Patents by Inventor John M. McCoy

John M. McCoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
    Patent number: 9029136
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: May 12, 2015
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Strains of Lactobacillus Rhamnosus GG Capable of Growth on Lactose and the Uses Thereof
    Publication number: 20150044330
    Abstract: The invention provides compositions and methods utilizing an improved strain of bacteria, a Lac+ Lactobacillus rhamnosus strain of bacteria.
    Type: Application
    Filed: August 6, 2014
    Publication date: February 12, 2015
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Biosynthesis of Human Milk Oligosaccharides in Engineered Bacteria
    Publication number: 20140080201
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: September 23, 2013
    Publication date: March 20, 2014
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Alpha (1,2) Fucosyltransferases Suitable for Use in the Production of Fucosylated Oligosaccharides
    Publication number: 20140031541
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 30, 2014
    Applicant: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Use Of Purified 2'-Fucosyllactose, 3-Fucosyllactose and Lactodifucotetraose as Prebiotics
    Publication number: 20120294840
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 22, 2012
    Inventors: David S. Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Biosynthesis Of Human Milk Oligosaccharides In Engineered Bacteria
    Publication number: 20120208181
    Abstract: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: February 16, 2012
    Publication date: August 16, 2012
    Inventors: Massimo Merighi, John M. McCoy, Matthew Ian Heidtman
  • Compositions and Methods For Engineering Probiotic Yeast
    Publication number: 20100120701
    Abstract: The invention provides compositions and methods for engineering probiotic yeast to display ?(1,2) fucosylated glycans on their cell surface, and the use thereof in the prevention or treatment of infection.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 13, 2010
    Applicant: Glycosyn, Inc.
    Inventors: John M. McCoy, Phillips W. Robbins
  • Interaction trap systems for detecting protein interactions
    Publication number: 20090130676
    Abstract: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed.
    Type: Application
    Filed: March 26, 2008
    Publication date: May 21, 2009
    Inventors: Roger Brent, John M. McCoy, Timm H. Jessen, Chanxing Wilson Xu
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20080139452
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 12, 2008
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 7344861
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: March 18, 2008
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, II, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Chemokine with amino-terminal modifications
    Patent number: 6852508
    Abstract: This invention provides polynucleotides comprising sequences encoding amino-terminal-modified chemokines, the encoded amino-terminal-modified chemokines, and uses thereof.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: February 8, 2005
    Assignees: Genetics Institute, LLC, The General Hospital Corporation
    Inventors: Stephen H. Herrmann, Zhijian Lu, John M. McCoy, Stephen L. Swanberg, Bruce Walker, Otto Yang
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040248256
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa Collins-Racie, David Merberg, Cheryl Evans, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Michael R. Bowman, Elizabeth DiBlasio-Smith, Angela Widom
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040038276
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: July 8, 2003
    Publication date: February 26, 2004
    Applicant: GENETICS INSTITUTE, LLC.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Novel proteins
    Publication number: 20030166044
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: March 30, 2001
    Publication date: September 4, 2003
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy
  • Interaction trap systems for detecting protein interactions
    Publication number: 20030113749
    Abstract: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed.
    Type: Application
    Filed: June 4, 2002
    Publication date: June 19, 2003
    Inventors: Roger Brent, John M. McCoy, Timm H. Jessen, Chanxing Wilson Xu
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20030100053
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 29, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. La Vallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy
  • SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20030096951
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: May 22, 2003
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MICHAEL J. AGOSTINO, ROBERT STEININGER, VIKKI SPAULDING, GORDON G. WONG, HILARY F. CLARK, KIM FECHTEL, CHERYL EVANS, MAURICE TREACY
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20030044935
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 21, 2000
    Publication date: March 6, 2003
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. La Vallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • HUMAN CHORDIN-RELATED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20020197666
    Abstract: Novel human chordin-related proteins and polynucleotides encoding them are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: December 26, 2002
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MAURICE TREACY, ELIZABETH DIBLASIO-SMITH, ANGELA WIDOM
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020193567
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Applicant: Genetics institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael R. Bowman, Vikki Spaulding, McKeough Carlin-Duckett, Kerry Kelleher