Abstract: Hair care cleansing composition comprising—a) from 1 to 50 wt % of a cleansing surfactant selected from the group consisting of anionic surfactant, zwitterionic or amphoteric surfactant, non-ionic and mixtures thereof; and b) from 0.01 to 3 wt %, by weight of the total composition, of defibrillated primary cell wall material comprising cellulose microfibrils, wherein • the defibrillated primary cell wall material comprises up to 20 wt. % of water, based on the total weight of the fibrils; and wherein • the cellulose has an average degree of crystallinity of less than 50%, and wherein • the defibrillated primary cell wall material comprises polyols distributed between the fibrils.

Abstract: Systems and methods are provided to create training data, validate, deploy and test artificial intelligence (AI) systems in a virtual development environment, incorporating virtual spaces, objects, machinery, devices, subsystems, and actual human action and behavior.

Abstract: In one embodiment, thermite matches are provided. For instance, thermite matches as described herein may be constructed as a multi-staged formulation comprising an outer ignition tip, an optional inner transition tip, and a bulk fuel thermite stage. The outer ignition tip may comprise an ignition compound that can be struck/scraped against an abrasive counter-chemical surface (e.g., red phosphorous) to initiate the reaction. The outer ignition tip can reach a first burn temperature that can further ignite the inner transition tip stage, which can in turn burn at a temperature that reaches the ignition temperature of the bulk fuel thermite. The high burn temperature of the thermite match may then be used to ignite other materials, such as hard-to-ignite materials, such as a thermite rod for cutting or welding. Other embodiments provide for thermite match handles and a two-piece ignition thermite matches.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: In an embodiment, a method includes: collecting usage and maintenance data for a rotorcraft at a computer of the rotorcraft; sending the usage and maintenance data to a fleet management server; generating individualized equipment data for the rotorcraft according to the usage and maintenance data at the fleet management server, the individualized equipment data including a lightweight digital representation of the rotorcraft and technical publications for the rotorcraft, the lightweight digital representation including mesh-based 3D visualizations of each component of the rotorcraft, the technical publications having views referencing the mesh-based 3D visualizations; sending the individualized equipment data to the computer of the rotorcraft; and persisting the individualized equipment data at the computer of the rotorcraft.

Abstract: The present invention achieves technical advantages as an aircraft having an augmented reality flight control system integrated with and operable from the pilot seat and an associated pilot headgear unit, wherein the flight control system is supplemented by flight-assisting artificial intelligence and geo-location systems. The present invention includes an augmented reality flight control system incorporating real-world objects with virtual elements to provide relevant data to a pilot during aircraft flight. A translucent substrate is disposed in the pilot's field of view such that the pilot can see therethrough, and observe virtual elements displayed on the substrate. The system includes a headgear that is worn by the pilot. A flight assistance module is configured to receive data related to the aircraft and provide predictive assistance to the pilot during flight based on the received data based in part on a pilot profile having preferences related to the pilot.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.

Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting certain protein- protein interactions, and for treating cancer.

Abstract: In an embodiment, a method includes: collecting usage and maintenance data for a rotorcraft at a computer of the rotorcraft; sending the usage and maintenance data to a fleet management server; generating individualized equipment data for the rotorcraft according to the usage and maintenance data at the fleet management server, the individualized equipment data including a lightweight digital representation of the rotorcraft and technical publications for the rotorcraft, the lightweight digital representation including mesh-based 3D visualizations of each component of the rotorcraft, the technical publications having views referencing the mesh-based 3D visualizations; sending the individualized equipment data to the computer of the rotorcraft; and persisting the individualized equipment data at the computer of the rotorcraft.

Abstract: The present invention relates to methods and compositions for preventing or reducing the likelihood of Coronavirus (CoV) and/or Respiratory syncytial virus (RSV) infection in an individual, preventing or reducing the likelihood or severity of a symptom associated with a CoV and/or RSV infection in an individual, reducing the severity and/or duration of a CoV and/or RSV infection in an individual, or treating a CoV and/or RSV infection in an individual, preventing or reducing viral shedding in an individual infected with a CoV and/or RSV infection, or reducing transmission of a CoV and/or RSV in a population comprising administering to the individual an effective amount of a macromolecule wherein the macromolecule comprises a dendrimer of 3-5 generations with one or more sulfonic acid or sulfonate containing moieties attached to one or more surface groups. The present invention also relates to a device for delivering a composition comprising such a macromolecule.

Abstract: One embodiment provides an information handling device, including: an electronic component; and a tape strip comprising: a top surface; and a bottom surface; wherein each of the top surface and the bottom surface comprise alternating sections of adhesive areas and non-adhesive areas; wherein the electronic component is adhered to the top surface of the tape strip via an adhesive connection between the adhesive areas located on the top surface of the tape strip and a bottom surface of the electronic component and wherein the tape strip is adhered to the information handling device via another adhesive connection between the adhesive areas. Other aspects are described and claimed.

Abstract: A system, device, and method for predicting an active set of compounds that bind to a biomolecular target is disclosed. The system and device contain modules allowing for the prediction of an active set of compounds. A core identification module can identify the core of an initial lead compound. A core hopping module is used to identify potential lead compounds having different cores compared to the core of an initial lead compound. A scoring module can use computational techniques to calculate the relative binding free energy of each identified potential lead compound. An activity prediction module can use the relative binding free energy calculations to predict an active set of compounds that bind to the biomolecular target. Empirical analysis can be used to inform the accuracy and completeness of the predicted active set of compounds.