Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.

Abstract: Provided are methods and compositions comprising antibodies capable of specific binding to human CEACAM1 molecules, for treating and diagnosing cancer as well as assessing CEACAM1 expression in tumor infiltrating immune cells (TILs) in a biological sample obtained from a [cancer] subject.

Abstract: An example electronic device includes a display; a communication circuit; a memory storing one or instructions; and a processor for executing the one or more instructions to configure the processor to control the electronic device to: display, on the display, a message compose screen; receive message compose inputs to the message compose screen for composing a message; receive a message send input for sending the message via the communication circuit; set a timer; and send the message, via the communication circuit, after expiration of the timer.

Abstract: Methods and devices for powdered sorbent regeneration of biologic fluids are disclosed. The present invention includes three novel methods, which may be used singly or in any combination, for constraining or immobilizing powders so that they can be perfused with a biological fluid or dialysate: a porous carbon block filter, a filtration bed of very fine powder, and a cone-shaped reactor.

Abstract: The invention is an automatic rod holder with a frame and two opposed clamping jaws pivotally connected to the frame by parallel axes of rotation such that the clamping jaws exhibit a range of motion between a closed configuration and an open configuration, wherein the closed configuration has a longitudinal opening defined by opposing concave portions of the clamping jaws configured to retain a rod.

Abstract: Systems and methods of calibrating listening devices are disclosed herein. In one embodiment, a method of calibrating a listening device (e.g., a headset) includes determining head related transfer functions (HRTF) corresponding to different parts of the user's anatomy. The resulting HRTFs are combined to form a composite HRTF.

Abstract: Methods and devices for powdered sorbent regeneration of biologic fluids are disclosed. The present invention includes three novel methods, which may be used singly or in any combination, for constraining or immobilizing powders so that they can be perfused with a biological fluid or dialysate: a porous carbon block filter, a filtration bed of very fine powder, and a cone-shaped reactor.

Abstract: A machine to continuously produce and hold ice is provided. The machine includes a compressor, an evaporator, and an auger that rotates across an outer surface of the evaporator to scrape ice forming thereon. Ice slices travel with auger rotation and neighboring ice slices coalesce together to form larger pieces of ice. A user input allows adjustment of the density of the ice produced. The controller alters compressor speed, such that a decrease in compressor speed results in an increase in the surface temperature of the evaporator and therefore slows down ice formation thereon, and an increase in compressor speed results in a decrease in the surface temperature of the evaporator and therefore speeds up the ice formation thereon. A change in ice formation speed results in a corresponding change in the rate of ice slice production and a corresponding change in density of ice produced by the machine.

Abstract: Masonry units, such a blocks, are fabricated in a sequential process, using improved mold structures, such as within a production corridor of a corresponding fabrication system. A compressible masonry feedstock or formula, which can be de-agglomerated before use, is filled within a block mold having releasable elements. The formula is then compressed within the mold structure. The compressed workpiece can be further processed, such as for any of final height adjustment, the establishment of a surface feature, or to remove cores. The block mold, having releasable elements or sides, such as using hinges or springs, is released from the formed block, wherein the formed masonry unit can be removed for curing, and wherein the block mold can be reused to fabricate a subsequent masonry unit.

Abstract: Disclosed is a deagglomeration apparatus, to improve the quality of a mixture used for the production of concrete blocks. An illustrative embodiment of the deagglomerator comprises a vertical shaft high-shear mixer, wherein a rotational force (hydraulic or electric) is mounted to a vertical shaft onto which are mounted chains and/or knives, housed within a flexible rubber “boot” or tube. The deagglomerator is configured to be controllably powered, to rotate the shaft and the attached tools. Partially mixed formula is introduced to a top region of the deagglomerator, and falls downwardly past the rotating tools wherein the formula is pulverized and mixed, before exiting the lower area of the mixing region.

Abstract: Systems and methods of calibrating listening devices are disclosed herein. In one embodiment, a method of calibrating a listening device (e.g., a headset) includes determining head related transfer functions (HRTF) corresponding to different parts of the user's anatomy. The resulting HRTFs are combined to form a composite HRTF.

Abstract: Disclosed is a block press and associated process, for dynamically forming a block mold, to produce a masonry block. In some embodiments, the block mold includes a plurality of mold elements, such as a lower impact plate, an upper impact plate, and a plurality of side plates, and can further include one or more block cores. In operation, one or more of the mold elements are moved to dynamically forming a block mold, which is then filled with product formula. The product formula is then compressed, to form a masonry block. One or more of the mold elements are then released, such as to release pressure on the formed masonry block, and to allow removal of the formed masonry block from the block press, wherein the formed masonry block can be moved to a curing area, and the block press can reform the block mold for subsequent production.

Abstract: Technologies are described for generating geographically-driven group communications involve maintaining location information for multiple user devices, data defining geographic regions, and rules that identify a geographical region to which the rules applies and a communication and payload to be sent. When an update in the location information, geographical regions or rules is detected, an evaluation is performed to determine whether a user client device is located in the geographical region identified for the rule. If so, the communication and payload defined in the rule are sent to the user client devices for a group of users located in the geographical region for the rule. In some examples, the rule defines a group characteristic condition and the communication and payload are sent to the user client devices for users that satisfy the group characteristic condition.

Abstract: A process for preparing an aliphatic or cycloaliphatic epoxy resin composition including the steps of: (I) reacting a mixture of the following components: (a) an aliphatic or cycloaliphatic hydroxyl-containing material, (b) an epihalohydrin, (c) a stoichiometric excess of a base compound or basic acting substance, (d) a catalyst, and (e) optionally, a solvent; wherein the reacting step (I) is carried out under reaction conditions sufficient to form a crude aliphatic or cycloaliphatic epoxy resin composition product in the resultant reaction mixture; (II) neutralizing the resultant reaction mixture of step (I) containing the crude aliphatic or cycloaliphatic epoxy resin composition product with a phosphate neutralizing agent sufficient to partially neutralize the base or basic acting substance and to form a neutralized fluid medium containing aliphatic or cycloaliphatic epoxy resin composition product; (III) removing at least a portion of unreacted epihalohydrin from the reaction mixture of step (II); and (IV)

Abstract: An order fulfillment cart including a first frame portion, the first frame portion including a first plurality of support members, a second frame portion positioned a distance from the first frame portion, the second frame portion including a second plurality of support members, and a connector, the connector operably coupled to the first frame portion and the second frame portion, wherein the connector extends diagonally from the first frame portion to the second frame portion, wherein the first plurality of support members and the second plurality of support members are configured to support a plurality of containers between the first frame portion and the second frame portion, is provided. Furthermore, an associated method is also provided.

Abstract: A refrigeration unit including an exterior lining that includes a bottom exterior surface and a top exterior surface facing the bottom exterior surface. The refrigeration unit further including an interior lining that includes a bottom planar-like interior surface and a top interior surface facing the bottom interior surface. The refrigeration unit including a bottom base, wherein the bottom exterior surface is positioned between the bottom base and the bottom planar-like interior surface. The refrigeration unit includes a condenser positioned between the bottom base and the bottom exterior surface, wherein the refrigeration unit is oriented within a gravitational field generated by the Earth so that the gravitational field flows from the top interior surface to the bottom base.

Abstract: Masonry units, such a blocks, are fabricated in a sequential process, using improved mold structures, such as within a production corridor of a corresponding fabrication system. A compressible masonry feedstock or formula, which can be de-agglomerated before use, is filled within a block mold having releasable elements. The formula is then compressed within the mold structure. The compressed workpiece can be further processed, such as for any of final height adjustment, the establishment of a surface feature, or to remove cores. The block mold, having releasable elements or sides, such as using hinges or springs, is released from the formed block, wherein the formed masonry unit can be removed for curing, and wherein the block mold can be reused to fabricate a subsequent masonry unit.

Abstract: Technologies are described for generating geographically-driven group communications involve maintaining location information for multiple user devices, data defining geographic regions, and rules that identify a geographical region to which the rules applies and a communication and payload to be sent. When an update in the location information, geographical regions or rules is detected, an evaluation is performed to determine whether a user client device is located in the geographical region identified for the rule. If so, the communication and payload defined in the rule are sent to the user client devices for a group of users located in the geographical region for the rule. In some examples, the rule defines a group characteristic condition and the communication and payload are sent to the user client devices for users that satisfy the group characteristic condition.