Abstract: Provided is a technique for detecting a cell-derived substance with high sensitivity without destroying cells. A cell detection device of the present disclosure includes: a medium adding device configured to add a part of a prepared culture medium to a culture container holding cells to be detected; a medium collection device configured to collect the culture medium from the culture container; and a detection device configured to detect light from the luminescent reagent mixed with the collected culture medium.

Abstract: Provided is a technique for suppressing false positives due to environmental contamination and easily performing a highly sensitive and highly accurate microbial test. A filtration cartridge according to the present disclosure includes a filter cup with a filter capturing microorganisms, a first filter cup attachment that covers a lower portion of the filter sup and at least one through-hole in a bottom surface portion, and a second filter cup attachment, being connected to the first filter cup attachment, that covers an upper portion of the filter cup, and that has a lid installed at a position away from an opening surface of the filter cup.

Abstract: Provided is a method for detecting a microorganism in a test sample containing cells, including a step of adding the sample to a microorganism culture medium, a step of culturing the microorganism culture medium containing the sample, a step of sampling a part of the culture medium at a predetermined time, a step of acquiring the ATP level of the sampled culture medium, and a step of detecting the microorganism in the sample based on the change of the ATP level over time.

Abstract: Provided is a technique capable of easily performing a microbial test with high accuracy. A microbial test kit of the present disclosure includes: a first syringe capable of collecting a specimen and having a first syringe needle; a second syringe containing an ATP extraction reagent and having a second syringe needle; a sealed reaction container having a first opening, a first sealing member fitted to the first opening, a nozzle, a nozzle cap covering the nozzle, and a filter disposed so as to partition the first opening and the nozzle; a waste liquid container including a second opening and a second sealing member fitted to the second opening, and sealed under reduced pressure; and a luminescence measurement container that includes a third opening and a third sealing member fitted to the third opening, stores a luminescent reagent that emits light in presence of ATP, and is sealed under reduced pressure.

Abstract: A cell detection device that detects a cell in a specimen with high sensitivity and includes a sealed container having a sealable specimen introduction portion, a culture portion that holds a culture solution, an extraction reagent portion that holds an extraction reagent, and a luminescent reagent portion that holds a luminescent reagent, a contact mechanism that controls contact between the culture solution, the extraction reagent, and the luminescent reagent, a photodetector that detects luminescence from the luminescent reagent portion, and a calculator that determines growth of a cell based on a detection signal of the photodetector. The culture solution, the extraction reagent, and the luminescent reagent are separately disposed in the sealed container, and the contact mechanism brings the culture solution to which a specimen is added and the extraction reagent into contact to obtain an extraction solution, and intermittently brings the extraction solution and the luminescent reagent into contact.

Abstract: An apparatus, system, and method for performing an efficient luminescence measurement are disclosed. The apparatus comprises a nozzle for dispensing a luminescent reagent into a well W in a microplate M, a luminescence measurement unit for measuring luminescence occurring in the well W caused by mixing of the luminescent reagent and a specimen, and a stage (moving unit) for moving the nozzle and the luminescence measurement unit together vertically and horizontally, wherein the nozzle is secured to the stage and the luminescence measurement unit is mounted to be movable vertically with respect to the stage through a holder and springs interposed between the luminescence measurement unit and the holder.

Abstract: Provided is a bacterium number measuring system comprising a database storing known bacterial growth patterns in advance and an analyzing part. The analyzing part has first cultures containing a bacterial liquid that contains a measurement target bacteria and second cultures being different from the first cultures and containing the bacterial liquid and an antimicrobial drug. The analyzing part performs bacterium number measurement which measures the number of bacteria in the first cultures on a culturing part where culturing has started in the first and second cultures. The analyzing part compares the bacterium number measurement result with the growth curves stored in the database and thereby determines a timing to perform MIC measurement which measures the number of bacteria in the second cultures to determine a minimum inhibitory concentration of the measurement target bacterium. The analyzing part performs the MIC measurement at the thus-determined timing.

Abstract: A cell detector and detecting method enhance detection sensitivity for microbes according to the ATP method and reduce the detection period. The cell detector includes a sealing container having a culture portion for containing a culture medium containing the specimen, a sealable specimen introducing portion, and a luminescent reagent portion that emits light upon contact with the culture medium, a contact mechanism for controlling the contact between the culture medium and the luminescent reagent portion, a photodetector for detecting a luminescence resulting from the contact between the culture medium and the luminescent reagent portion, and a calculation unit for calculating a luminescent quantity from detection signals of the photodetector to determine cell proliferation on the basis of change in the luminescent quantity over time.

Abstract: The present disclosure proposes a tissue-embedded section manufacturing method in which a control unit controls an embedded section manufacturing operation of an embedded block having a tissue embedded therein by a microtome and a collection operation of an embedded section by a chip. The method includes driving the blade of the microtome by the control unit to slice the embedded block and manufacture an embedded section, and driving the chip by the control unit to suck and collect the embedded section attached to the blade.

Abstract: An apparatus, system, and method for performing an efficient luminescence measurement are disclosed. The apparatus comprises a nozzle for dispensing a luminescent reagent into a well W in a microplate M, a luminescence measurement unit for measuring luminescence occurring in the well W caused by mixing of the luminescent reagent and a specimen, and a stage (moving unit) for moving the nozzle and the luminescence measurement unit together vertically and horizontally, wherein the nozzle is secured to the stage and the luminescence measurement unit is mounted to be movable vertically with respect to the stage through a holder and springs interposed between the luminescence measurement unit and the holder.

Abstract: When bacteria growth is determined in the related art using an ATP method, the bacteria growth is determined, based on an increase or a decrease in live bacteria ATP with the lapse of a culture time. Accordingly, it is necessary to measure the live bacteria ATP multiple times while antimicrobial susceptibility culture is carried out. It takes time and labor in sample preparation for each measurement, and it is difficult to quickly obtain an antimicrobial susceptibility result. Therefore, according to the present invention, the presence or absence of antimicrobial susceptibility of bacteria is determined, based on an ATP luminescence amount derived from dead bacteria in a culture liquid.

Abstract: Provided is a method for detecting a microorganism in a test sample containing cells, including a step of adding the sample to a microorganism culture medium, a step of culturing the microorganism culture medium containing the sample, a step of sampling a part of the culture medium at a predetermined time, a step of acquiring the ATP level of the sampled culture medium, and a step of detecting the microorganism in the sample based on the change of the ATP level over time.

Abstract: A luminometer apparatus includes, inside a light-shielded room, a container rack loaded with holding containers, a dispensation mechanism that dispenses a liquid, a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of a sample and a luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers, and a photodetection unit that performs luminescence measurements. The light-shielded room has an insertion opening having a width allowing for insertion of the container rack and provided to be openable and closable. The rotary plate is provided with a region in which the container rack can be installed inside a region of passage of the reaction containers, when turning, and is provided to be turnable where the light-shielded room is in a closed state.

Abstract: Provided is a signal processing circuit occupying a small circuit area. A common arithmetic operation element is shared between a plurality of arithmetic operation sequence control units. An arbitration circuit selects, when the plurality of arithmetic operation sequence control units simultaneously generate requests for arithmetic operations to use the common arithmetic operation element, the predetermined sequence control unit based on priority information about the plurality of arithmetic operation sequence control units, causes the common arithmetic operation element to execute the arithmetic operation requested from the selected arithmetic operation sequence control unit, and returns the result of the arithmetic operation to the selected arithmetic operation sequence control unit.

Abstract: Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts for holding reagents to be supplied to the reaction vessel, and a culture solution holding part for holding a culture solution to be supplied to the reaction vessel, and has plural layers that can be joined and separated; a gas feeding path for feeding a gas into the ATP examination culture plate; a heater; an optical detection unit; and a determination unit for determining sensitivity of a bacterial strain contained in the culture solution to a drug based on a detection result of the optical detection unit, wherein when the plural layers of the ATP examination culture plate are joined, at least the culture solution holding part and the reaction vessel are in a sealed state while communicating with each other.

Abstract: Provided is a signal processing circuit occupying a small circuit area. A common arithmetic operation element is shared between a plurality of arithmetic operation sequence control units. An arbitration circuit selects, when the plurality of arithmetic operation sequence control units simultaneously generate requests for arithmetic operations to use the common arithmetic operation element, the predetermined sequence control unit based on priority information about the plurality of arithmetic operation sequence control units, causes the common arithmetic operation element to execute the arithmetic operation requested from the selected arithmetic operation sequence control unit, and returns the result of the arithmetic operation to the selected arithmetic operation sequence control unit.

Abstract: Provided is a signal processing circuit occupying a small circuit area. A common arithmetic operation element is shared between a plurality of arithmetic operation sequence control units. An arbitration circuit selects, when the plurality of arithmetic operation sequence control units simultaneously generate requests for arithmetic operations to use the common arithmetic operation element, the predetermined sequence control unit based on priority information about the plurality of arithmetic operation sequence control units, causes the common arithmetic operation element to execute the arithmetic operation requested from the selected arithmetic operation sequence control unit, and returns the result of the arithmetic operation to the selected arithmetic operation sequence control unit.

Abstract: The data processing system has: a plurality of hardware resources each having at least one standby mode; a control part for controlling execution of a task achieved by using, of the plurality of hardware resources, predetermined ones, and a working status of each hardware resource; and a power-source part for controlling supply of a power source to each hardware resource. The control part performs the scheduling of a scheduled execution time of the task based on information for determining a timing of executing the task, and calculates a standby time of the hardware resource based on a result of the scheduling. The control part compares the standby time with a break-even time depending on the standby mode, thereby deciding whether or not to cause each hardware resource to transition to the standby mode.

Abstract: Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts for holding reagents to be supplied to the reaction vessel, and a culture solution holding part for holding a culture solution to be supplied to the reaction vessel, and has plural layers that can be joined and separated; a gas feeding path for feeding a gas into the ATP examination culture plate; a heater; an optical detection unit; and a determination unit for determining sensitivity of a bacterial strain contained in the culture solution to a drug based on a detection result of the optical detection unit, wherein when the plural layers of the ATP examination culture plate are joined, at least the culture solution holding part and the reaction vessel are in a sealed state while communicating with each other.

Abstract: A luminometer apparatus includes, inside a light-shielded room, a container rack loaded with holding containers, a dispensation mechanism that dispenses a liquid, a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of a sample and a luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers, and a photodetection unit that performs luminescence measurements. The light-shielded room has an insertion opening having a width allowing for insertion of the container rack and provided to be openable and closable. The rotary plate is provided with a region in which the container rack can be installed inside a region of passage of the reaction containers, when turning, and is provided to be turnable where the light-shielded room is in a closed state.