Patents by Inventor John M. McCoy

John M. McCoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted expressed sequence tags (sESTs)
    Publication number: 20020173635
    Abstract: Secreted expressed sequence tags (sESTs) isolated from a varie
    Type: Application
    Filed: January 7, 2002
    Publication date: November 21, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins
    Publication number: 20020165151
    Abstract: Novel proteins and methods of treatment using same are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: November 7, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, Maurice Treacy, Cheryl Evans, Michael J. Agostino, Zhijian Lu, David Merberg, Kei Tashiro, Tomoyuki Nakamura, Tasuku Honjo
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020146769
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: October 10, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding
  • Secreted proteins
    Patent number: 6451318
    Abstract: Novel proteins are disclosed.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 17, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. La Vallie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins
    Publication number: 20020106356
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: August 28, 2001
    Publication date: August 8, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • Methods and compositions for diagnosing and treating preeclampsia and gestational trophoblast disorders
    Publication number: 20020102530
    Abstract: The invention provides methods for identifying compounds which are modulators of syncytin expression. The invention also provides methods for diagnosing a subject who is suffering from or at risk for developing preeclampsia, and kits for diagnosing such a subject. The invention further provides methods for treating a subject who is suffering from or at risk for developing preeclampsia. The invention still further provides methods for treating a subject who is suffering from a gestational trophoblast disorder.
    Type: Application
    Filed: July 9, 2001
    Publication date: August 1, 2002
    Inventors: James C. Keith, John M. McCoy, Sha Mi
  • Interaction trap systems for detecting protein interactions
    Patent number: 6399296
    Abstract: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: June 4, 2002
    Assignee: The General Hospital Corporation
    Inventors: Roger Brent, John M. McCoy, Timm H. Jessen, Chanxing Wilson Xu
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020065394
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 22, 2000
    Publication date: May 30, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20010039335
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 4, 2000
    Publication date: November 8, 2001
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary Clark, Kim Fechtel
  • Secreted proteins and polynucleotides encoding them
    Patent number: 6312921
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 6, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy
  • Method of inhibiting angiogenesis using secreted proteins
    Patent number: 6280739
    Abstract: Novel proteins are disclosed.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: August 28, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • METHOD OF TREATMENT WITH A SECRETED PROTIEN
    Publication number: 20010016650
    Abstract: Novel proteins and methods of treatment using sameare disclosed.
    Type: Application
    Filed: May 21, 1998
    Publication date: August 23, 2001
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, LISA A. RACIE, EDWARD R. LAVALLIE, MAURICE TREACY, CHERYL EVANS, MICHAEL J. AGOSTINO, ZHIJIAN LU, DAVID MERBERG, KEI TASHIRO, TOMOYUKI NAKAMURA, TAKUKU HONJO
  • Interaction trap systems for detecting protein interactions
    Patent number: 6242183
    Abstract: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: June 5, 2001
    Assignees: The General Hospital Corporation, The Genetics Institute, Inc.
    Inventors: Roger Brent, John M. McCoy, Timm H. Jessen
  • Human L105 polypeptides and polynucleotides encoding same
    Patent number: 6084071
    Abstract: A chemokine, human L105, is disclosed.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: July 4, 2000
    Assignee: Genetics Institute
    Inventors: Lisa A. Racie, Kenneth Jacobs, Zhijian Lu, Edward R. LaVallie, John M. McCoy
  • Interaction trap systems for detecting protein interactions
    Patent number: 6004746
    Abstract: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed.
    Type: Grant
    Filed: July 20, 1995
    Date of Patent: December 21, 1999
    Assignees: The General Hospital Corporation, Genetics Institute, Inc.
    Inventors: Roger Brent, John M. McCoy, Timm H. Jessen
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5985602
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 16, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Cheryl Evans
  • Human semaphorin E, secreted proteins and polynucleotides encoding them
    Patent number: 5981222
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: November 9, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5976838
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: November 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5976837
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: November 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Polynucleotides encoding secreted proteins
    Patent number: 5972652
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 26, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg