.

Abstract: Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood, and the automated generation of immunotherapeutic products from those dendritic cells, all within a closed system. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.

Abstract: The present invention relates, in part, to systems configured to obtain samples from an organism in an autonomous manner. Such systems can employ a cartridge configured to provide bait to attract an organism, as well as channels to store and/or test samples obtained from the organism.

Abstract: Closure mechanisms for closing and sealing sterilization containers and indicators for indicating the seal integrity sterilization containers are provided. For example, a container closure mechanism may be configured to distribute a closure force along a gasket to seal a container lid to a container body. Further, a seal indicator may visibly indicate at the container exterior whether the container is sufficiently sealed to prevent an ingress of contaminants into the container. If the container is sufficiently sealed, the seal indicator is a first state, and if the sterilization container is not sufficiently sealed, the seal indicator is in a second state. Thus, the seal indicator undergoes a state change when the sterilization container transitions from unsealed to sealed or from sealed to unsealed, such that a user can ascertain whether the container is properly sealed to maintain sterility or whether the seal and sterility of the container have been compromised.

Abstract: An irradiation apparatus configured to be coupled to an irradiation chamber containing a material to be irradiated, comprising: a support structure; one or more radiation sources coupled to the support structure; and a heat exchange mechanism thermally coupled to the one or more radiation sources. The heat exchange mechanism comprises one or more of a thermoelectric cooling device, a vapor chamber, a heatsink, a heat dissipation structure, a fan, and a cooling coating. The one or more radiation sources comprise one or more UV radiation sources, one or more UV-C radiation sources, one or more visible radiation sources, or a combination thereof. Optionally, the one or more radiation sources comprise a plurality of radiation sources arranged in an array. Optionally, the one or more radiation sources deliver a combination of wavelengths to the material to be irradiated.

Abstract: A sanitizing system for sanitizing a laundry sling that is moveable along one or more support rails includes a motor, a cable operatively coupled to the motor, a sanitizing lamp coupled to the cable, and a controller configured to cause the motor to operate such that the sanitizing lamp is moved, via the cable, from a first position to a second position and actuate the sanitizing lamp such that the sanitizing lamp emits a sanitizing wavelength of light.

Abstract: Provided herein is a tissue culture device and a method of forming a tissue culture device. The tissue culture device includes a microfluidic layer including at least one hydrophobic microchannel and a reservoir portion over the at least one hydrophobic microchannel, the reservoir portion including an opening aligned with the at least one hydrophobic microchannel. The method of forming a tissue culture device includes providing a microfluidic layer mold, a reservoir layer mold, and a removable lid mold, filling each of the molds with a device material, curing the device material within the molds, removing the cured device material from the molds to provide a microfluidic layer, a reservoir layer, and a removable lid, and bonding the microfluidic layer to the reservoir layer. A method of culturing tissue with the tissue culture device is also provided herein.

Abstract: A sterilization process by means of heat treatment to preserve the ink of coleoid cephalopod molluscs includes the steps of homogenizing and first heat treating (1) the ink in a reactor for pasteurising treatment in which a temperature of at least 70° C. is attained for over 10 minutes; and cooling (2) the homogenized ink in a tank set to a temperature of below 30° C. and retaining the ink in the tank to lower its temperature. The process also includes the steps of continuing by filling, turning, blowing and marking (3) the expiry dates; and second heat treating (4) the ink in an autoclave in which a heat treatment is performed to achieve a sterilization temperature greater than or equal to 110° C. for a predetermined time based upon the quantity to be canned.

Abstract: The invention relates to a system (1) and a method for pasteurizing foods packed in closed containers (2). The containers (2) are supplied with a processing liquid (11) in at least one heating zone (5,6), at least one pasteurization zone (7, 8), and at least one cooling zone (9, 10). In order to cool and heat the processing liquid (11) as needed, a coolant (23) is cooled by means of a heat pump (22) in a cooling circuit (20), and a heating medium (33) is heated by means of the heat pump (22) in a heating circuit via a respective heat exchanger (19, 30) in each case. In order to provide cooling energy, the cooled coolant (23) is introduced into a lower end region of a cold buffer store (24), and in order to provide heating energy the heated heating medium (33) is introduced into an upper end region of a heat buffer store (35).

Abstract: A system and method of sterilization for medical instruments within a hydrogen peroxide sterilization process is provided. A medical instrument is housed in a sterilization tray, wherein the sterilization tray is formed from polypropylene and a glass material. The medical instrument and sterilization tray are subjected to a hydrogen peroxide sterilant.

Abstract: An apparatus for use in a method of decontaminating a device including a tray. A membrane permeable by a decontaminating fluid is positioned over the top of the tray to form an enclosed space. A lid is secured to the tray and the membrane is positioned between the tray and the lid. A hub assembly is positioned within the tray.

Abstract: A system for bacteria irradiation from an occupant zone of a vehicle is provided. The system comprises an interior portion disposed in the occupant zone. The interior portion has one of a predetermined surface porosity and a predetermined surface roughness. The interior portion has phosphorescent paint for visual indication. The system further comprises a high energy visible (HEV) light source integrated within the interior portion. The HEV light source has an emission wavelength of between about 375 nm and about 425 nm. The HEV light source further provides a cumulative energy of between about 1 J/cm2 and about 50 J/cm2. The system further comprises a vehicle processor in communication with the HEV light source. The vehicle processor is configured to enable the HEV light source. The system further comprises a sensor in communication with the vehicle processor and configured to provide input on when to enable light source.

Abstract: Provided herein is a microphysiological system that may be used in various cell culture applications and biological system studies, that facilitates co-culture, monitoring, and study of functional interactions among different types of cellular and biological materials under various environmental conditions. The system is configured for fast assembly and disassembly, thereby minimizing damage or contamination of the biological materials and environmental conditions inside the system. The system comprises a base, a lid, and a plurality of clamps that are connected to the base and the lid. The base has a recess surface for receiving cell culture support layers. The lid has a stepped surface configured to exert a contact force to a top layer of one or more cell culture support layers during use. The clamp involves an engagement mechanism that generates a contact force allowing for sealing of the cell culture support layers in a manner that minimizes leakage of fluids.

Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.

Abstract: The present invention relates to a microfluidic device to manipulate, select, treat, or cultivate living bodies, comprising a first chamber, a second chamber and a network of guiding tracks, wherein: said network of guiding tracks comprises at least one first guiding track connecting the first chamber and the second chamber and at least one second guiding track connecting said at least one first guiding track with at least two interconnections; and said at least one second guiding track comprises a curved part; said curved part exhibiting a concavity facing the second chamber or the part of the network connected to the second chamber.

Abstract: A consumable container for filling with a fluid in a bioprocessing process. The container comprises one or more sealable, removable portions, such that one or more samples of the fluid may be taken by sealing and removing one or more of said portions.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (T1) and a second test line (T2) each test line comprising binding moieties that bind a complex formed between beta-trace protein (betaTP) and an indicator attached to a betaTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone.