Abstract: A method includes receiving a bipolar signal sensed by a pair of electrodes at a location in a heart of a patient. One or more electrocardiogram (ECG) signals are received, sensed by body-surface electrodes attached to the patient. Two or more successive QRS complexes are identified in the bipolar signal. One or more activations are detected in the bipolar signal, which occur within a window-of-interest that begins at least a given time with respect to the identified QRS complexes. The detected activations are checked whether they are late potentials, by verifying whether (i) the activations do not coincide with a predefined event observed in the ECG signals, and (ii) the activations are repeatable in the successive QRS complexes. In response to deciding that at least one of the detected activations is a late potential, the latest of the at least one of the late potentials is visualized to a user.

Abstract: A computer-implemented method for contact photoplethysmography, abbreviated contact PPG, comprises obtaining during a time interval plural PPG signals for sub-regions of a lens or video frame; and combining the plural PPG signals to thereby obtain a multi-region PPG signal.

Abstract: The electronic device includes a pad module and a main module. At least part of the patch module is attached to a user to obtain a bio-signal of the user. The pad module includes a first housing and a plurality of first electrodes disposed in the first housing. The main module is configured to record the bio-signal of the user that is transferred through the pad module. The main module includes a second housing that is coupled with the first housing in a first direction. The main module also includes a plurality of second electrodes disposed in the second housing. The plurality of second electrodes are configured to make electrical contact with the plurality of first electrodes. The main module further includes a plurality of magnetic bodies disposed in the second housing to correspond to positions of the plurality of second electrodes.

Abstract: The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.

Abstract: Continuously monitoring heart rhythm can include grouping, using computer hardware, a plurality of inter-beat intervals (IBI) data for a user into a plurality of epochs, wherein each epoch includes a subset of the IBI data corresponding to a predetermined time span. For each epoch, a selected feature set selected from a plurality of feature sets is extracted based on a determination of temporal consistency of the epoch. A plurality of epoch classifications may be generated for the epochs using a selected feature processor, wherein each epoch classification indicates whether arrhythmia is detected for the epoch from which the epoch classification is generated. The selected feature processor is selected from a plurality of different feature processors on a per-epoch basis based on the selected feature set extracted from the epoch. An indication of arrhythmia may be output, via an output device of the computer hardware, based on the epoch classifications.

Abstract: The present disclosure provides methods of improving cardiac function, including transcutaneously inserting at least one catheter into a heart, delivering a band to a ventricle of the heart via the at least one catheter, guiding the band through a plurality of spaces among a trabeculae in the ventricle, tightening the band in a single loop, locking the band in a loop, and removing the at least one catheter from the heart.

Abstract: A method for operating a medical device includes activating a processor in the medical device in a low-power operating mode, measuring a first voltage level of the battery, applying at least one discharge pulse to the battery in response to the first voltage level of the battery being greater than a predetermined passivation minimum voltage threshold and less than a predetermined passivation maximum voltage threshold, measuring a second voltage level of the battery after the at least one discharge pulse, and operating the processor in the medical device in an increased-power operating mode to continue operation of the medical device only in response to the second voltage level being greater than or equal to a predetermined operating voltage threshold, the predetermined operating voltage threshold being greater than the predetermined passivation minimum voltage threshold and less than or equal to the predetermined passivation maximum voltage threshold.

Abstract: This specification describes methods of performing ECG analyses. In one approach, the system receives an ECG recording for a first duration, automatically performs a first analysis of the ECG recording for the first duration to detect events with reference to each of a plurality of arrhythmias, generates a GUI where areas within the GUI are designated for displaying detected events for each of the arrhythmias and enables a user to select at least one ECG segment of a second duration of the ECG recording. In response to the user's selection of the at least one ECG segment, the system presents the user with at least one option, and in response to the user's selection of the option, the system performs a second analysis of the ECG segment of the second duration and displays at least one output corresponding to the second analysis.

Abstract: Systems and methods for electrocardiographic waveform analysis, data presentation and actionable alert generation are described. Electrocardiographic waveform data can be received from a wearable device associated with a patient. A mathematical analysis of at least a portion of the electrocardiographic waveform data can be performed to provide cardiac analytics. In instances where (1) a pathologically prolonged QT interval and (2) an R on T premature ventricular contraction and/or a ventricular tachycardia are detected from the cardiac analytics of the at least a portion of the electrocardiographic waveform data, an actionable alert can be generated and displayed with a visualization of the cardiac analytics.

Abstract: A system includes a unit for capturing ECAP signals induced at electrodes of an electrode array in response to stimulation of a cochlea by applying auditory nerve stimulation signals to the electrodes; a memory unit for storing the captured ECAP signals and/or ECAP data derived from the captured ECAP signals; an electrode migration detection unit for detecting electrode migration relative to the cochlea by comparing presently captured ECAP signals and/or ECAP data derived from such presently captured ECAP signals to stored previously captured ECAP signals and/or ECAP data derived from such previously captured ECAP signals; and a unit for outputting an alarm signal in case that electrode migration is detected by the electrode migration detection unit.

Abstract: A bio electrode and a method of forming the same are provided. The bio electrode comprises a first core-shell nanowire/polymer composite comprising a first core-shell nanowire and a first polymer. The method of forming a bio electrode comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal.

Abstract: A pacemaker has a housing and a therapy delivery circuit enclosed by the housing for generating pacing pulses for delivery to a patient's heart. An electrically insulative distal member is coupled directly to the housing and at least one non-tissue piercing cathode electrode is coupled directly to the insulative distal member. A tissue piercing electrode extends away from the housing.

Abstract: Systems and apparatus for synthesizing (generating) 12-lead ECG dataset from 3-lead ECG data. In particular, one or more transformation parameters may be determined that may be applied to 3-lead ECG dataset to generate 12-lead ECG data with particular speed and accuracy. The transformation parameters, which may include a plurality of matrices, may be determined from a synchronized patient's 12-lead ECG dataset and 3-lead ECG data. The 12-lead ECG dataset may be collected at a different time than the 3-lead ECG data. In some embodiments, the 12-lead ECG dataset and/or the 3-lead ECG dataset may be resampled prior to determining the transformation parameters.

Abstract: A subcutaneous electrocardiography monitor configured for self-optimizing ECG data compression is provided. ECG waveform characteristics are rarely identical in patients with cardiac disease making this innovation crucial for the long-term data storage and analysis of complex cardiac rhythm disorders. The monitor includes a memory and a micro-controller operable to execute under a micro-programmable control and configured to: obtain a series of electrode voltage values; select one or more of a plurality of compression algorithms for compressing the electrode voltage series; apply one or more of the selected compression algorithms to the electrode voltage series; evaluate a degree of compression of the electrode voltage series achieved using the application of the selected algorithms; apply one or more of the compression algorithms to the compressed electrode voltage series upon the degree of compression not meeting a predefined threshold; and store the compressed electrode voltage series within the memory.

Abstract: In one embodiment, an ambulatory encoding monitor recorder optimized for rescalable encoding and a method of use are provided. The monitor recorder includes a memory configured to store a plurality of codes and a plurality of electrocardiographic values associated with each of the codes; and a micro-processor configured to obtain electrocardiographic values during a sequence of temporal windows and to process the electrocardiographic values within each of the windows, the processing including: perform a mathematical operation on two of the electrocardiographic values; analyze a result of each of the mathematical operations; based on the analysis, adjust the plurality of the electrocardiographic values associated with each of the codes; encode each of the electrocardiography values within that window with one of the codes based on the adjusted plurality of the electrocardiographic values associated with that code; and write each of the codes into a sequence in the memory.

Abstract: The present disclosure provides a method of reducing phantom limb pain or diabetic neuropathy pain, and increasing prosthetic control, by stimulating dorsal spinal rootlets and/or lateral spinal cord adjacent to the dorsal rootlets, of sensory neurons innervating the limb with the phantom limb pain or diabetic neuropathy pain, or the prosthetic.

Abstract: A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.

Abstract: A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.

Abstract: Conduction velocity information for a cardiac region can be used to map the cardiac muscle fiber orientation of that region. In particular, for a plurality of locations within the cardiac region, a relationship between a local conduction velocity, a maximum local conduction velocity within the region, and a minimum local conduction velocity within the region is used to determine the cardiac muscle fiber orientation at the respective location. Even more particularly, when the local conduction velocity at the respective location equals the maximum local conduction velocity, the cardiac muscle fiber orientation is parallel to a direction of a conduction velocity vector at the respective location, and when the local conduction velocity at the respective location equals the minimum local conduction velocity, the cardiac muscle fiber orientation is perpendicular to a direction of a conduction velocity vector at the respective location.

Abstract: A wearable, percutaneous device for suppressing appetite or hunger in a patient includes a microprocessor, electrical stimulator and at least one percutaneous electrode implanted and configured to deliver electrical stimulation through the patient's skin. The percutaneous device includes a pad and at least one needle, in which the electrode is disposed, for secure placement of the device within the skin of a patient. The percutaneous device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols.