Abstract: A system for providing non-invasive neuromodulation to a patient includes a mouthpiece and a controller. The mouthpiece includes an elongated housing, a printed circuit board, and control circuitry mounted within the elongated housing. The controller includes an elongated u-shaped element, an electronic receptacle, and a microcontroller. A method for providing non-invasive neurorehabilitation of a patient including connecting a mouthpiece to a controller, transmitting a numeric sequence to the mouthpiece, generating a first hash code, transmitting the first hash code to the controller, generating a second hash code, comparing the second hash code with the first hash code, enabling electrical communication between the mouthpiece and the controller only if the first hash code matches the second hash code, contacting the mouthpiece with the patient's intraoral cavity, and delivering neurostimulation to the patient's intraoral cavity.

Abstract: The local conduction velocity of a cardiac activation wavefront can be computed by collecting a plurality of electrophysiology (“EP”) data points using a multi-electrode catheter, with each EP data point including both position data and local activation time (“LAT”) data. For any EP data point, a neighborhood of EP data points, including the selected EP data point and at least two additional EP data points, can be defined. Planes of position and LATs can then be defined using the positions and LATs, respectively, of the EP data points within the neighborhood. A conduction velocity can be computed from an intersection of the planes of positions and LATs. The resultant plurality of conduction velocities can be output as a graphical representation (e.g., an electrophysiology map), for example by displaying vector icons arranged in a uniform grid over a three-dimensional cardiac model.

Abstract: A system for facilitating a cardiac rhythm disorder diagnosis with the aid of a digital computer is provided. A download station retrieves cutaneous action potentials of a patient by an ECG monitoring and recording device as ECG data. An R-R interval plot of the ECG data includes heart rates associated with R-R intervals plotted along a y-axis of the plot with respect to time, with time represented by an x-axis. The R-R intervals are calculated as a difference between recording times of successive pairs of R-wave peaks and each heart rate is associated with each time difference. Runs of the R-R intervals in the plot are identified and each run represents a cardiac event. Cardiac rhythm measurements are automatically calculated and occurrences of different types of the cardiac events are tracked. One or more of the cardiac events and the cardiac rhythm measurements are reported.

Abstract: A method includes storing an anatomical map of at least a portion of a surface of a heart. Respective electrogram (EGM) signal amplitudes measured at respective positions on the surface of the heart are stored. Based on the on the EGM signal amplitudes, defined are: one or more first regions of the surface in which the EGM signal amplitudes are fractionated, and one or more second regions of the surface in which the EGM signal amplitudes are non-fractionated. A first surface representation is generated for the fractionated EGM signal amplitudes in the first regions. Propagation times are extracted from the non-fractionated EGM signal amplitudes in the second regions, and a second surface representation of the propagation times is derived. The first and second surface representations of the respective first and second regions of the surface are simultaneously presented, overlaid on the anatomical map.

Abstract: Methods for treating, reducing or reversing a motor deficit in a subject after a stroke comprising administering continuous electrical stimulation to the mesencephalic locomotor region (MLR) of the subject under sufficient conditions so as to treat, reduce or reverse the motor deficit of the subject are provided.

Abstract: A method, including receiving sets of signals during multiple cardiac cycles, each set indicating, for a probe inserted into a cardiac chamber, a 3D location of a distal end of the probe, electrical potentials measured at the location, and respective times during a given cycle when the potentials were measured. The received measurements and the respective times are compared to a first template for a sinus rhythm cycle and a second template for a non-sinus rhythm cycle so as to identify a sequence of cycles including consecutive first, second, and third cycles wherein the first and second cycles match the first template and the third cycle matches the second template. A physical map is generated based on the locations. Based on the received locations and corresponding potentials, an electroanatomic map including the local activation times for the non-sinus rhythm cycle overlaid on the physical map is rendered to a display.

Abstract: A system for detecting an atrial tachyarrhythmia episode includes a medical device having sensing circuitry configured to receive a cardiac electrical signal from electrodes coupled to the medical device and a processor configured to detect an atrial tachyarrhythmia episode in response to a time duration of the cardiac electrical signal classified as an atrial tachyarrhythmia being greater than or equal to a first detection threshold. The processor is configured to determine if detection threshold adjustment criteria are met based on at least the detected first atrial tachyarrhythmia episode and adjust the first detection threshold to a second detection threshold different than the first detection threshold in response to the detection threshold adjustment criteria being met.

Abstract: TTFields therapy is a proven approach for treating tumors using electric fields. This application describes systems and methods for measuring the temperature at the electrode elements of the transducer arrays that are used to apply the TTFields to a subject. A distal circuit is positioned adjacent to each transducer array, and the distal circuit interfaces with temperature sensors in the transducer array to obtain temperature readings. Those temperature readings are transmitted to a central hub. In some embodiments, temperature measurements from all of the distal circuits occur simultaneously.

Abstract: The present invention provides an electroporation device and a method for controlling an electroporation device for facilitating delivering active substances into skin such as stratum corneum while minimizing discomfort of a user by modulating applied voltage pulses. The electroporation device according to the present invention comprises: a measurement unit being configured to provide multiple outputs of one or more resistance measurement voltage pulses for measuring a resistance of skin of a user at a predetermined interval; and an output unit being configured to provide an output of one or more electroporation voltage pulses to the skin of the user based on the resistance of the skin of the user per each output of the one or more resistance measurement voltage pulses.

Abstract: An information processing apparatus is described. This determines a physiological parameter of an individual, the apparatus comprising: image circuitry configured to obtain a series of images of a skin exposed region of the individual; and processing circuitry configured to perform a periodogram on at least one of the red, green and blue channels of the skin exposed region of the series of images to obtain frequency components of the channel; and to determine the physiological parameter based on the periodogram.

Abstract: A physiological information processing apparatus includes an acquiring section that acquires physiological information of a subject, a classifying section that classifies the physiological information that is acquired by the acquiring section, and an analyzing section that selects an algorithm from a plurality of algorithms according to a result of the classification performed by the classifying section, and that analyzes the classified physiological information by using the selected algorithm.

Abstract: A method, including receiving a bipolar ECG signal from a location in the heart from the pair of electrodes, receiving a unipolar ECG signal from the location in the heart from a selected one electrode of the pair of electrodes, computing a local unipolar minimum derivative of the unipolar signal at a plurality of times of occurrences of the local unipolar minimum derivative, computing a bipolar derivative of the bipolar signal, evaluating a ratio of the bipolar derivative to the local unipolar minimum derivative at the plurality of times of occurrences of the local unipolar minimum derivative, annotating each time of occurrence as a time of activation of the myocardium at the location in the heart when the ratio is greater than a preset threshold value, merging two annotations that arise from a single occurrence as a single annotation, evaluating features of the annotations and assigning a confidence level to each feature, eliminating annotations that have a confidence level below a threshold and generating

Abstract: A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.

Abstract: A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.

Abstract: Subcutaneous implantable medical device (IMD) recharging system, including a flexible rechargeable subcutaneous IMD and a charger transmitter, the flexible rechargeable subcutaneous IMD implanted in a patient and including at least one receiver antenna and at least one rechargeable battery, the charger transmitter including at least one transmitter antenna and a modulator, the charger transmitter for providing electromagnetic (EM) radiation to the receiver antenna wirelessly for recharging the rechargeable battery, the transmitter antenna being encased in a structure for temporarily coupling the transmitter antenna to the skin of the patient and the modulator being for modulating the EM radiation and for simultaneously transmitting programming information to the flexible rechargeable subcutaneous IMD as modulated EM radiation.

Abstract: An instrument drive unit for use with a surgical robotic arm includes a body, a first gear, and a driven coupler. The body has a proximal end and a distal end configured to be coupled to a surgical instrument. The first gear is non-rotatably coupled to the proximal end of the body. The driven coupler is disposed at the proximal end of the body and laterally offset from the first gear. The driven coupler is operably coupled to the first gear such that rotation of the driven coupler rotates the first gear to effect rotation of the body about a longitudinal axis defined by the body.

Abstract: An operating room cable assembly for an electrical stimulation system that includes a lead connector having a housing, a lead lumen extending inwardly from a first opening in the housing and configured and arranged to receive a portion of a lead or lead extension, and a contact assembly disposed within the housing and configured and arranged to move relative to the housing. The contact assembly is configured and arranged to move to a load position and is biased to return to a lock position. The contact assembly includes of contacts that are configured and arranged to engage a portion of any lead or lead extension within the lead lumen when the contact assembly is in the lock position and to disengage from the portion of the lead or lead extension within the lead lumen when the contact assembly is in the load position.

Abstract: A neurostimulation system configured for providing neurostimulation therapy to a patient. A user customizes a pulse pattern on a pulse-by-pulse basis. Electrical stimulation energy is delivered to at least one electrode in accordance with the customized pulse pattern.

Abstract: The present disclose generally relates to a system that controls blood pressure based on feedback-based neural stimulation. The system can include an electrode implantable within a nerve (e.g., an intra-fascicular electrode). The system can also include a hermetically-sealed electronics module connected to the electrode to record data related to neural activity from the nerve. The data related to the neural activity is indicative of the blood pressure. The system can also include an external device to communicate with the hermetically-sealed electronics module to receive and analyze the data related to the neural activity.

Abstract: Methods and apparatus for estimating flow rate in a blood circulation assist system employing impeller eccentricity. A method includes magnetically rotating an impeller within a blood flow channel of a blood pump. The impeller is levitated within the blood flow channel transverse to the impeller axis of rotation. A rotational speed for the impeller is determined. At least one impeller transverse position parameter is determined. The at least one impeller transverse position parameter is based on at least one of (1) an amount of a bearing current that is used to levitate the impeller transverse to the impeller axis of rotation, and (2) a position of the impeller within the blood flow channel transverse to the impeller axis of rotation. A flow rate of blood pumped by the blood pump is estimated based on the impeller rotational speed and the at least one impeller transverse position parameter.