Abstract: According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.

Abstract: The present invention relates to a device for flushing a body cavity with a fluid, the fluid being pumped by means of two lines from the body cavity. The respective pumping capacity is regulated via controllable pinch valves, the two pinch valves being coupled in an antiparallel manner.

Abstract: This disclosure relates to crystalline bis(4-hydroxy-N,N-d-n-propyltryptammonium)fumarate tetrahydrate (4-HO-DPT fumarate-4H2O) and to Crystalline 4-hydroxy-N,N-di-n-propyl-tryptammonium chloride (4-HO-DPT chloride). Compositions containing crystalline 4-HO-DPT fumarate-4H2O or crystalline 4-HO-DPT chloride, and methods of use are disclosed.

Abstract: One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.

Abstract: The invention relates generally to device and methods for controlling flatulence release. In particular, the device and method of the present invention is effective for suppressing, reducing, or eliminating noise and odor of flatus gas at the anal opening. The device contains an odor absorbing material and is configured to be inserted into or pressed against the anal opening.

Abstract: A process for producing a cyclic alkylene urea product of Formula I: in which a compound of Formula II and/or Formula III is contacted in a reaction zone with a compound of Formula IV and/or Formula V and in the presence of one or more carbonyl delivering compounds; wherein the compound of Formula II and/or the compound of Formula III are added to a reaction zone comprising compound of Formula IV and/or compound of Formula (V) continuously or semi-continuously over a period of time, or in two or more batches.

Abstract: The present application describes deuterium-enriched pioglitazone, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.

Abstract: A fluid management layer having an integrated, carded, nonwoven is described. The fluid management layer has a basis weight of between about 115 grams per square meter (gsm) and about 200 gsm; a plurality of absorbent fibers; a plurality of stiffening fibers; and a plurality of resilient fibers. The absorbent fibers make up from about 20 percent to about 60 percent by weight of the fluid management layer. The stiffening fibers have a dtex of between 4 and 10, and the resilient fibers have a dtex of between 3 and 12.

Abstract: Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are (6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones and their use as anti-tubercular agents are provided.

Abstract: A breast pad for receiving fluid leaked from a subject's breast includes an inner layer disposed for contacting the subject's breast. The inner layer has an inner surface and an outer surface opposite the inner surface. The inner layer includes wicking material for wicking fluid from the inner surface to the outer surface away from the subject's breast. An intermediate layer is disposed over the outer surface of the inner layer. The intermediate layer includes an absorbent material for absorbing the fluid wicked from the subject's breast by the wicking material of the inner layer. An outer layer is disposed over the intermediate layer. The outer layer includes a liquid-impermeable material for trapping the fluid absorbed by the intermediate layer within the breast pad.

Abstract: An intravenous (IV) spike for administering a medicinal fluid from a container may include a head portion at a proximal end thereof, a base portion at a distal end thereof, and an elongate body portion connecting the head and the base portions. The elongate body portion may be configured to be coupled to the container. The IV spike may further include a radial notch extending at least partially along a circumference of an outer surface of the elongate body portion. The radial notch may be recessed radially inward from the outer surface.

Abstract: This application provides a biphenyl diaryl pyrimidine derivative with an aromatic heterocyclic structure, a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, where the biphenyl diaryl pyrimidine derivative is shown in formula (I). This application also provides a pharmaceutical composition containing the biphenyl diaryl pyrimidine derivative, or a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, and a pharmaceutically-acceptable carrier. This application further provides a method of treating AIDS by administering a therapeutically effective amount of the pharmaceutical composition to a patient in need.

Abstract: Absorbent structures for absorbent articles are provided. The absorbent structure includes an absorbent layer with absorbent material supported by a supporting sheet, and a channel that is free of the absorbent material. The channel has a wet integrity of at least 20%.

Abstract: A film having low pressure values is provided. The film may have from about 20 wt. % to about 75 wt. % of a polyolefin component, from about 5 wt. % to about 35 wt. % of an elastomeric resin, and from about 20 wt. % to about 45 wt. % of a particle component. The film may have a basis weight of from about 5 gsm to about 25 gsm. The film may have a predicted sound pressure level over the frequency octave range of 2000 Hz-6300 Hz of less than about 43 dB.

Abstract: In one aspect, the invention provides compounds of Formula I, and salts, hydrates and isomers thereof. In another aspect, the invention provides a method of promoting bone formation in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides orthopedic and periodontal devices, as well as methods for the treatment of renal disease, diabetes, bone loss, and cancer, using a compound of Formula I.

Abstract: A disposable absorbent article may include a first waist region, a second waist region, a crotch region disposed between the first and the second waist regions, and a chassis having a topsheet, backsheet, absorbent core, and chassis periphery. The chassis periphery has a varying width, Wv.

Abstract: A compound 3-(4-chlorophenyl)-5-{[5-methyl-2-(propan-2-yl)phenoxy]methyl}-1,2,4-oxadiazole, its synthesis, and its use as an anticancer and/or antimicrobial agent.

Abstract: The invention relates to combined liposuction methods and can be used in surgical interventions to remove local fat deposits in the lower third of the face and neck. The method includes a preoperative examination of the patient when one or more areas of the lower third of the face and neck of the patient are designated as liposuction areas constituting the operative field. The contour boundaries of the operative field and at least one operative access point are determined. Uniform infiltration anesthesia of the adipose tissue to be removed in the liposuction areas is performed. From a Nd:YAG laser radiation source with a wavelength of 1064 nm, a Nd:YAG laser radiation with a wavelength of 1064 nm in a pulsed mode with a frequency of 50 Hz, with a pulse duration of 300 ?s and a power of the predetermined value is supplied directly to the adipose tissue to be removed.

Abstract: The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.

Abstract: A smart vial adapter is capable of measuring the dose of a drug that is withdrawn from a vial, measuring the time of a dose capture event, monitoring the vial temperature, measuring the amount of motion or perturbation the vial is subjected to, capturing various other parameters that can provide additional insights associated with the drug or the amount of the dose being drawn from the vial, and communicating the recorded information to a companion application on a computer, smartphone or other device. Related methods are also disclosed and claimed.