Abstract: The present disclosure provides heterocyclic amide and urea compounds and compositions thereof useful for inhibiting JAK2.

Abstract: In one embodiment, a coupler includes a glass tube having a refractive index n3 and a passageway, a first optical waveguide and a second optical waveguide positioned within the passageway, each of the first optical waveguide and the second optical waveguide comprising a core surrounded by a cladding. The glass tube further includes a tapered region having a taper length. A coupling region is present between the first optical waveguide and the second optical waveguide within the tapered region. A refractive index of the cladding is less than a refractive index of the core, and a lowest refractive index of the cladding of the first optical waveguide and the second optical waveguide is n2. Additionally, n3 is lower than n2 such that a value of ?2-3 is 0.07%??2-3?0.125, where ?2-3 equals (n22?n32)/2n22.

Abstract: Amino acid sequences of proteins can be produced using an autoencoder. For example, amino acid sequences of variant proteins can be produced by an autoencoder that is fed an amino acid sequence of a base protein as input. A decoding component of the autoencoder can include at least one or more components of a generative adversarial network.

Abstract: A system configured to generate tokens in response to the sequestration of carbon dioxide and a corresponding method are disclosed herein.

Abstract: A system configured to variably generate tokens in response to the sequestration of carbon dioxide and a corresponding method are disclosed herein.

Abstract: Embodiments described herein are directed to an annotation system having a remote processor, and a client processor in data communication with the remote processor. The client processor is adapted to send a first request for an electronic file to the remote processor, receive the electronic file from the remote processor, define at least one new annotation about the electronic file, and define at least one anchor associated with the at least one annotation. The at least one of the remote processor and the client processor is adapted to store the at least one anchor and the at least one annotation in an annotation file that is separate from the electronic file.