Abstract: A surgical device includes a guiding instrument; a protector comprised of a protective material held in a non-protecting state by the guiding instrument and having a protection state; and an actuator connected to the protector that is configured to advance the protector along the guiding instrument such that the protector is allowed to assume the protection state.

Abstract: Disclosed is an orthopedic implant that includes an anchor, a bore, and a compressible and expandable mesh. The anchor is configured to secure the implant at an implantation site and defines a longitudinal axis. The bore is defined by the anchor and extends along the longitudinal axis. The compressible and expandable mesh is aligned along the longitudinal axis and defines a plurality of openings. The mesh is configured to compress along the longitudinal axis and expand from the longitudinal axis to engage surrounding bone or tissue at the implantation site to secure the implant at the implantation site.

Abstract: An implant for a femoral head of a patient. The implant includes a shell implantable on the femoral head of the patient and correcting a defect of the femoral head. The shell is designed preoperatively to have a patient-specific first surface for articulation with the patient's acetabulum and a patient-specific periphery mateable with a periphery of the defect. The shell caps the defect and the first surface of the shell is continuous to a remaining healthy surface of the femoral head. The defect can be a bone defect, a cartilage defect or a combination thereof.

Abstract: Disclosed is an orthopedic implant that includes an anchor, a bore, and a compressible and expandable mesh. The anchor is configured to secure the implant at an implantation site and defines a longitudinal axis. The bore is defined by the anchor and extends along the longitudinal axis. The compressible and expandable mesh is aligned along the longitudinal axis and defines a plurality of openings. The mesh is configured to compress along the longitudinal axis and expand from the longitudinal axis to engage surrounding bone or tissue at the implantation site to secure the implant at the implantation site.

Abstract: A loader device includes a support pedestal movable over a range of longitudinal travel along a longitudinal axis, a support carriage movably mounted to the support pedestal, a loader actuator, and a dismount actuator. The support carriage is movable over a range of vertical travel along a normal axis, which is perpendicular to the longitudinal axis. The support carriage has a support arm adapted to support a tire casing. The loader actuator and dismount actuator are respectively adapted to selectively move: (1) at least a portion of a tire casing supported upon the support carriage in a loading direction along the longitudinal axis off of the support arm onto the expandable rim hub and (2) at least a portion of a tire casing supported upon the expandable rim hub in an opposing unloading direction off of the expandable rim hub and onto the support arm of the loader device.

Abstract: An implant for a femoral head of a patient. The implant includes a shell implantable on the femoral head of the patient and correcting a defect of the femoral head. The shell is designed preoperatively to have a patient-specific first surface for articulation with the patient's acetabulum and a patient-specific periphery mateable with a periphery of the defect. The shell caps the defect and the first surface of the shell is continuous to a remaining healthy surface of the femoral head. The defect can be a bone defect, a cartilage defect or a combination thereof.

Abstract: Disclosed is a modular trial system to select a neck length. The system may be in a hexagonal or click embodiments. A neck member may having at least a locating step with a locating step face. A head member may have at least a first groove and a second groove in an internal bore. The head member may be rotated relative to the neck member to select various trial lengths of the neck.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: A method for preparing a femoral neck for receiving a neck implant includes resecting a femoral head from a femoral neck of a patient according to a pre-operative patient-specific plan. The method also includes removing only cancellous bone from the femoral neck and proximal femoral bone of the patient using a patient-specific broach. The patient-specific broach has a three-dimensional cutting surface matching as a negative mold a cortical/cancellous bone interface surface of the femoral neck of the patient.

Abstract: A method for inserting an acetabular implant into the acetabulum of a patient. The method includes engaging a patient-specific surface of acetabular alignment guide to a complementary rim surface and periacetabular area of a patient. A plurality of alignment pins are inserted through corresponding alignment apertures of the acetabular alignment guide and into the periacetabular area of the patient. The acetabular alignment guide is removed without removing the alignment pins from the patient. An alignment adapter is coupled to an acetabular inserter over the alignment pins and an acetabular implant is implanted using the acetabular inserter.

Abstract: A method for preparing a femoral neck for receiving a neck implant includes resecting a femoral head from a femoral neck of a patient according to a pre-operative patient-specific plan. The method also includes removing only cancellous bone from the femoral neck and proximal femoral bone of the patient using a patient-specific broach. The patient-specific broach has a three-dimensional cutting surface matching as a negative mold a cortical/cancellous bone interface surface of the femoral neck of the patient.

Abstract: A surgical device includes a guiding instrument; a protector comprised of a protective material held in a non-protecting state by the guiding instrument and having a protection state; and an actuator connected to the protector that is configured to advance the protector along the guiding instrument such that the protector is allowed to assume the protection state.

Abstract: An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Abstract: Disclosed is a modular trial system to select a neck length. The system may be in a hexagonal or click embodiments. A neck member may having at least a locating step with a locating step face. A head member may have at least a first groove and a second groove in an internal bore. The head member may be rotated relative to the neck member to select various trial lengths of the neck.

Abstract: Disclosed is an orthopedic implant that includes an anchor, a bore, and a compressible and expandable mesh. The anchor is configured to secure the implant at an implantation site and defines a longitudinal axis. The bore is defined by the anchor and extends along the longitudinal axis. The compressible and expandable mesh is aligned along the longitudinal axis and defines a plurality of openings. The mesh is configured to compress along the longitudinal axis and expand from the longitudinal axis to engage surrounding bone or tissue at the implantation site to secure the implant at the implantation site.

Abstract: The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

Abstract: The present invention relates generally to modular demountable wall systems and more particularly, to a flexible and versatile demountable wall system for where control of air pressure and contaminants may be required.

Abstract: An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Abstract: Disclosed is an orthopedic implant that includes an anchor, a bore, and a compressible and expandable mesh. The anchor is configured to secure the implant at an implantation site and defines a longitudinal axis. The bore is defined by the anchor and extends along the longitudinal axis. The compressible and expandable mesh is aligned along the longitudinal axis and defines a plurality of openings. The mesh is configured to compress along the longitudinal axis and expand from the longitudinal axis to engage surrounding bone or tissue at the implantation site to secure the implant at the implantation site.

Abstract: A method for centering a stem of an implant at an implantation site. The method includes implanting at the implantation site the implant having a sleeve rigidly mounted to the stem of the implant, the stem extends through an interior area of the sleeve. The method further includes compressing the sleeve by applying force to the sleeve to expand a mesh portion of the sleeve outward from the stem and into engagement with sidewalls of the implantation site to thereby center the stem at the implantation site.