Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.

Abstract: This disclosure relates to remote control of dialysis machines. In certain aspects, a method includes receiving a request for a network connection from a dialysis machine and establishing the network connection with the dialysis machine. The method also includes receiving, from a client device, a request to access the dialysis machine, authorizing the client device to access the dialysis machine, receiving, from the dialysis machine, information pertaining to an operation of the dialysis machine, and providing, to the client device, the received information.

Abstract: A method for cleaning a water filtration membrane, the method having at least an alkaline cleaning step, wherein the method includes a first enzyme solution comprising a polypeptide having carbohydrase activity, and a second enzyme solution comprising a polypeptide having protease activity.

Abstract: Systems and methods for providing auto-completion options to input characters are presented. In response to receiving input characters, a plurality of items of content (that are non-textual items of content) of a corpus of content are identified. These items of content are clustered into n clusters of content according to similarities among the items of content. From the items of content of each cluster, a descriptive title is determined for the cluster. This descriptive title is an auto-completion option for the cluster. The descriptive titles/auto-completion options are provided in response to receiving the input characters.

Abstract: A method including: obtaining a detected representation of radiation redirected by each of a plurality of structures from a substrate additionally having a device pattern thereon, wherein each structure has an intentional different physical configuration of the respective structure than the respective nominal physical configuration of the respective structure, wherein each structure has geometric symmetry at the respective nominal physical configuration, wherein the intentional different physical configuration of the structure causes an asymmetric optical characteristic distribution and wherein a patterning process parameter measures change in the physical configuration; and determining a value, based on the detected representations and based on the intentional different physical configurations, to setup, monitor or correct a measurement recipe for determining the patterning process parameter.

Abstract: Systems and methods for presenting an interface for additional content suggestion can include obtaining data descriptive of the displayed content and determining additional content associated with the displayed content. An interface can then be provided that displays data associated with the displayed content and the additional content. The interface can include a first viewing window for displaying a portion of the displayed content and a second viewing window for displaying a snippet associated with the additional content.

Abstract: Embodiments of the present invention are directed to a wildcard matching solution that uses a combination of static random access memories (SRAMs) and ternary content addressable memories (TCAMs) in a hybrid solution. In particular, the wildcard matching solution uses a plurality of SRAM pools for lookup and a spillover TCAM pool for unresolved hash conflicts.

Abstract: A surgical device that includes a first support member extending along a longitudinal axis; a bladder located on the first support member; a first sealing member located on the bladder; and a second sealing member located on the bladder. The sealing member is located on one side of the longitudinal axis; and the second sealing member is located on another side of the longitudinal axis. The bladder is inflatable, and inflating the bladder changes a position of the first sealing member, the second sealing member, or both relative to the first support member.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: Certain aspects involve providing automated performance monitoring of statistical models. For example, a processing device is used for performing a statistical analysis on information in an archive to extract historical data, scores, and attributes. The processing device calculates performance metrics based at least in part on the historical data, scores, and attributes. The processing device pre-calculates summary performance data based at least in part on the performance metrics. The summary performance data is stored in files with predefined layouts, which are stored in a non-transitory, computer-readable medium. Segmented data is presented from a file to a user through a graphical user interface (GUI). In some aspects, various reports of the segmented data are presented interactively by detecting a selection by the user of a segmentation and displaying the corresponding segmented data.

Abstract: A best available video stream is determined for each of multiple conference participants within a conference room including multiple cameras based on scores determined for video streams obtained from the cameras. The scores are determined based on representations of the conference participants within the video streams, for example, based on percentages of conference participant faces visible within the video streams, directions of conference participant faces relative to the cameras, directions of eye gaze of the conference participants relative to the cameras, and/or degrees to which conference participant faces are obscured within the video streams. The best available video streams are output for rendering within separate user interface tiles of conferencing software.

Abstract: Electronic devices, methods, and program storage devices for achieving smooth zooming operations during video capture are disclosed. In particular, smooth zooming may be desirable during video capture operations that involve a single image capture device and/or transitioning between two or more distinct image capture devices, e.g., having different optical and/or zooming properties, during the video capture. When video zooming is done abruptly, it can lead to an unpleasant user experience. The techniques described herein to improve the smoothness of zooming operations include: the use of longer zoom “ramps” for image capture devices; the “early” transitioning between image capture devices during video capture; and the performance of additional “digital zoom smoothing-aware” video image stabilization operations. The embodiments described herein also provide for a more consistent user experience between video streaming (i.e., “preview”) modes and the recorded (i.e.

Abstract: A variable gain amplifier system includes a variable gain amplifier circuit configured to receive an input signal, apply a gain to the input signal, and generate an output signal in accordance with the gain applied to the input signal. The variable gain amplifier circuit is further configured to receive a gain control signal and a bandwidth control signal. A control module is configured to generate the gain control signal to adjust the gain of the variable gain amplifier circuit and generate, separately from the gain control signal, the bandwidth control signal to adjust a bandwidth of the variable gain amplifier circuit by selectively varying an amount of inductance contributed by an inductor circuit of the variable gain amplifier circuit.

Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents.

Abstract: In some implementations, a system may receive, from a first user, data associated with a new database entry to be added to a master database that is associated with multiple sets of users having different access permissions to entries in the master database. The system may write the data to a first repository, write an entry including the data to a master repository, and generate a record of the entry. The system may receive, from a second user, additional data associated with the new database entry. The system may write the additional data to a second repository, modify the entry in the master repository based on the additional data, and generate a record of the modified entry. The system may perform verifications and output a notification based on the verifications. The system may further output, to a public repository, the modified entry with at least one data value removed.

Abstract: Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

Abstract: Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.

Abstract: In some implementations, a system may receive, from a first user, data associated with a new database entry to be added to a master database that is associated with multiple sets of users having different access permissions to entries in the master database. The system may write the data to a first repository, write an entry including the data to a master repository, and generate a record of the entry. The system may receive, from a second user, additional data associated with the new database entry. The system may write the additional data to a second repository, modify the entry in the master repository based on the additional data, and generate a record of the modified entry. The system may perform verifications and output a notification based on the verifications. The system may further output, to a public repository, the modified entry with at least one data value removed.