Patents by Inventor John M. McCoy

John M. McCoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ß-1,3-GALACTOSYLTRANSFERASES FOR USE IN THE BIOSYNTHESIS OF OLIGOSACCHARIDES
    Publication number: 20240084246
    Abstract: Methods and compositions for the production of Type 1 human milk oligosaccharides are described.
    Type: Application
    Filed: August 25, 2023
    Publication date: March 14, 2024
    Inventors: Kelly A. Miller, John M. McCoy
  • Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
    Patent number: 11643675
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: May 9, 2023
    Assignee: Glycosyn LLC
    Inventors: John M. McCoy, Matthew Ian Heidtman, Massimo Merighi
  • Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides
    Patent number: 11618912
    Abstract: The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: April 4, 2023
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, Matthew Ian Heidtman, John M. McCoy
  • Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
    Patent number: 11453900
    Abstract: The invention relates to methods and compositions for the production of fucosylated oligosaccharides.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 27, 2022
    Assignee: GLYCOSYN LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • SIALYLTRANSFERASES AND USES THEREOF
    Publication number: 20220243237
    Abstract: Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.
    Type: Application
    Filed: March 8, 2022
    Publication date: August 4, 2022
    Inventors: Srikrishnan Mallipeddi, Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Fucosylated oligosaccharides for prevention of coronavirus infection
    Patent number: 11331329
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection in the respiratory system and/or the GI tract of a subject.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 17, 2022
    Assignee: Glycosyn LLC
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation
    Patent number: 11324766
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection-induced host inflammation and/or to promote recovery from a respiratory pathogen infection-induced host inflammation in a subject.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 10, 2022
    Assignee: Glycosyn LLC
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • Sialyltransferases and uses thereof
    Patent number: 11274325
    Abstract: Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 15, 2022
    Assignee: Glycosyn LLC
    Inventors: Srikrishnan Mallipeddi, Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • ALPHA (1,2) FUCOSYLTRANSFERASE SYNGENES FOR USE IN THE PRODUCTION OF FUCOSYLATED OLIGOSACCHARIDES
    Publication number: 20220056497
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: June 22, 2021
    Publication date: February 24, 2022
    Inventors: John M. McCoy, Matthew Ian Heidtman, Massimo Merighi
  • Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
    Patent number: 11236376
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: February 1, 2022
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • FUCOSYLATED OLIGOSACCHARIDES FOR PREVENTION OF CORONAVIRUS INFECTION
    Publication number: 20210353654
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection in the respiratory system and/or the GI tract of a subject.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 18, 2021
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • 2'-FUCOSYLLACTOSE FOR THE PREVENTION AND TREATMENT OF CORONAVIRUS-INDUCED INFLAMMATION
    Publication number: 20210353653
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection-induced host inflammation and/or to promote recovery from a respiratory pathogen infection-induced host inflammation in a subject.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 18, 2021
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN ENGINEERED BACTERIA
    Publication number: 20210261995
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 26, 2021
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
    Patent number: 11046984
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: June 29, 2021
    Assignee: Glycosyn LLC
    Inventors: John M. McCoy, Matthew Ian Heidtman, Massimo Merighi
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 11028419
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 8, 2021
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 10815511
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: October 27, 2020
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • MICROORGANISMS AND METHODS FOR PRODUCING SIALYLATED AND N-ACETYLGLUCOSAMINE-CONTAINING OLIGOSACCHARIDES
    Publication number: 20200190548
    Abstract: The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: August 28, 2019
    Publication date: June 18, 2020
    Inventors: Massimo Merighi, Matthew Ian Heidtman, John M. McCoy
  • ALPHA (1,2) FUCOSYLTRANSFERASES SUITABLE FOR USE IN THE PRODUCTION OF FUCOSYLATED OLIGOSACCHARIDES
    Publication number: 20200087691
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: April 29, 2019
    Publication date: March 19, 2020
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN ENGINEERED BACTERIA
    Publication number: 20200080119
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 12, 2020
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Biosynthesis of human milk oligosaccharides in engineered bacteria
    Patent number: 10487346
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 26, 2019
    Assignee: Glycosyn LLC
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman