Abstract: The present invention provides an article of manufacture having a coating or is otherwise surrounded in large measure by a second polymer which has non-blocking characteristics. In a preferred embodiment, the article possesses a core polymer which has a Tg of less than 25° C. which is coated with or otherwise surrounded by a second polymer which has a Tg of greater than 25° C., but less than 230° C. Further, preferred core polymers have a number average molecular weight of about 3000 to about 100,000. A further feature of the articles of the present invention is that when heated to temperatures of about 100 to 300° C., they undergo an ester exchange reaction to provide a substantially homogeneous polymer product useful in hot melt adhesive applications.

Abstract: The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

Abstract: The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: An apparatus for facilitating transactions between a prospective purchaser and unrelated product or service suppliers is described. The apparatus comprises: a product or service database for storing product and/or service information for the suppliers; a supplier database for storing supplier contact information; a buyer's database for storing buyer contact information; and a product or service selection database into which products or services selected by the buyer are stored. A processor is provided for generating a purchase order pertaining to the selected products or services in response to a command from a purchaser. The processor splits the purchase order into separate orders of products or services pertaining to respective suppliers. These are then transmitted to the respective suppliers so that they can supply the buyer with the desired products or services.

Abstract: The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention is directed to an antiblock coating comprised of a composition that contains a dibenzoate ester moiety. The dibenzoate ester compounds, particularly 1,4-CHDM dibenzoate, provide an excellent non-stick coating to hot melt adhesives, thus providing for easier packaging, storage, and processing. In addition, such a coating facilitates recycling of materials to which the hot melt adhesive is applied.

Abstract: The present invention is directed to an antiblock coating comprised of a composition that contains a dibenzoate ester moiety. The dibenzoate ester compounds, particularly 1,4-CHDM dibenzoate, provide an excellent non-stick coating to hot melt adhesives, thus providing for easier packaging, storage, and processing. In addition, such a coating facilitates recycling of materials to which the hot melt adhesive is.

Abstract: The invention comprises a device, namely a housing, which includes an intake for filtering and collecting water and channeling it into the livewell pump system. The intake is positioned rearwardly of the boat's transom and generally in the same plane as the boat's bottom surface as to contact a body of water continuously and to convey said water, creating a low pressure supply to the boat's livewell pump system. The device is mounted utilizing the boat's existing thru-hull livewell pump stem and nut or thru-hull fitting. The base 1 is positioned over the livewell pump stem or fitting utilizing its adjustable slot 3 and is held secure by the livewell pump or fitting nut. In operation, as the boat is being propelled through the water the intake collects water as the water naturally rises up from the boat's transom channeling a low-pressure water supply to the livewell pump at all navigational speeds.

Abstract: Provided are water-dispersible sulfopolyester compositions having relatively large proportions of pigments and/or fillers. Such compositions are useful as packaging materials and are substantially non-blocking when processed using packaging rolls and are comprised of at least one sulfopolyester as described herein, about 10 to about 75 weight percent of a pigment and/or filler, and a wax.

Abstract: Disclosed are linear, water-dispersible sulfopolyesters incorporating a low molecular weight polyethylene glycol and blocks of a high molecular weight polyethylene glycol. The block sulfopolyesters have improved toughness, abrasion resistance, flexibility, and adhesion. Particular utility is realized in polyester fiber sizing applications and as an adhesive.

Abstract: The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

Abstract: Disclosed is an essentially odorless water dissipatable or dispersible adhesive composition that is useful in forming paper articles and other products that can be recycled through repulping in both neutral and alkaline media. The water dispersible adhesive composition is preferably a hot melt adhesive that is a low molecular weight, branched copolyester containing a sulfomonomer. The copolyester adhesive composition can be used neat or formulated and exhibits broad compatibility with a variety of adhesive additives, including non polar tackifiers.

Abstract: This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.

Abstract: Disclosed is an essentially odorless water dissipatable or dispersible adhesive composition that is useful in forming paper articles and other products that can be recycled through repulping in both neutral and alkaline media. The water dispersible adhesive composition is preferably a hot melt adhesive that is a low molecular weight, branched copolyester containing a sulfomonomer. The copolyester adhesive composition can be used neat or formulated and exhibits broad compatibility with a variety of adhesive additives, including non polar tackifiers.

Abstract: The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of these compounds.

Abstract: Disclosed is a radiation crosslinkable water-dispersible adhesive composition that is useful in forming paper and plastic articles and other products that can be recycled through a process which includes washing or repulping in aqueous media. The cross-linkable water-dispersible adhesive composition is preferably used as a hot melt adhesive. The cross-linkable water-dispersible adhesive composition is a low molecular weight, branched copolyester containing a sulfomonomer and unsaturated moieties. The radiation crosslinked adhesive composition has more cohesive strength and viscosity than its corresponding uncross-linked adhesive, yet is still water-dispersible during product recycling.

Abstract: Disclosed is an essentially odorless water dissipatable or dispersible adhesive composition that is useful in forming paper articles and other products that can be recycled through repulping in both neutral and alkaline media. The water dispersible adhesive composition is preferably a hot melt adhesive that is a low molecular weight, branched copolyester containing a sulfomonomer. The copolyester adhesive composition can be used neat or formulated and exhibits broad compatibility with a variety of adhesive additives, including non polar tackifiers.