Abstract: Disclosed is a system for replacing a portion of cartilage in an acetabulum. A prosthesis can be positioned within an acetabulum to form a portion of the articulation surface within the acetabulum and to articulate with a femoral bone. For example, an acetabular prosthesis can be implanted to articulate with the natural femoral head.

Abstract: A prosthetic device for replacement of a first pelvic portion of a pelvis of a patient opposite to a second pelvic portion relative to a median plane includes an acetabular component a flange component and a pubis component. The acetabular component has a first connecting portion and a second connecting portion at an angle relative to the first connecting portion, the angle selected for a corresponding anatomy of the patient. The flange component is coupled to the first connecting portion and configured to attach to a healthy pelvic portion on a same side of the median plane from the first pelvic portion. The pubis component is connected to the second connecting portion of the acetabular component and having a clamping portion configured to attach to a healthy pubis bone on an opposite side of the median plane from the first pelvic portion.

Abstract: A prosthetic system for replacement of a portion of a hip bone including a plurality of acetabular components and a plurality of flange components. The prosthetic system also includes a plurality of pubis components. Each of the pubis components and each of the flange components are operable to connect to each of the acetabular components. Each of the pubis components define a clamping portion that is configured to attach to an opposed healthy pubis bone. An angle between the flange component and the pubis component varies among the acetabular components.

Abstract: The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.

Abstract: An acetabular device includes a patient-specific acetabular alignment guide including a bone engagement surface. The bone engagement surface has a first portion configured and shaped to be conforming and complementary to an acetabular rim surface and a second portion configured and shaped to be conforming and complementary to a periacetabular area of an acetabulum of a patient. The acetabular alignment guide includes a plurality of guiding formations extending through the second portion for guiding a plurality of alignment pins therethrough. The bone engagement surface and the plurality of guiding formations are prepared from a three-dimensional model of the acetabulum of the specific patient reconstructed pre-operatively from a scan of the patient.

Abstract: An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Abstract: A method for preparing a femoral neck for receiving a neck implant includes obtaining image data of a proximal femoral bone and femoral neck of a patient by a medical imaging method and constructing a three-dimensional image model of the proximal femoral bone and neck of the patient using the image data. The method further includes identifying a three-dimensional cortical boundary surface at an interface between cortical and cancellous bone of the patient using the image model. A patient-specific broach having a three-dimensional cutting surface closely matching and complementary to the cortical boundary surface of the patient using the image model is designed and manufactured.

Abstract: An orthopedic implant. The implant has a first portion including at least one patient-adjustable feature, and a second portion including at least one standard feature.

Abstract: A patient-specific acetabular resection guide includes a dome-shaped surface bounded by a periphery. The dome-shaped surface is a three-dimensional patient-specific surface designed to anatomically match and be received into an acetabulum of the patient, based on a three-dimensional image of a hip joint of the patient reconstructed from a medical scan of the hip joint. The resection guide includes a plurality of guiding formations defined on the resection guide and having patient-specific shapes and orientations for guiding corresponding osteotomies relative to the acetabulum for correcting hip dysplasia.

Abstract: A method for producing ammonium metatungstate from ammonium paratungstate includes preparing an ammonium paratungstate mixture including solid ammonium paratungstate and water. The mixture is contacted with a cation exchange material to lower a pH of the mixture to a pH range wherein metatungstate ion is stable and an insoluble tungstic acid is not formed. The pH of the mixture may be maintained in the pH range until the ammonium paratungstate mixture is converted into an ammonium metatungstate solution.

Abstract: A method for producing ammonium metatungstate from ammonium paratungstate includes preparing an ammonium paratungstate mixture including solid ammonium paratungstate and water. The mixture is contacted with a cation exchange material to lower a pH of the mixture to a pH range wherein metatungstate ion is stable and an insoluble tungstic acid is not formed. The pH of the mixture may be maintained in the pH range until the ammonium paratungstate mixture is converted into an ammonium metatungstate solution.

Abstract: An intramedullary fixation device and associated method. The intramedullary fixation device includes a first intramedullary component having a first bone-attachment end and a first elongated member, a second intramedullary component having a second bone-attachment end and a second elongated member, and a compliant member coupling the first and second intramedullary components for applying bone-compressing stress. The second intramedullary component defines a sleeve such that the first elongated member can pass therethrough.

Abstract: A drive line (A) for testing a component (D) of a drive train of a vehicle comprises a torque sensor. The torque sensor measures AC variations in torque due to the operation of the component (D). The component (D) is coupled to the drive line by an adapter having a coupling for coupling the drive line to the axle. The torque sensor may output both AC and DC components of measured torque variation. A servo controller controls the drive line so that the drive line is driven into abutment with the axle and then backed off by a small preset distance.

Abstract: A method of selecting a patient matched hip joint prosthesis includes identifying a plurality of first parameters of a hip joint anatomy of the patient. The method also includes selecting a standard modular neck member from a set of different standard modular neck members to substantially match the first parameters of the hip joint anatomy of the patient. Moreover, the method includes performing a hip joint mechanical analysis using the selected standard modular neck member. Further, the method includes choosing for implantation either the selected modular neck member, a different standard modular neck member, or a custom designed neck member based on the hip joint mechanical analysis.

Abstract: A method for producing ammonium metatungstate from ammonium paratungstate includes preparing an ammonium paratungstate mixture including solid ammonium paratungstate and water. The mixture is contacted with a cation exchange material to lower a pH of the mixture to a pH range wherein metatungstate ion is stable and an insoluble tungstic acid is not formed. The pH of the mixture may be maintained in the pH range until the ammonium paratungstate mixture is converted into an ammonium metatungstate solution.

Abstract: An orthopedic apparatus includes an alignment guide attachable to one of a femoral joint surface of a femur of a patient. The alignment guide has a patient-specific three-dimensional engagement surface, and at least one guiding portion defining a guiding passage. The engagement surface anatomically matches a corresponding portion of the femoral joint surface.

Abstract: The present invention relates generally to the use of PA131 polypeptides and polynucleotides for healing various wounds arising from different causes.

Abstract: The present invention relates generally to the use of PA126 polypeptides and polynucleotides for healing various wounds arising from different causes.

Abstract: The present invention relates to a non-invasive expandable implant utilizing energy from an epiphyseal growth plate of a human long bone to expand the implant. A bone replacement section includes a housing, an expansion shaft, a connection system, and an implant member. An anchoring member is secured to the second bone portion and spaced from the implant member. The expansion shaft is configured to translate a first distance between the housing and the first bone member. Growth of the bone causes an increase of a second distance between an implant portion and the anchoring member. The increase of the second distance causes the anchoring member to exert a force on a connection system causing an increase of the first distance, thus expanding the implant.

Abstract: A pelvic implant assembly and associated methods. The implant assembly includes an acetabular component, and a compliant fixator coupling the acetabular component to the pelvis.