Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: A method for aligning displayed data in an augmented reality (AR) display includes determining a selected location context associated with a piece of equipment, determining a process element associated with the piece of equipment and according to a selected engineering process, determining, according to a digital representation of the equipment, a first location of the process element, receiving meta-sensor location data for one or more meta-sensors in the piece of equipment and indicating a second location for each of the meta-sensors with respect to the selected location context, determining a third location of the AR display with respect to the selected location context, determining overlay data for the process element, determining a display location according to the first location, the third location and the location data of each meta-sensor, and displaying the overlay data at the display location.

Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: One embodiment provides an electronic device, including: two or more ports; two or more charging circuits, wherein the two or more ports have an associated charging circuit; a battery; a processor; and a memory device that stores instructions executable by the processor to: detect, at a first port, a physically connected plug; detect, at a second port, a physically connected plug; and provide, via the two or more charging circuits, charging to the battery from both of the detected plugs. Other aspects are described and claimed.

Abstract: In one aspect a device includes at least one processor, a battery that powers the at least one processor, and storage accessible to the at least one processor. The device also includes circuitry to, responsive to a user command to decommission the battery, discharge the battery to render the battery inoperable.

Abstract: The present invention provides compounds of Formula I?: compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: In an embodiment, a method includes: adjusting a first flight control device of a rotorcraft to control flight around a first axis of the rotorcraft, the first flight control device exercising flight control authority around the first axis of the rotorcraft; detecting a failure of the first flight control device; transitioning at least a portion of the flight control authority around the first axis of the rotorcraft from the first flight control device to a second flight control device of the rotorcraft, the transitioning being performed automatically in response to detecting the failure of the first flight control device; and adjusting the second flight control device to control flight around the first axis of the rotorcraft, the second flight control device being adjusted by a first control process when the rotorcraft is in a first flight mode, the second flight control device being adjusted by a second control process when the rotorcraft is in a second flight mode.

Abstract: Novel tools and techniques are provided for implementing split and parallelized encoding or transcoding of audio and video. In various embodiments, a computing system might split an audio-video file that is received from a content source into a single video file and a single audio file. The computing system might encode or transcode the single audio file. Concurrently, the computing system might split the single video file into a plurality of video segments. A plurality of parallel video encoders/transcoders might concurrently encode or transcode the plurality of video segments, each video encoder/transcoder encoding or transcoding one video segment of the plurality of video segments. Subsequently, the computing system might assemble the plurality of encoded or transcoded video segments with the encoded or transcoded audio file to produce an encoded or transcoded audio-video file, which may be output to a display device(s), an audio playback device(s), or the like.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: In an embodiment, a method includes: adjusting a first flight control device of a rotorcraft to control flight around a first axis of the rotorcraft, the first flight control device exercising flight control authority around the first axis of the rotorcraft; detecting a failure of the first flight control device; transitioning at least a portion of the flight control authority around the first axis of the rotorcraft from the first flight control device to a second flight control device of the rotorcraft, the transitioning being performed automatically in response to detecting the failure of the first flight control device; and adjusting the second flight control device to control flight around the first axis of the rotorcraft, the second flight control device being adjusted by a first control process when the rotorcraft is in a first flight mode, the second flight control device being adjusted by a second control process when the rotorcraft is in a second flight mode.

Abstract: A tool and method of securing a clamp is provided. The tool includes a first handle having a first jaw portion on one end. An arm is pivotally coupled to the first handle, the having a second jaw portion on one end. A second handle is adjacent the first handle. A force adjustment mechanism is rotatably coupled between the arm and the second handle. The force adjustment mechanism has a biasing member operably coupled between the arm and an adjustment member, the force adjustment mechanism further having at least one bearing member disposed between the arm and the adjustment member. The second handle is arranged to rotate relative to the arm based at least in part on a force applied on the second handle by the biasing member via the at least one bearing member.

Abstract: Methods and systems for interacting with a user to build a customer profile include: receiving, by a processor, an identifier of the user; retrieving, by the processor, personal information of the user from a database system based on the identifier; recognizing, by the processor, preference information of the user from an image of the user; obtaining, by the processor, additional preference information of the user by managing a dialog between the user and a mirror display system; and storing, by the processor, the customer profile based on the personal information, the preference information, and the additional dialog information.

Abstract: In one aspect a device includes at least one processor, a battery that powers the at least one processor, and storage accessible to the at least one processor. The device also includes circuitry to, responsive to a user command to decommission the battery, discharge the battery to render the battery inoperable.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: A microbial infection in an eye of a subject is treated or prevented by topically administering to the eye an effective amount of a macromolecule or a pharmaceutically acceptable salt thereof that includes a dendrimer of 1 to 8 generations with one or more sulfonic acid- or sulfonate-containing moieties attached to one or more surface groups of the outermost generation of the dendrimer. Compositions containing the macromolecule or salt are useful in these methods.

Abstract: Provided herein are dendrimers comprising: a core unit, five generations of building units which are lysine residues or analogues thereof, first terminal groups comprising a cabazitazel residue covalently attached to a diglycolyl linker group, and second terminal groups comprising a PEG group. Also provided herein are pharmaceutical compositions comprising the dendrimers, and methods and uses of the dendrimers in therapy of disorders such as cancers. Processes for making the dendrimers and intermediates are also provided.

Abstract: Systems and methods are provided to stop both external and internal fraud, ensure correct actions are being followed, and information is available to fraud teams for investigation. The system includes components that can address: 1) behavioral analytics (ANI reputation, IVR behavior, account activity)—this gives a risk assessment event before a call gets to an agent; 2) fraud detection—the ability to identify, in real time, if a caller is part of a fraudster cohort' and alert the agent and escalate to the fraud team; 3) identity authentication—the ability to identify through natural language if the caller is who they say they are; and 4) two factor authentication—the ability to send a text message to the caller and automatically process the response and create a case in the event of suspected fraud.