Abstract: Provided are water-in-oil emulsion compositions which comprise: a. an alkalizing agent; b. a dimethicone surfactant; c. a fatty alcohol having a C16-36 alkyl group; d. an amphoteric surfactant; e. a waxy ether or a waxy ester; and f. a thickener. Such compositions may further comprise a hair colorant compound comprising an oxidation dye, and are suitable as a hair color-altering composition. Also provided are kits and methods of using said compositions.

Abstract: Disclosed herein is a hair treatment composition containing a polymer selected from crosslinked copolymers of (meth)acrylic acid and (C1-C6)alkyl esters, cross-linked anionic acrylate polymers, and acrylic associative polymers; a carbomer compound; a fatty alcohol that is liquid at room temperature; a fatty substance other than the fatty alcohol that is liquid at room temperature; an anionic surfactant; an amphoteric surfactant; a basic compound; a cosmetically acceptable solvent; and optionally, a colorant compound. Also disclosed is a process for altering the color of hair involving applying onto hair, a composition comprising the hair treatment composition and an oxidizing composition.

Abstract: The present disclosure relates to transparent ready-to-use hair bleaching compositions and compositions useful for preparing the transparent ready-to-use hair bleaching compositions. The transparent ready-to-use bleaching compositions typically include: (i) one or more oxidizing agents selected from the group consisting of persulfates, perborates, percarbonates, a salt thereof, and a mixture thereof; (ii) one or more non-acrylic thickening polymers; (iii) one or more acrylic polymers; (iv) hydrogen peroxide; (v) one or more polyurethane polyethers; and (vi) water. Kits and methods for bleaching hair also disclosed.

Abstract: The invention provides extracts and compositions derived from Tripterygium wilfordii for overcoming drug resistance in cancer therapy. This invention relates to organic solvent extracts of T. wilfordii and their use in cancer treatment, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods of treating a cancer are disclosed. The method administers to a patient in need thereof a combination of (a) an organic solvent extract of T. wilfordii and (b) a chemotherapeutic drug. The organic solvent extract of T. wilfordii (a) and chemotherapeutic drug (b) are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug (b) alone. Also disclosed are chemotherapeutic compositions comprising a combination of (a) an organic solvent extract of T.

Abstract: The present disclosure pertains to methods, devices and systems for neurological regulation. The methods, devices and systems described herein are useful, for example, in the treatment of conditions of the bladder such as overactive bladder.

Abstract: The present disclosure pertains to methods, devices and systems for neurological regulation. The methods, devices and systems described herein are useful, for example, in the treatment of conditions of the bladder such as overactive bladder.

Abstract: Methods and systems are disclosed for receiving and processing data analysis expressions. A particular method includes receiving a data analysis expression at a pivot table of a spreadsheet. The data analysis expression is executed for a particular cell of the pivot table by determining a context associated with the particular cell, calculating a value of the data analysis expression based on the context, and outputting the calculated value at the particular cell.

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

Abstract: This invention is directed to a novel method of treating an individual suffering from a bacterial infection, such as bacterial infections of various tissues or organs of an individual. In general, the method of treatment involves administering to an individual a pharmaceutical formulation that comprises a liposome-encapsulated antimicrobial agent, wherein polyethylene glycol (PEG) molecules are covalently attached to the surface of the liposomes.

Abstract: The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical co-morbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.

Abstract: Methods and systems are disclosed for receiving and processing data analysis expressions. A particular method includes receiving a data analysis expression at a pivot table of a spreadsheet. The data analysis expression is executed for a particular cell of the pivot table by determining a context associated with the particular cell, calculating a value of the data analysis expression based on the context, and outputting the calculated value at the particular cell.

Abstract: The application is to antibodies which have been labelled with polyenzymes (multiple enzymes), specifically polyperoxidases, for use in direct immunohistochemical assays of tissues. The antibodies used diagnostically may also be antibodies which are used therapeutically.

Abstract: Disclosed herein is a hair treatment composition containing a polymer selected from crosslinked copolymers of (meth)acrylic acid and (C1-C6)alkyl esters, cross-linked anionic acrylate polymers, and acrylic associative polymers; a carbomer compound; a fatty alcohol that is liquid at room temperature; a fatty substance other than the fatty alcohol that is liquid at room temperature; an anionic surfactant; an amphoteric surfactant; a basic compound; a cosmetically acceptable solvent; and optionally, a colorant compound. Also disclosed is a process for altering the color of hair involving applying onto hair, a composition comprising the hair treatment composition and an oxidizing composition.

Abstract: The invention provides compositions comprising wilforlide A for overcoming drug resistance in cancer therapy, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods and compositions for treating a cancer are disclosed. The method administers to a patient in need thereof a combination of wilforlide A and a chemotherapeutic drug. Wilforlide A and chemotherapeutic drug are administered in a combined amount effective to treat the can cer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug alone.

Abstract: A system for stabilizing a superior vertebra relative to an inferior vertebra includes a plate having a first surface for mating with the superior and inferior vertebra and a second surface opposite the first surface. The plate has a first hole configured for overlying the superior vertebra and a second hole configured for overlying the inferior vertebra. An alignment instrument has a leading portion and a trailing portion. The leading portion has a securing mechanism configured for removable attachment to a fastening mechanism of the plate. The alignment instrument also includes an alignment prong extending past the first surface of the plate when the plate is attached to the fastening mechanism. The alignment prong provides tactile information to the trailing portion of the alignment instrument for use in positioning the plate with respect to the superior and inferior vertebra.

Abstract: Methods and systems are disclosed for receiving and processing data analysis expressions. A particular method includes receiving a data analysis expression at a pivot table of a spreadsheet. The data analysis expression is executed for a particular cell of the pivot table by determining a context associated with the particular cell, calculating a value of the data analysis expression based on the context, and outputting the calculated value at the particular cell.

Abstract: The present disclosure pertains to methods, devices and systems for neurological regulation. The methods, devices and systems described herein are useful, for example, in the treatment of conditions of the bladder such as overactive bladder.

Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

Abstract: Methods and systems are disclosed for receiving and processing data analysis expressions. A particular method includes receiving a data analysis expression at a pivot table of a spreadsheet. The data analysis expression is executed for a particular cell of the pivot table by determining a context associated with the particular cell, calculating a value of the data analysis expression based on the context, and outputting the calculated value at the particular cell.

Abstract: The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical comorbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.