Abstract: Disclosed is a block press and associated process, for dynamically forming a block mold, to produce a masonry block. In some embodiments, the block mold includes a plurality of mold elements, such as a lower impact plate, an upper impact plate, and a plurality of side plates, and can further include one or more block cores. In operation, one or more of the mold elements are moved to dynamically forming a block mold, which is then filled with product formula. The product formula is then compressed, to form a masonry block. One or more of the mold elements are then released, such as to release pressure on the formed masonry block, and to allow removal of the formed masonry block from the block press, wherein the formed masonry block can be moved to a curing area, and the block press can reform the block mold for subsequent production.

Abstract: Indicator devices, systems, and methods are provided. Indicator devices include a housing having a bore and an indicating component placed therein. The indicator devices are activated in response to an increase in temperature or pressure. Indicator systems include an indicator device coupled to a housing, such as a conduit or enclosure. Methods include utilizing an indicator device to determine if an area within a conduit or enclosure has been sealed.

Abstract: The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2 are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

Abstract: Environmental conditions within an enclosure containing critical equipment and devices are monitored and when outside of acceptable parameters corrective action is taken to modify these environmental conditions so as to bring them within acceptable limits. Unless an environmental condition is outside of an acceptable limit, no energy expenditure is made by the environmental conditioning equipment since it does not need to be in use. When the environmental conditioning equipment is called into operation, its environmental modification influence is monitored to determine if the expected environmental modification is occurring within an expected time period(s). If the expected environmental modification does not occur within the expected time period, and/or does not occur at an expected time rate of change, then an alarm is generated to indicate that maintenance may be required for the environmental conditioning equipment.

Abstract: Indicator devices, systems, and methods are provided. Indicator devices include a housing having a bore and an indicating component placed therein. The indicator devices are activated in response to an increase in temperature or pressure. Indicator systems include an indicator device coupled to a housing, such as a conduit or enclosure. Methods include utilizing an indicator device to determine if an area within a conduit or enclosure has been sealed.

Abstract: In one aspect of the invention, a method includes determining an amount of carbon dioxide (CO2) in dialysate flowing through a dialysis system using a CO2 sensor associated with the dialysis system, determining, using a pH sensor associated with the dialysis system, a pH level of the dialysate, and calculating a level of bicarbonate in the dialysate based at least in part on the determined amount of CO2 measured in the gas and the determined pH level of the dialysate.

Abstract: Apparatus and methods are described for treatment of morbid obesity using minimally invasive techniques. The apparatus includes a system of components that may be used separately or in combination for effectively reducing stomach volume, bypassing a portion of the stomach and/or small intestines, reducing nutrient absorption in the stomach and/or small intestines and/or depositing minimally or undigested food farther than normal into the intestines, thereby stimulating intestinal responses. The components described include an artificial stoma device, a gastric sleeve device, an intestinal sleeve device, a combined gastrointestinal sleeve device and permanent and detachable attachment systems. Also described are devices for delivering and deploying the components of the system.

Abstract: Masonry units, such a blocks, are fabricated in a sequential process, using improved mold structures, such as within a production corridor of a corresponding fabrication system. A compressible masonry feedstock or formulated material, which can be de-agglomerated before use, is filled within a block mold having releasable elements. The feedstock or formulated material is then compressed within the mold structure. The compressed workpiece can be further processed, such as for any of final height adjustment, the establishment of a surface feature, or to remove cores. The block mold, having releasable elements or sides, such as using hinges or springs, is released from the formed block, wherein the formed masonry unit can be removed for curing, and wherein the block mold can be reused to fabricate a subsequent masonry unit.

Abstract: The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2 are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

Abstract: In one aspect of the invention, a method includes determining an amount of carbon dioxide (CO2) in dialysate flowing through a dialysis system using a CO2 sensor associated with the dialysis system, determining, using a pH sensor associated with the dialysis system, a pH level of the dialysate, and calculating a level of bicarbonate in the dialysate based at least in part on the determined amount of CO2 measured in the gas and the determined pH level of the dialysate.

Abstract: The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2 are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

Abstract: The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2 are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: A light beam guided liquid delivery device, including: a liquid delivery device; a light beam generator; and a bracket coupling the light beam generator to the liquid delivery device such that a beam of light is selectively delivered approximate to a tip of the liquid delivery device. The bracket couples the light beam generator to the liquid delivery device at a first attachment point. The bracket includes one or more hinges at the first attachment point for varying the orientation of the light beam generator. Optionally, the bracket also couples the light beam generator to the liquid delivery device at a second contact point. The bracket includes a support member at the second contact point for varying the orientation of the light beam generator. Optionally, the support member is translatable with respect to the one or more hinges along a length of the bracket.

Abstract: A sensor is coupled to a device positioned within an enclosure and is configured to determine the status of the device or its surrounding environment. The sensor transmits the information to a central computer and/or a local indicator. Once the information is received at the central computer, the information is processed for the operators and maintainers to interpret. Based on the information received, the operators and maintainers may implement procedures to maintain the device or its surrounding environment under observation. In certain embodiments, the central computer provides instructions to a second device within or adjacent to the enclosure to implement corrective actions. In some embodiments, the sensor is coupled to a microcontroller which performs analysis received from the sensor and provides instructions to the second device to implement corrective actions.

Abstract: The invention is an automatic rod holder with a frame and two opposed clamping jaws pivotally connected to the frame by parallel axes of rotation such that the clamping jaws exhibit a range of motion between a closed configuration and an open configuration, wherein the closed configuration has a longitudinal opening defined by opposing concave portions of the clamping jaws configured to retain a rod.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.