Abstract: A pelvic implant assembly and associated methods. The implant assembly includes an acetabular component, and a compliant fixator coupling the acetabular component to the pelvis.

Abstract: An orthopedic implant manufacturing method. The method includes preparing a preliminary pre-operative surgical plan for a specific patient, communicating the plan to a surgeon of the patient, and receiving an orthopedic implant design recommendation of the surgeon. The implant design recommendation can include selecting one of first, second or third options, the first option being a patient-specific implant, the second option being a semi-custom implant, and the third option being an off-the-shelf implant. The method further includes sending a request for manufacturing the selected implant to a manufacturing center, receiving the implant, and forwarding the implant for implantation.

Abstract: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.

Abstract: An orthopedic implant. The implant has a first portion including at least one patient-adjustable feature, and a second portion including at least one standard feature.

Abstract: A fixation device and method for attaching an external prosthesis to a bone. The fixation device includes a main body having a compliant portion operable to be expanded and contracted. The main body has a first end fixedly retained in the bone and a second end coupled to an extension for receiving the external prosthesis. The main body and the extension define respectively first and second engagement surfaces for constraining a bone graft therebetween.

Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: An implant for the anatomy, which includes a connecting portion that can be used during a secondary or revisionary procedure to interconnect the first implant with a second anatomical implant. For example, an elongated shaft may be implanted into a femur to reinforce the femur. In addition, the elongated implant includes a connecting portion, which is covered by a temporary or provisional cap. If a revision or secondary procedure is necessary, the provisional cap may be removed to expose an interconnecting portion to receive a secondary implant during the revisionary procedure.

Abstract: A fixation device and method for attaching an external prosthesis to a bone. The fixation device includes a main body having a compliant portion operable to be expanded and contracted. The main body has a first end fixedly retained in the bone and a second end coupled to an extension for receiving the external prosthesis. The main body and the extension define respectively first and second engagement surfaces for constraining a bone graft therebetween.

Abstract: Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.

Abstract: Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.

Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: A bone screw, and method of using the same, are described. The bone screw includes (1) a distal threaded portion having a first orientation, (2) a proximal head portion, and (3) an intermediate portion including a compressive member, such as but not limited to a single or double helix, integral with the distal and proximal portions, wherein the compressive member has a second orientation opposite that of the first orientation. When a force (e.g., rotational or axial) is applied to the bone screw in the first direction, the spaces between the surfaces of the compressive member increase, due to the difference in orientation. In this stressed state, a resorbable material is then applied within the spaces and is allowed to cure. Once the bone screw is inserted into the bone member, the resorbable material will begin to be resorbed, whereupon the compressive member will relax and exert tension between the bone member and any other object the bone screw is secured to.

Abstract: Human Chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Abstract: Phenylalanine sulfonamide derivatives and their use as CCR-3 receptor antagonist.

Abstract: An acetabular prosthesis for implantation in an acetabulum includes an acetabular cup and a modular attachment component. The acetabular cup includes an outer surface operable to be received in the acetabulum and an inner surface operable to receive a bearing liner. The modular attachment component includes an attachment member and an engagement member. The attachment member is operable for use in attaching the modular attachment component to the acetabular cup and the engagement member is operable to engage a region of the acetabulum. The attachment member may nest within an anti-rotation counterbore or be slidably received within a channel of an attachment plate extending from the acetabular cup. The engagement member may be an elongated intramedullary blade, a flange or a hook.

Abstract: Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract: An improved method is provided for transferring data files between a first computing device and a second computing device interconnected by a network. The method includes: establishing a first network connection between the first computing device and a second computing device using the hypertext transfer protocol (HTTP); registering a file transfer request for a given data file with a server application residing on the second computing device; establishing a second network connection between the first computing device and the second computing device using HTTP; retrieving the file transfer request from the server application via the second network connection; and transferring the data file via the second network connection in response to the file transfer request retrieved from the server application.