Abstract: 1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.

Abstract: Disclosed herein are bispecific antibodies comprising a first targeting moiety that specifically binds to CD47 and a second targeting moiety that specifically binds to EpCAM or EGFR and, pharmaceutical compositions and methods comprising the bispecific antibodies.

Abstract: A printed circuit board (PCB) (4) including an upper surface having one or more electrical terminals (9) thereon, said terminal adapted for connection to corresponding terminal of one or more electrical components, and further including one or more platforms (10) fabricated thereon, said platforms being located adjacent to corresponding component terminals, said platforms being adapted to support an electrical component thereupon, such that a portion of the component overhangs said platform above said corresponding PCB terminal.

Abstract: A method for editing and updating content of a collaborative document within a preview user interface is provided. The method includes receiving, by a content management platform, a request for a document stored within the content management platform in a format of a first application, wherein the request is received from a client device of a first user of the content management platform via a second application that is different from the first application, and wherein the document includes a first comment provided by a second user of the content management platform at a first point in time with respect to a first portion of the collaborative document.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: A first request to create a folder to organize data files that are to be stored at a third-party storage server is received at an application server and from a user device. Responsive to receiving the first request to create the folder, a second request indicating that the folder is to be created at the third-party storage server is sent by the application server and to the third-party storage server. An indication that the folder has been created at the third-party storage server is received from the third-party storage server. Responsive to receiving the indication that the folder has been created at the third-party storage server, an instance of the folder is generated by the application server.

Abstract: A method for editing and updating content of a collaborative document within a preview user interface is provided. The method includes a content management platform receives a request for a file stored which is stored in a third-party application format. The system causes a rendered graphical image of the file to be presented within a preview user interface. The rendered graphical image of the file represents a view of the file as if opened within a third-party application. The system receives from the preview user interface, content associated with a portion of the file. The system generates a new version of the file that includes the content associated with the portion of the file.

Abstract: The present invention provides antibodies that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further provides bispecific antibodies that bind to EGFRvIII and another antigen (e.g., CD3) as well as antibody conjugates (e.g., antibody-drug-conjugates). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific) and antibody conjugates. The invention further relates to therapeutic methods for use of these antibodies and antibody conjugates for the treatment of EGFRvIII-mediated pathologies, including cancer such as glioblastoma.

Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.

Abstract: An automotive power package includes a heat sink layer fabricated onto at least one surface of the automotive power package. The heat sink layer includes a material having a thermal conductivity higher than 130 W/m-K and a coefficient of thermal expansion between 5 and 15 ppm/° C.

Abstract: An application server receives from a user device a first request to create a data file that is to be stored at a third-party storage server. Responsive to receiving the first request to create a data file that is to be stored at the third-party storage server, the application server sends to the third-party storage server a second request indicating that the data file is to be created at the third-party storage server. An indication that the data file has been created at the third-party storage server is received from the third-party storage server. Responsive to receiving the indication that the data file has been created at the third-party storage server, the application server generates an instance of the data file that is stored at the application server. The application server provides to the user device the instance of the data file for edit via a relevant application.

Abstract: A cord lock has a housing with an interior cavity and an opening extending between the front and the back for receiving a cord, and an actuator having two legs that are configured to slide within the interior cavity of the housing. A spring is disposed between the housing and the actuator to bias the actuator in a raised position relative to the housing. There is a cam disposed in the interior cavity of the housing. The bottom of the cam is rotatably connected to the housing and the top is rotatably connected to the legs of the actuator. In a resting position, the spring presses the top of the cam against the housing such that when a cord is extended through the opening, the cam locks the cord in place between the cam and the housing. Depressing the actuator compresses the spring and rotates the cam.

Abstract: A attachment system is formed by a primary device and a secondary device connected to the primary device in a pivoting manner. The primary device has a main body, two lateral sides and a bar for attaching the primary device to another object. Each of the lateral sides has a protrusion extending laterally outward from the lateral sides. The secondary device has two lateral sides, each equipped with an aperture that corresponds to one of the protrusions on the primary device, so that fitting the protrusions into the apertures pivotally connects the primary device to the secondary device, with the lateral sides of the secondary device being disposed outside of the lateral sides of the primary device. The secondary device can be pivoted between a folded position where the secondary device lies against the primary device, and an open position where the secondary device is raised up.

Abstract: A cord lock has a housing with an interior cavity and an opening extending between the front and the back for receiving a cord, and an actuator having two legs that are configured to slide within the interior cavity of the housing. A spring is disposed between the housing and the actuator to bias the actuator in a raised position relative to the housing. There is a cam disposed in the interior cavity of the housing. The bottom of the cam is rotatably connected to the housing and the top is rotatably connected to the legs of the actuator. In a resting position, the spring presses the top of the cam against the housing such that when a cord is extended through the opening, the cam locks the cord in place between the cam and the housing. Depressing the actuator compresses the spring and rotates the cam.

Abstract: An application server receives from a user device a first request to create a data file that is to be stored at a third-party storage server. Responsive to receiving the first request to create a data file that is to be stored at the third-party storage server, the application server sends to the third-party storage server a second request indicating that the data file is to be created at the third-party storage server. An indication that the data file has been created at the third-party storage server is received from the third-party storage server. Responsive to receiving the indication that the data file has been created at the third-party storage server, the application server generates an instance of the data file that is stored at the application server. The application server provides to the user device the instance of the data file for edit via a relevant application.

Abstract: A cord lock has a housing with an interior cavity and an opening extending between the front and the back for receiving a cord, and an actuator having two legs that are configured to slide within the interior cavity of the housing. A spring is disposed between the housing and the actuator to bias the actuator in a raised position relative to the housing. There is a cam disposed in the interior cavity of the housing. The bottom of the cam is rotatably connected to the housing and the top is rotatably connected to the legs of the actuator. In a resting position, the spring presses the top of the cam against the housing such that when a cord is extended through the opening, the cam locks the cord in place between the cam and the housing. Depressing the actuator compresses the spring and rotates the cam.

Abstract: A strap adjustment system has a base body having a bottom wall, two side walls and a strap retaining bar extending between the two side walls, the bottom wall having an aperture therethrough with screw threads extending around an inside surface, and a screw disc having a central protrusion and screw threads extending around the central protrusion. The central protrusion fits through the aperture in the base body by rotating the screw disc so that the threads in the screw disc mate with the threads in the aperture, such that a height of the protrusion above the bottom wall of the base body is adjustable by turning the screw disc. In situations where a high degree of friction is required, the protrusion can be positioned at a maximum height through the aperture, and in situations where a low degree of friction is desired, the protrusion can be positioned lower.

Abstract: Clip-on sunglasses for plastic eyeglass frames are shaped more like a bracket, with a nearly 90° bend to accommodate the thickness of plastic eyeglass frames. The ends of the bracket also angle for 45° towards each other to avoid hitting the nose piece of the plastic eyeglass frame. In the clip-on sunglasses, a latch controls two arms to rotate the arms up to a 45° angle with respect to a pair of plastic eyeglass frames. The arms are formed in three bent portions so as to extend away from an interconnecting rod portion. The three bent portions of the arms allows the latch to fit the shape of the plastic eyeglass frame along the bridge portion of the eyeglass frame as effectively as possible and minimizes movement of the clip-on sunglasses relative to the eyeglass frame.

Abstract: Systems and methods disclosed herein provide access to a data file stored at a remote data storage system. A user device can send a file access request, via a user interface provided by the remote storage server, to the application server to access a data file stored at the remote storage server. The application server can then optionally identify a relevant application for accessing the data file, and send, to the remote server, a metadata-and-content request relating to the data file. The metadata-and-content request includes version information of a previously cached version of the data file cached at the application server. When the cached version is not the latest version, the application server receives the latest version of the data file from the remote storage server. The latest version of the data file is then presented, via the relevant application on the application server, to the user device.