Abstract: A charged particle beam device which prevents an appearance of a shading contrast due to azimuth discrimination and obtains a clear magnetic domain contrast image with a high resolution and a high throughput. The charged particle beam device includes an electron beam source; a sample stage; an objective lens configured to focus electron beams on a sample; a detector that is mounted on a charged particle beam source side with respect to the objective lens and separately detects secondary electrons emitted in azimuth angle ranges of two or more different azimuths for the same observation region; an image processing and image management device including an image processing unit configured to perform synthesis after performing shading correction and contrast adjustment on an image obtained by detecting a first emission azimuth and an image obtained by detecting a second emission azimuth; an image database; and an image display unit.

Abstract: A travel sickness estimation system includes an estimation unit and an output unit. The estimation unit is configured to perform estimation processing of estimating, based on person information indicating conditions of a person who is on board a moving vehicle, whether or not the person is in circumstances that would cause travel sickness for him or her. The output unit is configured to output a result of the estimation processing performed by the estimation unit.

Abstract: A method for closing a wound in a tubular organ using a suture thread introduced into the tubular organ, includes: inflating the tubular organ by supplying gas into the tubular organ; resecting a lesion while the tubular organ is inflated, so that the wound is formed; deflating the tubular organ by discharging gas from the tubular organ; passing the suture thread through a tissue around the wound; and gathering the tissue around the wound by pulling the suture thread passing through the tissue while the tubular organ is deflated.

Abstract: A method for closing a wound in a tubular organ using a suture thread includes: a first step of connecting a first edge portion and a second edge portion with the suture thread; and a second step of connecting a third edge portion and a fourth edge portion with the suture thread. The first step includes passing the suture thread through a first position on a mucosal surface of at least one of the first edge portion and the second edge portion. The second step includes passing the suture thread through a third position on the mucosal surface of at least one of the third edge portion and the fourth edge portion. A shortest distance between the wound and the third position is larger than a shortest distance between the wound and the first position.

Abstract: A method for closing a wound in a tubular organ using a suture thread includes: a first step of connecting a first edge portion and a second edge portion with the suture thread; and a second step of connecting a third edge portion and a fourth edge portion with the suture thread. The first step includes passing the suture thread through a first position on a mucosal surface of at least one of the first edge portion and the second edge portion. The second step includes passing the suture thread through a third position on the mucosal surface of at least one of the third edge portion and the fourth edge portion. A shortest distance between the wound and the third position is larger than a shortest distance between the wound and the first position.

Abstract: A traction tool for performing traction, of a suture thread under a flexible endoscope is provided. The traction toot includes a first holder configured to hold the suture thread or a suture needle attached to the suture thread; a second holder having an engaging surface configured to engage the suture, thread such that the suture thread is capable of advancing and retracting and configured to release an engagement with the suture thread; and a guide member holding the first holder and the second holder such that the first holder and the second holder are relatively movable.

Abstract: A method for closing a wound in a tubular organ using a suture thread includes: a first step of connecting a first edge portion and a second edge portion with the suture thread; and a second step of connecting a third edge portion and a fourth edge portion with the suture thread. The first step includes passing the suture thread through a first position on a mucosal surface of at least one of the first edge portion and the second edge portion. The second step includes passing the suture thread through a third position on the mucosal surface of at least one of the third edge portion and the fourth edge portion. A shortest distance between the wound and the third position is larger than a shortest distance between the wound and the first position.

Abstract: A method for resecting a lesion in a wall of an organ of a patient includes injecting a fluid into the wall of the organ at a location proximate to the lesion, creating a wound in the wall of the organ by cutting the lesion from the wall of the luminal organ, removing at least a portion of the fluid injected into the wall of the organ, and closing the wound using a suture thread. The portion of fluid may be removed prior to or after partially threading the suture thread into the wall of the organ.

Abstract: A method for closing a wound in a tubular organ using a suture thread introduced into the tubular organ, includes: inflating the tubular organ by supplying gas into the tubular organ; resecting a lesion while the tubular organ is inflated, so that the wound is formed; deflating the tubular organ by discharging gas from the tubular organ; passing the suture thread through a tissue around the wound; and gathering the tissue around the wound by pulling the suture thread passing through the tissue while the tubular organ is deflated.

Abstract: An endoscope puncture needle including a tubular portion that includes first and second needle tip portions at a distal end thereof. The first needle tip portion includes a first needle tip at a distal end, and first and second blade surfaces extending towards the first needle tip. The second needle tip portion includes a second needle tip at a distal end, and third and fourth blade surfaces extending towards the second needle tip. The first blade surface and the third blade surface face in directions approaching each other, and the second blade surface and the fourth blade surface face in directions approaching each other.

Abstract: A dispersion composition contains a pigment, a dispersant, and a cyclic or chain-like polyester compound. A curable composition contains the above-described dispersion composition. A light-shielding film, a color filter, and a solid-state imaging device contain the curable composition.

Abstract: An endoscope treatment tool includes: a sheath having a lumen; a basket section protruding from the lumen and having an elastic wire; and an operating wire. The elastic wire has: a maximum section where the outer diameter of the basket section is largest of the elastic wire; a first section that, in a lateral view from a direction orthogonal to a normal from the maximum section to the central axis of the basket section, is largest on the opposite side of the central axis from the maximum section between the maximum section and the proximal end; and a second section that is largest at a position away from the normal between the maximum section and the first section, and in the front view, the first section is located on the opposite side of a straight line orthogonal to the normal at the central axis from the maximum section side.

Abstract: A gastrointestinal-tract constricting method comprises: while observing the gastrointestinal tract with an endoscope inserted into the gastrointestinal tract, placing a protection substance, which does not damage tissue, in at least one of a region between the mucosal layer and muscular layer of the gastrointestinal tract and a region in a mucosal surface of the mucosal layer so as to form a protection region that protects the mucosa basal layer from a medical substance that damages the tissue; and, after forming the protection region, supplying the medical substance to a mucosal surface in a target region, which is at a position different from the protection region in a circumferential direction of the gastrointestinal tract, or to a position between the mucosal layer and the muscular layer.

Abstract: A drug supply device includes: a tube body; a first expansion member configured to be expanded to a first outer diameter and a second expansion member configured to be expanded to a second outer diameter that is greater than the first outer diameter, the first expansion member and the second expansion member being positioned on a distal-end side of the tube body; and a masking member that extends between the expansion members and that is connected to outer surfaces of the expansion members at two ends thereof. The tube body includes an outlet that opens between the expansion members and a channel that is in communication with the outlet, the masking member is formed in an arc shape in a lateral cross-section that is orthogonal to the longitudinal axis, and the masking member stretches between the expansion members in a state in which the expansion members are expanded.

Abstract: A needle holder for holding a curved needle to which a suture thread is connected. The needle holder includes a flexible tube; and a grasper provided at a distal end of the flexible tube. The grasper includes a first jaw having a groove, and a protrusion at a distal end portion of the first jaw; and a second jaw movably connected to the first jaw. The grasper can hold the curved needle between the second jaw and the protrusion of the first jaw, and can hold a part of the suture thread between a surface of the groove and the second jaw such that another part of the suture thread passes through a gap formed between another surface of the groove and the second jaw. The protrusion has a hook surface for hooking the suture thread extending outside the groove.

Abstract: A gastrointestinal tract constricting method according to the present invention aims to constrict the gastrointestinal tract by contracting a desired region of the gastrointestinal tract by a simple and low-invasive procedure. The method includes forming spreading blocks while observing the gastrointestinal tract with an endoscope inserted into the gastrointestinal tract, the spreading blocks being formed at a position between a mucosa layer and a muscle layer and on both sides of a target region, which is to be damaged by a substance, in a circumferential direction of the gastrointestinal tract so that the spreading blocks block spreading of the substance in the circumferential direction of the gastrointestinal tract to prevent spreading of the substance to an outer side of the target region, and supplying the substance to a mucosal surface of the target region or to the position between the mucosa layer and the muscle layer after formation of the spreading blocks.

Abstract: A gastrointestinal-tract constricting method includes: while observing the gastrointestinal tract by inserting an endoscope into the gastrointestinal tract, forming a spreading block that suppresses infiltration of a substance, which damages a mucosa basal layer of the gastrointestinal tract, into the muscular layer underlying the mucosa basal layer, the spreading block being formed along a circumferential direction of the gastrointestinal tract and between the mucosa basal layer and the muscular layer; and supplying the substance to a gap between the spreading block and the mucosa basal layer while forming a contact surface between the spreading block and the substance along the circumferential direction of the gastrointestinal tract.

Abstract: A gastrointestinal-tract constricting method includes, while observing the gastrointestinal tract by inserting an endoscope into the gastrointestinal tract, forming a spreading block that blocks infiltration of a substance, which damages a mucosa basal layer of the gastrointestinal tract, into the muscular layer underlying the mucosa basal layer, the spreading block being formed along a circumferential direction of the gastrointestinal tract and between the mucosa basal layer and the muscular layer; and supplying the substance along the circumferential direction of the gastrointestinal tract and to a surface of the mucosa that lies within a region that overlaps an inner side of the gastrointestinal tract with respect to the spreading block out of the entire circumference of the gastrointestinal tract in a transverse section of the gastrointestinal tract.

Abstract: A gastrointestinal-tract constricting method comprises: while observing the gastrointestinal tract with an endoscope inserted into the gastrointestinal tract, placing a protection substance, which does not damage tissue, in at least one of a region between the mucosal layer and muscular layer of the gastrointestinal tract and a region in a mucosal surface of the mucosal layer so as to form a protection region that protects the mucosa basal layer from a medical substance that damages the tissue; and, after forming the protection region, supplying the medical substance to a mucosal surface in a target region, which is at a position different from the protection region in a circumferential direction of the gastrointestinal tract, or to a position between the mucosal layer and the muscular layer.

Abstract: A gastrointestinal-tract constricting method includes: while observing the gastrointestinal tract by inserting an endoscope into the gastrointestinal tract, forming a spreading block that suppresses infiltration of a substance, which damages a mucosa basal layer of the gastrointestinal tract, into the muscular layer underlying the mucosa basal layer, the spreading block being formed along a circumferential direction of the gastrointestinal tract and between the mucosa basal layer and the muscular layer; and supplying the substance to a gap between the spreading block and the mucosa basal layer while forming a contact surface between the spreading block and the substance along the circumferential direction of the gastrointestinal tract.