Abstract: A vehicle charging station includes a shroud configured to guide a vehicle charge plug that is lowered from a vehicle toward a charge connector as the vehicle moves toward the charging station. The vehicle charge plug and the charge connector have contacts arranged on a connector face that is generally perpendicular to a surface on which the vehicle charging station rests.

Abstract: Systems and methods are directed to a pull-through winding method, and a manufacturing fixture, or mandrel, that guides the layup of material in the pull-through winding method, for fabrication of a three-dimensional load bearing structure. These systems and methods allow fibers of material of the 3D load bearing structure to be pulled as straight as possible during winding, and maintained as straight as possible during curing, to take full advantage of properties associated with the fiber or filament-based materials used in these structures, including, for example, carbon fiber material. The manufacturing fixture includes a plurality of pull-through slots at end portions thereof, that provide for the pulling of the fiber-based material, and the application and maintenance of tension in the material that maintains the alignment of the fibers as the material is wound, cured and hardened.

Abstract: The present invention relates to the use of hypoxia-inducible factor (HIF) inhibitors in cancer immunotherapy. Specifically, the disclosure provides methods of treating a cancer in a subject in need of cancer immunotherapy, comprising administering a HIF-1a inhibitor to the subject and a second cancer immunotherapeutic agent to the subject, wherein the HIF-1a inhibitor comprising echinomycin, and wherein the second cancer immunotherapeutic agent comprising an anti-CTLA-4 antibody including Ipilimumab or Tremelimumab.

Abstract: Enhancements to existing gaming controllers facilitating expedient response time and fine-tuned accuracy are described. The enhancements comprise the internal modification of the stock resistance force supplied by the analog stick centering spring mechanism. Through modification, the force of resistance supplied may be increased to over 200 grams of force, or down to 40 grams of force, while maintaining full function of the analog stick mechanism. A second primary enhancement replaces the stock triggers, conventionally equipped with progressive resistance sensors, to a momentary ‘snap-action’ two-way switch, minimizing trigger pull distance, and removing the analog nature of the trigger to achieve optimal performance.

Abstract: Enhancements to existing gaming controllers facilitating expedient response time and fine-tuned accuracy are described. The enhancements comprise the internal modification of the stock resistance force supplied by the analog stick centering spring mechanism. Through modification, the force of resistance supplied may be increased to over 200 grams of force, or down to 40 grams of force, while maintaining full function of the analog stick mechanism. A second primary enhancement replaces the stock triggers, conventionally equipped with progressive resistance sensors, to a momentary ‘snap-action’ two-way switch, minimizing trigger pull distance, and removing the analog nature of the trigger to achieve optimal performance.

Abstract: Systems and methods for protecting access to network ports on a server are provided herein. A system comprises a server configured to receive a data packet comprising a cryptoken corresponding to a network port address. The server is further configured to generate a plurality of cryptokens based on a plurality of timecodes, a network port configuration, and the destination address. The server generates a plurality of hashes based on the plurality of cryptokens. The server generates, based on a comparison of each of the plurality of cryptokens to the cryptoken, a rule to allow inbound connections to a first network port corresponding to the network port address.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: An automated apparatus can provide pre-analytical processing of samples, racking and forwarding to an adjacent analyzer for analysis. The apparatus may have a controller that implements an auto-learn process to teach robotic handlers the locations within the workspace(s) of the apparatus. A robotic sample handler may include a sensor configured to generate a detection signal when in a near vicinity of a fiducial beacon in the workspace of the apparatus for biological sample preparation, preprocessing and/or diagnostic assay performed by one or more analyzers of the automated apparatus. The controller may control the robotic sample handler to conduct a search pattern so that a location of the fiducial beacon may be detected and thereafter calculated to obtain a more accurate location of the beacon. The calculated positions may then serve as a basis for the controlled movement of samples by the robot to and from locations of the workspace.

Abstract: In User Equipment (UE) at various geographic locations, circuitry exchanges TCP packets with radios, and the radios wirelessly exchange the TCP packets with wireless communication nodes. The circuitry determines TCP retransmission rates for the radios at the geographic locations. The circuitry estimates TCP retransmission rates for the radios at a new geographic location based on the TCP retransmission rates for the radios at the past geographic locations. The circuitry selects one of the radios based on the estimated TCP retransmission rates at the new geographic location. At the new geographic location, the circuitry exchanges new TCP packets with the selected one of the radios, and the selected one of the radios wirelessly exchanges the new TCP packets with one of the wireless communication nodes.

Abstract: A leather product such as a leather covering for a vehicular part includes a segment of leather with a base coat applied to a hide side and a color coat applied to the base coat to create an intermediate stage leather segment. A foil transfer is embossed into and secured with an adhesive to the intermediate stage leather segment. A top coat is then applied to the foil transfer and a surrounding portion of the intermediate stage leather segment after the foil transfer is secured to complete the leather product. A system and method of making the leather product is also disclosed.

Abstract: The present invention relates to treating TP53-mutated AML using a Hypoxia-Inducible Factor (HIF inhibitor). The invention further relates to a new HIF inhibitor formulation with longer half-life and significantly improved therapeutic effect for TP53-mutated AML.

Abstract: A system including a first luminaire housing, a second luminaire housing, and a controller. The first luminaire housing includes a first light source configured to provide illumination to a first location, and a first I/O device configured to sense a first data set corresponding the first location. The second luminaire housing is separate from the first luminaire housing and includes a second light source configured to provide illumination to a second location, and a second I/O device configured to sense a second data set corresponding to the second location. The controller is configured to receive a portion of the first data set and a portion of the second data set, combine the portion of the first data set and the portion of the second data set to form a third data set corresponding to the first location and second location, and output the third data set.

Abstract: Systems and methods are provided for extending dialogue between a mobile device and a point-of-interaction (POI). One example computer-implemented method includes receiving, by a by a host server, from a POI computing device, an identifier specific to an account of a user, a receipt for an interaction, and one or more encrypted actions. The method also includes decrypting, by the host server, the one or more encrypted actions and storing the receipt. The method then includes, based on the decrypted one or more actions, notifying, by the host server, the user, via a mobile device of the user, of the receipt and accessibility of the receipt.

Abstract: Techniques for managing sequencing requests for storage node operations based on types of operations being sequenced. The techniques manage sequencing requests for different types of operations, such as backup and recovery operations, replication operations, migration operations, and so on, in a manner that avoids overwhelming storage node capacity. The techniques include receiving a sequencing request for an operation of a specified operation type at a request manager of a storage node and determining whether a capacity of the storage node is available for running the operation by a capacity manager for the specified operation type, in which the capacity manager is provided by a storage client and implemented on the storage node separate from the request manager. In this way, throttling, limiting, and/or prioritization requirements of the operation of the specified operation type can be defined by the storage client in a manner agnostic to the request manager.

Abstract: The invention relates to compounds of formula (A): or a salt thereof, wherein R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n, and G are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?V?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Enhancements to existing gaming controllers facilitating expedient response time and fine-tuned accuracy are described. The enhancements comprise the internal modification of the stock resistance force supplied by the analog stick centering spring mechanism. Through modification, the force of resistance supplied may be increased to over 200 grams of force, or down to 40 grams of force, while maintaining full function of the analog stick mechanism. A second primary enhancement replaces the stock triggers, conventionally equipped with progressive resistance sensors, to a momentary ‘snap-action’ two-way switch, minimizing trigger pull distance, and removing the analog nature of the trigger to achieve optimal performance.

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

Abstract: Systems and methods are provided for extending dialogue between a mobile device and a point-of-interaction (POI). One example computer-implemented method includes receiving, by a conduit server, from the POI, via a first connection between the conduit server and the POI, a request for an extended connection between the POI and the mobile device, and notifying a host server of the request. The method then includes receiving, from the mobile device, via a second connection between the conduit server and the mobile device, an identifier for the mobile device and pairing, based on the identifier, the first and second connections, to establish a wireless connection between the POI and the mobile device, via the conduit server. The method further includes submitting a wake-up call to the mobile device, whereby the mobile device publishes the identifier to establish a wireless connection directly between the POI and the mobile device.

Abstract: A system comprising a pumping system configured to pump respective exhaust gases from each of a plurality of chemical etching process chambers and to combine the exhaust gases to provide a combined exhaust gas, and a noble gas recovery system configured to process the combined exhaust gas to remove one or more noble gases therefrom.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).