Abstract: An absorbent article which can have an improved feeling of comfort next to the skin of the wearer and a reduction in the feelings of wetness and rewet. An absorbent article can have a longitudinal direction, a transverse direction, and a depth direction. The absorbent article can have a topsheet layer, a backsheet layer, and an absorbent core positioned between the topsheet layer and the backsheet layer. The topsheet layer can have a hydrophilic central layer, a semi-hydrophilic first side layer, and a semi-hydrophilic second side layer. Each of the semi-hydrophilic side layers can be bonded to the central layer utilizing an embossing technique in the regions of overlap of each of the semi-hydrophilic side layers with the central layer. The area of the body-facing surface of each of the regions of overlap can contain from about 10% to about 35% of at least one embossment.

Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Abstract: The present invention relates to a method for preparing Asenapine. In particular, the present invention relates to a method for preparing pharmaceutically acceptable Asenapine free base and new crystal form thereof, and also relates to methods for preparing the intermediate compounds used in said method.

Abstract: The pyrazolidinedione derivatives were found to possess blood glucose lowering properties. These compounds were designed as potential PPAR gamma inhibitors, an essential molecular target for clinically used antidiabetic drugs. Owing to their promising anti-hyperglycemic activity, these derivatives may find useful applications for the treatment and/or prevention of obesity, diabetes type II and I, hyperglycemia and other diseases where PPAR gamma is implicated such as cancer, atherosclerosis and hyperlipidemia.

Abstract: Absorbent articles comprising a multilayer outer cover comprising a first outer layer and a second outer layer comprising a component that exhibits at least partial elastic recovery after mechanical activation in the machine direction; an inner layer, disposed between the first outer layer and the second outer layer, the inner layer comprising elastic strands; and wherein at least one of the first outer layer and second outer layer is laminated to the inner layer.

Abstract: An absorbent article is provided, the absorbent article comprising a nonwoven material. The nonwoven material comprises core/sheath bicomponent fibers wherein the core is formed of PET resin. The present disclosure also provides a wipe comprising a nonwoven material, the nonwoven material comprising core/sheath bicomponent fibers wherein the core is formed of PET resin. The PET has less than 150 ppm of antimony.

Abstract: Benzoxazine compounds, methods of making them, polymers made therefrom and methods of polymerizing the benzoxazines. These renewable benzoxazine monomers and polymers that utilize the variety of building blocks found in renewable plant biomass, demonstrate excellent processability and large temperature windows for processing of resin systems.

Abstract: An absorbent article includes a first waist region, a second waist region and a crotch region disposed between the first and second waist regions. The absorbent article further includes a topsheet, a backsheet, an absorbent core disposed between the topsheet and the backsheet, and a laminate. The laminate has an elasticized region. The laminate includes a first nonwoven, a second nonwoven and an elastomeric material sandwiched between said first and second nonwovens in the elasticized region. The laminate includes a bonding region with a bond density of at least 4% and at least partially overlapping the elastomeric material. The laminate exhibits an Unload Force at 50% of at least 0.90 N.

Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological diseases.

Abstract: A lid adapter for coupling with a lid of a collection container where the lid includes an outlet vent. The lid adapter including a housing including a top surface and one or more side panels that are configured to couple with a top of the lid and a port coupled to the top surface and configured to rotate between a first position and a second position, wherein when the lid adapter is coupled to the lid and the port is in the first position, a fluid seal is established between a distal end of the port and the top of the lid surrounding the outlet vent thereby enabling fluid flow from the outlet vent and through the port. When the port is in the second position, the fluid seal is not established, and when the port is in the first position, the port is disposed perpendicularly to the top surface.

Abstract: The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.

Abstract: Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A catheterization system including a catheter, drainage bag and one or more indicators configured to measure an attribute relating to the usage of the catheter system and communicate information about the attribute to a network, such as an EMR database. The indicators may include a location indicator, a duration indicator, an elevation indicator, a tamper indicator, a dependent loop indicator, a floor contact indicator, and a patient securement indicator. The system may autonomously detect and record one or more attributes relating to the usage of the catheter system.

Abstract: Methods of inhibiting cyclooxygenase enzyme-2 (COX-2) using thieno[2,3-d]pyrimidine compounds. These methods can be effective for treating inflammation, pain, or any other COX-2 mediated disorder.

Abstract: A feminine care absorbent article comprising an absorbent member positioned between a topsheet and a baffle is provided. The absorbent member contains at least one layer that comprises superabsorbent particles containing nanopores having an average cross-sectional dimension of from about 10 to about 500 nanometers.

Abstract: According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.

Abstract: The present invention relates to a device for flushing a body cavity with a fluid, the fluid being pumped by means of two lines from the body cavity. The respective pumping capacity is regulated via controllable pinch valves, the two pinch valves being coupled in an antiparallel manner.

Abstract: This disclosure relates to crystalline bis(4-hydroxy-N,N-d-n-propyltryptammonium)fumarate tetrahydrate (4-HO-DPT fumarate-4H2O) and to Crystalline 4-hydroxy-N,N-di-n-propyl-tryptammonium chloride (4-HO-DPT chloride). Compositions containing crystalline 4-HO-DPT fumarate-4H2O or crystalline 4-HO-DPT chloride, and methods of use are disclosed.

Abstract: The invention relates generally to device and methods for controlling flatulence release. In particular, the device and method of the present invention is effective for suppressing, reducing, or eliminating noise and odor of flatus gas at the anal opening. The device contains an odor absorbing material and is configured to be inserted into or pressed against the anal opening.